MX2022001204A - Métodos de identificación de receptores de linfocitos t. - Google Patents

Métodos de identificación de receptores de linfocitos t.

Info

Publication number
MX2022001204A
MX2022001204A MX2022001204A MX2022001204A MX2022001204A MX 2022001204 A MX2022001204 A MX 2022001204A MX 2022001204 A MX2022001204 A MX 2022001204A MX 2022001204 A MX2022001204 A MX 2022001204A MX 2022001204 A MX2022001204 A MX 2022001204A
Authority
MX
Mexico
Prior art keywords
methods
identifying
mhc class
cell receptors
certain aspects
Prior art date
Application number
MX2022001204A
Other languages
English (en)
Inventor
Naoto Hirano
Kenji Sugata
Munehide Nakatsugawa
Yuki Yamashita
Muhammed Aashiq Rahman
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Publication of MX2022001204A publication Critical patent/MX2022001204A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

La presente descripción hace referencia a métodos de identificación de receptores de linfocitos T (TCR) específicos de MHC de clase II. En determinados aspectos, el método comprende poner un linfocito T en contacto con un complejo que comprende (i) una molécula de MHC de clase II que tiene una mayor afinidad por CD4 que las moléculas de MHC de clase II de origen natural y (ii) un péptido, por ejemplo, un epítopo. En determinados aspectos, la molécula de HLA de clase II comprende una cadena beta que tiene una o más mutaciones con respecto a una secuencia de cadena beta de tipo salvaje.
MX2022001204A 2019-07-30 2020-07-29 Métodos de identificación de receptores de linfocitos t. MX2022001204A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962880492P 2019-07-30 2019-07-30
US202063029103P 2020-05-22 2020-05-22
PCT/IB2020/057176 WO2021019476A1 (en) 2019-07-30 2020-07-29 Methods of identifying t cell receptors

Publications (1)

Publication Number Publication Date
MX2022001204A true MX2022001204A (es) 2022-05-03

Family

ID=74228602

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001204A MX2022001204A (es) 2019-07-30 2020-07-29 Métodos de identificación de receptores de linfocitos t.

Country Status (11)

Country Link
US (1) US20220291215A1 (es)
EP (1) EP4004546A1 (es)
JP (1) JP2022542445A (es)
KR (1) KR20220052941A (es)
CN (1) CN114761802A (es)
AU (1) AU2020321710A1 (es)
CA (1) CA3146290A1 (es)
IL (1) IL290226A (es)
MX (1) MX2022001204A (es)
TW (1) TW202118779A (es)
WO (1) WO2021019476A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022001208A (es) * 2019-07-30 2022-05-03 Univ Health Network Moléculas del complejo mayor de histocompatibilidad (mhc) de clase ii y métodos para su uso.

Also Published As

Publication number Publication date
US20220291215A1 (en) 2022-09-15
CA3146290A1 (en) 2021-02-04
IL290226A (en) 2022-03-01
TW202118779A (zh) 2021-05-16
WO2021019476A1 (en) 2021-02-04
CN114761802A (zh) 2022-07-15
JP2022542445A (ja) 2022-10-03
EP4004546A1 (en) 2022-06-01
AU2020321710A1 (en) 2022-03-03
KR20220052941A (ko) 2022-04-28

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