MX344190B - Procesos para la preparacion de (s) - 1 - (3 - etoxi - 4 - metoxifenil) - 2 - metansulfoniletilamina. - Google Patents

Procesos para la preparacion de (s) - 1 - (3 - etoxi - 4 - metoxifenil) - 2 - metansulfoniletilamina.

Info

Publication number
MX344190B
MX344190B MX2014010002A MX2014010002A MX344190B MX 344190 B MX344190 B MX 344190B MX 2014010002 A MX2014010002 A MX 2014010002A MX 2014010002 A MX2014010002 A MX 2014010002A MX 344190 B MX344190 B MX 344190B
Authority
MX
Mexico
Prior art keywords
ethoxy
processes
preparation
methanesulfonylethylamine
methoxyphenyl
Prior art date
Application number
MX2014010002A
Other languages
English (en)
Other versions
MX2014010002A (es
Inventor
Rajendiran Chinnapillai
L Ruchelman Alexander
Joseph Connolly Terrence
Venkateswaralu Jasti
Ravikumar Reddy Nallamaddi
Eckert Jeffrey
Joseph Frank Anthony
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47755073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX344190(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2014010002A publication Critical patent/MX2014010002A/es
Publication of MX344190B publication Critical patent/MX344190B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/06—Sulfinamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En el presente documento se proveen nuevos procesos para la preparación de intermediarios de aminosulfona para la síntesis de 2-[1-(3-etoxi-4-metoxifenil)-2-metilsulfonil-etil]-4-acetilaminoi soindolino-1,3-diona, que es útil para prevenir o tratar enfermedades o condiciones relacionadas con un nivel o actividad anormalmente alto de TNF-a. Además, en el presente documento se proveen procesos para la producción comercial de (S)-1-(3-etoxi-4-metoxifenil)-2-metansulfonil-etilamina.
MX2014010002A 2012-02-21 2013-02-20 Procesos para la preparacion de (s) - 1 - (3 - etoxi - 4 - metoxifenil) - 2 - metansulfoniletilamina. MX344190B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261601226P 2012-02-21 2012-02-21
PCT/US2013/026780 WO2013126360A2 (en) 2012-02-21 2013-02-20 Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine

Publications (2)

Publication Number Publication Date
MX2014010002A MX2014010002A (es) 2014-09-08
MX344190B true MX344190B (es) 2016-12-08

Family

ID=47755073

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014010002A MX344190B (es) 2012-02-21 2013-02-20 Procesos para la preparacion de (s) - 1 - (3 - etoxi - 4 - metoxifenil) - 2 - metansulfoniletilamina.
MX2016016157A MX350731B (es) 2012-02-21 2013-02-20 Procesos para la preparacion de (s)-1-(3-etoxi-4-metoxifenil)-2-me tansulfoniletilamina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2016016157A MX350731B (es) 2012-02-21 2013-02-20 Procesos para la preparacion de (s)-1-(3-etoxi-4-metoxifenil)-2-me tansulfoniletilamina.

Country Status (36)

