EA201390011A1 - Т-клеточные рецепторы - Google Patents

Т-клеточные рецепторы

Info

Publication number
EA201390011A1
EA201390011A1 EA201390011A EA201390011A EA201390011A1 EA 201390011 A1 EA201390011 A1 EA 201390011A1 EA 201390011 A EA201390011 A EA 201390011A EA 201390011 A EA201390011 A EA 201390011A EA 201390011 A1 EA201390011 A1 EA 201390011A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tcr
cell receptors
evdpighly
hla
bind
Prior art date
Application number
EA201390011A
Other languages
English (en)
Inventor
Бент Карстен Джейкобсон
Натаниэль Росс Лидди
Original Assignee
Иммьюнокор Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иммьюнокор Лтд. filed Critical Иммьюнокор Лтд.
Publication of EA201390011A1 publication Critical patent/EA201390011A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/464486—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Т-клеточный рецептор (ТКР), обладающий способностью связывать комплекс EVDPIGHLY с HLA-A1 и включающий определенный ТКР дикого типа, который имеет определенные мутации в вариабельном домене альфа- и/или бета-цепи для увеличения аффинности. Такие ТКР можно использовать для адоптивной терапии.
EA201390011A 2010-07-28 2010-07-28 Т-клеточные рецепторы EA201390011A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2010/001433 WO2012013913A1 (en) 2010-07-28 2010-07-28 T cell receptors

Publications (1)

Publication Number Publication Date
EA201390011A1 true EA201390011A1 (ru) 2013-07-30

Family

ID=43836620

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390011A EA201390011A1 (ru) 2010-07-28 2010-07-28 Т-клеточные рецепторы

Country Status (11)

Country Link
US (2) US8283446B2 (ru)
EP (1) EP2598528A1 (ru)
JP (1) JP2013535199A (ru)
CN (1) CN103097407A (ru)
AU (1) AU2010358291A1 (ru)
BR (1) BR112013003647A2 (ru)
CA (1) CA2805320A1 (ru)
EA (1) EA201390011A1 (ru)
MX (1) MX2013000989A (ru)
WO (1) WO2012013913A1 (ru)
ZA (1) ZA201300621B (ru)

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Also Published As

Publication number Publication date
BR112013003647A2 (pt) 2017-11-07
WO2012013913A1 (en) 2012-02-02
MX2013000989A (es) 2013-03-05
CA2805320A1 (en) 2012-02-02
JP2013535199A (ja) 2013-09-12
EP2598528A1 (en) 2013-06-05
US20130149289A1 (en) 2013-06-13
ZA201300621B (en) 2014-06-25
US8283446B2 (en) 2012-10-09
US20120027739A1 (en) 2012-02-02
AU2010358291A1 (en) 2013-02-28
CN103097407A (zh) 2013-05-08

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