DK2914965T3 - Aflukker til biologiske mikroobjekter - Google Patents

Aflukker til biologiske mikroobjekter Download PDF

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Publication number
DK2914965T3
DK2914965T3 DK13850976.5T DK13850976T DK2914965T3 DK 2914965 T3 DK2914965 T3 DK 2914965T3 DK 13850976 T DK13850976 T DK 13850976T DK 2914965 T3 DK2914965 T3 DK 2914965T3
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DK
Denmark
Prior art keywords
microbjects
biological
biological microbjects
Prior art date
Application number
DK13850976.5T
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English (en)
Inventor
Kevin T Chapman
Igor Y Khandros
Gaetan L Mathieu
J Tanner Nevill
Ming C Wu
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Berkeley Lights Inc
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Publication of DK2914965T3 publication Critical patent/DK2914965T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Electrochemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DK13850976.5T 2012-10-31 2013-10-30 Aflukker til biologiske mikroobjekter DK2914965T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261720956P 2012-10-31 2012-10-31
US14/060,117 US9857333B2 (en) 2012-10-31 2013-10-22 Pens for biological micro-objects
PCT/US2013/067479 WO2014070873A1 (en) 2012-10-31 2013-10-30 Pens for biological micro-objects

Publications (1)

Publication Number Publication Date
DK2914965T3 true DK2914965T3 (da) 2021-04-26

Family

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Family Applications (1)

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DK13850976.5T DK2914965T3 (da) 2012-10-31 2013-10-30 Aflukker til biologiske mikroobjekter

Country Status (11)

