BR112013006718A2 - epítopos de células t e receptores de células t antígeno-específicos - Google Patents

epítopos de células t e receptores de células t antígeno-específicos

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Publication number
BR112013006718A2
BR112013006718A2 BR112013006718A BR112013006718A BR112013006718A2 BR 112013006718 A2 BR112013006718 A2 BR 112013006718A2 BR 112013006718 A BR112013006718 A BR 112013006718A BR 112013006718 A BR112013006718 A BR 112013006718A BR 112013006718 A2 BR112013006718 A2 BR 112013006718A2
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Brazil
Prior art keywords
specific
antigen
cell
receptors
epitopes
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BR112013006718A
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English (en)
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BR112013006718B1 (pt
BR112013006718A8 (pt
Inventor
Petra Simon
Tana Omokoko
Ugur Sahin
Özlem Türeci
Original Assignee
Biontech Ag
Tron Translationale Onkologie An Der Universitäsmedizin Der Johannes Gutenberg Universität Mainz
Universitätsmedizin Der Johannes Gutenberg Universität Mainz
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Application filed by Biontech Ag, Tron Translationale Onkologie An Der Universitäsmedizin Der Johannes Gutenberg Universität Mainz, Universitätsmedizin Der Johannes Gutenberg Universität Mainz filed Critical Biontech Ag
Priority to BR122020026648-1A priority Critical patent/BR122020026648B1/pt
Publication of BR112013006718A2 publication Critical patent/BR112013006718A2/pt
Publication of BR112013006718A8 publication Critical patent/BR112013006718A8/pt
Publication of BR112013006718B1 publication Critical patent/BR112013006718B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/464488—NY-ESO
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Abstract

epítopos de células t e receptores de células t antígeno-específicos. a presente invenção refere-se a métodos eficientes para fornecer células linfoides antígeno-específicas. estas células linfoides podem ser utilizadas para fornecer receptores de células t antígeno-específicos que possuem uma restrição do mhc definida e para identificar epítopos de células t imunologicamente revelantes. além disso, a presente invenção refere-se a receptores de células t antígeno-específicos e a epítopos de células t e à sua utilização em imunoterapia.
BR112013006718-7A 2010-09-20 2011-09-19 Receptor de células t com especificidade para ny-eso-1, composição farmacêutica compreendendo o mesmo e uso do mesmo BR112013006718B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020026648-1A BR122020026648B1 (pt) 2010-09-20 2011-09-19 Receptor de células t com especificidade para ny-eso-1, composição farmacêutica compreendendo o mesmo e uso do mesmo

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10009990.2 2010-09-20
EP10009990 2010-09-20
EP11000045 2011-01-05
EP11000045.2 2011-01-05
PCT/EP2011/004674 WO2012038055A1 (en) 2010-09-20 2011-09-19 Antigen-specific t cell receptors and t cell epitopes

Publications (3)

Publication Number Publication Date
BR112013006718A2 true BR112013006718A2 (pt) 2016-11-01
BR112013006718A8 BR112013006718A8 (pt) 2017-09-19
BR112013006718B1 BR112013006718B1 (pt) 2021-12-07

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ID=45873461

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BR112013006718-7A BR112013006718B1 (pt) 2010-09-20 2011-09-19 Receptor de células t com especificidade para ny-eso-1, composição farmacêutica compreendendo o mesmo e uso do mesmo
BR122020026648-1A BR122020026648B1 (pt) 2010-09-20 2011-09-19 Receptor de células t com especificidade para ny-eso-1, composição farmacêutica compreendendo o mesmo e uso do mesmo

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BR122020026648-1A BR122020026648B1 (pt) 2010-09-20 2011-09-19 Receptor de células t com especificidade para ny-eso-1, composição farmacêutica compreendendo o mesmo e uso do mesmo

Country Status (19)

