DK3301447T3 - Anti-tumorrespons til modificerede selvepitoper - Google Patents

Anti-tumorrespons til modificerede selvepitoper Download PDF

Info

Publication number
DK3301447T3
DK3301447T3 DK17194252.7T DK17194252T DK3301447T3 DK 3301447 T3 DK3301447 T3 DK 3301447T3 DK 17194252 T DK17194252 T DK 17194252T DK 3301447 T3 DK3301447 T3 DK 3301447T3
Authority
DK
Denmark
Prior art keywords
pitopes
tumor response
modified self
self
modified
Prior art date
Application number
DK17194252.7T
Other languages
English (en)
Inventor
Linda Gillian Durrant
Victoria Anne Brentville
Rachel Louise Metheringham
Original Assignee
Scancell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scancell Ltd filed Critical Scancell Ltd
Application granted granted Critical
Publication of DK3301447T3 publication Critical patent/DK3301447T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001162—Kinases, e.g. Raf or Src
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001176—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001188—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
DK17194252.7T 2012-08-07 2013-08-07 Anti-tumorrespons til modificerede selvepitoper DK3301447T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1214007.5A GB201214007D0 (en) 2012-08-07 2012-08-07 Anti-tumour immune responses to modified self-epitopes
EP13750368.6A EP2883054B1 (en) 2012-08-07 2013-08-07 Anti-tumour response to modified self-epitopes

Publications (1)

Publication Number Publication Date
DK3301447T3 true DK3301447T3 (da) 2021-03-08

Family

ID=46934958

Family Applications (3)

Application Number Title Priority Date Filing Date
DK17194251.9T DK3287787T3 (da) 2012-08-07 2013-08-07 Anti-tumorrespons til modificerede selv-epitoper
DK13750368.6T DK2883054T3 (da) 2012-08-07 2013-08-07 Antitumor-respons på modificerede selv-epitoper
DK17194252.7T DK3301447T3 (da) 2012-08-07 2013-08-07 Anti-tumorrespons til modificerede selvepitoper

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK17194251.9T DK3287787T3 (da) 2012-08-07 2013-08-07 Anti-tumorrespons til modificerede selv-epitoper
DK13750368.6T DK2883054T3 (da) 2012-08-07 2013-08-07 Antitumor-respons på modificerede selv-epitoper

Country Status (18)

