DK3200818T3 - Fremgangsmåder til isolering af t-cellereceptorer med antigen specificitet over for en cancer-specifik mutation - Google Patents

Fremgangsmåder til isolering af t-cellereceptorer med antigen specificitet over for en cancer-specifik mutation Download PDF

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Publication number
DK3200818T3
DK3200818T3 DK14796317.7T DK14796317T DK3200818T3 DK 3200818 T3 DK3200818 T3 DK 3200818T3 DK 14796317 T DK14796317 T DK 14796317T DK 3200818 T3 DK3200818 T3 DK 3200818T3
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isolating
cancer
methods
cell receptors
antigen specificity
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DK14796317.7T
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Eric Tran
Paul E Robbins
Steven A Rosenberg
Yong-Chen Lu
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Us Health
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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DK14796317.7T 2014-10-02 2014-10-02 Fremgangsmåder til isolering af t-cellereceptorer med antigen specificitet over for en cancer-specifik mutation DK3200818T3 (da)

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PCT/US2014/058796 WO2016053338A1 (en) 2014-10-02 2014-10-02 Methods of isolating t cell receptors having antigenic specificity for a cancer-specific mutation

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DK3200818T3 true DK3200818T3 (da) 2022-08-22

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US (2) US20170218042A1 (da)
EP (2) EP3200818B1 (da)
JP (1) JP6686008B2 (da)
CN (1) CN107074932A (da)
AU (3) AU2014407539B2 (da)
CA (1) CA2963362A1 (da)
DK (1) DK3200818T3 (da)
ES (1) ES2924709T3 (da)
WO (1) WO2016053338A1 (da)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170044496A1 (en) 2014-04-10 2017-02-16 H. Lee Moffitt Cancer Center And Research Institute, Inc. Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
US10973894B2 (en) 2014-10-02 2021-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Methods of isolating T cells having antigenic specificity for a cancer-specific mutation
EP3075389A1 (en) * 2015-03-31 2016-10-05 Technische Universität München T cell receptors and peptides derived by mutations for the treatment of cancer
US10544392B2 (en) 2015-05-01 2020-01-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood
WO2017023803A1 (en) 2015-07-31 2017-02-09 Regents Of The University Of Minnesota Modified cells and methods of therapy
WO2017048614A1 (en) 2015-09-15 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating tumor-reactive t cell receptors from tumor or peripheral blood
CN109843921B (zh) 2016-07-07 2023-05-26 艾欧凡斯生物治疗公司 程序性死亡1配体1(pd-l1)结合蛋白及其应用方法
GB2605540B (en) 2016-10-18 2022-12-21 Univ Minnesota Tumor infiltrating lymphocytes and methods of therapy
MX2019004707A (es) 2016-10-26 2019-08-12 Iovance Biotherapeutics Inc Reestimulacion de linfocitos infiltrantes de tumor crioconservados.
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
CN110199016A (zh) 2016-11-17 2019-09-03 艾欧凡斯生物治疗公司 残余肿瘤浸润淋巴细胞及其制备和使用方法
JP2020503351A (ja) 2017-01-06 2020-01-30 アイオバンス バイオセラピューティクス，インコーポレイテッド カリウムチャネルアゴニストによる腫瘍浸潤リンパ球の増殖及びその治療的使用
JOP20190224A1 (ar) 2017-03-29 2019-09-26 Iovance Biotherapeutics Inc عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي
US11254913B1 (en) 2017-03-29 2022-02-22 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
AU2018244371A1 (en) * 2017-03-31 2019-10-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating neoantigen-specific T cell receptor sequences
US11819517B2 (en) 2017-06-05 2023-11-21 Iovance Biotherapeutics, Inc. Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
JP2020530307A (ja) 2017-06-30 2020-10-22 インティマ・バイオサイエンス，インコーポレーテッド 遺伝子治療のためのアデノ随伴ウイルスベクター
EP3684799A1 (en) * 2017-09-20 2020-07-29 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hla class ii restricted t cell receptors against mutated ras
JP7391015B2 (ja) * 2017-09-29 2023-12-04 アメリカ合衆国 Ｐ５３がん特異的変異に対して抗原特異性を有するｔ細胞を単離する方法
BR112020006012A2 (pt) * 2017-09-29 2020-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services receptores de células t que reconhecem p53 mutado
CN111787930A (zh) * 2017-10-06 2020-10-16 芝加哥大学 针对癌症特异性抗原对t淋巴细胞的筛选
MX2020004967A (es) * 2017-11-17 2020-08-27 Iovance Biotherapeutics Inc Expansion de linfocitos infiltrantes del tumor (til) de aspirados con aguja fina y biopsias por puncion.
CA3085765A1 (en) * 2017-12-15 2019-06-20 Iovance Biotherapeutics, Inc. Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
AU2019260656A1 (en) * 2018-04-24 2020-12-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T cell populations using hydroxycitric acid and/or a salt thereof
MX2020011134A (es) 2018-04-27 2020-11-11 Iovance Biotherapeutics Inc Proceso cerrado para expansion y edicion de genes de linfocitos infiltrantes de tumor y usos de los mismos en inmunoterapia.
WO2019217753A1 (en) * 2018-05-10 2019-11-14 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
CN110857319B (zh) * 2018-08-24 2023-12-08 杭州康万达医药科技有限公司 一种分离的t细胞受体、其修饰的细胞、编码核酸及其应用
CN109136278B (zh) * 2018-09-30 2020-09-29 北京鼎成肽源生物技术有限公司 一种mrfft1细胞
CN109294983A (zh) * 2018-09-30 2019-02-01 北京鼎成肽源生物技术有限公司 一种lff2细胞
CN109294982B (zh) * 2018-09-30 2020-11-06 北京鼎成肽源生物技术有限公司 一种rff2细胞
CN109136269A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种aff细胞
CN109136279A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种mrfft2细胞的构建方法
CN110093317A (zh) * 2018-09-30 2019-08-06 北京鼎成肽源生物技术有限公司 一种lff2细胞的构建方法
CN109295097B (zh) * 2018-09-30 2020-09-25 北京鼎成肽源生物技术有限公司 一种mrfft2细胞
CN109136280A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种lrfft1细胞的构建方法
CN109136268A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种lrff细胞的构建方法
CN110093316A (zh) * 2018-09-30 2019-08-06 北京鼎成肽源生物技术有限公司 一种aff细胞的构建方法
CN109136277A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种lrfft2细胞的构建方法
CN109136284B (zh) * 2018-09-30 2020-12-29 北京鼎成肽源生物技术有限公司 一种afft2细胞
CN109136281A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种mrfft1细胞的构建方法
CN109294997B (zh) * 2018-09-30 2020-09-25 北京鼎成肽源生物技术有限公司 一种lrfft1细胞
CN110093373B (zh) * 2018-09-30 2021-05-07 北京鼎成肽源生物技术有限公司 一种afft2细胞的构建方法
CN109679917B (zh) * 2018-09-30 2020-09-25 北京鼎成肽源生物技术有限公司 一种lrfft2细胞
CN109294998B (zh) * 2018-09-30 2020-11-06 北京鼎成肽源生物技术有限公司 一种rff1细胞
CN109136183A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种rff2细胞的构建方法
EP3927370B1 (en) 2019-02-19 2024-04-24 Myst Therapeutics, LLC Methods for producing autologous t cells useful to treat cancers and compositions thereof