Country Link
US (4) US9586997B2 (pt)
EP (3) EP3213765B1 (pt)
JP (5) JP6378485B2 (pt)
CN (4) CN103249430A (pt)
AU (4) AU2011304728A1 (pt)
BR (2) BR112013006718B1 (pt)
CA (3) CA2812153C (pt)
CY (1) CY1119332T1 (pt)
DK (1) DK2618835T3 (pt)
ES (1) ES2635335T3 (pt)
HK (1) HK1243003A1 (pt)
HR (1) HRP20171164T1 (pt)
LT (1) LT2618835T (pt)
ME (1) ME02810B (pt)
PL (1) PL2618835T3 (pt)
PT (1) PT2618835T (pt)
RS (1) RS56339B1 (pt)
SI (1) SI2618835T1 (pt)
WO (1) WO2012038055A1 (pt)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2387627B1 (en) 2009-01-15 2016-03-30 Adaptive Biotechnologies Corporation Adaptive immunity profiling and methods for generation of monoclonal antibodies
WO2013134162A2 (en) 2012-03-05 2013-09-12 Sequenta, Inc. Determining paired immune receptor chains from frequency matched subunits
RU2631797C2 (ru) 2012-05-08 2017-09-26 Эдэптив Байотекнолоджиз Корпорейшн Композиции и способы измерения и калибровки систематической ошибки амплификации в мультиплексных пцр-реакциях
US9487573B2 (en) 2012-05-22 2016-11-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Murine anti-NY-ESO-1 T cell receptors
CN104968675B (zh) * 2012-09-14 2021-09-24 美国政府卫生与公众服务部 识别mhc ii类限制性mage-a3的t细胞受体
GB2508414A (en) 2012-11-30 2014-06-04 Max Delbrueck Centrum Tumour specific T cell receptors (TCRs)
EP2932264B1 (en) 2012-12-14 2019-01-30 BioNTech RNA Pharmaceuticals GmbH Novel mhc-independent tumor-associated antigens
EP2971045B1 (en) * 2013-03-13 2019-06-19 Health Research, Inc. Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen
CN105555756B (zh) 2013-06-28 2018-12-07 奥克兰联合服务有限公司 氨基酸缀合物和肽缀合物及缀合方法
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
GB201314404D0 (en) * 2013-08-12 2013-09-25 Immunocore Ltd T Cell Receptors
WO2015058780A1 (en) 2013-10-25 2015-04-30 Biontech Ag Method and kit for determining whether a subject shows an immune response
CN106103711A (zh) 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用
WO2015077615A1 (en) 2013-11-22 2015-05-28 The Board Of Trustees Of The University Of Illinois Engineered high-affinity human t cell receptors
GB201322430D0 (en) * 2013-12-18 2014-02-05 Immunocore Ltd T cell receptors
EP3083674B1 (en) * 2013-12-19 2018-10-03 Friedrich-Alexander-Universität Erlangen-Nürnberg Influenza-specific t-cell receptor and its uses in the detection, prevention and/or treatment of influenza
JP6508873B2 (ja) * 2014-01-20 2019-05-08 国立大学法人富山大学 抗原特異的ｔ細胞受容体の取得方法
EP3114240B1 (en) 2014-03-05 2019-07-24 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
EP3132059B1 (en) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
EP2944652A1 (en) * 2014-05-13 2015-11-18 Technische Universität München Glypican-3-specific T-cell receptors and their uses for immunotherapy of hepatocellular carcinoma
CN112979828A (zh) * 2014-07-17 2021-06-18 恺兴生命科技(上海)有限公司 靶向cld18a2的t淋巴细胞及其制备方法和应用
CA2956545A1 (en) * 2014-08-04 2016-02-11 Fred Hutchinson Cancer Research Center T cell immunotherapy specific for wt-1
GB201417803D0 (en) * 2014-10-08 2014-11-19 Adaptimmune Ltd T cell receptors
EP3715455A1 (en) 2014-10-29 2020-09-30 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
AU2015339744B2 (en) 2014-10-31 2021-03-25 The Trustees Of The University Of Pennsylvania Altering gene expression in CART cells and uses thereof
JP2017534280A (ja) * 2014-10-31 2017-11-24 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 腫瘍を標的にするがｔ細胞を標的にしないサバイビン特異的ｔ細胞受容体
MX2017005707A (es) 2014-11-05 2017-08-21 Memorial Sloan Kettering Cancer Center Metodos para seleccionar una linea de celulas t y el donador de la misma para terapia celular adoptiva.
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
WO2016095783A1 (zh) * 2014-12-17 2016-06-23 中国科学院广州生物医药与健康研究院 识别eb病毒短肽的t细胞受体
CN107995926B (zh) * 2014-12-19 2021-07-06 苏黎世联邦理工学院 嵌合抗原受体和使用方法
BR112017013574A2 (pt) 2014-12-23 2018-03-06 Verdon Daniel conjugados de aminoácido e peptídeo e usos dos mesmos
