|
HRP20141228T1
(en)
|
2003-12-19 |
2015-03-13 |
Plexxikon Inc. |
Compounds and methods for development of ret modulators
|
|
PL1730146T3
(pl)
|
2004-03-30 |
2011-10-31 |
Vertex Pharma |
Azaindole użyteczne jako inhibitor JAK i innych kinaz białkowych
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
ATE428421T1
(de)
|
2004-09-17 |
2009-05-15 |
Eisai R&D Man Co Ltd |
Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
|
|
CA2608733A1
(en)
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
MY153898A
(en)
|
2005-06-22 |
2015-04-15 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
EP2251341A1
(en)
|
2005-07-14 |
2010-11-17 |
Astellas Pharma Inc. |
Heterocyclic Janus kinase 3 inhibitors
|
|
JP5071374B2
(ja)
|
2005-07-14 |
2012-11-14 |
アステラス製薬株式会社 |
ヘテロ環ヤヌスキナーゼ3阻害剤
|
|
EP1925676A4
(en)
|
2005-08-02 |
2010-11-10 |
Eisai R&D Man Co Ltd |
TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR
|
|
EP1938842A4
(en)
*
|
2005-09-01 |
2013-01-09 |
Eisai R&D Man Co Ltd |
METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION COMPRISING IMPROVED CRASHING CHARACTERISTICS
|
|
LT2455382T
(lt)
|
2005-12-13 |
2017-02-10 |
Incyte Holdings Corporation |
Heteroarilu pakeisti pirolo[2,3-b]piridinai ir prolo[2,3-b]pirimidinai kaip janus kinazės inhibitoriai
|
|
EP1973911B1
(en)
|
2006-01-17 |
2016-01-13 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful for the treatment of (inter alia) proliferative, cardiac, neurodegenerative, autoimmune or inflammatory disorders
|
|
US20070208053A1
(en)
*
|
2006-01-19 |
2007-09-06 |
Arnold Lee D |
Fused heterobicyclic kinase inhibitors
|
|
BRPI0709866B8
(pt)
*
|
2006-04-03 |
2021-05-25 |
Astellas Pharma Inc |
compostos héteros e composição farmacêutica compreendendo ditos compostos
|
|
ES2556173T3
(es)
|
2006-05-18 |
2016-01-13 |
Eisai R&D Management Co., Ltd. |
Agente antitumoral para un cáncer de tiroides
|
|
WO2007135398A1
(en)
*
|
2006-05-22 |
2007-11-29 |
Astrazeneca Ab |
Indole derivatives
|
|
US7964728B2
(en)
*
|
2006-07-06 |
2011-06-21 |
Solvay Pharmaceuticals B.V. |
Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition
|
|
EA015700B1
(ru)
*
|
2006-07-06 |
2011-10-31 |
Солвей Фармасьютикалс Б.В. |
Азаиндольные производные с сочетанием частичного агонизма к никотиновому ацетилхолиновому рецептору и ингибирования обратного захвата дофамина
|
|
GB0617161D0
(en)
*
|
2006-08-31 |
2006-10-11 |
Vernalis R&D Ltd |
Enzyme inhibitors
|
|
ES2617150T3
(es)
|
2006-09-22 |
2017-06-15 |
Pharmacyclics Llc |
Inhibidores de tirosina cinasa de Bruton
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
PE20121126A1
(es)
*
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
|
CN101641351A
(zh)
*
|
2006-12-21 |
2010-02-03 |
普莱希科公司 |
用于激酶调节的化合物和方法及其适应症
|
|
US8247421B2
(en)
|
2006-12-21 |
2012-08-21 |
Vertex Pharmaceuticals Incorporated |
5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
|
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
CA3143428A1
(en)
*
|
2007-03-28 |
2008-10-09 |
Pharmacyclics Llc |
8-amino-3-substituted-imidazo[1,5-a]pyrazine and use thereof as inhibitors of bruton's tyrosine kinase
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
WO2008127710A2
(en)
|
2007-04-13 |
2008-10-23 |
Dana Farber Cancer Institute |
Methods for treating cancer resistant to erbb therapeutics
|
|
GB0710528D0
(en)
*
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
DK2740731T3
(en)
|
2007-06-13 |
2016-04-11 |
Incyte Holdings Corp |
CRYSTALLINE SALTS OF JANUSKINASEINHIBITOREN (R) -3- (4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-CYCLOPENTYLPROPANNITRIL
|
|
MX2010000617A
(es)
*
|
2007-07-17 |
2010-05-17 |
Plexxikon Inc |
Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
|
|
MX2010001636A
(es)
*
|
2007-08-14 |
2010-03-15 |
Hoffmann La Roche |
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
|
|
US8476273B2
(en)
|
2007-08-17 |
2013-07-02 |
University Of Maryland, Baltimore |
Small molecule inhibitors of Lck SH2 domain binding
