TR201905447T4 - Yeni mhc bağımsız tümörle ilişkili antijenler. - Google Patents

Yeni mhc bağımsız tümörle ilişkili antijenler. Download PDF

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Publication number
TR201905447T4
TR201905447T4 TR2019/05447T TR201905447T TR201905447T4 TR 201905447 T4 TR201905447 T4 TR 201905447T4 TR 2019/05447 T TR2019/05447 T TR 2019/05447T TR 201905447 T TR201905447 T TR 201905447T TR 201905447 T4 TR201905447 T4 TR 201905447T4
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Turkey
Prior art keywords
antigens
cells
cell
tumor associated
nucleic acids
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TR2019/05447T
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English (en)
Inventor
Schadendorf Dirk
Paschen Anette
Lübcke Silke
Fatho Martina
Eberts Daniela
Echchannaoui Hakim
Lennerz Volker
Wölfel Catherine
Wölfel Thomas
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Biontech Rna Pharmaceuticals Gmbh
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Publication of TR201905447T4 publication Critical patent/TR201905447T4/tr

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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03012—L-Dopachrome isomerase (5.3.3.12)

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Abstract

Mevcut buluş, MHC aracılığıyla bir CD8 pozitif T hücre yanıtı prezentasyonundan bağımsız olarak ortaya çıkan yeni tümörle ilişkili antijenler ile ilgilidir. GM-CSF Reseptörü alfa zincirinin (CSF2RA) ve Tirozinaz ilişkili proteinin (2) (TRP-2), HLA I negatif melanom hücrelerinin yüzeyindeki proteinleri saptayabilecek CD8 pozitif T hücre klonlarının hedefleri olduğu bulundu. Dolayısıyla, buluş ilaç olarak, örneğin, bir tümör hastalığının tedavisi, teşhisi ve önlenmesi için kullanıma yönelik yeni antijenlerin proteinlerini, protein fragmanlarını ve polipeptidlerini sağlar. Ayrıca, buluşun antijenlerini eksprese eden nükleik asitler, buluşun antijenlerine özel, buluşun antijenlerine karşı reaktif olan ve buluşun T hücresi reseptörlerini eksprese eden T hücresi reseptörü zincirleri ve izole edilmiş T hücreleri gibi bağlayıcı maddeler sağlanmaktadır. Buluş ayrıca, buluşa uygun olarak antijenler, nükleik asitler, bağlayıcı maddeler veya T hücreleri içeren farmasötik bileşimleri, özellikle aşı bileşimleri ve bir MHC bağımsız şeklinde buluşun antijenlerine özellikle reaktif T hücrelerini oluşturma yöntemleri ile ilgilidir.
TR2019/05447T 2012-12-14 2013-12-16 Yeni mhc bağımsız tümörle ilişkili antijenler. TR201905447T4 (tr)

Applications Claiming Priority (1)

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EP12197289 2012-12-14

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TR201905447T4 true TR201905447T4 (tr) 2019-05-21

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US (2) US9861688B2 (tr)
EP (1) EP2932264B1 (tr)
JP (1) JP6475166B2 (tr)
AU (2) AU2013357239B2 (tr)
CA (2) CA3108192A1 (tr)
DK (1) DK2932264T3 (tr)
ES (1) ES2721159T3 (tr)
HU (1) HUE042967T2 (tr)
PL (1) PL2932264T3 (tr)
PT (1) PT2932264T (tr)
SI (1) SI2932264T1 (tr)
TR (1) TR201905447T4 (tr)
WO (1) WO2014091034A1 (tr)

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EA034110B1 (ru) * 2013-03-15 2019-12-27 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Противораковые вакцины и способы лечения с их применением
US10414812B2 (en) * 2015-02-16 2019-09-17 The Trustees Of The University Of Pennsylvania Fully-human T-cell receptor specific for the 369-377 epitope derived from the Her2/neu (ERBB2) receptor protein
CN111886243A (zh) 2018-02-11 2020-11-03 纪念斯隆-凯特琳癌症中心 非-hla限制性t细胞受体及其用途
WO2022093333A1 (en) * 2020-10-27 2022-05-05 T-Cure Biosciences, Inc. Recombinant t-cell receptors that bind the ny-eso-1 and/or lage-1a cancer antigens
WO2022155375A2 (en) * 2021-01-13 2022-07-21 Washington University MHC-INDEPENDENT TCRs AND METHODS OF MAKING AND USING SAME
KR20240038028A (ko) * 2021-07-27 2024-03-22 이매틱스 바이오테크놀로지스 게엠베하 Ct45에 특이적으로 결합하는 항원 결합 단백질

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DE69031914T2 (de) * 1989-08-11 1998-07-30 Amrad Corp. Ltd., Kew, Victoria Rezeptor für granulozyten-macrophagen-koloniestimulierungsfaktor und seine derivate
US5840839A (en) * 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
WO2002048370A2 (en) 2000-10-31 2002-06-20 Diadexus, Inc. Compositions and methods relating to colon specific genes and proteins
PL1999152T3 (pl) * 2006-03-27 2013-05-31 Medimmune Ltd Element wiążący receptor GM-CSF
US20090304657A1 (en) * 2006-05-03 2009-12-10 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Chimeric t cell receptors and related materials and methods of use
US8088379B2 (en) * 2006-09-26 2012-01-03 The United States Of America As Represented By The Department Of Health And Human Services Modified T cell receptors and related materials and methods
AU2007314164B2 (en) * 2006-11-03 2013-05-02 Central Adelaide Local Health Network Inc Operating As Sa Pathology Crystalline composition of GM-CSF/GM-CSFR
US8785601B2 (en) 2009-01-28 2014-07-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors and related materials and methods of use
WO2011029126A1 (en) * 2009-09-14 2011-03-17 Walter And Eliza Hall Institute Of Medical Research Methods and reagents for producing antibodies against autoantigens
EP3213765B1 (en) * 2010-09-20 2019-08-28 BioNTech Cell & Gene Therapies GmbH Antigen-specific t cell receptors and t cell epitopes

Also Published As

Publication number Publication date
US20150313978A1 (en) 2015-11-05
HUE042967T2 (hu) 2019-07-29
CA2894966C (en) 2021-03-30
PT2932264T (pt) 2019-05-21
ES2721159T3 (es) 2019-07-29
DK2932264T3 (da) 2019-05-06
SI2932264T1 (sl) 2019-05-31
EP2932264B1 (en) 2019-01-30
WO2014091034A1 (en) 2014-06-19
CA3108192A1 (en) 2014-06-19
JP6475166B2 (ja) 2019-02-27
US9861688B2 (en) 2018-01-09
AU2013357239A1 (en) 2015-06-18
PL2932264T3 (pl) 2019-09-30
US20180099033A1 (en) 2018-04-12
AU2013357239B2 (en) 2019-10-17
EP2932264A1 (en) 2015-10-21
AU2019236675A1 (en) 2019-10-17
CA2894966A1 (en) 2014-06-19
US10987413B2 (en) 2021-04-27
JP2016501268A (ja) 2016-01-18
AU2019236675B2 (en) 2022-02-24

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