Country Link
US (4) US10233220B2 (da)
EP (3) EP2883054B1 (da)
JP (2) JP6490581B2 (da)
KR (1) KR102203096B1 (da)
CN (2) CN107043414A (da)
AU (1) AU2013301341B2 (da)
BR (1) BR112015002574A8 (da)
CA (1) CA2874515A1 (da)
DK (3) DK3287787T3 (da)
ES (3) ES2681973T3 (da)
GB (1) GB201214007D0 (da)
HK (1) HK1206427A1 (da)
IN (1) IN2014DN10629A (da)
PL (2) PL3287787T3 (da)
PT (3) PT3287787T (da)
SG (2) SG10201701001VA (da)
WO (1) WO2014023957A2 (da)
ZA (1) ZA201409095B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2725450T3 (es) 2007-07-02 2019-09-24 Etubics Corp Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples
GB201214007D0 (en) 2012-08-07 2012-09-19 Scancell Ltd Anti-tumour immune responses to modified self-epitopes
US9605276B2 (en) 2012-08-24 2017-03-28 Etubics Corporation Replication defective adenovirus vector in vaccination
WO2015169602A1 (en) * 2014-05-05 2015-11-12 Noviosmart Method for the serological diagnosis of rheumatoid arthritis.
CN104360070B (zh) * 2014-11-28 2017-02-22 山东新创生物科技有限公司 肽基精氨酸脱亚胺酶2在制备肿瘤临床血液诊断试剂中的应用
US11352642B2 (en) 2015-01-09 2022-06-07 Etubics Corporation Methods and compositions for combination immunotherapy
US11149087B2 (en) 2015-04-20 2021-10-19 Etubics Corporation Methods and compositions for combination immunotherapy
WO2016183486A1 (en) 2015-05-13 2016-11-17 Agenus Inc. Vaccines for treatment and prevention of cancer
GB201512703D0 (en) * 2015-07-20 2015-08-26 Scancell Ltd Anti-tumour immune responses to modified self-epitopes
GB201522667D0 (en) 2015-12-22 2016-02-03 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers
SG10202111399YA (en) 2015-12-22 2021-11-29 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers
WO2018046648A1 (en) * 2016-09-08 2018-03-15 Katholieke Universiteit Leuven Citrullinated peptides for diagnosis or treatment of diabetes
KR102184377B1 (ko) * 2018-02-19 2020-11-30 고려대학교 산학협력단 열충격단백질의 에피토프를 포함하는 백신 및 이의 용도
EP3784688A2 (en) 2018-04-26 2021-03-03 Agenus Inc. Heat shock protein-binding peptide compositions and methods of use thereof
GB201815041D0 (en) 2018-09-14 2018-10-31 Scancell Ltd Epitopes
GB202005779D0 (en) 2020-04-21 2020-06-03 Scancell Ltd Anti-tumour immune responses
CN112194719A (zh) * 2020-09-01 2021-01-08 中日友好医院(中日友好临床医学研究所) Crt抗原和mage-a1抗原的制备及其应用
GB202018395D0 (en) 2020-11-23 2021-01-06 Scancell Ltd Immunotherapy
CN114404570B (zh) * 2022-01-20 2023-05-30 中国药科大学 一种新型抗肿瘤转移多肽及其应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002051785A (ja) * 2000-08-09 2002-02-19 Hagiwara Yoshihide 抗癌ヒトモノクローナル抗体ＣＬＮ−ＩｇＧによって認識される抗原エピトープのアミノ酸配列およびそれをコードするＤＮＡヌクレオチド配列
AU2002210407A1 (en) * 2000-10-27 2002-05-06 Pharmexa A/S Therapeutic vaccine formulations containing chitosan
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
WO2003024191A2 (en) * 2001-09-21 2003-03-27 Raven Biotechnologies, Inc. Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof
WO2003057168A2 (en) * 2002-01-03 2003-07-17 The Scripps Research Institute Cancer-associated epitope
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
EP2426139B1 (en) 2002-08-27 2014-10-01 Biokine Therapeutics Ltd. CXCR4 antagonist and use thereof
CN101185754A (zh) * 2002-10-02 2008-05-28 霍夫曼-拉罗奇有限公司 新mhc ii相关肽
US7670604B2 (en) * 2002-12-13 2010-03-02 Aurelium Biopharma, Inc. Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
DE10313819A1 (de) * 2003-03-24 2004-10-07 Immatics Biotechnologies Gmbh An MHC-Moleküle bindende Tumor-assoziierte Peptide
JP2007515924A (ja) 2003-12-15 2007-06-21 アウレリウム バイオファーマ インク． ビメンチン指向性診断法、および、多剤耐性を示す腫瘍性疾患の治療法
WO2006120474A2 (en) * 2005-05-13 2006-11-16 Oxxon Therapeutics Ltd Compositions for inducing an immune response against tumor antigens
DE102005029845B4 (de) * 2005-06-27 2017-03-23 Orgentec Diagnostika Gmbh Verfahren zur Diagnose von rheumatischen Erkrankungen
CN1712964A (zh) * 2005-07-18 2005-12-28 山东省医药生物技术研究中心 类风湿性关节炎特异性抗原性标志物及其应用
US20070248628A1 (en) * 2005-12-06 2007-10-25 Keller Lorraine H Immunogens in cancer stem cells
BRPI0707948A2 (pt) * 2006-02-17 2011-05-17 Univ Indiana Res & Tech Corp inibição baseado em peptìdeo da interação capcna em cáncer
WO2007098093A2 (en) * 2006-02-17 2007-08-30 Five Prime Therapeutics, Inc. Compositions and methods of use for modulators of polypeptides and polynucleotides in treating breast cancer and melanoma
US20070248539A1 (en) * 2006-04-24 2007-10-25 Shantha West Inc. AgRM2 antigen
EP1882697B1 (en) * 2006-07-24 2010-04-21 Institut Pasteur Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins
JP5352586B2 (ja) * 2007-07-27 2013-11-27 イマティクス バイオテクノロジーズ ゲーエムベーハー 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物
EP2249865A4 (en) * 2008-02-08 2012-04-04 Scripps Research Inst RUPTURE OF IMMUNOLOGICAL TOLERANCE WITH GENETICALLY CODED NON-NATURAL AMINO ACID
WO2010117694A2 (en) * 2009-03-30 2010-10-14 Prometheus Laboratories Inc. Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis
HUE049886T2 (hu) * 2010-05-14 2020-10-28 Massachusetts Gen Hospital Tumorspecifikus neoantigéneket tartalmazó készítmények, tumorok kezelésében történõ alkalmazásra
WO2012095849A1 (en) 2011-01-10 2012-07-19 Biokine Therapeutics Ltd. Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma
EP2667888A4 (en) 2011-01-28 2015-11-11 Univ Oregon Health & Science LIGMPHES OF RECOMBINANT T LYMPHOCYTES AND ANTIBODIES BINDING TO LYMPHOCYTES B FOR THE TREATMENT OF AUTOIMMUNE DISEASES
EP3301107B1 (en) 2011-04-05 2020-05-06 Curara AB Novel peptides that bind to types of mhc class ii and their use in diagnosis and treatment
US20120295292A1 (en) * 2011-05-19 2012-11-22 University Of South Carolina Detecting Protein Arginine Deiminase (PAD) Activity in Human Tissues and Sera
US20130274125A1 (en) * 2012-04-16 2013-10-17 Bio-Rad Laboratories Inc. Multiplex immunoassay for rheumatoid arthritis and other autoimmune diseases
GB201214007D0 (en) 2012-08-07 2012-09-19 Scancell Ltd Anti-tumour immune responses to modified self-epitopes

Also Published As

Publication number Publication date
KR102203096B1 (ko) 2021-01-14
BR112015002574A8 (pt) 2018-01-23
SG10201701001VA (en) 2017-05-30
US10233220B2 (en) 2019-03-19
SG11201407804RA (en) 2015-02-27
US20150232525A1 (en) 2015-08-20
PT3301447T (pt) 2021-02-18
JP2018197236A (ja) 2018-12-13
CA2874515A1 (en) 2014-02-13
JP6490581B2 (ja) 2019-03-27
AU2013301341A1 (en) 2014-12-18
US20180346537A1 (en) 2018-12-06
EP3287787B1 (en) 2020-09-23
WO2014023957A3 (en) 2014-05-15
ES2833962T3 (es) 2021-06-16
ES2681973T3 (es) 2018-09-17
PL3287787T3 (pl) 2021-06-14
AU2013301341B2 (en) 2018-09-20
EP2883054B1 (en) 2018-06-13
WO2014023957A2 (en) 2014-02-13
EP3301447B1 (en) 2020-12-02
ES2843777T3 (es) 2021-07-20
DK2883054T3 (da) 2018-09-17
EP3301447A1 (en) 2018-04-04
US20230192790A1 (en) 2023-06-22
CN104823054A (zh) 2015-08-05
PT3287787T (pt) 2020-11-26
PT2883054T (pt) 2018-10-15
KR20150040314A (ko) 2015-04-14
IN2014DN10629A (da) 2015-09-11
GB201214007D0 (en) 2012-09-19
HK1206427A1 (en) 2016-01-08
BR112015002574A2 (pt) 2017-11-07
EP3287787A1 (en) 2018-02-28
CN104823054B (zh) 2019-03-26
JP2015525569A (ja) 2015-09-07
CN107043414A (zh) 2017-08-15
DK3287787T3 (da) 2020-12-21
EP2883054A2 (en) 2015-06-17
US20210198334A1 (en) 2021-07-01
ZA201409095B (en) 2016-09-28
PL3301447T3 (pl) 2021-09-06

Similar Documents

Publication Publication Date Title
DK3301447T3 (da) Anti-tumorrespons til modificerede selvepitoper
SMT201700065B (it) Derivato piridonico
DK3354728T3 (da) Alpha-amylase-varianter
DK2859055T3 (da) Polymercoatings
DK2825087T3 (da) Otoscanner
DK2839013T3 (da) Ikke-disruptiv-gen-targetering
CO6990736A2 (es) Pirrolidina-2-carboxamidas sustituídas
DK2873977T3 (da) Dobbeltdækker-rørdispenser
DE112012006109A5 (de) Okklusionsschienenanordnung
DK2854722T3 (da) Stomipose
DK2825157T3 (da) Aminosyrelipider
CL2014002030A1 (es) Alfa-amilasa
DK2831122T3 (da) Anthocyanidin-kompleks
DE112012006214T8 (de) Wulstringwickler
DE112012005566T8 (de) Seltenerdnanoverbundmagnet
FI9831U1 (fi) Aurinkosuojan kiinnike
ES1080381Y (es) Fachada de medios
FR2995782B1 (fr) Sucres anti-pelliculaires
FR2985656B1 (fr) Oxymetre
DK2885638T3 (da) Molekylenet
DK2858657T3 (da) Feijoafrugtekstrakt
ES1077590Y (es) Columbario
DE102013212400A8 (de) Abdeckplattenstützbaugruppe
DK2897570T3 (da) Spin-elueringsrør
ES1077210Y (es) Columbario cinerario