|
|
CA2639416C
(en)
|
2007-09-11 |
2019-12-31 |
F. Hoffmann-La Roche Ag |
Diagnostic test for susceptibility to b-raf kinase inhibitors
|
|
DE102007045956A1
(de)
|
2007-09-26 |
2009-04-09 |
Bayer Cropscience Ag |
Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
|
|
DE102007045919B4
(de)
|
2007-09-26 |
2018-07-05 |
Bayer Intellectual Property Gmbh |
Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
|
|
AU2008317406B2
(en)
|
2007-10-25 |
2013-07-18 |
Merck Sharp & Dohme Corp. |
Therapeutic compounds
|
|
US8841304B2
(en)
|
2008-01-08 |
2014-09-23 |
Array Biopharma, Inc. |
Pyrrolopyridines as kinase inhibitors
|
|
US8426396B2
(en)
*
|
2008-01-08 |
2013-04-23 |
Shriners Hospitals For Children |
Treatment for achondroplasia
|
|
JP5608098B2
(ja)
|
2008-01-09 |
2014-10-15 |
アレイ バイオファーマ、インコーポレイテッド |
キナーゼ阻害薬としてのピラゾロピリジン
|
|
AU2009206775A1
(en)
*
|
2008-01-22 |
2009-07-30 |
Merck Patent Gmbh |
Protein kinase inhibitors and use thereof
|
|
WO2009106445A1
(en)
*
|
2008-02-25 |
2009-09-03 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine kinase inhibitors
|
|
JP2011513331A
(ja)
|
2008-02-29 |
2011-04-28 |
アレイ バイオファーマ、インコーポレイテッド |
ピラゾール[3,4−b]ピリジンRAF阻害剤
|
|
US20110003859A1
(en)
|
2008-02-29 |
2011-01-06 |
Array Biopharma Inc. |
N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
|
|
MX2010009410A
(es)
|
2008-02-29 |
2010-11-30 |
Array Biopharma Inc |
Compuestos del inhibidor de raf y métodos de uso de los mismos.
|
|
UA103319C2
(en)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Thiazole- and oxazole-benzene sulfonamide compounds
|
|
US8158636B2
(en)
|
2008-05-19 |
2012-04-17 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
JP2011520937A
(ja)
*
|
2008-05-21 |
2011-07-21 |
ビーエーエスエフ ソシエタス・ヨーロピア |
殺菌剤としての置換ピリジン−4−イルメチルスルホンアミド
|
|
BRPI0912109A2
(pt)
*
|
2008-05-28 |
2015-07-28 |
Basf Se |
Composto, processo para preparar os mesmos, composições agroquímicas, método para combater fungos nocivos fitopatogênicos, uso dos compostos, e, semente
|
|
CA2727389A1
(en)
|
2008-06-10 |
2009-12-17 |
Prabha N. Ibrahim |
5h-pyrrolo [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor
|
|
US8110576B2
(en)
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
|
AR072008A1
(es)
*
|
2008-06-13 |
2010-07-28 |
Merck & Co Inc |
Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38
|
|
US9447049B2
(en)
|
2010-03-01 |
2016-09-20 |
University Of Tennessee Research Foundation |
Compounds for treatment of cancer
|
|
WO2009157196A1
(ja)
|
2008-06-25 |
2009-12-30 |
武田薬品工業株式会社 |
アミド化合物
|
|
EP3311818A3
(en)
|
2008-07-16 |
2018-07-18 |
Pharmacyclics, LLC |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
|
DE102008052943A1
(de)
|
2008-10-23 |
2010-04-29 |
Merck Patent Gmbh |
Azaindolderivate
|
|
WO2010059771A1
(en)
*
|
2008-11-20 |
2010-05-27 |
Osi Pharmaceuticals, Inc. |
Substituted pyrrolo[2,3-b]-pyridines and-pyrazines
|
|
EP2379561B1
(en)
*
|
2008-11-25 |
2015-11-04 |
University Of Rochester |
Mlk inhibitors and methods of use
|
|
WO2010065927A2
(en)
*
|
2008-12-05 |
2010-06-10 |
California Institute Of Technology |
Dna-damage-induced proteolysis
|
|
EP3587413A1
(en)
*
|
2009-02-10 |
2020-01-01 |
Monsanto Technology LLC |
Compositions and methods for controlling nematodes comprising oxadiazoles
|
|
BRPI1011515A2
(pt)
*
|
2009-03-11 |
2016-03-29 |
Plexxikon Inc |
derivados de pirrolo[2,3-b] piridina para a inibição de raf cinases
|
|
AU2010224184A1
(en)
*
|
2009-03-11 |
2011-09-29 |
Plexxikon, Inc. |
Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of Raf kinases
|
|
WO2010111527A1
(en)
*
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
MY172424A
(en)
*
|
2009-04-03 |
2019-11-25 |
Hoffmann La Roche |
Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof
|
|
TW201041888A
(en)
*
|
2009-05-06 |
2010-12-01 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
MX2011012353A
(es)
|
2009-05-22 |
2011-12-14 |
Incyte Corp |
Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.
|
|
WO2010135621A1
(en)
|
2009-05-22 |
2010-11-25 |
Incyte Corporation |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
|
US9034875B2
(en)
|
2009-05-26 |
2015-05-19 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
CA2759182C
(en)
*
|
2009-05-26 |
2016-06-07 |
Abbott Laboratories |
(hetero)aryl substituted sulfonyl-2-(1h-pyrrolo[2,3-b]pyridine-5-oxy) benzamide compounds and their use as apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US8546399B2
(en)
*
|
2009-05-26 |
2013-10-01 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US20220315555A1
(en)
|
2009-05-26 |
2022-10-06 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
UY32717A
(es)
|
2009-06-17 |
2011-01-31 |
Vertex Pharma |
Inhibidores de la replicación de virus de la gripe
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
US8329724B2
(en)
*
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
NZ598291A
(en)
|
2009-08-19 |
2013-02-22 |
Eisai R&D Man Co Ltd |
Quinoline derivative-containing pharmaceutical composition
|
|
JP2013502444A
(ja)
|
2009-08-24 |
2013-01-24 |
アスセピオン ファーマスーティカル、インコーポレイテッド |
キナーゼ阻害剤としての5,6−ビシクロヘテロアリール含有尿素化合物
|
|
SG178853A1
(en)
|
2009-08-28 |
2012-04-27 |
Array Biopharma Inc |
Raf inhibitor compounds and methods of use thereof
|
|
US20120157453A1
(en)
|
2009-08-28 |
2012-06-21 |
Genentech, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
CA2772316A1
(en)
|
2009-08-28 |
2011-03-03 |
Array Biopharma Inc. |
1h-pyrazolo [3,4-b] pyridine compounds for inhibiting raf kinase
|
|
SG178534A1
(en)
*
|
2009-08-28 |
2012-03-29 |
Array Biopharma Inc |
Raf inhibitor compounds and methods of use thereof
|
|
CA2772575A1
(en)
|
2009-08-28 |
2011-03-03 |
Genentech, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
SG178899A1
(en)
|
2009-08-28 |
2012-04-27 |
Array Biopharma Inc |
Raf inhibitor compounds and methods of use thereof
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
MX2012004721A
(es)
|
2009-10-23 |
2012-06-25 |
Mannkind Corp |
Inmunoterapia de cancer y metodo de tratamiento.
|
|
JP2013510166A
(ja)
|
2009-11-06 |
2013-03-21 |
プレキシコン インコーポレーテッド |
キナーゼ調節のための化合物、方法およびその適用
|
|
WO2011060216A1
(en)
|
2009-11-12 |
2011-05-19 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
AU2010321883A1
(en)
*
|
2009-11-18 |
2012-05-31 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
DE102009058280A1
(de)
*
|
2009-12-14 |
2011-06-16 |
Merck Patent Gmbh |
Thiazolderivate
|
|
MX2012007429A
(es)
*
|
2009-12-23 |
2012-07-23 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de quinasa e indicaciones de la misma.
|
|
US9180127B2
(en)
*
|
2009-12-29 |
2015-11-10 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
|
EP2521553A4
(en)
|
2010-01-06 |
2013-08-28 |
Errico Joseph P |
METHODS AND COMPOSITIONS FOR THE DEVELOPMENT OF TARGETED MEDICAMENTS
|
|
US8658170B2
(en)
|
2010-01-06 |
2014-02-25 |
Joseph P. Errico |
Combination therapy with MDM2 and EFGR inhibitors
|
|
AU2011215638B2
(en)
*
|
2010-02-11 |
2016-04-28 |
Vanderbilt University |
Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mGluR4 allosteric potentiators, compounds, and methods of treating neurological dysfunction
|
|
US11084811B2
(en)
|
2010-03-01 |
2021-08-10 |
Oncternal Therapeutics, Inc. |
Compounds for treatment of cancer
|
|
US8765734B2
(en)
|
2010-03-10 |
2014-07-01 |
Incyte Corporation |
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
|
|
JP2013529181A
(ja)
|
2010-03-25 |
2013-07-18 |
ザ ジェイ. デヴィッド グラッドストーン インスティテューツ |
神経障害を治療するための組成物および方法
|
|
MX337548B
(es)
*
|
2010-04-16 |
2016-03-10 |
Ac Immune Sa |
Nuevos compuestos para tratamiento de enfermedades asociadas con proteinas amiloides o tipo amiloide.
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
EP2566481A4
(en)
*
|
2010-05-06 |
2014-01-22 |
Merck Sharp & Dohme |
AS FAAH MODULATORS SUITABLE AZA-INDOL DERIVATIVES
|
|
AR081039A1
(es)
*
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
WO2011143646A1
(en)
|
2010-05-14 |
2011-11-17 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
WO2011146336A1
(en)
|
2010-05-20 |
2011-11-24 |
Array Biopharma Inc. |
Macrocyclic compounds as trk kinase inhibitors
|
|
AU2011255443B2
(en)
|
2010-05-21 |
2014-07-03 |
Incyte Holdings Corporation |
Topical formulation for a JAK inhibitor
|
|
WO2011147764A1
(en)
*
|
2010-05-28 |
2011-12-01 |
N.V. Organon |
Thieno (2, 3b) pyrazine compounds as b - raf inhibitors
|
|
CA3007788C
(en)
|
2010-06-03 |
2020-03-10 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
|
US9593317B2
(en)
|
2010-06-09 |
2017-03-14 |
Bayer Cropscience Nv |
Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
|
|
US8779150B2
(en)
|
2010-07-21 |
2014-07-15 |
Hoffmann-La Roche Inc. |
Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
|
|
US9376709B2
(en)
|
2010-07-26 |
2016-06-28 |
Biomatrica, Inc. |
Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
|
|
WO2012018639A2
(en)
|
2010-07-26 |
2012-02-09 |
Biomatrica, Inc. |
Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
|
|
US8709419B2
(en)
|
2010-08-17 |
2014-04-29 |
Hoffmann-La Roche, Inc. |
Combination therapy
|
|
US20120045433A1
(en)
|
2010-08-17 |
2012-02-23 |
Kapil Dhingra |
Combination therapy
|
|
EP2616467A1
(en)
|
2010-09-13 |
2013-07-24 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
MX349533B
(es)
|
2010-10-29 |
2017-08-02 |
Abbvie Inc |
Dispersiones solidas que contienen un agente inductor de apoptosis.
|
|
UA113500C2
(xx)
|
2010-10-29 |
2017-02-10 |
|
Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
|
|
KR101236731B1
(ko)
|
2010-11-02 |
2013-02-25 |
한국과학기술원 |
아자인돌 화합물, 이를 포함하는 pi3k 저해제용 약학 조성물 및 pi3k와 연관된 질환 치료용 약학 조성물
|
|
EP2640725B1
(en)
|
2010-11-19 |
2015-01-07 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
SG190839A1
(en)
|
2010-11-19 |
2013-07-31 |
Incyte Corp |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
WO2012071374A1
(en)
|
2010-11-23 |
2012-05-31 |
Abbott Laboratories |
Methods of treatment using selective bcl-2 inhibitors
|
|
BR112013012740A2
(pt)
|
2010-11-23 |
2016-09-13 |
Abbvie Inc |
sais e formas cristalinas de um agente que induz apoptose
|
|
US8771687B2
(en)
|
2010-12-02 |
2014-07-08 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Methods for treating a tumor using an antibody that specifically binds GRP94
|
|
US9295669B2
(en)
*
|
2010-12-14 |
2016-03-29 |
Hoffman La-Roche Inc. |
Combination therapy for proliferative disorders
|
|
EP2651940A1
(en)
|
2010-12-16 |
2013-10-23 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
JP2014505052A
(ja)
|
2011-01-06 |
2014-02-27 |
ベータ ファルマ カナダ インコーポレーテッド |
癌の治療および予防用の新規なウレア
|
|
EA028821B9
(ru)
|
2011-02-07 |
2018-10-31 |
Плексксикон, Инк. |
Соединения и способы для модуляции киназ, а также показания к их применению
|
|
EP2672963A4
(en)
|
2011-02-08 |
2015-06-24 |
Childrens Medical Center |
METHOD FOR THE TREATMENT OF MELANOMA
|
|
BR112013020798B1
(pt)
|
2011-02-18 |
2022-03-15 |
Incyte Corporation |
Uso e composição contendo uma combinação de um inibidor mtor e de um inibidor de jak para tratamento de neoplasisas mieloproliferativas
|
|
AR085279A1
(es)
|
2011-02-21 |
2013-09-18 |
Plexxikon Inc |
Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
|
|
WO2012123504A1
(en)
*
|
2011-03-15 |
2012-09-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Compositions and methods for inhibiting tumor development caused by chemotherapy induced senescence
|
|
BR112013025353A8
(pt)
*
|
2011-04-01 |
2018-01-02 |
Genentech Inc |
combinação de a) um composto de fórmula ia, composto de fórmula ia ou um sal farmaceuticamente aceitável do mesmo, método para tratamento de um distúrbio hiperproliferativo em um mamífero, uso de um composto de fórmula ia ou um sal farmaceuticamente aceitável do mesmo, kit e produto
|
|
WO2012138809A1
(en)
*
|
2011-04-05 |
2012-10-11 |
Dawei Zhang |
Heterocyclic compounds as kinase inhibitors
|
|
AU2012246490B2
(en)
|
2011-04-18 |
2016-08-04 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
|
US9222137B2
(en)
*
|
2011-05-10 |
2015-12-29 |
Trovagene, Inc. |
Method for monitoring minimal residual hairy cell leukemia
|
|
EP2710003A1
(en)
|
2011-05-16 |
2014-03-26 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
BR112013029163A2
(pt)
|
2011-05-17 |
2017-01-31 |
Plexxikon Inc |
modulação quinase e indicações dos mesmos
|
|
WO2012160464A1
(en)
|
2011-05-26 |
2012-11-29 |
Daiichi Sankyo Company, Limited |
Heterocyclic compounds as protein kinase inhibitors
|
|
JP6038128B2
(ja)
|
2011-06-03 |
2016-12-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
|
|
JP2014516084A
(ja)
|
2011-06-10 |
2014-07-07 |
グラクソスミスクライン、インテレクチュアル、プロパティー、リミテッド |
新規化合物
|
|
WO2012177606A1
(en)
|
2011-06-20 |
2012-12-27 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
JP2014520863A
(ja)
|
2011-07-13 |
2014-08-25 |
ファーマサイクリックス,インク. |
Bruton型チロシンキナーゼの阻害剤
|
|
MY193562A
(en)
|
2011-08-01 |
2022-10-19 |
Genentech Inc |
Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
JP2014521725A
(ja)
|
2011-08-10 |
2014-08-28 |
ノバルティス・ファルマ・アクチェンゲゼルシャフト |
JAKPI3K/mTOR併用療法
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
WO2013029043A1
(en)
*
|
2011-08-25 |
2013-02-28 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
|
CN107245056A
(zh)
|
2011-08-26 |
2017-10-13 |
润新生物公司 |
化学实体、组合物及方法
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
JP6093768B2
(ja)
|
2011-09-14 |
2017-03-08 |
ニューファーマ, インコーポレイテッド |
特定の化学的実体、組成物、および方法
|
|
EP2570127A1
(en)
|
2011-09-16 |
2013-03-20 |
Sanofi |
Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors
|
|
WO2013043715A1
(en)
|
2011-09-19 |
2013-03-28 |
Genentech, Inc. |
Combination treatments comprising c-met antagonists and b-raf antagonists
|
|
WO2013062945A1
(en)
*
|
2011-10-24 |
2013-05-02 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical compounds
|
|
AU2012340200B2
(en)
|
2011-11-17 |
2017-10-12 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-Jun-N-Terminal Kinase (JNK)
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
EA025597B1
(ru)
|
2011-12-31 |
2017-01-30 |
Бейджен, Лтд. |
КОНДЕНСИРОВАННЫЕ ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Raf КИНАЗЫ
|
|
WO2013109142A1
(en)
|
2012-01-16 |
2013-07-25 |
Stichting Het Nederlands Kanker Instituut |
Combined pdk and mapk/erk pathway inhibition in neoplasia
|
|
CN102603734A
(zh)
*
|
2012-01-19 |
2012-07-25 |
盛世泰科生物医药技术(苏州)有限公司 |
一种蛋白激酶抑制剂及其应用
|
|
US9670180B2
(en)
|
2012-01-25 |
2017-06-06 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
US9216170B2
(en)
|
2012-03-19 |
2015-12-22 |
Hoffmann-La Roche Inc. |
Combination therapy for proliferative disorders
|
|
HK1202452A1
(en)
*
|
2012-03-28 |
2015-10-02 |
Neuropore Therapies, Inc. |
Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation
|
|
RU2635359C2
(ru)
*
|
2012-04-23 |
2017-11-13 |
Дженентек Инк. |
Промежуточные химические соединения и способы получения соединений
|
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
EP2858501A4
(en)
*
|
2012-05-22 |
2015-12-09 |
Merck Sharp & Dohme |
TRKA KINASE INHIBITORS, COMPOSITIONS AND METHOD THEREFOR
|
|
US10077474B2
(en)
*
|
2012-05-29 |
2018-09-18 |
Abbott Molecular, Inc. |
Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
|
|
US9150570B2
(en)
*
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
JP6231085B2
(ja)
|
2012-05-31 |
2017-11-15 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
アミノキナゾリン誘導体及びピリドピリミジン誘導体
|
|
BR112014030424A8
(pt)
|
2012-06-04 |
2017-07-11 |
Pharmacyclics Inc |
Formas cristalinas de um inibidor de quinase de tirosina de bruton
|
|
EA201590041A1
(ru)
|
2012-07-03 |
2015-04-30 |
Ратиофарм Гмбх |
Твердая форма холиновой соли вемурафениба
|
|
CN104704129A
(zh)
|
2012-07-24 |
2015-06-10 |
药品循环公司 |
与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
|
|
WO2014024077A1
(en)
*
|
2012-08-07 |
2014-02-13 |
Aurigene Discovery Technologies Limited |
5-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS
|
|
KR20190057421A
(ko)
|
2012-08-17 |
2019-05-28 |
에프. 호프만-라 로슈 아게 |
코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
|
|
CN103626765B
(zh)
*
|
2012-08-27 |
2016-08-10 |
广东东阳光药业有限公司 |
取代的氮杂吲哚化合物及其盐、组合物和用途
|
|
TWI601725B
(zh)
*
|
2012-08-27 |
2017-10-11 |
加拓科學公司 |
取代的氮雜吲哚化合物及其鹽、組合物和用途
|
|
AU2013312477B2
(en)
|
2012-09-06 |
2018-05-31 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CN104812389B
(zh)
|
2012-09-24 |
2020-07-17 |
润新生物公司 |
某些化学实体、组合物及方法
|
|
CN103613591B
(zh)
*
|
2012-09-29 |
2016-04-13 |
上海科州药物研发有限公司 |
作为cMet抑制剂的化合物及其制备方法和用途
|
|
US9163021B2
(en)
|
2012-10-04 |
2015-10-20 |
Pfizer Limited |
Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
|
|
EP2903649A1
(en)
*
|
2012-10-08 |
2015-08-12 |
Westfälische Wilhelms-Universität Münster |
Mek inhibitors in the treatment of virus diseases
|
|
US10112927B2
(en)
|
2012-10-18 |
2018-10-30 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
|
US9758522B2
(en)
|
2012-10-19 |
2017-09-12 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
EP2916838B1
(en)
|
2012-11-12 |
2019-03-13 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
MX2015006168A
(es)
|
2012-11-15 |
2015-08-10 |
Pharmacyclics Inc |
Compuestos de pirrolopirimidina como inhibidores de quinasas.
|
|
NZ748448A
(en)
|
2012-11-15 |
2019-12-20 |
Incyte Holdings Corp |
Sustained-release dosage forms of ruxolitinib
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
US9725703B2
(en)
|
2012-12-20 |
2017-08-08 |
Biomatrica, Inc. |
Formulations and methods for stabilizing PCR reagents
|
|
JPWO2014098176A1
(ja)
|
2012-12-21 |
2017-01-12 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体のアモルファス及びその製造方法
|
|
TWI617552B
(zh)
|
2012-12-21 |
2018-03-11 |
普雷辛肯公司 |
用於激酶調節及其適應症之化合物及方法
|
|
WO2014110574A1
(en)
|
2013-01-14 |
2014-07-17 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
|
|
MX376306B
(es)
|
2013-01-15 |
2025-03-07 |
Incyte Holdings Corp |
Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de cinasa pim.
|
|
WO2014130856A2
(en)
*
|
2013-02-21 |
2014-08-28 |
Wayne Rothbaum |
Treatment of skeletal-related disorders
|
|
KR20150118159A
(ko)
|
2013-02-22 |
2015-10-21 |
에프. 호프만-라 로슈 아게 |
암의 치료 방법 및 약물 내성의 예방 방법
|
|
US10022356B2
(en)
*
|
2013-03-05 |
2018-07-17 |
University Of Tennessee Research Foundation |
Compounds for treatment of cancer
|
|
EP3489239B1
(en)
|
2013-03-06 |
2021-09-15 |
Incyte Holdings Corporation |
Processes and intermediates for making a jak inhibitor
|
|
US20140275082A1
(en)
|
2013-03-14 |
2014-09-18 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
CA2900951A1
(en)
|
2013-03-14 |
2014-10-02 |
Ratiopharm Gmbh |
Solid state forms of vemurafenib hydrochloride
|
|
US20140303121A1
(en)
|
2013-03-15 |
2014-10-09 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
TWI634111B
(zh)
|
2013-03-15 |
2018-09-01 |
普雷辛肯公司 |
雜環化合物及其用途
|
|
WO2014140286A1
(en)
|
2013-03-15 |
2014-09-18 |
Sanofi |
Anti-tumoral composition comprising a pi3kbeta inhibitor and a raf inhibitor, to overcome cancer cells resistance
|
|
EP2968537A1
(en)
|
2013-03-15 |
2016-01-20 |
Genentech, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
US9206188B2
(en)
*
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
AU2014266223B2
(en)
|
2013-05-14 |
2020-06-25 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
RU2015149937A
(ru)
|
2013-05-30 |
2017-07-06 |
Плексксикон Инк. |
Соединения для модулирования киназы и показания к их применению
|
|
CN105491883B
(zh)
|
2013-06-13 |
2018-11-02 |
生物马特里卡公司 |
细胞稳定化
|
|
EP3013797B1
(en)
|
2013-06-28 |
2018-01-03 |
BeiGene, Ltd. |
Fused tricyclic amide compounds as multiple kinase inhibitors
|
|
AU2014288857B2
(en)
*
|
2013-07-12 |
2019-03-14 |
Piramal Enterprises Limited |
A pharmaceutical combination for the treatment of melanoma
|
|
JP6800750B2
(ja)
|
2013-08-02 |
2020-12-16 |
ファーマサイクリックス エルエルシー |
固形腫瘍の処置方法
|
|
EP3721873A1
(en)
|
2013-08-07 |
2020-10-14 |
Incyte Corporation |
Sustained release dosage forms for a jak1 inhibitor
|
|
US9415050B2
(en)
|
2013-08-12 |
2016-08-16 |
Pharmacyclics Llc |
Methods for the treatment of HER2 amplified cancer
|
|
EA201690458A1
(ru)
|
2013-08-23 |
2016-07-29 |
Инсайт Корпорейшн |
Фуро- и тиенопиридинкарбоксамиды, используемые в качестве ингибиторов pim-киназы
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
EP3046557A1
(en)
|
2013-09-20 |
2016-07-27 |
Stichting Het Nederlands Kanker Instituut |
Rock in combination with mapk-pathway
|
|
US9624224B2
(en)
|
2013-09-30 |
2017-04-18 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
EP3057955B1
(en)
|
2013-10-18 |
2018-04-11 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
|
US10047070B2
(en)
|
2013-10-18 |
2018-08-14 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
CA2930297C
(en)
|
2013-11-13 |
2022-04-05 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing inhibitors of influenza viruses replication
|
|
WO2015073476A1
(en)
|
2013-11-13 |
2015-05-21 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
CA2930584A1
(en)
|
2013-11-15 |
2015-05-21 |
The Wistar Institute Of Anatomy And Biology |
Ebna1 inhibitors and their method of use
|
|
WO2015075749A1
(en)
*
|
2013-11-22 |
2015-05-28 |
Laurus Labs Private Limited |
Novel processes for the preparation of vemurafenib
|
|
CZ2013943A3
(cs)
|
2013-11-27 |
2015-06-03 |
Zentiva, K.S. |
Krystalické formy vemurafenibu
|
|
CN104710417B
(zh)
*
|
2013-12-11 |
2020-09-08 |
上海科州药物研发有限公司 |
氮杂吲哚类衍生物及其合成方法
|
|
CA3240745A1
(en)
*
|
2013-12-20 |
2015-06-25 |
Biomed Valley Discoveries, Inc. |
Cancer treatment using combinations of erk and raf inhibitors
|
|
CN104739823A
(zh)
*
|
2013-12-28 |
2015-07-01 |
复旦大学附属华山医院 |
淫羊藿素在制备维罗非尼增敏剂中的用途
|
|
CA2935804A1
(en)
|
2014-01-14 |
2015-07-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
WO2015134536A1
(en)
|
2014-03-04 |
2015-09-11 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
WO2015143400A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics, Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
|
WO2015156674A2
(en)
|
2014-04-10 |
2015-10-15 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
WO2015164604A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
WO2015164614A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
WO2015171833A1
(en)
*
|
2014-05-06 |
2015-11-12 |
The Regents Of The University Of California |
Wound healing using braf inhibitors
|
|
WO2015178770A1
(en)
|
2014-05-19 |
2015-11-26 |
Stichting Het Nederlands Kanker Instituut |
Compositions for cancer treatment
|
|
WO2015181628A1
(en)
*
|
2014-05-27 |
2015-12-03 |
Eisai R&D Management Co., Ltd. |
Treatment of acute myeloid leukemia with an hck inhibitor
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
TW201613916A
(en)
*
|
2014-06-03 |
2016-04-16 |
Gilead Sciences Inc |
TANK-binding kinase inhibitor compounds
|
|
US10064404B2
(en)
|
2014-06-10 |
2018-09-04 |
Biomatrica, Inc. |
Stabilization of thrombocytes at ambient temperatures
|
|
EP3154589A1
(en)
|
2014-06-13 |
2017-04-19 |
Genentech, Inc. |
Methods of treating and preventing cancer drug resistance
|
|
WO2015191996A1
(en)
*
|
2014-06-13 |
2015-12-17 |
Genentech, Inc. |
Methods of treating and preventing cancer drug resistance
|
|
US20170114323A1
(en)
|
2014-06-19 |
2017-04-27 |
Whitehead Institute For Biomedical Research |
Uses of kinase inhibitors for inducing and maintaining pluripotency
|
|
WO2016000615A1
(en)
*
|
2014-07-02 |
2016-01-07 |
Sunshine Lake Pharma Co., Ltd. |
Heteroaryl compounds and pharmaceutical applications thereof
|
|
TW201613919A
(en)
|
2014-07-02 |