AU2016220324B2 (en) 2015-02-16 2020-07-02 The Trustees Of The University Of Pennsylvania A fully-human T cell receptor specific for the 369-377 epitope derived from the HER2/Neu (ERBB2) receptor protein
AU2016222788B2 (en) 2015-02-24 2022-03-31 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
EP3067366A1 (en) * 2015-03-13 2016-09-14 Max-Delbrück-Centrum Für Molekulare Medizin Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1
SG11201707540QA (en) * 2015-03-16 2017-10-30 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library
EP3273975A4 (en) * 2015-03-26 2018-10-17 The Trustees Of The University Of Pennsylvania In vitro artificial lymph node for sensitization and expansion of t cells for therapy and epitope mapping
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
CA2984380A1 (en) * 2015-05-05 2016-11-10 The Regents Of The University Of California H3.3 ctl peptides and uses thereof
US10441644B2 (en) 2015-05-05 2019-10-15 The Regents Of The University Of California H3.3 CTL peptides and uses thereof
WO2016180468A1 (en) 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Claudin-18.2-specific immunoreceptors and t cell epitopes
AU2016323017B2 (en) * 2015-09-15 2020-11-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing HLA-Cw8 restricted mutated KRAS
MX2018003534A (es) * 2015-09-25 2019-04-25 Abvitro Llc Proceso de alto rendimiento para identificacion de blanco de receptor de celula t de secuencias de receptor de celula t apareadas de manera natural.
EP3156067A1 (en) 2015-10-16 2017-04-19 Max-Delbrück-Centrum Für Molekulare Medizin High avidity hpv t-cell receptors
GB201520191D0 (en) * 2015-11-16 2015-12-30 Cancer Rec Tech Ltd T-cell receptor and uses thereof
GB201520570D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
WO2017096247A1 (en) 2015-12-04 2017-06-08 Mayo Foundation For Medical Education And Research Methods and vaccines for inducing immune responses to multiple different mhc molecules
GB201522592D0 (en) * 2015-12-22 2016-02-03 Immunocore Ltd T cell receptors
WO2017112944A1 (en) 2015-12-23 2017-06-29 Fred Hutchinson Cancer Research Center High affinity t cell receptors and uses thereof
US11020431B2 (en) 2016-01-06 2021-06-01 Health Research, Inc. Compositions and libraries comprising recombinant T-cell receptors and methods of using recombinant T-cell receptors
EP3202784A1 (en) * 2016-02-08 2017-08-09 Polybiocept AB T-cell receptor sequences for active immunotherapy
JP7161404B2 (ja) 2016-02-26 2022-10-26 オークランド ユニサービシーズ リミティド アミノ酸及びペプチド接合体及び接合方法
TWI826891B (zh) 2016-03-16 2023-12-21 德商英麥提克生物技術股份有限公司 轉染 t 細胞和 t 細胞受體用於癌症免疫治療
GB201604492D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
PL3430037T3 (pl) 2016-03-16 2022-12-19 Immatics Biotechnologies Gmbh Transfekowane komórki t oraz receptory komórek t do stosowania w immunoterapii przeciwnowotworowej
CN106749620B (zh) * 2016-03-29 2020-09-25 广东香雪精准医疗技术有限公司 识别mage-a1抗原短肽的t细胞受体
JP7204484B2 (ja) 2016-04-08 2023-01-16 アダプティミューン・リミテッド Ｔ細胞受容体
HRP20211493T1 (hr) 2016-04-08 2022-01-21 Adaptimmune Limited Receptori t stanica
MA45491A (fr) * 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
WO2018006054A1 (en) * 2016-06-30 2018-01-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Herv-e reactive t cell receptors and methods of use
DK3494133T3 (da) * 2016-08-02 2022-09-19 Us Health Anti-kras-g12d-t-cellereceptorer
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
AU2017356322B2 (en) * 2016-11-14 2023-09-21 Fred Hutchinson Cancer Center High affinity merkel cell polyomavirus T antigen-specific TCRs and uses thereof
CN108117596B (zh) * 2016-11-29 2023-08-29 香雪生命科学技术（广东）有限公司 针对ny-eso的高亲和力tcr
MA47265A (fr) 2017-01-13 2019-11-20 Agenus Inc Récepteurs de lymphocytes t qui se lient à ny-eso-1 et méthodes d'utilisation de ces derniers
