MX2010008633A - Ruptura de tolerancia inmunologica con un aminoacido no natural geneticamente codificado. - Google Patents

Ruptura de tolerancia inmunologica con un aminoacido no natural geneticamente codificado.

Info

Publication number
MX2010008633A
MX2010008633A MX2010008633A MX2010008633A MX2010008633A MX 2010008633 A MX2010008633 A MX 2010008633A MX 2010008633 A MX2010008633 A MX 2010008633A MX 2010008633 A MX2010008633 A MX 2010008633A MX 2010008633 A MX2010008633 A MX 2010008633A
Authority
MX
Mexico
Prior art keywords
amino acid
unnatural amino
genetically encoded
immunological tolerance
target moiety
Prior art date
Application number
MX2010008633A
Other languages
English (en)
Inventor
Jan Grunewald
Meng-Lin Tsao
Roshan Perea
Richard A Lerner
Vaughn V Smider
Peter G Schultz
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of MX2010008633A publication Critical patent/MX2010008633A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Abstract

La presente invención comprende métodos y composiciones para producir y/o mejorar una respuesta inmunológica en un sujeto contra una porción objetivo tal como una porción relacionada a enfermedad, por administración de una version antigénica de la porción objetivo que tiene uno o más aminoácidos no naturales y/o por administración de un anticuerpo contra una versión de una porción objetivo que tiene uno o más aminoácidos no naturales, este anticuerpo es de reacción cruzada con la porción objetivo natural.
MX2010008633A 2008-02-08 2009-02-07 Ruptura de tolerancia inmunologica con un aminoacido no natural geneticamente codificado. MX2010008633A (es)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US6514808P 2008-02-08 2008-02-08
US6514708P 2008-02-08 2008-02-08
US6551508P 2008-02-12 2008-02-12
US6559008P 2008-02-12 2008-02-12
US13596908P 2008-07-25 2008-07-25
US13594708P 2008-07-25 2008-07-25
US13763508P 2008-07-31 2008-07-31
US13767608P 2008-07-31 2008-07-31
US20394808P 2008-12-29 2008-12-29
US20394708P 2008-12-29 2008-12-29
PCT/US2009/000813 WO2009099672A2 (en) 2008-02-08 2009-02-07 Breaking immunological tolerance with a genetically encoded unnatural amino acid

Publications (1)

Publication Number Publication Date
MX2010008633A true MX2010008633A (es) 2010-09-30

Family

ID=40952613

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008633A MX2010008633A (es) 2008-02-08 2009-02-07 Ruptura de tolerancia inmunologica con un aminoacido no natural geneticamente codificado.

Country Status (11)

Country Link
US (2) US20110052525A1 (es)
EP (1) EP2249865A4 (es)
JP (1) JP2011514322A (es)
KR (1) KR20100125290A (es)
CN (1) CN101970005A (es)
AU (1) AU2009210677A1 (es)
BR (1) BRPI0906388A2 (es)
CA (1) CA2712080A1 (es)
IL (1) IL207013A0 (es)
MX (1) MX2010008633A (es)
WO (1) WO2009099672A2 (es)

