BR112015002574A8 - epítopo associado a tumor que estimula uma reação imune contra o tumor para uso na medicina; epítopo associado a tumor que estimula uma reação imune contra o tumor, e/ou um ácido nucleico; epítopo para uso; epítopo e/ou ácido nucleico para uso; epítopo; peptídeo; epítopo modificado que estimula uma reação imune de il-10 contra auto-antígenos para uso na medicina; método para prever a sobrevivência em câncer colorretal; e método para prever a sobrevivência em câncer de ovário. - Google Patents

epítopo associado a tumor que estimula uma reação imune contra o tumor para uso na medicina; epítopo associado a tumor que estimula uma reação imune contra o tumor, e/ou um ácido nucleico; epítopo para uso; epítopo e/ou ácido nucleico para uso; epítopo; peptídeo; epítopo modificado que estimula uma reação imune de il-10 contra auto-antígenos para uso na medicina; método para prever a sobrevivência em câncer colorretal; e método para prever a sobrevivência em câncer de ovário.

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Publication number
BR112015002574A8
BR112015002574A8 BR112015002574A BR112015002574A BR112015002574A8 BR 112015002574 A8 BR112015002574 A8 BR 112015002574A8 BR 112015002574 A BR112015002574 A BR 112015002574A BR 112015002574 A BR112015002574 A BR 112015002574A BR 112015002574 A8 BR112015002574 A8 BR 112015002574A8
Authority
BR
Brazil
Prior art keywords
epitope
tumor
stimulates
immune reaction
medicine
Prior art date
Application number
BR112015002574A
Other languages
English (en)
Other versions
BR112015002574A2 (pt
Inventor
Gillian Durrant Linda
Louise Metheringham Rachel
Anne Brentville Victoria
Original Assignee
Scancell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scancell Ltd filed Critical Scancell Ltd
Publication of BR112015002574A2 publication Critical patent/BR112015002574A2/pt
Publication of BR112015002574A8 publication Critical patent/BR112015002574A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001162—Kinases, e.g. Raf or Src
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001176—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001188—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
BR112015002574A 2012-08-07 2013-08-07 epítopo associado a tumor que estimula uma reação imune contra o tumor para uso na medicina; epítopo associado a tumor que estimula uma reação imune contra o tumor, e/ou um ácido nucleico; epítopo para uso; epítopo e/ou ácido nucleico para uso; epítopo; peptídeo; epítopo modificado que estimula uma reação imune de il-10 contra auto-antígenos para uso na medicina; método para prever a sobrevivência em câncer colorretal; e método para prever a sobrevivência em câncer de ovário. BR112015002574A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1214007.5A GB201214007D0 (en) 2012-08-07 2012-08-07 Anti-tumour immune responses to modified self-epitopes
PCT/GB2013/052109 WO2014023957A2 (en) 2012-08-07 2013-08-07 Anti-tumour response to modified self-epitopes

Publications (2)

Publication Number Publication Date
BR112015002574A2 BR112015002574A2 (pt) 2017-11-07
BR112015002574A8 true BR112015002574A8 (pt) 2018-01-23

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BR112015002574A BR112015002574A8 (pt) 2012-08-07 2013-08-07 epítopo associado a tumor que estimula uma reação imune contra o tumor para uso na medicina; epítopo associado a tumor que estimula uma reação imune contra o tumor, e/ou um ácido nucleico; epítopo para uso; epítopo e/ou ácido nucleico para uso; epítopo; peptídeo; epítopo modificado que estimula uma reação imune de il-10 contra auto-antígenos para uso na medicina; método para prever a sobrevivência em câncer colorretal; e método para prever a sobrevivência em câncer de ovário.

Country Status (18)

Country Link
US (4) US10233220B2 (pt)
EP (3) EP3301447B1 (pt)
JP (2) JP6490581B2 (pt)
KR (1) KR102203096B1 (pt)
CN (2) CN107043414A (pt)
AU (1) AU2013301341B2 (pt)
BR (1) BR112015002574A8 (pt)
CA (1) CA2874515A1 (pt)
DK (3) DK3301447T3 (pt)
ES (3) ES2833962T3 (pt)
GB (1) GB201214007D0 (pt)
HK (1) HK1206427A1 (pt)
IN (1) IN2014DN10629A (pt)
PL (2) PL3301447T3 (pt)
PT (3) PT3287787T (pt)
SG (2) SG11201407804RA (pt)
WO (1) WO2014023957A2 (pt)
ZA (1) ZA201409095B (pt)

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US20210198334A1 (en) 2021-07-01
CN104823054B (zh) 2019-03-26
PT3301447T (pt) 2021-02-18
EP3287787A1 (en) 2018-02-28
ES2833962T3 (es) 2021-06-16
ES2681973T3 (es) 2018-09-17
EP3287787B1 (en) 2020-09-23
AU2013301341B2 (en) 2018-09-20
PT2883054T (pt) 2018-10-15
SG11201407804RA (en) 2015-02-27
EP3301447B1 (en) 2020-12-02
SG10201701001VA (en) 2017-05-30
US10233220B2 (en) 2019-03-19
KR102203096B1 (ko) 2021-01-14
JP6490581B2 (ja) 2019-03-27
EP3301447A1 (en) 2018-04-04
JP2015525569A (ja) 2015-09-07
EP2883054A2 (en) 2015-06-17
DK3287787T3 (da) 2020-12-21
KR20150040314A (ko) 2015-04-14
WO2014023957A3 (en) 2014-05-15
ES2843777T3 (es) 2021-07-20
ZA201409095B (en) 2016-09-28
JP2018197236A (ja) 2018-12-13
PL3287787T3 (pl) 2021-06-14
CN104823054A (zh) 2015-08-05
GB201214007D0 (en) 2012-09-19
US20150232525A1 (en) 2015-08-20
IN2014DN10629A (pt) 2015-09-11
DK2883054T3 (en) 2018-09-17
US20180346537A1 (en) 2018-12-06
PT3287787T (pt) 2020-11-26
DK3301447T3 (da) 2021-03-08
AU2013301341A1 (en) 2014-12-18
BR112015002574A2 (pt) 2017-11-07
HK1206427A1 (en) 2016-01-08
US20230192790A1 (en) 2023-06-22
CN107043414A (zh) 2017-08-15
EP2883054B1 (en) 2018-06-13
WO2014023957A2 (en) 2014-02-13
CA2874515A1 (en) 2014-02-13
PL3301447T3 (pl) 2021-09-06

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