Country Link
US (4) US9857333B2 (da)
EP (2) EP2914965B1 (da)
JP (3) JP6529908B2 (da)
KR (3) KR101998918B1 (da)
CN (2) CN108070582B (da)
AU (3) AU2013337937B2 (da)
CA (1) CA2888810C (da)
DK (1) DK2914965T3 (da)
IL (2) IL272535B2 (da)
SG (2) SG10201606540RA (da)
WO (1) WO2014070873A1 (da)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
CN110437975B (zh) * 2013-10-22 2023-06-09 伯克利之光生命科技公司 具有隔离围栏的微流体装置及用它测试生物微目标的方法
KR102113377B1 (ko) * 2013-10-22 2020-05-21 버클리 라잇츠, 인크. 격리 펜을 갖는 미세유체 소자 및 이를 사용한 생물학적 미세 물체를 시험하는 방법
JP6465878B2 (ja) 2013-10-22 2019-02-06 バークレー ライツ，インコーポレイテッド 生体アクティビティをアッセイするための微少流体デバイス
US20150166326A1 (en) 2013-12-18 2015-06-18 Berkeley Lights, Inc. Capturing Specific Nucleic Acid Materials From Individual Biological Cells In A Micro-Fluidic Device
US11192107B2 (en) 2014-04-25 2021-12-07 Berkeley Lights, Inc. DEP force control and electrowetting control in different sections of the same microfluidic apparatus
US20150306599A1 (en) 2014-04-25 2015-10-29 Berkeley Lights, Inc. Providing DEP Manipulation Devices And Controllable Electrowetting Devices In The Same Microfluidic Apparatus
US20150306598A1 (en) * 2014-04-25 2015-10-29 Berkeley Lights, Inc. DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus
WO2015188171A1 (en) 2014-06-06 2015-12-10 Berkeley Lights, Inc. Isolating microfluidic structures and trapping bubbles
EP3227025B1 (en) 2014-12-05 2019-03-27 The Regents of The University of California Single-sided light-actuated microfluidic device with integrated mesh ground
TWI678232B (zh) 2014-12-08 2019-12-01 美商柏克萊燈光有限公司 側向式／垂直式電晶體結構及其製造與使用方法
WO2016094333A1 (en) * 2014-12-08 2016-06-16 Berkeley Lights, Inc. Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
CN113075113A (zh) * 2014-12-09 2021-07-06 伯克利之光生命科技公司 微流体装置中微物体的自动检测和重新定位
US10578630B2 (en) 2014-12-09 2020-03-03 Berkeley Lights, Inc. Automated identification of assay areas in a microfluidic device and detection of assay positive areas based on rate of change of image light intensity
WO2016094715A2 (en) * 2014-12-10 2016-06-16 Berkeley Lights, Inc. Movement and selection of micro-objects in a microfluidic apparatus
KR20230125849A (ko) * 2014-12-10 2023-08-29 버클리 라잇츠, 인크. 전기역학적 디바이스들을 동작시키기 위한 시스템들
HK1246623A1 (zh) * 2015-03-04 2018-09-14 伯克利之光生命科技公司 体外胚胎的生殖和选择
AU2016226008A1 (en) * 2015-03-04 2017-10-26 Berkeley Lights, Inc. Generation and selection of embryos in vitro
WO2016172623A1 (en) * 2015-04-22 2016-10-27 Berkeley Lights, Inc. Manipulation of cell nuclei in a micro-fluidic device
WO2016172621A2 (en) * 2015-04-22 2016-10-27 Berkeley Lights, Inc. Freezing and archiving cells on a microfluidic device
US10751715B1 (en) 2015-04-22 2020-08-25 Berkeley Lights, Inc. Microfluidic reporter cell assay methods and kits thereof
TWI819383B (zh) * 2015-04-22 2023-10-21 美商伯克利之光生命科技公司 微流體器件及在該微流體器件中培養生物細胞之方法
CA3176115A1 (en) * 2015-04-22 2016-10-27 Berkeley Lights, Inc. Microfluidic device for culturing biological cells and methods of use thereof
