MX2012001853A - Composicion farmaceutica para aliviar el dolor. - Google Patents
Composicion farmaceutica para aliviar el dolor.Info
- Publication number
- MX2012001853A MX2012001853A MX2012001853A MX2012001853A MX2012001853A MX 2012001853 A MX2012001853 A MX 2012001853A MX 2012001853 A MX2012001853 A MX 2012001853A MX 2012001853 A MX2012001853 A MX 2012001853A MX 2012001853 A MX2012001853 A MX 2012001853A
- Authority
- MX
- Mexico
- Prior art keywords
- hyaluronic acid
- pharmaceutical composition
- carboxyl groups
- administration
- suppressing pain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica para aliviar el dolor en una enfermedad articular, incluyendo un ácido hialurónico y un portador farmacéuticamente aceptable, en el cual el ácido hialurónico es reticulado por ciclización de un doble enlace en la porción de un ácido cinámico en un ácido hialurónico parcialmente arnidado representado por la Fórmula (1): [Ar-CH=CH-COO-(CH2)n-NH-]m-HA (1) para formar un anillo de ciclobutano, en la cual Ar representa un grupo fenilo opcionalmente sustituido, n representa un número entero de 2 o 3, HA representa un residuo carboxi de un ácido hialurónico, y m representa un intervalo de amidación del ácido hialurónico al grupo total de carboxilo y representa de 3 a 50% con relación al grupo total de carboxilo. La composición farmacéutica de la presente invención es una formulación interarticular que tiene efectos analgésicos después de administración, y muestra efectos extremadamente duraderos para una enfermedad articular humana con solamente una administración mejor que las múltiples administraciones de una manera convencional.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009187899 | 2009-08-13 | ||
| PCT/JP2010/005060 WO2011018902A1 (ja) | 2009-08-13 | 2010-08-13 | 疼痛抑制用医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012001853A true MX2012001853A (es) | 2012-05-22 |
Family
ID=43586085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012001853A MX2012001853A (es) | 2009-08-13 | 2010-08-13 | Composicion farmaceutica para aliviar el dolor. |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8828969B2 (es) |
| EP (2) | EP2918277A1 (es) |
| JP (4) | JP5788798B2 (es) |
| KR (2) | KR101813487B1 (es) |
| CN (2) | CN106890131A (es) |
| AU (1) | AU2010283380B2 (es) |
| BR (1) | BR112012003149B8 (es) |
| CA (1) | CA2770583C (es) |
| ES (1) | ES2537128T3 (es) |
| JO (1) | JO3008B1 (es) |
| MX (1) | MX2012001853A (es) |
| NZ (1) | NZ597680A (es) |
| RU (1) | RU2558064C2 (es) |
| TW (2) | TWI612965B (es) |
| WO (1) | WO2011018902A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356694B (zh) | 2006-12-06 | 2015-09-02 | 生化学工业株式会社 | 治疗关节炎病症的长效药剂 |
| AU2014205213B2 (en) | 2013-01-11 | 2017-09-21 | Carbylan Therapeutics, Inc. | Stabilized compositions comprising hyaluronic acid |
| GB2518405A (en) * | 2013-09-20 | 2015-03-25 | Zeiss Carl Meditec Ag | Composition comprising at least one viscoelastic polymer |
| EP3511408A1 (en) * | 2016-09-12 | 2019-07-17 | Kelin, Leonid Valerievich | Composition for the treatment or prophylaxis of viral infections |
| JPWO2018168921A1 (ja) | 2017-03-14 | 2020-01-16 | 生化学工業株式会社 | 関節疾患処置用組成物およびこれを含むキット |
| MY193963A (en) | 2017-03-14 | 2022-11-03 | Seikagaku Kogyo Co Ltd | Composition for treating joint diseases and kit containing same |