CN111748029B (zh) * 2019-03-29 2022-12-13 苏州蓝马医疗技术有限公司 一种针对egfr l858r基因突变的特异性t细胞受体及其应用
CN111748028A (zh) * 2019-03-29 2020-10-09 天津亨佳生物科技发展有限公司 一种针对egfr l858r基因突变的特异性t细胞受体及其应用
CN111748027A (zh) * 2019-03-29 2020-10-09 天津亨佳生物科技发展有限公司 一种针对egfr l858r基因突变的特异性t细胞受体及其应用
CN111848782A (zh) * 2019-04-25 2020-10-30 天津亨佳生物科技发展有限公司 一种针对egfr l858r基因突变的特异性t细胞受体及其应用
WO2021026290A1 (en) 2019-08-07 2021-02-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cells having enhanced anti-tumor activity
JP2023504042A (ja) 2019-11-27 2023-02-01 ミスト セラピューティクス リミテッド ライアビリティ カンパニー 調節物質を使用した腫瘍反応性ｔ細胞組成物の生成方法
CN111019959B (zh) * 2019-12-30 2022-09-13 北京立康生命科技有限公司 一种体外转录mRNA的核苷酸分子、呈递细胞及应用
JP2023516636A (ja) 2020-02-27 2023-04-20 ミスト セラピューティクス リミテッド ライアビリティ カンパニー 腫瘍反応性ｔ細胞のエクスビボ富化および増大のための方法ならびに関連するその組成物
EP4121513A1 (en) 2020-03-20 2023-01-25 The United States of America, as represented by the Secretary, Department of Health and Human Services Methods of isolating t cells and t-cell receptors from peripheral blood by single-cell analysis for immunotherapy
US20230138309A1 (en) 2020-03-20 2023-05-04 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods of isolating t-cells and t-cell receptors from tumor by single-cell analysis for immunotherapy
WO2021216920A1 (en) 2020-04-22 2021-10-28 Iovance Biotherapeutics, Inc. Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
CN112133372B (zh) * 2020-08-18 2022-06-03 北京臻知医学科技有限责任公司 抗原特异性tcr数据库的建立方法及抗原特异性tcr的评估方法
JP2023540361A (ja) 2020-09-08 2023-09-22 アメリカ合衆国 養子細胞療法に対する応答に関連するｔ細胞表現型
KR20220052299A (ko) * 2020-10-20 2022-04-27 연세대학교 산학협력단 단일 세포 분석법을 이용한 tcr-항원의 특이성을 확인하는 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004021995A2 (en) 2002-09-06 2004-03-18 The Government Of The United States Of America, Represented By The Secretary, Departement Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
JP5079697B2 (ja) * 2005-08-05 2012-11-21 ヘルムホルツ ツェントラム ミュンヘン ドイチェス フォーシュングスツェントラム フュール ゲズントハイト ウント ウンヴェルト ゲーエムベーハー 抗原特異的ｔ細胞の生成方法
GB0911566D0 (en) * 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
CN102597222B (zh) * 2009-10-27 2015-07-15 因缪尼卡姆股份公司 用于增殖抗原特异性t细胞的方法
US20120244133A1 (en) 2011-03-22 2012-09-27 The United States of America, as represented by the Secretary, Department of Health and Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
EP3392270B1 (en) * 2011-09-15 2020-08-26 The United States of America, as Represented by the Secretary Department of Health and Human Services T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
JP6126804B2 (ja) * 2012-07-25 2017-05-10 国立大学法人富山大学 Ｔ細胞受容体のクローニング方法
US10682399B2 (en) * 2012-09-05 2020-06-16 The University Of Birmingham Target peptides for colorectal cancer therapy and diagnostics
US9879065B2 (en) * 2012-09-14 2018-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing MHC class II-restricted MAGE-A3
EP3628322A1 (en) * 2013-03-01 2020-04-01 The United States of America, as represented by the Secretary, Department of Health and Human Services Cd8+ t cells that also express pd-1 and/or tim-3 for the treatment of cancer
JP6416131B2 (ja) * 2013-03-01 2018-10-31 アメリカ合衆国 濃縮された腫瘍反応性ｔ細胞集団を腫瘍から作製する方法

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