EP3354658A1 (en) * 2017-01-25 2018-08-01 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Novel t cell receptors and immune therapy using the same for the treatment of cancer and infectious diseases
SG11201908527SA (en) * 2017-03-15 2019-10-30 Hutchinson Fred Cancer Res High affinity mage-a1-specific tcrs and uses thereof
EP3601594A4 (en) * 2017-03-24 2021-04-14 The Board of Trustees of the Leland Stanford Junior University ANTIGEN DETECTION FOR T-CELL RECEPTORS ISOLATED FROM PATIENT TUMORS THAT DETECT WILD TYPE ANTIGENS AND POTENT PEPTIDE MIMOTOPES
KR20200006985A (ko) * 2017-05-12 2020-01-21 오거스타 유니버시티 리서치 인스티튜트, 인크. 인간 알파 태아단백-특이적 t 세포 수용체 및 이의 용도
CN108929378B (zh) * 2017-05-22 2021-04-23 香雪生命科学技术（广东）有限公司 一种识别prame抗原的t细胞受体及编码该受体的核酸
CA3067772A1 (en) * 2017-06-30 2019-01-03 Marieke GRIFFIOEN Treatment of haematological malignancies
CN107630005A (zh) * 2017-09-19 2018-01-26 深圳市北科生物科技有限公司 表达plac1特异性tcr的t细胞及其应用
CN107557339A (zh) * 2017-09-19 2018-01-09 深圳市北科生物科技有限公司 特异性识别plac1的t细胞及其与细胞因子的联合的应用
CN109776671B (zh) * 2017-11-14 2022-05-27 杭州康万达医药科技有限公司 分离的t细胞受体、其修饰的细胞、编码核酸、表达载体、制备方法、药物组合物和应用
EP3714275A4 (en) * 2017-11-22 2021-10-27 Gritstone bio, Inc. REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2019204683A1 (en) * 2018-04-19 2019-10-24 Board Of Regents, The University Of Texas System T cell receptors with mage-b2 specificity and uses thereof
CN110857319B (zh) * 2018-08-24 2023-12-08 杭州康万达医药科技有限公司 一种分离的t细胞受体、其修饰的细胞、编码核酸及其应用
JP2022500034A (ja) * 2018-09-10 2022-01-04 トルク セラピューティクス， インコーポレイテッド 抗原特異的ｔリンパ球ならびに抗原特異的ｔリンパ球を作製および使用する方法
CA3107859A1 (en) * 2018-09-12 2020-03-19 Universitat Basel Mr1 restricted t cell receptors for cancer immunotherapy
GB201817172D0 (en) * 2018-10-22 2018-12-05 Autolus Ltd Antibody
GB201819540D0 (en) * 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
WO2020118094A1 (en) * 2018-12-06 2020-06-11 Guangdong Tcrcure Biopharma Technology Co., Ltd. Combinational tcr-t cell therapy targeting tumor antigens, tgf-beta, and immune checkpoints
EP3670530A1 (en) * 2018-12-18 2020-06-24 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Cd22-specific t cell receptors and adoptive t cell therapy for treatment of b cell malignancies
US20220169695A1 (en) * 2019-03-04 2022-06-02 University Health Network T cell receptors and methods of use thereof
BR112021017464A2 (pt) * 2019-03-04 2021-11-16 Univ Health Network Receptores de células t e métodos de uso dos mesmos
WO2021016109A1 (en) * 2019-07-19 2021-01-28 The Regents Of The University Of California T-cell receptors and methods of use thereof
DE102019121007A1 (de) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigenbindende Proteine, die spezifisch an MAGE-A binden
WO2021022447A1 (zh) * 2019-08-05 2021-02-11 广东香雪精准医疗技术有限公司 识别afp抗原短肽的t细胞受体
CN112442119B (zh) * 2019-09-05 2023-02-24 香雪生命科学技术（广东）有限公司 一种识别ssx2的高亲和力t细胞受体
WO2021080847A1 (en) * 2019-10-21 2021-04-29 Flaskworks, Llc Systems and methods for cell culturing
GB201915282D0 (en) * 2019-10-22 2019-12-04 Immunocore Ltd Specific binding molecules
WO2021142081A1 (en) * 2020-01-07 2021-07-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t cell populations using induced pluripotent stem cells
CN111234004B (zh) * 2020-02-28 2023-03-28 陕西九州新药评价研究有限公司(西安新药评价研究中心) 识别wt1抗原短肽的t细胞受体及其应用
CN113512124A (zh) * 2020-04-10 2021-10-19 香雪生命科学技术（广东）有限公司 一种识别hpv16的高亲和力tcr
CN113667008A (zh) * 2020-05-15 2021-11-19 香雪生命科学技术（广东）有限公司 一种识别afp抗原的高亲和力t细胞受体
CN114106144B (zh) * 2020-08-27 2024-01-26 溧阳瑅赛生物医药有限公司 识别hla-a*02/wt1靶点的tcr及其应用
WO2022098750A1 (en) * 2020-11-03 2022-05-12 La Jolla Institute For Immunology Hla class ii-restricted tcrs against the kras g12>v activating mutation
CN115171787A (zh) * 2022-07-08 2022-10-11 腾讯科技（深圳）有限公司 抗原预测方法、装置、设备以及存储介质
WO2024054863A1 (en) * 2022-09-06 2024-03-14 Board Of Regents, The University Of Texas System T-cell receptor that targets egfr mutation and methods of using the same

