BR112023020597A2 - Nanocarreadores sintéticos que compreendem um imunossupressante em combinação com agonistas do receptor de il-2 de alta afinidade para aumentar a tolerância imune - Google Patents

Nanocarreadores sintéticos que compreendem um imunossupressante em combinação com agonistas do receptor de il-2 de alta afinidade para aumentar a tolerância imune

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Publication number
BR112023020597A2
BR112023020597A2 BR112023020597A BR112023020597A BR112023020597A2 BR 112023020597 A2 BR112023020597 A2 BR 112023020597A2 BR 112023020597 A BR112023020597 A BR 112023020597A BR 112023020597 A BR112023020597 A BR 112023020597A BR 112023020597 A2 BR112023020597 A2 BR 112023020597A2
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BR
Brazil
Prior art keywords
combination
immunosuppressant
high affinity
immune tolerance
synthetic nanocarriers
Prior art date
Application number
BR112023020597A
Other languages
English (en)
Inventor
Petr Ilyinskii
Kei Kishimoto Takashi
Original Assignee
Selecta Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selecta Biosciences Inc filed Critical Selecta Biosciences Inc
Publication of BR112023020597A2 publication Critical patent/BR112023020597A2/pt

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Abstract

nanocarreadores sintéticos que compreendem um imunossupressante em combinação com agonistas do receptor de il-2 de alta afinidade para aumentar a tolerância imune. são descritos métodos e composições relacionadas para administração de um agonista do receptor de il-2 de alta afinidade em combinação com imunossupressores. os métodos e composições fornecidos podem ser usados para melhorar células t reguladoras, incluindo células t reguladoras específicas para antígeno.
BR112023020597A 2021-04-09 2022-04-08 Nanocarreadores sintéticos que compreendem um imunossupressante em combinação com agonistas do receptor de il-2 de alta afinidade para aumentar a tolerância imune BR112023020597A2 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202163173333P 2021-04-09 2021-04-09
US202163228931P 2021-08-03 2021-08-03
US202163240749P 2021-09-03 2021-09-03
US202163274706P 2021-11-02 2021-11-02
US202163274673P 2021-11-02 2021-11-02
US202163274626P 2021-11-02 2021-11-02
US202263304255P 2022-01-28 2022-01-28
PCT/US2022/024081 WO2022217095A1 (en) 2021-04-09 2022-04-08 Synthetic nanocarriers comprising an immunosuppressant in combination with high affinity il-2 receptor agonists to enhance immune tolerance

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BR112023020597A2 true BR112023020597A2 (pt) 2023-12-12

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US (1) US20220323607A1 (pt)
EP (1) EP4319747A1 (pt)
JP (1) JP2024514577A (pt)
KR (1) KR20230167405A (pt)
AU (1) AU2022253064A1 (pt)
BR (1) BR112023020597A2 (pt)
CA (1) CA3216364A1 (pt)
IL (1) IL307481A (pt)
WO (1) WO2022217095A1 (pt)

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Publication number Priority date Publication date Assignee Title
BR112013027500A2 (pt) 2011-04-29 2017-01-10 Selecta Biosciences Inc liberação controlada de imunossupressores de nanotransportadores sintéticos
WO2023133319A1 (en) * 2022-01-10 2023-07-13 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and synthetic nanocarrier dose sparing
US20230322884A1 (en) * 2022-03-09 2023-10-12 Selecta Biosciences, Inc. Immunosuppressant in combination with high affinity il-2 receptor agonists and related dosing
WO2023196566A1 (en) * 2022-04-08 2023-10-12 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and immunosuppressants to enhance immune tolerance

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