BRPI0509755A - composição compreendendo um inibidor de jnk e ciclosporina - Google Patents
composição compreendendo um inibidor de jnk e ciclosporinaInfo
- Publication number
- BRPI0509755A BRPI0509755A BRPI0509755-0A BRPI0509755A BRPI0509755A BR PI0509755 A BRPI0509755 A BR PI0509755A BR PI0509755 A BRPI0509755 A BR PI0509755A BR PI0509755 A BRPI0509755 A BR PI0509755A
- Authority
- BR
- Brazil
- Prior art keywords
- jnk
- inhibitor
- composition
- cyclosporine
- cyclosporin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPOSIçãO COMPREENDENDO UM INIBIDOR DE JNK E CICLOSPORINA A presente invenção refere-se a uma composição que compreende um inibidor de JNK e uma ciclosporina, em particular para o tratamento de distúrbios neuronais, doenças auto-imunes, câncer e doenças cardiovasculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04101468 | 2004-04-08 | ||
PCT/EP2005/051572 WO2005097116A1 (en) | 2004-04-08 | 2005-04-08 | Composition comprising a jnk inhibitor and cyclosporin |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509755A true BRPI0509755A (pt) | 2007-10-16 |
Family
ID=34928946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509755-0A BRPI0509755A (pt) | 2004-04-08 | 2005-04-08 | composição compreendendo um inibidor de jnk e ciclosporina |
Country Status (13)
Country | Link |
---|---|
US (1) | US20080039377A1 (pt) |
EP (1) | EP1850846A1 (pt) |
JP (2) | JP5080241B2 (pt) |
KR (2) | KR20120135441A (pt) |
CN (1) | CN1960726A (pt) |
AU (2) | AU2005230416B2 (pt) |
BR (1) | BRPI0509755A (pt) |
CA (1) | CA2561907A1 (pt) |
EA (1) | EA017893B1 (pt) |
IL (1) | IL178417A0 (pt) |
NO (1) | NO20065117L (pt) |
UA (1) | UA91676C2 (pt) |
WO (1) | WO2005097116A1 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
EP2026802A2 (en) * | 2006-06-02 | 2009-02-25 | Laboratoires Serono SA | Jnk inhibitors for treatment of skin diseases |
US20100121057A1 (en) * | 2007-04-17 | 2010-05-13 | Merck Serono Sa | Process for the Preparation of Piperazine Benzothiazoles |
CA2700536A1 (en) * | 2007-09-26 | 2009-04-02 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
WO2009143864A1 (en) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
WO2009143865A1 (en) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
US8828924B2 (en) * | 2009-05-14 | 2014-09-09 | University Of Maryland, Baltimore | Methods of treating a diabetic embryopathy |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
JP5857056B2 (ja) | 2010-10-14 | 2016-02-10 | ザイジェン インフラメーション エルティーディー | 慢性又は非慢性の炎症性眼疾患を治療するためのjnkシグナル伝達経路の細胞透過性ペプチド阻害剤の使用 |
US9265815B2 (en) * | 2011-04-29 | 2016-02-23 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers |
US20140163075A1 (en) * | 2011-06-01 | 2014-06-12 | Netherland Cancer Institute | Modulation of the ubiquitin-proteasome system (ups) |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2014114186A1 (zh) * | 2013-01-24 | 2014-07-31 | 山东亨利医药科技有限责任公司 | Jnk抑制剂 |
JP7028556B2 (ja) | 2013-05-03 | 2022-03-02 | セレクタ バイオサイエンシーズ インコーポレーテッド | 特定の薬力学的有効期間および免疫寛容の誘発のための抗原を有する免疫抑制剤の送達 |
CA2903275A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
MX2017002933A (es) | 2014-09-07 | 2017-05-30 | Selecta Biosciences Inc | Metodos y composiciones para atenuar las respuestas inmunes del vector de transferencia anti-viral de edicion del gen. |
WO2018169811A1 (en) | 2017-03-11 | 2018-09-20 | Selecta Biosciences, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
KR20230164862A (ko) * | 2022-05-26 | 2023-12-05 | 연세대학교 산학협력단 | 아토피피부염의 예방 또는 치료용 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
DE3884470T2 (de) * | 1987-06-17 | 1994-03-10 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel. |
US6514745B1 (en) * | 1993-07-19 | 2003-02-04 | The Regents Of The University Of California | Oncoprotein protein kinase |
US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
EP1110957A1 (en) * | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
EP1193267A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases |
-
2005
- 2005-04-08 JP JP2007506786A patent/JP5080241B2/ja not_active Expired - Fee Related
- 2005-04-08 WO PCT/EP2005/051572 patent/WO2005097116A1/en active Application Filing
- 2005-04-08 CA CA002561907A patent/CA2561907A1/en not_active Abandoned
- 2005-04-08 CN CNA2005800177053A patent/CN1960726A/zh active Pending
- 2005-04-08 EA EA200601841A patent/EA017893B1/ru not_active IP Right Cessation
- 2005-04-08 UA UAA200610429A patent/UA91676C2/ru unknown
- 2005-04-08 US US11/547,967 patent/US20080039377A1/en not_active Abandoned
- 2005-04-08 KR KR1020127030807A patent/KR20120135441A/ko not_active Application Discontinuation
- 2005-04-08 EP EP05729575A patent/EP1850846A1/en not_active Withdrawn
- 2005-04-08 BR BRPI0509755-0A patent/BRPI0509755A/pt not_active IP Right Cessation
- 2005-04-08 AU AU2005230416A patent/AU2005230416B2/en not_active Ceased
- 2005-04-08 KR KR1020067023208A patent/KR20060134198A/ko not_active Application Discontinuation
-
2006
- 2006-10-03 IL IL178417A patent/IL178417A0/en unknown
- 2006-11-07 NO NO20065117A patent/NO20065117L/no not_active Application Discontinuation
-
2010
- 2010-08-13 AU AU2010212339A patent/AU2010212339B2/en not_active Ceased
-
2012
- 2012-03-15 JP JP2012058551A patent/JP2012136550A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2010212339B2 (en) | 2012-07-19 |
US20080039377A1 (en) | 2008-02-14 |
UA91676C2 (ru) | 2010-08-25 |
WO2005097116A1 (en) | 2005-10-20 |
KR20060134198A (ko) | 2006-12-27 |
KR20120135441A (ko) | 2012-12-13 |
JP2007532517A (ja) | 2007-11-15 |
EA200601841A1 (ru) | 2007-04-27 |
EA017893B1 (ru) | 2013-04-30 |
AU2005230416B2 (en) | 2010-05-13 |
CN1960726A (zh) | 2007-05-09 |
EP1850846A1 (en) | 2007-11-07 |
JP5080241B2 (ja) | 2012-11-21 |
AU2010212339A1 (en) | 2010-09-09 |
AU2005230416A1 (en) | 2005-10-20 |
CA2561907A1 (en) | 2005-10-20 |
IL178417A0 (en) | 2007-02-11 |
NO20065117L (no) | 2006-11-07 |
JP2012136550A (ja) | 2012-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: LABORATOIRES SERONO S.A. (CH) Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
|
B25D | Requested change of name of applicant approved |
Owner name: MERCK SERONO S.A. (CH) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |