ES2681973T3 - Respuesta antitumoral contra autoepítopos modificados - Google Patents
Respuesta antitumoral contra autoepítopos modificados Download PDFInfo
- Publication number
- ES2681973T3 ES2681973T3 ES13750368T ES13750368T ES2681973T3 ES 2681973 T3 ES2681973 T3 ES 2681973T3 ES 13750368 T ES13750368 T ES 13750368T ES 13750368 T ES13750368 T ES 13750368T ES 2681973 T3 ES2681973 T3 ES 2681973T3
- Authority
- ES
- Spain
- Prior art keywords
- autoepitopes
- response against
- tumor response
- against modified
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000006023 anti-tumor response Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000006329 citrullination Effects 0.000 abstract 1
- 229960002173 citrulline Drugs 0.000 abstract 1
- 235000013477 citrulline Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001162—Kinases, e.g. Raf or Src
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/00117—Mucins, e.g. MUC-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001176—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
Un epítopo de linfocitos T asociado a tumor que estimula una reacción inmunitaria contra el tumor para su uso en medicina, teniendo el epítopo una modificación de desiminación de arginina en citrulina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1214007.5A GB201214007D0 (en) | 2012-08-07 | 2012-08-07 | Anti-tumour immune responses to modified self-epitopes |
PCT/GB2013/052109 WO2014023957A2 (en) | 2012-08-07 | 2013-08-07 | Anti-tumour response to modified self-epitopes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2681973T3 true ES2681973T3 (es) | 2018-09-17 |
Family
ID=46934958
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES13750368T Active ES2681973T3 (es) | 2012-08-07 | 2013-08-07 | Respuesta antitumoral contra autoepítopos modificados |
ES17194252T Active ES2843777T3 (es) | 2012-08-07 | 2013-08-07 | Respuesta antitumoral contra autoepítopos modificados |
ES17194251T Active ES2833962T3 (es) | 2012-08-07 | 2013-08-07 | Respuesta antitumoral a epítopos propios modificados |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES17194252T Active ES2843777T3 (es) | 2012-08-07 | 2013-08-07 | Respuesta antitumoral contra autoepítopos modificados |
ES17194251T Active ES2833962T3 (es) | 2012-08-07 | 2013-08-07 | Respuesta antitumoral a epítopos propios modificados |
Country Status (18)
Country | Link |
---|---|
US (4) | US10233220B2 (es) |
EP (3) | EP3301447B1 (es) |
JP (2) | JP6490581B2 (es) |
KR (1) | KR102203096B1 (es) |
CN (2) | CN107043414A (es) |
AU (1) | AU2013301341B2 (es) |
BR (1) | BR112015002574A8 (es) |
CA (1) | CA2874515A1 (es) |
DK (3) | DK2883054T3 (es) |
ES (3) | ES2681973T3 (es) |
GB (1) | GB201214007D0 (es) |
HK (1) | HK1206427A1 (es) |
IN (1) | IN2014DN10629A (es) |
PL (2) | PL3301447T3 (es) |
PT (3) | PT2883054T (es) |
SG (2) | SG10201701001VA (es) |
WO (1) | WO2014023957A2 (es) |
ZA (1) | ZA201409095B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3539567A1 (en) | 2007-07-02 | 2019-09-18 | Etubics Corporation | Methods and compositions for producing an adenovirus vector for use with multiple vaccinations |
GB201214007D0 (en) | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
US9605276B2 (en) | 2012-08-24 | 2017-03-28 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
ES2674393T3 (es) * | 2014-05-05 | 2018-06-29 | Novio Th B.V. | Método para el diagnóstico serológico de la artritis reumatoide |
CN104360070B (zh) * | 2014-11-28 | 2017-02-22 | 山东新创生物科技有限公司 | 肽基精氨酸脱亚胺酶2在制备肿瘤临床血液诊断试剂中的应用 |
JP6647315B2 (ja) | 2015-01-09 | 2020-02-14 | イーチュービクス コーポレイション | 組み合わせ免疫療法のための方法および組成物 |
US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
MA42420A (fr) | 2015-05-13 | 2018-05-23 | Agenus Inc | Vaccins pour le traitement et la prévention du cancer |
GB201512703D0 (en) * | 2015-07-20 | 2015-08-26 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
SG10202111399YA (en) | 2015-12-22 | 2021-11-29 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
GB201522667D0 (en) * | 2015-12-22 | 2016-02-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
WO2018046648A1 (en) * | 2016-09-08 | 2018-03-15 | Katholieke Universiteit Leuven | Citrullinated peptides for diagnosis or treatment of diabetes |
KR102184377B1 (ko) * | 2018-02-19 | 2020-11-30 | 고려대학교 산학협력단 | 열충격단백질의 에피토프를 포함하는 백신 및 이의 용도 |
WO2019210055A2 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
GB201815041D0 (en) | 2018-09-14 | 2018-10-31 | Scancell Ltd | Epitopes |
GB202005779D0 (en) | 2020-04-21 | 2020-06-03 | Scancell Ltd | Anti-tumour immune responses |
CN112194719A (zh) * | 2020-09-01 | 2021-01-08 | 中日友好医院(中日友好临床医学研究所) | Crt抗原和mage-a1抗原的制备及其应用 |
GB202018395D0 (en) | 2020-11-23 | 2021-01-06 | Scancell Ltd | Immunotherapy |
CN114404570B (zh) * | 2022-01-20 | 2023-05-30 | 中国药科大学 | 一种新型抗肿瘤转移多肽及其应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002051785A (ja) * | 2000-08-09 | 2002-02-19 | Hagiwara Yoshihide | 抗癌ヒトモノクローナル抗体CLN−IgGによって認識される抗原エピトープのアミノ酸配列およびそれをコードするDNAヌクレオチド配列 |
