MX2020005634A - Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. - Google Patents

Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva.

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Publication number
MX2020005634A
MX2020005634A MX2020005634A MX2020005634A MX2020005634A MX 2020005634 A MX2020005634 A MX 2020005634A MX 2020005634 A MX2020005634 A MX 2020005634A MX 2020005634 A MX2020005634 A MX 2020005634A MX 2020005634 A MX2020005634 A MX 2020005634A
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MX
Mexico
Prior art keywords
tumor
cell therapy
adoptive cell
infiltrating lymphocytes
disclosed
Prior art date
Application number
MX2020005634A
Other languages
English (en)
Inventor
Amod A Sarnaik
Shari Pilon-Thomas
Mark Mclaughlin
Hao Liu
Original Assignee
H Lee Moffitt Cancer Ct & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lee Moffitt Cancer Ct & Res filed Critical H Lee Moffitt Cancer Ct & Res
Publication of MX2020005634A publication Critical patent/MX2020005634A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
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    • C12N2501/05—Adjuvants
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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Abstract

Se describen composiciones y métodos para la expansión ex vivo de linfocitos infiltrantes de tumor para usar en la terapia celular adoptiva (ACT). También se describen composiciones y métodos para identificar un agente para la expansión ex vivo de linfocitos infiltrantes de tumor para usar en la ACT. También se describen métodos para el tratamiento del cáncer usando linfocitos infiltrantes de tumor expandidos mediante los métodos descritos.
MX2020005634A 2014-03-20 2016-09-20 Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. MX2020005634A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461955970P 2014-03-20 2014-03-20
US201461973002P 2014-03-31 2014-03-31

Publications (1)

Publication Number Publication Date
MX2020005634A true MX2020005634A (es) 2020-08-20

Family

ID=54145388

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016012176A MX2016012176A (es) 2014-03-20 2015-03-20 Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva.
MX2020005634A MX2020005634A (es) 2014-03-20 2016-09-20 Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva.

Family Applications Before (1)

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MX2016012176A MX2016012176A (es) 2014-03-20 2015-03-20 Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva.

Country Status (11)

Country Link
US (3) US20170081635A1 (es)
EP (2) EP3698850A1 (es)
JP (3) JP2017511375A (es)
KR (2) KR20160146713A (es)
CN (2) CN106659913A (es)
AU (3) AU2015231041B2 (es)
CA (1) CA2943389C (es)
EA (1) EA036386B1 (es)
ES (1) ES2776407T3 (es)
MX (2) MX2016012176A (es)
WO (1) WO2015143328A1 (es)

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Also Published As

Publication number Publication date
EA036386B1 (ru) 2020-11-03
BR112016021370A2 (pt) 2017-08-15
JP2023123877A (ja) 2023-09-05
AU2023200308A1 (en) 2023-03-02
KR20230085225A (ko) 2023-06-13
EP3698850A1 (en) 2020-08-26
EP3119477A4 (en) 2018-03-07
US20220282215A1 (en) 2022-09-08
AU2015231041A1 (en) 2016-11-03
US20190177693A1 (en) 2019-06-13
AU2020256412A1 (en) 2020-11-26
BR112016021370A8 (pt) 2021-07-20
EP3119477A1 (en) 2017-01-25
AU2015231041B2 (en) 2020-07-16
EA201691866A1 (ru) 2017-01-30
EP3119477B1 (en) 2020-01-01
CN112080467A (zh) 2020-12-15
WO2015143328A1 (en) 2015-09-24
CN106659913A (zh) 2017-05-10
US11518980B2 (en) 2022-12-06
MX2016012176A (es) 2017-04-13
JP2020182477A (ja) 2020-11-12
CA2943389A1 (en) 2015-09-24
ES2776407T3 (es) 2020-07-30
JP2017511375A (ja) 2017-04-20
US20170081635A1 (en) 2017-03-23
CA2943389C (en) 2023-10-31
KR20160146713A (ko) 2016-12-21

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