JP2015534810A - 生物学的微小物体用ペン - Google Patents
生物学的微小物体用ペン Download PDFInfo
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Abstract
Description
Claims (41)
- 生物学的微小物体の処理方法であって、
マイクロ流体デバイス内の保持ペンの内部空間に個々の生物学的微小物体を能動的に置くことと、
ある期間にわたって前記ペンに第1の液状媒体の流れを提供することと、
前記流れを提供する一方で、前記流れからの前記第1の媒体が前記保持ペンの前記内部空間へ直接流入するのを妨げることと、
を備える、方法。 - 前記妨げることは、実質的に前記流れからの前記第1の媒体と前記ペンの前記内部空間内の第2の媒体との拡散混合のみを可能にすることを含む、請求項1の方法。
- 前記期間中に前記ペン内の前記微小物体の特徴を監視することをさらに備える、請求項1の方法。
- 前記特徴は、前記ペン内の前記微小物体の生物活動である、請求項3の方法。
- 前記生物活動は、クローン化を含み、
前記監視することは、前記ペンの各々における前記微小物体の前記クローン化を監視することを含む、請求項4の方法。 - 前記生物活動は、分泌物を分泌することを含み、
前記監視することは、前記ペンの各々の内部における前記微小物体の前記分泌物を監視することを含む、請求項4の方法。 - 前記特徴は、前記ペン内の前記微小物体の生物学的状態である、請求項3の方法。
- 前記第1の媒体は、前記第2の媒体とは異なる種類の媒体である、請求項1の方法。
- 前記第1の媒体は、前記第2の媒体と同じ種類の媒体である、請求項1の方法。
- 前記マイクロ流体デバイス内の複数の前記微小物体から所定の特徴を有する前記微小物体のサブセットを選択することをさらに備え、
前記能動的に置くことは、前記微小物体の前記選択されたサブセットのみを前記ペン内に置くことを含む、請求項1の方法。 - 前記複数の微小物体は、前記マイクロ流体デバイス内の共通の場所にあり、
前記選択することは、前記共通の場所において前記選択されたサブセット中の前記微小物体の1つ1つを選択することを含み、
前記能動的に置くことは、前記選択されたサブセット中の前記微小物体の1つ1つを個々に前記共通の場所から前記ペンのうち1つに移動させることを含む、請求項10の方法。 - 前記能動的に置くことは、前記ペンの各々の内部に前記個々の微小物体のうち1つだけを置くことを含む、請求項1の方法。
- 前記能動的に置くことは、前記個々の微小物体にかかるDEP力を作り出す誘電泳動(DEP)電極を活性化することを含む、請求項1の方法。
- 前記DEP電極を活性化することは、光電子ピンセット装置によって前記DEP電極を活性化することを含む、請求項13の方法。
- 前記提供することは、開口部によって前記ペン内に前記第1の媒体を流すことを含む、請求項1の方法。
- 前記個々の微小物体を前記期間中前記ペン内で維持することをさらに備える、請求項1の方法。
- 前記置くことは、複数の異なる種類の前記微小物体の各々を前記ペンのうち1つの内部の複数の異なる保持空間の各々に置くことを含む、請求項1の方法。
- 基部上に配設された、第1の液状媒体のための流路を備えるハウジングと、
前記ハウジング内に配設された保持ペンと、を備え、
各前記ペンは、内部空間を取り囲む筐体を備え、
前記筐体は、第2の液状媒体中に懸濁された生物学的微小物体を保持するように構成されるとともに前記第1の媒体が前記内部空間内の前記第2の媒体へと直接流入するのを妨げる、
マイクロ流体装置。 - 各前記ペンは、前記筐体に、前記流路に隣接して配設され実質的に前記流路からの前記第1の液状媒体と前記内部空間内の前記第2の液状媒体との拡散混合のみを可能にするように構成された開口部をさらに備える、請求項18のマイクロ流体装置。
- 前記媒体が配設されている前記基部の表面の誘電泳動(DEP)電極を選択的に活性化及び非活性化する誘電泳動(DEP)装置をさらに備える、請求項18のマイクロ流体装置。
- 前記ペンは、前記ペンの前記開口部が前記流路にすぐ隣接するように前記ハウジング内に配設される、請求項18のマイクロ流体装置。
- 前記流路は、前記ハウジング内に流体チャネルを備え、
前記ペンの前記開口部は、前記流体チャネルに直接接続される、請求項21のマイクロ流体装置。 - 前記ペンのうち1つは、前記開口部から前記筐体内へと延びる内壁を備える、請求項18のマイクロ流体装置。
- 前記内壁は、前記ペンの前記開口部と前記ペンの前記筐体内の内部収容空間との間のバリアを備える、請求項23のマイクロ流体装置。
- 筐体と開口部とを備えた内ペンをさらに備え、
前記内ペンは、前記ペンのうち1つの前記筐体の内部に配設される、請求項18のマイクロ流体装置。 - 前記ペンのうち1つは、前記ペンのうち前記1つの前記筐体の内部に配設された内壁により分離された保持空間を備え、
各前記保持空間は、前記微小物体のうち1つを保持するように構成される、請求項18のマイクロ流体装置。 - 前記ペンの前記開口部のいずれかにおいて誘電泳動(DEP)扉を選択的に作り出すとともに除去する手段をさらに備える、請求項18のマイクロ流体装置。
