BR112019008560A2 - célula artificial que apresenta antígeno, método para expandir linfócitos infiltrantes de tumor, para tratar um câncer com uma população de linfócitos infiltrantes de tumor e para avaliar a potência de linfócitos infiltrantes de tumor, kit, população de linfócitos infiltrantes de tumor, e, combinação - Google Patents
célula artificial que apresenta antígeno, método para expandir linfócitos infiltrantes de tumor, para tratar um câncer com uma população de linfócitos infiltrantes de tumor e para avaliar a potência de linfócitos infiltrantes de tumor, kit, população de linfócitos infiltrantes de tumor, e, combinaçãoInfo
- Publication number
- BR112019008560A2 BR112019008560A2 BR112019008560A BR112019008560A BR112019008560A2 BR 112019008560 A2 BR112019008560 A2 BR 112019008560A2 BR 112019008560 A BR112019008560 A BR 112019008560A BR 112019008560 A BR112019008560 A BR 112019008560A BR 112019008560 A2 BR112019008560 A2 BR 112019008560A2
- Authority
- BR
- Brazil
- Prior art keywords
- tumor infiltrating
- infiltrating lymphocytes
- population
- aapcs
- assessing
- Prior art date
Links
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 210000000612 antigen-presenting cell Anatomy 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 210000000066 myeloid cell Anatomy 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000013603 viral vector Substances 0.000 abstract 2
- 239000000592 Artificial Cell Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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Abstract
em algumas modalidades, as composições e métodos relacionados a células artificiais que apresentam antígeno isoladas (aapcs) são divulgados, incluindo aapcs compreendendo uma célula mieloide transduzida com um ou mais vetores virais, tal como uma molm-14 ou uma célula em-3 mieloide, em que a célula mieloide endogenamente expressa hla-a/b/c, icos-l, e cd58, e em que o um ou mais vetores virais compreendem um ácido nucléico codificando cd86 e um ácido nucléico codificando 4-1bbl e/ou ox40l e transduzem a célula mieloide para expressar cd86 e as proteínas 4-1bbl e/ou ox40l. em algumas modalidades, métodos de expandir linfócitos infiltrantes de tumor (t1l5) com aapcs e métodos de tratar cânceres usando tils depois de expansão com aapcs também são divulgados.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662415274P | 2016-10-31 | 2016-10-31 | |
US201662438600P | 2016-12-23 | 2016-12-23 | |
US201762475053P | 2017-03-22 | 2017-03-22 | |
US201762481831P | 2017-04-05 | 2017-04-05 | |
PCT/US2017/059271 WO2018081789A1 (en) | 2016-10-31 | 2017-10-31 | Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion |
Publications (1)
Publication Number | Publication Date |
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BR112019008560A2 true BR112019008560A2 (pt) | 2019-09-17 |
Family
ID=60702946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019008560A BR112019008560A2 (pt) | 2016-10-31 | 2017-10-31 | célula artificial que apresenta antígeno, método para expandir linfócitos infiltrantes de tumor, para tratar um câncer com uma população de linfócitos infiltrantes de tumor e para avaliar a potência de linfócitos infiltrantes de tumor, kit, população de linfócitos infiltrantes de tumor, e, combinação |
Country Status (14)
Country | Link |
---|---|
US (4) | US10415015B2 (pt) |
EP (1) | EP3532608A1 (pt) |
JP (2) | JP2019531744A (pt) |
KR (2) | KR20240013295A (pt) |
CN (2) | CN110312790A (pt) |
AU (1) | AU2017347942A1 (pt) |
BR (1) | BR112019008560A2 (pt) |
CA (1) | CA3041673A1 (pt) |
IL (1) | IL266221A (pt) |
MA (1) | MA46668A (pt) |
MX (2) | MX2019004708A (pt) |
SG (1) | SG11201903825SA (pt) |
TW (1) | TWI788307B (pt) |
WO (1) | WO2018081789A1 (pt) |
Families Citing this family (33)
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GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
US11026974B2 (en) | 2016-10-26 | 2021-06-08 | Iovance Biotherapeutics, Inc. | Restimulation of cryopreserved tumor infiltrating lymphocytes |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
US20200377855A1 (en) * | 2017-05-05 | 2020-12-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Rapid method for the culture of tumor infiltrating lymphocytes |
WO2018226714A1 (en) | 2017-06-05 | 2018-12-13 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
US20190284553A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
SG11202010319RA (en) | 2018-04-27 | 2020-11-27 | Iovance Biotherapeutics Inc | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
TW202031273A (zh) * | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療 |
EP3867242A1 (en) | 2018-10-15 | 2021-08-25 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
EP3877513A2 (en) * | 2018-11-05 | 2021-09-15 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
CN109439632A (zh) * | 2018-11-16 | 2019-03-08 | 中国科学院合肥肿瘤医院 | 一种提高car-t细胞转染效率的方法 |
US20220193131A1 (en) * | 2018-12-19 | 2022-06-23 | Iovance Biotherapeutics, Inc. | Methods of Expanding Tumor Infiltrating Lymphocytes Using Engineered Cytokine Receptor Pairs and Uses Thereof |
GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
WO2020232029A1 (en) * | 2019-05-13 | 2020-11-19 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
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US11667890B2 (en) | 2023-06-06 |
WO2018081789A8 (en) | 2019-05-09 |
US20220315892A1 (en) | 2022-10-06 |
CN110312790A (zh) | 2019-10-08 |
KR20240013295A (ko) | 2024-01-30 |
MX2022012409A (es) | 2023-05-03 |
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