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
AU2016344171B2 (en) * 2015-10-27 2021-09-23 Berkeley Lights, Inc. Microfluidic electrowetting device apparatus having a covalently bound hydrophobic surface
EP3380238A1 (en) * 2015-11-23 2018-10-03 Berkeley Lights, Inc. In situ-generated microfluidic isolation structures, kits and methods of use thereof
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
CN108603878A (zh) 2015-12-08 2018-09-28 伯克利之光生命科技公司 微流体设备和试剂盒及其使用方法
JP6964590B2 (ja) * 2015-12-30 2021-11-10 バークレー ライツ，インコーポレイテッド 光学的に駆動される対流及び変位のマイクロ流体デバイス、そのキット及び方法
TWI808934B (zh) 2015-12-31 2023-07-21 美商伯克利之光生命科技公司 經工程化以表現促發炎多肽之腫瘤浸潤細胞
WO2017123978A1 (en) 2016-01-15 2017-07-20 Berkeley Lights, Inc. Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
CN109922885B (zh) 2016-03-16 2022-05-10 伯克利之光生命科技公司 用于基因组编辑克隆的选择和传代的方法、系统和装置
AU2017234787B2 (en) 2016-03-17 2022-12-22 Berkeley Lights, Inc. Selection and cloning of T lymphocytes in a microfluidic device
SG11201808573YA (en) 2016-03-31 2018-10-30 Berkeley Lights Inc Nucleic acid stabilization reagent, kits, and methods of use thereof
CN115184315A (zh) 2016-04-15 2022-10-14 伯克利之光生命科技公司 用于坞内测定的方法、系统和试剂盒
US10675625B2 (en) 2016-04-15 2020-06-09 Berkeley Lights, Inc Light sequencing and patterns for dielectrophoretic transport
WO2017205830A1 (en) 2016-05-26 2017-11-30 Berkeley Lights, Inc. Covalently modified surfaces, kits, and methods of preparation and use
ES2802261T3 (es) 2016-06-21 2021-01-18 Quantumdx Group Ltd Concentración de células diana mejorada mediante dielectroforesis (DEP)
SG11201900442PA (en) 2016-07-21 2019-02-27 Berkeley Lights Inc Sorting of t lymphocytes in a microfluidic device
CN110114520B (zh) 2016-10-01 2023-08-08 伯克利之光生命科技公司 Dna条形码组合物和在微流体装置中原位识别的方法
EP3549099B1 (en) 2016-12-01 2024-08-21 Bruker Cellular Analysis, Inc. Automated detection and repositioning of micro-objects in microfluidic devices
TWI814112B (zh) 2016-12-01 2023-09-01 美商伯克利之光生命科技公司 用於成像微物件的設備、系統及方法
US11473081B2 (en) 2016-12-12 2022-10-18 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CA3048904A1 (en) 2016-12-30 2018-07-05 xCella Biosciences, Inc. Multi-stage sample recovery system
AU2017388874A1 (en) 2016-12-30 2019-07-18 Berkeley Lights, Inc. Methods for selection and generation of genome edited T cells
EP3623461A4 (en) * 2017-05-12 2021-01-20 Nikon Corporation OBJECT MANIPULATION DEVICE AND OBJECT MANIPULATION METHOD
WO2018226900A2 (en) 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving fungal strains
CN118846017A (zh) 2017-07-21 2024-10-29 伯克利之光生命科技公司 抗原呈递合成表面、共价官能化表面、活化t细胞及其用途
US11684917B2 (en) 2017-09-29 2023-06-27 Schlumberger Technology Corporation Microfluidic technique for detection of multi-contact miscibility
WO2019075476A2 (en) 2017-10-15 2019-04-18 Berkeley Lights, Inc. METHODS, SYSTEMS AND KITS FOR ENCLOSED TESTS