| WO2018175788A1 (en) | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| JP2020532643A (ja) * | 2017-09-01 | 2020-11-12 | ピーエムアイディージー・エルエルシーＰｍｉｄｇ，Ｌｌｃ | 官能基化および架橋ポリマー |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
| JP2855307B2 (ja) | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
| JP3308742B2 (ja) * | 1994-11-17 | 2002-07-29 | 生化学工業株式会社 | 光架橋性ヒアルロン酸誘導体とその架橋体およびそれらの製造方法 |
| US6025444A (en) * | 1994-11-17 | 2000-02-15 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Cinnamic acid derivative |
| US5690961A (en) | 1994-12-22 | 1997-11-25 | Hercules Incorporated | Acidic polysaccharides crosslinked with polycarboxylic acids and their uses |
| US6031017A (en) * | 1995-11-15 | 2000-02-29 | Seikagaku Corporation | Photocured cross-linked-hyaluronic acid gel and method of preparation thereof |
| DE69822285T2 (de) | 1998-02-27 | 2005-01-27 | Stichting Hyppomedics | Verfahren zur Herstellung von vernetzter Hyaluronsäure |
| NZ521079A (en) | 2000-02-03 | 2004-08-27 | Denki Kagaku Kogyo Kk | Hyaluronic acid gel, process for producing the same, and medical material containing the same |
| EP1217008B1 (en) | 2000-12-19 | 2006-03-01 | Seikagaku Corporation | Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked hyaluronic acid derivative and medical material using the same |
| JP4172176B2 (ja) | 2000-12-19 | 2008-10-29 | 生化学工業株式会社 | 光反応性ヒアルロン酸およびその製造方法ならびに光架橋ヒアルロン酸および医用材料 |
| EP2664335A3 (en) | 2004-12-30 | 2015-12-16 | Genzyme Corporation | Regimens for intra-articular viscosupplementation |
| US8354392B2 (en) * | 2005-07-06 | 2013-01-15 | Seikagaku Corporation | Drug-introduced photo-crosslinked hyaluronic acid derived gel |
| CN103356694B (zh) * | 2006-12-06 | 2015-09-02 | 生化学工业株式会社 | 治疗关节炎病症的长效药剂 |
-
2010
- 2010-08-10 JO JOP/2010/0285A patent/JO3008B1/ar active
- 2010-08-13 KR KR1020127004612A patent/KR101813487B1/ko active IP Right Grant
- 2010-08-13 CN CN201611263701.XA patent/CN106890131A/zh active Pending
- 2010-08-13 CA CA2770583A patent/CA2770583C/en active Active
- 2010-08-13 US US13/390,261 patent/US8828969B2/en active Active
- 2010-08-13 KR KR1020177036970A patent/KR20180000746A/ko not_active Application Discontinuation
- 2010-08-13 MX MX2012001853A patent/MX2012001853A/es active IP Right Grant
- 2010-08-13 NZ NZ597680A patent/NZ597680A/en unknown
- 2010-08-13 BR BR112012003149A patent/BR112012003149B8/pt active IP Right Grant
- 2010-08-13 AU AU2010283380A patent/AU2010283380B2/en active Active
- 2010-08-13 EP EP15157125.4A patent/EP2918277A1/en not_active Withdrawn
- 2010-08-13 ES ES10808087.0T patent/ES2537128T3/es active Active
- 2010-08-13 RU RU2012109392/15A patent/RU2558064C2/ru active
- 2010-08-13 EP EP10808087.0A patent/EP2465512B1/en active Active
- 2010-08-13 TW TW105129117A patent/TWI612965B/zh active
- 2010-08-13 WO PCT/JP2010/005060 patent/WO2011018902A1/ja active Application Filing
- 2010-08-13 CN CN2010800352195A patent/CN102481313A/zh active Pending
- 2010-08-13 TW TW099127068A patent/TWI565470B/zh active
- 2010-08-13 JP JP2011526692A patent/JP5788798B2/ja active Active
-
2014
- 2014-08-05 US US14/452,324 patent/US9579342B2/en active Active
-
2015
- 2015-07-30 JP JP2015150298A patent/JP6058090B2/ja active Active
-
2016
- 2016-12-06 US US15/370,442 patent/US10420795B2/en active Active
- 2016-12-06 JP JP2016236428A patent/JP6280628B2/ja active Active
-
2018
- 2018-01-19 JP JP2018006893A patent/JP6417488B2/ja active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |