MX2022012409A - Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores. - Google Patents

Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores.

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Publication number
MX2022012409A
MX2022012409A MX2022012409A MX2022012409A MX2022012409A MX 2022012409 A MX2022012409 A MX 2022012409A MX 2022012409 A MX2022012409 A MX 2022012409A MX 2022012409 A MX2022012409 A MX 2022012409A MX 2022012409 A MX2022012409 A MX 2022012409A
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Mexico
Prior art keywords
aapcs
presenting cells
antigen presenting
tumor infiltrating
myeloid cell
Prior art date
Application number
MX2022012409A
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English (en)
Inventor
Michael T Lotze
Anand Veerapathran
Aishwarya Gokuldass
Brian Rabinovich
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Iovance Biotherapeutics Inc
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Publication date
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of MX2022012409A publication Critical patent/MX2022012409A/es

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Abstract

En algunas modalidades, se describen composiciones y métodos relacionados con células aisladas que presentan antígeno artificial (aAPCs), incluyendo aAPCs que comprenden una célula mieloide transducida con uno o varios vectores virales, tales como una célula mieloide MOLM-14 o EM-3, en donde la célula mieloide expresa endógenamente HLA-A/B/C, ICOS-L y CD58 y en donde los uno o varios vectores virales comprenden un ácido nucleico que codifica CD86 y un ácido nucleico que codifica 4-1BBL y/u OX40L y transduce la célula mieloide para expresar proteínas CD86 y 4-1BBL y/u OX40L. En algunas modalidades, se describen métodos de expansión de linfocitos infiltrantes de tumores (TILs) con aAPCs y métodos de tratamiento de cánceres usando TILs después de la expansión con aAPCs.
MX2022012409A 2016-10-31 2019-04-23 Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores. MX2022012409A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662415274P 2016-10-31 2016-10-31
US201662438600P 2016-12-23 2016-12-23
US201762475053P 2017-03-22 2017-03-22
US201762481831P 2017-04-05 2017-04-05

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MX2022012409A true MX2022012409A (es) 2023-05-03

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MX2019004708A MX2019004708A (es) 2016-10-31 2017-10-31 Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores.
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US (4) US10415015B2 (es)
EP (1) EP3532608A1 (es)
JP (2) JP2019531744A (es)
KR (2) KR20240013295A (es)
CN (2) CN110312790A (es)
AU (2) AU2017347942A1 (es)
BR (1) BR112019008560A2 (es)
CA (1) CA3041673A1 (es)
IL (1) IL266221A (es)
MA (1) MA46668A (es)
MX (2) MX2019004708A (es)
SG (1) SG11201903825SA (es)
TW (1) TWI788307B (es)
WO (1) WO2018081789A1 (es)

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