- 前記流路へと続く前記ハウジングへの注入口と、
前記流路から続く前記ハウジングからの排出口と、
をさらに備える、請求項18のマイクロ流体装置。 - 前記ペンは、前記注入口と前記排出口との間の前記流路内に配設される、請求項28のマイクロ流体装置。
- 前記注入口と前記ペンとの間の前記流路内に配設された気体交換器をさらに備える、請求項29のマイクロ流体装置。
- 前記ハウジング内に配設された気体交換器をさらに備える、請求項18のマイクロ流体装置。
- 前記ペン内の前記微小物体の生物活動を監視する手段をさらに備える、請求項18のマイクロ流体装置。
- 生物学的微小物体の処理方法であって、
保持ペンの形をした光のパターンをマイクロ流体デバイス内に向けることで誘電泳動(DEP)電極を活性化することによりマイクロ流体デバイス内に仮想の保持ペンを作り出すことと、
個々の生物学的微小物体を、各々が前記保持ペンのうち前記1つの内部にある前記個々の微小物体のうちいずれか1つ以上を前記保持ペンのうち前記1つの外部の前記微小物体のすべてから隔離する前記保持ペン内に置くことと、
ある期間にわたって前記保持ペン内の前記微小物体に液状媒体の共通の流れを提供することと、
を備える、方法。 - 前記共通の流れの前記液状媒体は、前記保持ペンの内部の液状媒体とは異なる媒体である、請求項33の方法。
- 前記期間中、前記保持ペン内の前記個々の微小物体の特徴を監視することをさらに備える、請求項33の方法。
- 前記特徴は、前記保持ペン内の前記個々の微小物体の生物活動である、請求項35の方法。
- 前記生物活動は、クローン化を含み、
前記監視することは、前記保持ペンの各々における前記個々の微小物体の前記クローン化を監視することを含む、請求項36の方法。 - 前記生物活動は、分泌物を分泌することを含み、
前記監視することは、前記保持ペンの各々における前記個々の微小物体の前記分泌物を監視することを含む、請求項36の方法。 - 前記特徴は、前記ペン内の前記個々の微小物体の生物学的状態である、請求項35の方法。
- 前記保持ペンのうち対応する1つから、監視された特徴が所定の基準を満たす前記微小物体のうち1つを除去することをさらに備える、請求項35の方法。
- 前記期間中、前記ペン内の前記個々の微小物体を維持することをさらに備える、請求項33の方法。
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US14/060,117 US9857333B2 (en) | 2012-10-31 | 2013-10-22 | Pens for biological micro-objects |
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2021
- 2021-06-21 JP JP2021102379A patent/JP2021141902A/ja not_active Ceased
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2023
- 2023-05-25 US US18/324,026 patent/US20240027396A1/en active Pending
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JP2019510959A (ja) * | 2015-12-30 | 2019-04-18 | バークレー ライツ,インコーポレイテッド | 光学的に駆動される対流及び変位のマイクロ流体デバイス、そのキット及び方法 |
US11802264B2 (en) | 2015-12-30 | 2023-10-31 | Phenomex Inc. | Microfluidic devices for optically-driven convection and displacement, kits and methods thereof |
JP2020099325A (ja) * | 2016-06-21 | 2020-07-02 | クァンタムディーエックス グループ リミテッドQuantumdx Group Limited | 誘電泳動(dep)を用いた標的細胞濃度の改善 |
US10710075B2 (en) | 2016-06-21 | 2020-07-14 | Quantumdx Group Limited | Target cell concentration using dielectrophoresis (DEP) |
JP6991192B2 (ja) | 2016-06-21 | 2022-01-12 | クァンタムディーエックス グループ リミテッド | 誘電泳動(dep)を用いた標的細胞濃度の改善 |
US11850593B2 (en) | 2016-06-21 | 2023-12-26 | Quantumdx Group Limited | Target cell concentration using dielectrophoresis (DEP) |
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