WO2002034287A2 (en) * | 2000-10-27 | 2002-05-02 | Pharmexa A/S | Therapeutic vaccine formulations containing chitosan |
US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
WO2003024191A2 (en) * | 2001-09-21 | 2003-03-27 | Raven Biotechnologies, Inc. | Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof |
EP1461001A4 (en) * | 2002-01-03 | 2010-03-31 | Scripps Research Inst | EPITOPE ASSOCIATED WITH CANCER |
US20040013649A1 (en) * | 2002-05-10 | 2004-01-22 | Inex Pharmaceuticals Corporation | Cancer vaccines and methods of using the same |
US7423007B2 (en) | 2002-08-27 | 2008-09-09 | Biokine Therapeutics Ltd. | Cxcr4 antagonist and use thereof |
CN100347191C (zh) * | 2002-10-02 | 2007-11-07 | 霍夫曼-拉罗奇有限公司 | 新mhcⅱ相关肽 |
US7670604B2 (en) * | 2002-12-13 | 2010-03-02 | Aurelium Biopharma, Inc. | Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease |
DE10313819A1 (de) * | 2003-03-24 | 2004-10-07 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
EP1695089A1 (en) | 2003-12-15 | 2006-08-30 | Aurelium Biopharma Inc. | Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease |
EP1890724A2 (en) * | 2005-05-13 | 2008-02-27 | Oxxon Therapeutics Limited | Compositions for inducing an immune response |
DE102005029845B4 (de) | 2005-06-27 | 2017-03-23 | Orgentec Diagnostika Gmbh | Verfahren zur Diagnose von rheumatischen Erkrankungen |
CN1712964A (zh) * | 2005-07-18 | 2005-12-28 | 山东省医药生物技术研究中心 | 类风湿性关节炎特异性抗原性标志物及其应用 |
US20070248628A1 (en) * | 2005-12-06 | 2007-10-25 | Keller Lorraine H | Immunogens in cancer stem cells |
WO2007098093A2 (en) * | 2006-02-17 | 2007-08-30 | Five Prime Therapeutics, Inc. | Compositions and methods of use for modulators of polypeptides and polynucleotides in treating breast cancer and melanoma |
CN101384618A (zh) * | 2006-02-17 | 2009-03-11 | 印第安纳大学研究及科技有限公司 | 癌中capcna蛋白-蛋白相互作用的肽基抑制 |
WO2007127160A2 (en) * | 2006-04-24 | 2007-11-08 | Shantha West, Inc. | Agrm2 antigen |
EP1882697B1 (en) * | 2006-07-24 | 2010-04-21 | Institut Pasteur | Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins |
CN101765434B (zh) * | 2007-07-27 | 2014-12-17 | 伊玛提克斯生物技术有限公司 | 抗肿瘤相关肽及相关抗癌疫苗组合物 |
MX2010008633A (es) * | 2008-02-08 | 2010-09-30 | Scripps Research Inst | Ruptura de tolerancia inmunologica con un aminoacido no natural geneticamente codificado. |
AU2010234942B2 (en) * | 2009-03-30 | 2015-03-05 | Nestec S.A. | Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis |
KR102095670B1 (ko) * | 2010-05-14 | 2020-03-31 | 더 제너럴 하스피톨 코포레이션 | 종양 특이적 신생항원을 확인하는 조성물 및 방법 |
WO2012095849A1 (en) | 2011-01-10 | 2012-07-19 | Biokine Therapeutics Ltd. | Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma |
WO2012103365A1 (en) | 2011-01-28 | 2012-08-02 | Oregon Health & Science University | Recombinant t cell ligands and antibodies that bind b cells for the treatment of autoimmune diseases |
US20150218546A1 (en) | 2011-04-05 | 2015-08-06 | Lars Klareskog | Novel peptides that bind to types of mhc class ii and their use on diagnosis and treatment |
US20120295292A1 (en) * | 2011-05-19 | 2012-11-22 | University Of South Carolina | Detecting Protein Arginine Deiminase (PAD) Activity in Human Tissues and Sera |
US20130274125A1 (en) * | 2012-04-16 | 2013-10-17 | Bio-Rad Laboratories Inc. | Multiplex immunoassay for rheumatoid arthritis and other autoimmune diseases |
GB201214007D0 (en) | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
-
2012
- 2012-08-07 GB GBGB1214007.5A patent/GB201214007D0/en not_active Ceased
-
2013
- 2013-08-07 WO PCT/GB2013/052109 patent/WO2014023957A2/en active Application Filing
- 2013-08-07 PT PT13750368T patent/PT2883054T/pt unknown
- 2013-08-07 PT PT171942519T patent/PT3287787T/pt unknown
- 2013-08-07 KR KR1020157004947A patent/KR102203096B1/ko active IP Right Grant
- 2013-08-07 EP EP17194252.7A patent/EP3301447B1/en active Active
- 2013-08-07 EP EP17194251.9A patent/EP3287787B1/en active Active
- 2013-08-07 DK DK13750368.6T patent/DK2883054T3/en active
- 2013-08-07 DK DK17194251.9T patent/DK3287787T3/da active
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- 2013-08-07 IN IN10629DEN2014 patent/IN2014DN10629A/en unknown
- 2013-08-07 CN CN201611090520.1A patent/CN107043414A/zh active Pending
- 2013-08-07 SG SG10201701001VA patent/SG10201701001VA/en unknown
- 2013-08-07 BR BR112015002574A patent/BR112015002574A8/pt not_active Application Discontinuation
- 2013-08-07 CN CN201380041701.3A patent/CN104823054B/zh active Active
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- 2013-08-07 AU AU2013301341A patent/AU2013301341B2/en active Active
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2014
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2015
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2018
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2020
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2022
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