CN108300654B (zh) * 2018-02-09 2021-08-17 华中科技大学同济医学院附属协和医院 评估可移动生物活体药代动力学的芯片及实时检测系统
DE102018203047A1 (de) * 2018-03-01 2019-09-05 Robert Bosch Gmbh Mikrofluidische Vorrichtung
WO2019173276A1 (en) * 2018-03-06 2019-09-12 Waters Technologies Corporation A high surface area chromatographic device with low pressure drop
EP3803341A4 (en) 2018-05-31 2022-03-23 Berkeley Lights, Inc. AUTOMATIC DETECTION AND CHARACTERIZATION OF MICROOBJECTS IN MICROFLUIDIC DEVICES
KR20210018219A (ko) 2018-06-06 2021-02-17 지머젠 인코포레이티드 발효 및 생산 중 곰팡이 형태를 제어하기 위한 신호 전달에 포함된 유전자의 조작
US10953408B2 (en) * 2018-09-04 2021-03-23 The Governing Council Of The University Of Toronto Banting Institute Patterned optoelectronic tweezers
GB2577074B (en) 2018-09-12 2022-06-01 Quantumdx Group Ltd Microfluidic device with DEP arrays
CA3112333A1 (en) * 2018-09-14 2020-03-19 Berkeley Lights, Inc. Methods for assaying binding affinity
WO2020061499A1 (en) 2018-09-21 2020-03-26 Berkeley Lights, Inc. Functionalized well plate, methods of preparation and use thereof
CN113166697B (zh) * 2018-10-10 2025-07-15 斯塔姆韦格公司 连续流动式微型生物反应器
SG11202103348TA (en) 2018-10-11 2021-04-29 Berkeley Lights Inc Systems and methods for identification of optimized protein production and kits therefor
AU2019362009A1 (en) 2018-10-18 2021-06-03 Berkeley Lights, Inc. Proto-antigen-presenting synthetic surfaces, activated t cells, and uses thereof
EP3874265A4 (en) 2018-11-01 2022-09-28 Berkeley Lights, Inc. Methods for assaying biological cells in a microfluidic device
WO2020106646A1 (en) 2018-11-19 2020-05-28 Berkeley Lights, Inc. Microfluidic device with programmable switching elements
EP4371930B1 (en) 2018-12-06 2025-08-20 Xcella Biosciences, Inc. Lateral loading of microcapillary arrays
WO2020168258A1 (en) 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
WO2020223555A1 (en) 2019-04-30 2020-11-05 Berkeley Lights, Inc. Methods for encapsulating and assaying cells
EP3980186A1 (en) * 2019-06-05 2022-04-13 Amgen Inc. Systems for performing cellular analysis and related devices for conditioning environments adjacent chips in such systems
CN110618095A (zh) * 2019-11-08 2019-12-27 武汉大学深圳研究院 一种光流控水体溶解氧探测器
TW202142856A (zh) 2019-11-17 2021-11-16 美商伯克利之光生命科技公司 用於生物樣本之分析的系統及方法
CN115362043B (zh) 2020-02-03 2025-10-17 斯塔姆韦格公司 用于3d打印的平台、系统和设备
CA3170874A1 (en) 2020-03-09 2021-09-16 Phillip J. M. ELMS Methods, systems and kits for in-pen assays
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
WO2022051570A1 (en) 2020-09-07 2022-03-10 Berkeley Lights, Inc. Methods of assaying a biological cell
EP4397466A4 (en) 2021-08-31 2025-09-03 Canon Kk UNFOAMISHED MOLDED BODY CONTAINING POLYURETHANE
EP4239333A1 (en) 2022-03-03 2023-09-06 Lonza Biologics plc Method for selecting clonal cells expressing correctly assembled multi-specific binding molecules
WO2024076923A1 (en) * 2022-10-03 2024-04-11 Bruker Cellular Analysis, Inc. Micro-object displacement within a microfluidic environment

