SG11201405035XA - Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine - Google Patents

Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine

Info

Publication number
SG11201405035XA
SG11201405035XA SG11201405035XA SG11201405035XA SG11201405035XA SG 11201405035X A SG11201405035X A SG 11201405035XA SG 11201405035X A SG11201405035X A SG 11201405035XA SG 11201405035X A SG11201405035X A SG 11201405035XA SG 11201405035X A SG11201405035X A SG 11201405035XA
Authority
SG
Singapore
Prior art keywords
methanesulfonylethylamine
ethoxy
processes
preparation
Prior art date
Application number
SG11201405035XA
Inventor
Jasti Venkateswaralu
Chinnapillai Rajendiran
Nallamaddi Ravikumar Reddy
Terrence Joseph Connolly
Alexander L Ruchelman
Jeffrey Eckert
Anthony Joseph Frank
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47755073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201405035X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of SG11201405035XA publication Critical patent/SG11201405035XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02Sulfinic acids; Derivatives thereof
    • C07C313/06Sulfinamides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/24Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/26Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
SG11201405035XA 2012-02-21 2013-02-20 Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine SG11201405035XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261601226P 2012-02-21 2012-02-21
PCT/US2013/026780 WO2013126360A2 (en) 2012-02-21 2013-02-20 Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine

Publications (1)

Publication Number Publication Date
SG11201405035XA true SG11201405035XA (en) 2014-09-26

Family

ID=47755073

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201405035XA SG11201405035XA (en) 2012-02-21 2013-02-20 Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine

Country Status (36)

Country Link
US (3) US9187417B2 (en)
EP (4) EP3378850B8 (en)
JP (1) JP2015509496A (en)
KR (1) KR101993248B1 (en)
CN (3) CN112812044B (en)
AR (2) AR090100A1 (en)
AU (1) AU2013203283B2 (en)
BR (2) BR122021020046B1 (en)
CA (1) CA2864517A1 (en)
CO (1) CO7061071A2 (en)
CR (1) CR20140395A (en)
CY (1) CY1122799T1 (en)
DK (2) DK3378850T3 (en)
ES (3) ES2735801T3 (en)
HK (1) HK1205501A1 (en)
HR (2) HRP20191249T1 (en)
HU (2) HUE044192T2 (en)
IL (3) IL234135A (en)
IN (1) IN2014DN06740A (en)
LT (2) LT3378850T (en)
MX (2) MX350731B (en)
MY (1) MY168296A (en)
NI (1) NI201400093A (en)
NZ (1) NZ628028A (en)
PH (1) PH12014501865B1 (en)
PL (2) PL3312156T3 (en)
PT (2) PT3312156T (en)
RS (2) RS60036B1 (en)
RU (1) RU2632875C2 (en)
SG (1) SG11201405035XA (en)
SI (2) SI3378850T1 (en)
TR (1) TR201910430T4 (en)
TW (1) TW201336815A (en)
UA (1) UA116773C2 (en)
WO (1) WO2013126360A2 (en)
ZA (1) ZA201405892B (en)

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CN104803897A (en) * 2015-04-23 2015-07-29 中山奕安泰医药科技有限公司 Synthetic process of Apremilast intermediate
US10370329B2 (en) * 2015-04-27 2019-08-06 Mylan Laboratories Limited Process for the enantiomeric resolution of apremilast intermediates
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WO2017094031A2 (en) * 2015-12-04 2017-06-08 Sun Pharmaceutical Industries Limited Novel process for preparation of apremilast
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CN106543050B (en) * 2016-09-28 2018-04-10 中南大学湘雅医院 A kind of synthesis technique of Apremilast intermediate
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EP3504013B1 (en) 2016-11-10 2021-08-11 SMS Group GmbH Method for producing a metal strip in a cast-rolling installation
CN107445875A (en) * 2017-03-22 2017-12-08 陕西科技大学 A kind of chiral separation method for being used to prepare the high-purity intermediate of Apremilast
ES2866476T3 (en) 2017-04-04 2021-10-19 Quim Sintetica S A Racemic beta-aminosulfone compounds
SI3606908T1 (en) 2017-04-04 2020-10-30 Quimica Sintetica, S.A. Resolution of racemic beta-aminosulfone compounds
CN107966509B (en) * 2017-11-23 2020-06-23 中山奕安泰医药科技有限公司 Detection method of (S) -1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethylamine
CN107976501B (en) * 2017-11-23 2020-08-25 中山奕安泰医药科技有限公司 Detection method of 1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethylamine
CN107827722B (en) * 2017-11-23 2021-02-19 中山奕安泰医药科技有限公司 Synthetic method of 3-ethoxy-4-methoxybenzaldehyde
CN107941945B (en) * 2017-11-23 2020-12-22 中山奕安泰医药科技有限公司 Detection method of 3-ethoxy-4-methoxybenzonitrile
CN108008035B (en) * 2017-11-23 2020-07-07 中山奕安泰医药科技有限公司 Method for detecting purity of 3-ethoxy-4-methoxybenzaldehyde
CN108084066A (en) * 2017-12-12 2018-05-29 中山大学 A kind of synthetic method of Apremilast and enantiomter
CN113896674B (en) * 2021-09-01 2023-10-27 深圳华中科技大学研究院 Synthesis method of apremilast
CN115850129B (en) * 2023-02-28 2023-05-16 凯莱英生命科学技术(天津)有限公司 Process for the preparation of (S) -1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethylamine