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MXPA03009563A (es) * 2001-04-19 2004-12-06 Scripps Research Inst Incorporacion in vivo de aminoacidos no naturales.
ATE542894T1 (de) 2003-04-17 2012-02-15 Scripps Research Inst Ausweitung des eukaryotischen genetischen codes
ATE386133T1 (de) 2003-07-07 2008-03-15 Scripps Research Inst Zusammensetzungen der orthogonalen lysyl-trna und aminoacyl-trna synthetase paaren und ihre verwendungen
KR101732054B1 (ko) 2008-09-26 2017-05-02 암브룩스, 인코포레이티드 비천연 아미노산 복제 의존성 미생물 및 백신
GB201214007D0 (en) * 2012-08-07 2012-09-19 Scancell Ltd Anti-tumour immune responses to modified self-epitopes
JP6134392B2 (ja) 2013-01-25 2017-05-24 サイモン・エルエルシー 循環している生物学的に活性な可溶性ｔｎｆの選択的低減用の組成物およびｔｎｆ媒介性疾患を処置する方法
CN103183734B (zh) * 2013-02-21 2016-01-20 中国药科大学 含有非天然氨基酸的突变蛋白及其应用
AU2016215049B2 (en) 2015-02-06 2021-12-02 Cell Idx, Inc. Antigen-coupled immunoreagents
CN104761631A (zh) * 2015-04-15 2015-07-08 中国药科大学 多位点引入对硝基苯丙氨酸的人肿瘤坏死因子-α
JP6830448B2 (ja) 2015-06-25 2021-02-17 ダウ グローバル テクノロジーズ エルエルシー 高いｇ’及び広いｍｗｄを有する管状エチレン系ポリマーを作製するための改善されたプロセス
US10400046B2 (en) 2015-06-25 2019-09-03 Joseph J. Matsko Portable powered paint system
BR112017027794A2 (pt) 2015-06-25 2018-08-28 Dow Global Technologies Llc polímeros à base de etileno com baixos extraíveis de hexano e baixas densidades
CN107787334B (zh) 2015-06-25 2020-07-24 陶氏环球技术有限责任公司 具有低己烷可萃取物的乙烯类聚合物
WO2016210308A1 (en) 2015-06-25 2016-12-29 Dow Global Technologies Llc Improved process to make tubular ethylene based polymers with high melt strength
CN106929482A (zh) * 2015-12-31 2017-07-07 北京大学 定点突变的流感病毒、其活疫苗及其制备方法和应用
CN107033232A (zh) * 2016-02-04 2017-08-11 上海亨臻实业有限公司 一种低生物活性的肿瘤坏死因子α突变蛋白及其制法和用途
CN107459580A (zh) * 2016-06-06 2017-12-12 易金阳 一种利用酵母菌表达含有穿膜肽的寡肽‑1（egf）创新制备工艺
US20190233876A1 (en) * 2016-07-18 2019-08-01 Cell Idx, Inc. Antigen-coupled hybridization reagents
CN109748952B (zh) * 2018-05-02 2020-09-15 中国药科大学 辅助性表位肽及其应用
CN112611864B (zh) * 2020-12-03 2024-03-12 重庆市畜牧科学院 筛分病菌模型的系统及筛分方法
WO2023025147A1 (zh) * 2021-08-23 2023-03-02 南通壹宸生物医药科技有限公司 抗原表位修饰

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MXPA03009563A (es) * 2001-04-19 2004-12-06 Scripps Research Inst Incorporacion in vivo de aminoacidos no naturales.
KR20050073559A (ko) * 2002-10-16 2005-07-14 더 스크립스 리서치 인스티튜트 당단백질 합성
AU2003300389B2 (en) * 2002-12-22 2009-10-08 The Scripps Research Institute Protein arrays
ATE542894T1 (de) * 2003-04-17 2012-02-15 Scripps Research Inst Ausweitung des eukaryotischen genetischen codes
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ATE386133T1 (de) * 2003-07-07 2008-03-15 Scripps Research Inst Zusammensetzungen der orthogonalen lysyl-trna und aminoacyl-trna synthetase paaren und ihre verwendungen
US20060160175A1 (en) * 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
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EP1687401B1 (en) * 2003-10-14 2012-11-21 The Scripps Research Institute Site-specific incorporation of redox active amino acids into proteins
EP1725251A4 (en) * 2003-12-18 2009-07-01 Scripps Research Inst SELECTIVE INCORPORATION OF 5-HYDROXYTRYPTOPHANE IN PROTEINS IN MAMMALIAN CELLS
JP2008500050A (ja) * 2004-05-25 2008-01-10 ザ スクリップス リサーチ インスティテュート 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み
AU2005327906B2 (en) * 2004-07-21 2010-05-13 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
US20060134746A1 (en) * 2004-09-21 2006-06-22 The Scripps Research Institute Adding photoregulated amino acids to the genetic code
EP2770053B1 (en) * 2004-09-21 2018-02-21 The Scripps Research Institute In vivo incorporation of alkynyl amino acids into proteins in eubacteria
WO2006036779A2 (en) * 2004-09-22 2006-04-06 The Scripps Research Institute Site-specific labeling of proteins for nmr studies
JP2008516637A (ja) * 2004-10-20 2008-05-22 ザ スクリップス リサーチ インスティテュート 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み
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CA2653748A1 (en) * 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides

Also Published As

Publication number Publication date
CA2712080A1 (en) 2009-08-13
KR20100125290A (ko) 2010-11-30
JP2011514322A (ja) 2011-05-06
IL207013A0 (en) 2010-12-30
BRPI0906388A2 (pt) 2015-07-07
US20110052525A1 (en) 2011-03-03
EP2249865A4 (en) 2012-04-04
CN101970005A (zh) 2011-02-09
WO2009099672A3 (en) 2009-11-12
US8318172B2 (en) 2012-11-27
WO2009099672A2 (en) 2009-08-13
EP2249865A2 (en) 2010-11-17
AU2009210677A1 (en) 2009-08-13
US20090263376A1 (en) 2009-10-22

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