BR112013027517A2 - nanotransportadores sintéticos tolerogênicos para indução de células b reguladoras - Google Patents

nanotransportadores sintéticos tolerogênicos para indução de células b reguladoras

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Publication number
BR112013027517A2
BR112013027517A2 BR112013027517A BR112013027517A BR112013027517A2 BR 112013027517 A2 BR112013027517 A2 BR 112013027517A2 BR 112013027517 A BR112013027517 A BR 112013027517A BR 112013027517 A BR112013027517 A BR 112013027517A BR 112013027517 A2 BR112013027517 A2 BR 112013027517A2
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BR
Brazil
Prior art keywords
regulatory
nanotransport
synthetic
cell induction
cells
Prior art date
Application number
BR112013027517A
Other languages
English (en)
Inventor
A Maldonado Roberto
Original Assignee
Selecta Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selecta Biosciences Inc filed Critical Selecta Biosciences Inc
Publication of BR112013027517A2 publication Critical patent/BR112013027517A2/pt

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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Abstract

abstract disclosed are synthetic nanocarrier methods, and related compositions, comprising b cell and/or mhc class ii-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory b cells. tradução do resumo resumo patente de invenção: "nanotransportadores sintéticos tolerogênicos para indução de células b reguladoras". são divulgados métodos de nanotransportadores sintéticos, e composições relacionadas, compreendendo células b e/ou epítopos restritos a mhc de classe ii e imunossupressores de modo a gerar respostas imunes tolerogênicas, tais como a geração de células b reguladoras específicas de antigênio.
BR112013027517A 2011-04-29 2012-04-27 nanotransportadores sintéticos tolerogênicos para indução de células b reguladoras BR112013027517A2 (pt)

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US201161480946P 2011-04-29 2011-04-29
US201161513514P 2011-07-29 2011-07-29
US201161531180P 2011-09-06 2011-09-06
US201161531153P 2011-09-06 2011-09-06
US201161531215P 2011-09-06 2011-09-06
US201161531204P 2011-09-06 2011-09-06
US201161531164P 2011-09-06 2011-09-06
US201161531168P 2011-09-06 2011-09-06
US201161531209P 2011-09-06 2011-09-06
US201161531147P 2011-09-06 2011-09-06
US201161531175P 2011-09-06 2011-09-06
US201161531194P 2011-09-06 2011-09-06
PCT/US2012/035431 WO2012149301A2 (en) 2011-04-29 2012-04-27 Tolerogenic synthetic nanocarriers for inducing regulatory b cells

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BR112013027500A BR112013027500A2 (pt) 2011-04-29 2012-04-27 liberação controlada de imunossupressores de nanotransportadores sintéticos
BR112013027517A BR112013027517A2 (pt) 2011-04-29 2012-04-27 nanotransportadores sintéticos tolerogênicos para indução de células b reguladoras
BR112013027514-6A BR112013027514B1 (pt) 2011-04-29 2012-04-27 Composição compreendendo nanotransportadores sintéticos tolerogênicos, sua forma de dosagem e seu uso
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