Country Link
US (3) US9187417B2 (es)
EP (4) EP3312156B1 (es)
JP (1) JP2015509496A (es)
KR (1) KR101993248B1 (es)
CN (3) CN107033042A (es)
AR (2) AR090100A1 (es)
AU (1) AU2013203283B2 (es)
BR (3) BR122021020040B1 (es)
CA (1) CA2864517A1 (es)
CO (1) CO7061071A2 (es)
CR (1) CR20140395A (es)
CY (2) CY1121833T1 (es)
DK (2) DK3312156T3 (es)
ES (4) ES2773686T3 (es)
HK (1) HK1205501A1 (es)
HR (2) HRP20191249T1 (es)
HU (2) HUE048412T2 (es)
IL (3) IL234135A (es)
IN (1) IN2014DN06740A (es)
LT (2) LT3378850T (es)
MX (2) MX344190B (es)
MY (1) MY168296A (es)
NI (1) NI201400093A (es)
NZ (1) NZ628028A (es)
PH (1) PH12014501865A1 (es)
PL (2) PL3378850T3 (es)
PT (2) PT3312156T (es)
RS (2) RS59071B1 (es)
RU (1) RU2632875C2 (es)
SG (1) SG11201405035XA (es)
SI (2) SI3378850T1 (es)
TR (1) TR201910430T4 (es)
TW (1) TW201336815A (es)
UA (1) UA116773C2 (es)
WO (1) WO2013126360A2 (es)
ZA (1) ZA201405892B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US9126906B2 (en) * 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds
US9468605B2 (en) 2013-06-17 2016-10-18 Celgene Corporation Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
IN2014MU01283A (es) 2014-04-04 2015-10-09 Cadila Healthcare Ltd
US9994522B2 (en) 2014-05-11 2018-06-12 Mapi Pharma Ltd. Amorphous form of apremilast
EP2949645A1 (en) 2014-05-28 2015-12-02 LEK Pharmaceuticals d.d. Processes for the preparation of ß-aminosulfone compounds
CN105622380B (zh) * 2014-10-29 2020-06-30 南京安源生物医药科技有限公司 一种阿普斯特的制备方法及其中间体
CN104447445B (zh) * 2014-12-05 2016-07-06 新发药业有限公司 一种合成阿普斯特中间体的制备方法
CN104761474B (zh) * 2015-03-11 2016-11-30 中山奕安泰医药科技有限公司 一种阿普斯特手性胺中间体的合成方法
CN104744323B (zh) * 2015-03-11 2016-08-31 中山奕安泰医药科技有限公司 一种阿普斯特手性胺中间体的合成工艺
CN104803897A (zh) * 2015-04-23 2015-07-29 中山奕安泰医药科技有限公司 一种阿普斯特中间体的合成工艺
US10370329B2 (en) * 2015-04-27 2019-08-06 Mylan Laboratories Limited Process for the enantiomeric resolution of apremilast intermediates
MX2017016054A (es) * 2015-06-09 2018-04-11 Dr Reddys Laboratories Ltd Proceso para la preparacion de apremilast y sus intermedios.
EP3106457A1 (en) 2015-06-15 2016-12-21 LEK Pharmaceuticals d.d. A novel synthetic pathway towards apremilast
EP3144393A1 (en) 2015-09-18 2017-03-22 LEK Pharmaceuticals d.d. A synthetic pathway towards apremilast
WO2017059040A1 (en) 2015-09-29 2017-04-06 Pliva Hrvatska D.O.O. Processes for the preparation of apremilast and intermediates thereof
WO2017085568A1 (en) * 2015-11-19 2017-05-26 Alembic Pharmaceuticals Limited An improved process and novel polymorphic form of apremilast
CN105330586B (zh) * 2015-11-27 2017-12-22 东华大学 一种阿普斯特的制备方法
CN105461602B (zh) * 2015-11-27 2018-01-02 东华大学 手性S或R‑3‑乙氧基‑4‑甲氧基‑α‑[(甲磺酰基)甲基]苯甲醇的制备方法
WO2017094031A2 (en) * 2015-12-04 2017-06-08 Sun Pharmaceutical Industries Limited Novel process for preparation of apremilast
CN106866475B (zh) * 2015-12-11 2018-03-30 北大方正集团有限公司 一种阿普斯特中间体及其制备方法
WO2017179065A1 (en) 2016-04-15 2017-10-19 Davuluri Ramamohan Rao Improved process for the preparation of apremilast