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Publication number Publication date
BR112014020444A2 (en) 2020-10-27
PL3312156T3 (en) 2019-10-31
US9187417B2 (en) 2015-11-17
SI3378850T1 (en) 2020-07-31
RS60036B1 (en) 2020-04-30
EP3702347A1 (en) 2020-09-02
CN104245668A (en) 2014-12-24
RU2632875C2 (en) 2017-10-11
CN112812044A (en) 2021-05-18
LT3312156T (en) 2019-08-12
MX2014010002A (en) 2014-09-08
CN104245668B (en) 2017-05-17
MX350731B (en) 2017-09-15
HUE044192T2 (en) 2019-10-28
CR20140395A (en) 2014-11-17
KR101993248B1 (en) 2019-06-26
MX344190B (en) 2016-12-08
EP3702347B1 (en) 2023-11-08
TR201910430T4 (en) 2019-08-21
HUE048412T2 (en) 2020-07-28
CO7061071A2 (en) 2014-09-19
IL234135A (en) 2017-06-29
AR117963A2 (en) 2021-09-08
IL252459B (en) 2020-03-31
AU2013203283B2 (en) 2015-11-26
EP3312156A1 (en) 2018-04-25
MY168296A (en) 2018-10-23
ES2675168T3 (en) 2018-07-09
PH12014501865A1 (en) 2014-11-17
EP3312156B1 (en) 2019-06-05
SI3312156T1 (en) 2019-09-30
AR090100A1 (en) 2014-10-22
PH12014501865B1 (en) 2014-11-17
HRP20200245T1 (en) 2020-05-15
IL252459A0 (en) 2017-07-31
US9688623B2 (en) 2017-06-27
JP2015509496A (en) 2015-03-30
IL273050A (en) 2020-04-30
US9586897B2 (en) 2017-03-07
HK1205501A1 (en) 2015-12-18
RS59071B1 (en) 2019-09-30
EP3378850A1 (en) 2018-09-26
RU2014138037A (en) 2016-04-10
CN107033042A (en) 2017-08-11
PT3378850T (en) 2020-03-06
EP2817288B1 (en) 2018-05-30
PL3378850T3 (en) 2020-07-27
PT3312156T (en) 2019-07-19
UA116773C2 (en) 2018-05-10
ES2735801T3 (en) 2019-12-20
TW201336815A (en) 2013-09-16
ZA201405892B (en) 2015-11-25
ES2773686T3 (en) 2020-07-14
EP3378850B1 (en) 2020-01-08
US20160031808A1 (en) 2016-02-04
HRP20191249T1 (en) 2019-10-18
US20130217918A1 (en) 2013-08-22
WO2013126360A3 (en) 2013-10-31
NI201400093A (en) 2016-11-30
BR122021020040B1 (en) 2022-05-31
WO2013126360A2 (en) 2013-08-29
NZ628028A (en) 2016-03-31
EP3378850B8 (en) 2020-03-04
CN112812044B (en) 2023-05-30
EP2817288A2 (en) 2014-12-31
DK3312156T3 (en) 2019-07-22
IN2014DN06740A (en) 2015-05-22
KR20140126389A (en) 2014-10-30
BR122021020046B1 (en) 2022-05-31
LT3378850T (en) 2020-04-10
CY1122799T1 (en) 2021-05-05
CA2864517A1 (en) 2013-08-29
US20170129852A1 (en) 2017-05-11
AU2013203283A1 (en) 2013-09-05
DK3378850T3 (en) 2020-03-16

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