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677139A (en) 1995-04-21 1997-10-14 President And Fellows Of Harvard College In vitro differentiation of CD34+ progenitor cells into T lymphocytes
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
WO1997024447A1 (en) 1996-01-02 1997-07-10 Chiron Corporation Immunostimulation mediated by gene-modified dendritic cells
US6268411B1 (en) * 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
DE19821060A1 (de) 1997-09-23 1999-04-15 Bundesrepublik Deutschland Let Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung
AU752433B2 (en) 1997-09-23 2002-09-19 Bundesrepublik Deutschland letzvertreten durch Den Direktor des Robert-Koch-Instituts Costimulating T-cell polypeptide, monoclonal antibodies, their preparation and use
US6800730B1 (en) * 1998-10-02 2004-10-05 Ludwig Institute For Cancer Research Isolated peptides which bind to MHC class II molecules, and uses thereof
EP2311950A1 (en) * 2000-01-28 2011-04-20 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Novel MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1
US20020107388A1 (en) * 2000-05-12 2002-08-08 Vandenbark Arthur A. Methods of identifying and monitoring disease-associated T cells
AUPQ776100A0 (en) 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
DE10109854A1 (de) * 2001-03-01 2002-09-12 Thomas Stanislawski Polypeptide eines hdm2-Protein spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung
US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
DK1453471T3 (da) * 2001-11-07 2011-03-28 Mannkind Corp Ekspressionsvektorer, der koder for epitoper af antigener, og fremgangsmåde til deres konstruktion
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
CA2535665A1 (en) 2003-08-14 2005-02-24 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivative and use thereof
DE10341812A1 (de) * 2003-09-10 2005-04-07 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
DE10347710B4 (de) * 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
JP5186209B2 (ja) * 2004-05-26 2013-04-17 イムノコア リミテッド テロメラーゼ高親和性ｔ細胞受容体
EP1786465A4 (en) * 2004-07-30 2009-01-21 Univ Oregon Health & Science METHODS FOR DETECTION AND TREATMENT OF AUTOIMMUNE DISORDERS
US20060127377A1 (en) * 2004-08-03 2006-06-15 Stanislav Vukmanovic T cell receptors with enhanced sensitivity recognition of antigen
WO2006031221A1 (en) * 2004-09-13 2006-03-23 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Compositions comprising t cell receptors and methods of use thereof
EP3369812B1 (en) * 2005-08-05 2020-10-07 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Generation of antigen specific t cells
EP1795599A1 (en) * 2005-12-09 2007-06-13 Schuler, Gerold, Prof. Dr. Methods for generating antigen-specific effector T cells
US7820174B2 (en) * 2006-02-24 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services T cell receptors and related materials and methods of use
US8119772B2 (en) * 2006-09-29 2012-02-21 California Institute Of Technology MART-1 T cell receptors
JP5292550B2 (ja) * 2007-03-23 2013-09-18 静岡県 Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子
US20110030074A1 (en) * 2007-05-21 2011-02-03 Dana Farber Cancer Institute, Inc. Compositions and methods for cancer gene discovery
US7928190B2 (en) * 2007-07-05 2011-04-19 Darnell Robert B Methods and compositions for tumor vaccination and therapy
CN101182531B (zh) * 2007-11-09 2010-06-02 暨南大学 Eb病毒特异性tcr基因相关的重组质粒及构建抗ebv特异性ctl的方法
JP2009278927A (ja) * 2008-05-23 2009-12-03 Tohoku Univ Ｔ細胞受容体を模倣する抗体断片及びその製造方法
US20100011199A1 (en) 2008-07-09 2010-01-14 Au Group Electronics Method and device of bootloader-to-go
WO2010105298A1 (en) 2009-03-18 2010-09-23 Simon Barry Peptidase inhibitor 16 (pi16) as a biomarker for regulatory t (treg) cells and uses thereof

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