US10196355B2 (en) 2016-06-20 2019-02-05 Johnson Matthey Public Limited Company Forms of apremilast
CN106543050B (zh) * 2016-09-28 2018-04-10 中南大学湘雅医院 一种阿普斯特中间体的合成工艺
WO2018061034A1 (en) * 2016-09-30 2018-04-05 Sun Pharmaceutical Industries Limited Novel process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine
JP6684968B2 (ja) 2016-11-10 2020-04-22 エス・エム・エス・グループ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 連続鋳造圧延設備内において、金属的なストリップを製造するための方法
CN107445875A (zh) * 2017-03-22 2017-12-08 陕西科技大学 一种用于制备阿普斯特的高纯度中间体的手性拆分方法
ES2866476T3 (es) 2017-04-04 2021-10-19 Quim Sintetica S A Compuestos de beta-aminosulfona racémicos
US11149003B2 (en) 2017-04-04 2021-10-19 Quimica Sintetica, S.A. Resolution of racemic beta-aminosulfone compounds
CN107966509B (zh) * 2017-11-23 2020-06-23 中山奕安泰医药科技有限公司 一种(s)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法
CN107827722B (zh) * 2017-11-23 2021-02-19 中山奕安泰医药科技有限公司 一种3-乙氧基-4-甲氧基苯甲醛的合成方法
CN107941945B (zh) * 2017-11-23 2020-12-22 中山奕安泰医药科技有限公司 一种3-乙氧基-4-甲氧基苯甲腈的检测方法
CN107976501B (zh) * 2017-11-23 2020-08-25 中山奕安泰医药科技有限公司 一种1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法
CN108008035B (zh) * 2017-11-23 2020-07-07 中山奕安泰医药科技有限公司 3-乙氧基-4-甲氧基苯甲醛纯度的检测方法
CN108084066A (zh) * 2017-12-12 2018-05-29 中山大学 一种阿普斯特及对映异构体的合成方法
JP6673614B1 (ja) * 2018-10-16 2020-03-25 東芝エレベータ株式会社 防音装置
CN113896674B (zh) * 2021-09-01 2023-10-27 深圳华中科技大学研究院 一种阿普斯特的合成方法
CN115850129B (zh) * 2023-02-28 2023-05-16 凯莱英生命科学技术(天津)有限公司 （s）-1-(3-乙氧基-4-甲氧基苯基)-2-（甲磺酰基）乙胺的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878252A (en) * 1970-09-24 1975-04-15 Burroughs Wellcome Co Ring substituted beta-hydroxy-phenyethylmethyl sulphone or sulphoxide
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles
DE2051871A1 (en) * 1969-05-16 1971-11-18 The Wellcome Foundation Ltd., London Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents
SK127398A3 (en) 1996-03-22 1999-04-13 Du Pont Pharm Co Novel asymmetric synthesis of r-'alpha'-propyl-piperonyl amine and its analogs
US6020358A (en) * 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7173058B2 (en) 2002-12-30 2007-02-06 Celgene Corporation Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses
US7208526B2 (en) 2005-05-20 2007-04-24 Hoffmann-La Roche Inc. Styrylsulfonamides
CA2711576C (en) * 2008-01-25 2016-06-21 High Point Pharmaceuticals, Llc Tricyclic compounds as inhibitors of tnf-.alpha. synthesis and as pde4 inhibitors
CA2736171A1 (en) * 2008-09-10 2010-03-18 Celgene Corporation Processes for the preparation of aminosulfone compounds
ME01883B (me) * 2009-06-18 2014-12-20 Concert Pharmaceuticals Inc Deuterijumski derivati izoindolin-1,3-diona kao inhibitori pde4 i tnf-alfa
BR112012007737A2 (pt) 2009-10-09 2015-09-15 Celgene Corp processos para a preparação de compostos de 2-(1-feniletil)isoindolin-1-ona
US9045417B2 (en) 2011-01-14 2015-06-02 Celgene Corporation Isotopologues of isoindole derivatives
AR090100A1 (es) * 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US9126906B2 (en) * 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds

Also Published As

Publication number Publication date
LT3378850T (lt) 2020-04-10
CY1121833T1 (el) 2020-10-14
TW201336815A (zh) 2013-09-16
IL252459B (en) 2020-03-31
ES2675168T3 (es) 2018-07-09
KR20140126389A (ko) 2014-10-30
PL3312156T3 (pl) 2019-10-31
JP2015509496A (ja) 2015-03-30
HUE048412T2 (hu) 2020-07-28
PH12014501865B1 (en) 2014-11-17
TR201910430T4 (tr) 2019-08-21
SI3312156T1 (sl) 2019-09-30
BR122021020046B1 (pt) 2022-05-31
DK3312156T3 (da) 2019-07-22
ES2971710T3 (es) 2024-06-06
ES2735801T3 (es) 2019-12-20
BR112014020444A2 (pt) 2020-10-27
BR122021020040B1 (pt) 2022-05-31
CA2864517A1 (en) 2013-08-29
WO2013126360A2 (en) 2013-08-29
MX350731B (es) 2017-09-15
DK3378850T3 (da) 2020-03-16
HRP20191249T1 (hr) 2019-10-18
US9187417B2 (en) 2015-11-17
HRP20200245T1 (hr) 2020-05-15
RS59071B1 (sr) 2019-09-30
AR117963A2 (es) 2021-09-08
AR090100A1 (es) 2014-10-22
US9688623B2 (en) 2017-06-27
ES2773686T3 (es) 2020-07-14
PT3312156T (pt) 2019-07-19
EP3378850B1 (en) 2020-01-08
EP2817288A2 (en) 2014-12-31
RS60036B1 (sr) 2020-04-30
CO7061071A2 (es) 2014-09-19
IN2014DN06740A (es) 2015-05-22
IL273050A (en) 2020-04-30
CN104245668A (zh) 2014-12-24
US9586897B2 (en) 2017-03-07
EP3378850B8 (en) 2020-03-04
IL252459A0 (en) 2017-07-31
CY1122799T1 (el) 2021-05-05
SI3378850T1 (sl) 2020-07-31
AU2013203283B2 (en) 2015-11-26
UA116773C2 (uk) 2018-05-10
CR20140395A (es) 2014-11-17
BR112014020444B1 (pt) 2021-12-07
PT3378850T (pt) 2020-03-06
MY168296A (en) 2018-10-23
CN107033042A (zh) 2017-08-11
EP3312156B1 (en) 2019-06-05
NI201400093A (es) 2016-11-30
US20130217918A1 (en) 2013-08-22
EP3702347A1 (en) 2020-09-02
SG11201405035XA (en) 2014-09-26
CN112812044B (zh) 2023-05-30
RU2014138037A (ru) 2016-04-10
WO2013126360A3 (en) 2013-10-31
IL234135A (en) 2017-06-29
PL3378850T3 (pl) 2020-07-27
EP2817288B1 (en) 2018-05-30
US20170129852A1 (en) 2017-05-11
CN112812044A (zh) 2021-05-18
RU2632875C2 (ru) 2017-10-11
EP3378850A1 (en) 2018-09-26
EP3312156A1 (en) 2018-04-25
US20160031808A1 (en) 2016-02-04
HK1205501A1 (en) 2015-12-18
KR101993248B1 (ko) 2019-06-26
AU2013203283A1 (en) 2013-09-05
NZ628028A (en) 2016-03-31
PH12014501865A1 (en) 2014-11-17
HUE044192T2 (hu) 2019-10-28
ZA201405892B (en) 2015-11-25
LT3312156T (lt) 2019-08-12
MX2014010002A (es) 2014-09-08
EP3702347B1 (en) 2023-11-08
CN104245668B (zh) 2017-05-17

Similar Documents

Publication Publication Date Title
PH12014501865A1 (en) Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine
MX2012003770A (es) Metodos para la modulacion de autofagia a traves de la modulacion de productos de genes que aumentan la autofagia.
MY184882A (en) Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathyway inhibitors
MX358128B (es) Compuestos y métodos para la modulación de quinasas e indicaciones para los mismos.
NZ588104A (en) Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
EA201891833A1 (ru) Комбинация для лечения амиотрофического бокового склероза или родственных болезней
GT201400034A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit
NZ711896A (en) Compounds and methods for kinase modulation, and indications therefor
MX2013000301A (es) Factores quimericos de coagulacion.
EA201490088A1 (ru) Соединения, ингибирующие металлоферменты
EA201490036A1 (ru) Соединения, ингибирующие металлоферменты
PH12014502513A1 (en) Nampt inhibitors
MX2014013752A (es) Inhibidores de nampt.
UA113750C2 (xx) Склад (+)-2-$1-(3-етокси-4-метоксифеніл)-2-метансульфонілетил]-4-ацетиламіноізоіндолін-1,3-діону
EA201390704A1 (ru) Соединения, ингибирующие металлоферменты
MX2013001906A (es) Metodos para reducir la concentracion de lactato en la sangre.
CU20160083A7 (es) Un proceso para preparar el compuesto (r)-1-((s)-2,2-dimetil-1,3-dioxolan-4-il)etanol y sus productos intermediarios
CR11631A (es) Paramyxovirus eficaz como antitumoral
EA201390876A1 (ru) Соединения, ингибирующие металлоферменты
EA201492169A1 (ru) Новые соединения
EA201001362A1 (ru) Хинолины в качестве ингибиторов фарнезилпирофосфатсинтазы
EA201270176A1 (ru) Производные тазаротена
NI201200049A (es) Proceso para la preparación de compuestos de 2 - ( 1 - feniletil ) isoindolina - 1 - uno
EA033160B1 (ru) Соединения для лечения заболеваний, связанных с ишемией-реперфузией
AR118704A2 (es) Polipéptido del factor vii para tratar enfermedades

Legal Events

Date Code Title Description
FG Grant or registration