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
IL147302A0 (en) 1999-06-28 2002-08-14 California Inst Of Techn Microfabricated elastomeric valve and pump systems
US20030007894A1 (en) 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
ITTO20010411A1 (it) 2001-05-02 2002-11-02 Silicon Biosystems S R L Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti.
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
CN1291035C (zh) * 2001-10-09 2006-12-20 清华大学 用于样品制备和分析的集成式生物芯片系统
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
EP2666849A3 (en) 2002-04-01 2014-05-28 Fluidigm Corporation Microfluidic particle-analysis systems
US6958132B2 (en) 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US7790443B2 (en) 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
WO2004065618A2 (en) 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
WO2004103565A2 (de) * 2003-05-19 2004-12-02 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung und verfahren zur strukturierung von flüssigkeiten und zum zudosieren von reaktionsflüssigkeiten zu in separationsmedium eingebetteten flüssigkeitskompartimenten
JP4328168B2 (ja) 2003-10-02 2009-09-09 ソニー株式会社 毛細管現象を利用する物質間の相互作用検出部と該検出部を用いる方法及びバイオアッセイ用基板
US7425253B2 (en) 2004-01-29 2008-09-16 Massachusetts Institute Of Technology Microscale sorting cytometer
US7612355B2 (en) 2004-04-12 2009-11-03 The Regents Of The University Of California Optoelectronic tweezers for microparticle and cell manipulation
WO2006037033A2 (en) 2004-09-24 2006-04-06 The Regents Of The University Of California A microfluidic device for enabling the controlled growth of cells
US20060091015A1 (en) 2004-11-01 2006-05-04 Applera Corporation Surface modification for non-specific adsorption of biological material
CA2597739A1 (en) 2005-02-23 2006-08-31 M.B.T.L. Limited Culture device
WO2007008609A2 (en) 2005-07-07 2007-01-18 The Regents Of The University Of California Methods and apparatus for cell culture array
EP1915467A2 (en) 2005-08-19 2008-04-30 The Regents of the University of California Microfluidic methods for diagnostics and cellular analysis
CN101548004A (zh) * 2005-08-19 2009-09-30 加利福尼亚大学董事会 用于诊断学和细胞分析的微流体方法
WO2007102839A2 (en) 2005-10-27 2007-09-13 Applera Corporation Optoelectronic separation of biomolecules
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
WO2008119066A1 (en) 2007-03-28 2008-10-02 The Regents Of The University Of California Single-sided lateral-field and phototransistor-based optoelectronic tweezers
WO2008147530A1 (en) 2007-05-24 2008-12-04 The Regents Of The University Of California Integrated fluidics devices with magnetic sorting
EP2078958A1 (en) 2007-10-25 2009-07-15 Koninklijke Philips Electronics N.V. A reconfigurable microfluidic filter based on eletric fields
CN102037351A (zh) 2008-04-03 2011-04-27 加利福尼亚大学董事会 分离并离析细胞、囊泡、纳米颗粒和生物标记的离体多维系统
JP2009273459A (ja) 2008-04-15 2009-11-26 Tosoh Corp 細胞選別装置、およびそれを用いた細胞選別方法
US20110117634A1 (en) 2008-04-21 2011-05-19 Asaf Halamish Flat cell carriers with cell traps
JP5623399B2 (ja) 2008-07-28 2014-11-12 アギア システムズ エルエルシーＡｇｅｒｅ Ｓｙｓｔｅｍｓ ＬＬＣ 変量補償浮上量測定システムおよび方法
GB2464300A (en) 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
CN102449163A (zh) 2009-04-03 2012-05-09 加利福尼亚大学董事会 分选细胞和其它生物微粒的方法和装置
US20100273681A1 (en) 2009-04-27 2010-10-28 Wisconsin Alumni Research Foundation Combinatorial chemistry reaction cell with optical tweezers
GB0909923D0 (en) 2009-06-09 2009-07-22 Oxford Gene Tech Ip Ltd Picowell capture devices for analysing single cells or other particles
GB0910330D0 (en) * 2009-06-16 2009-07-29 Univ Leiden A biological microfluidics chip and related methods
JP2011000079A (ja) * 2009-06-19 2011-01-06 Univ Of Tokyo 粒子を操作する方法及びマイクロ流体装置
CN201834907U (zh) * 2010-04-15 2011-05-18 四川国兴盛生物科技有限公司 半封闭式围栏
JPWO2011149032A1 (ja) 2010-05-26 2013-07-25 東ソー株式会社 生体試料固定装置
CN101947124B (zh) * 2010-06-25 2012-07-04 博奥生物有限公司 一种集成式微流控芯片装置及其使用方法
WO2012002515A1 (ja) 2010-06-30 2012-01-05 東ソー株式会社 粒子固定用構造体、及び、粒子解析装置
US10087408B2 (en) 2010-07-07 2018-10-02 The University Of British Columbia System and method for microfluidic cell culture
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
US9533306B2 (en) 2010-08-02 2017-01-03 The Regents Of The University Of California Single sided continuous optoelectrowetting (SCEOW) device for droplet manipulation with light patterns
JP5804620B2 (ja) * 2010-08-09 2015-11-04 一般財団法人生産技術研究奨励会 電気的機能を持つマイクロチャンバーアレイ装置およびそれを用いた検査対象物解析方法
EP2616551B1 (en) 2010-09-14 2020-08-19 The Regents of The University of California Method for isolating cells from heterogeneous solution using microfluidic trapping vortices
EP3035031B1 (en) 2010-12-03 2022-06-01 Cellply S.R.L. Microanalysis of cellular function
EP2646830B1 (en) 2010-12-03 2016-04-13 Cellply S.R.L. Rapid screening of monoclonal antibodies
CN102580794B (zh) * 2011-01-13 2014-03-19 博奥生物有限公司 可定位细胞及生物体的微流控芯片及其应用
US9227200B2 (en) 2011-06-03 2016-01-05 The Regents Of The University Of California Microfluidic devices with flexible optically transparent electrodes
ES2797448T3 (es) 2011-08-01 2020-12-02 Bio Rad Laboratories Sistema de captura de células
WO2013148745A1 (en) 2012-03-28 2013-10-03 Northeastern University Nanofluidic device for isolating, growing, and characterizing microbial cells
KR102402451B1 (ko) 2013-03-28 2022-05-26 더 유니버시티 오브 브리티쉬 콜롬비아 미세유동 장치 및 분비물의 다세포 검정법에서의 그의 사용 방법

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