2016-04-16 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
US9580418B2
(en)
|
2014-07-14 |
2017-02-28 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
WO2016010897A1
(en)
|
2014-07-14 |
2016-01-21 |
Incyte Corporation |
Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
|
|
BR112017000672A2
(pt)
|
2014-07-15 |
2017-11-14 |
Genentech Inc |
composições para tratamento de câncer utilizando antagonistas de ligação de eixo pd-1 e inibidores de mek
|
|
AU2015296215A1
(en)
|
2014-08-01 |
2017-03-23 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
JP2017523206A
(ja)
|
2014-08-07 |
2017-08-17 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼ阻害剤の新規製剤
|
|
ES2926687T3
(es)
|
2014-08-28 |
2022-10-27 |
Eisai R&D Man Co Ltd |
Derivado de quinolina muy puro y método para su producción
|
|
JP6832846B2
(ja)
|
2014-09-15 |
2021-02-24 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
ヘテロ環化合物およびその用途
|
|
EA201790395A1
(ru)
|
2014-09-26 |
2017-08-31 |
Джилид Сайэнс, Инк. |
Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
|
|
EP3204516B1
(en)
|
2014-10-06 |
2023-04-26 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
|
US10611765B2
(en)
|
2014-11-06 |
2020-04-07 |
Ohio State Innovation Foundation |
Pyrrolopyrimidine derivatives as Mps1/TTK kinase inhibitors
|
|
US10414764B2
(en)
|
2014-11-29 |
2019-09-17 |
Shilpa Medicare Limited |
Substantially pure vemurafenib and its salts
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
WO2016105518A1
(en)
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
HK1245260A1
(zh)
|
2014-12-23 |
2018-08-24 |
Dana-Farber Cancer Institute, Inc. |
细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
|
|
US20180028662A1
(en)
|
2015-02-25 |
2018-02-01 |
Eisai R&D Management Co., Ltd. |
Method for Suppressing Bitterness of Quinoline Derivative
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
AU2015384801B2
(en)
|
2015-03-04 |
2022-01-06 |
Eisai R&D Management Co., Ltd. |
Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
|
|
EP3273966B1
(en)
|
2015-03-27 |
2023-05-03 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
US10160755B2
(en)
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CZ2015250A3
(cs)
|
2015-04-14 |
2016-10-26 |
Zentiva, K.S. |
Amorfní formy vemurafenibu
|
|
JP6530826B2
(ja)
|
2015-05-06 |
2019-06-12 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼを修飾する1h−ピロロ[2,3−b]ピリジン誘導体の合成
|
|
SMT202000535T1
(it)
|
2015-05-06 |
2020-11-10 |
Plexxikon Inc |
Forme solide di composto modulante chinasi
|
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
|
WO2016183120A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
KR102616818B1
(ko)
|
2015-05-14 |
2023-12-22 |
더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 |
Ebna1 억제제 및 그의 사용 방법
|
|
CA2986739C
(en)
|
2015-05-22 |
2023-03-14 |
Plexxikon Inc. |
Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases
|
|
JP6722200B2
(ja)
|
2015-05-22 |
2020-07-15 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
複素環化合物の合成
|
|
US9540347B2
(en)
|
2015-05-29 |
2017-01-10 |
Incyte Corporation |
Pyridineamine compounds useful as Pim kinase inhibitors
|
|
PE20230683A1
(es)
*
|
2015-06-09 |
2023-04-21 |
Abbvie Inc |
Moduladores de receptor nuclear
|
|
WO2016201370A1
(en)
|
2015-06-12 |
2016-12-15 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
MX373231B
(es)
|
2015-06-16 |
2020-05-08 |
Eisai R&D Man Co Ltd |
Agente anticancerigeno.
|
|
DK3322706T3
(da)
|
2015-07-16 |
2021-02-01 |
Array Biopharma Inc |
Substituerede pyrazolo[1,5-a]pyridin-forbindelser som ret-kinaseinhibitorer
|
|
US11274108B2
(en)
|
2015-07-20 |
2022-03-15 |
Genzyme Corporation |
Colony stimulating factor-1 receptor (CSF-1R) inhibitors
|
|
US10829484B2
(en)
|
2015-07-28 |
2020-11-10 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
US10729669B2
(en)
*
|
2015-07-28 |
2020-08-04 |
University Of Iowa Research Foundation |
Compositions and methods for treating cancer
|
|
US12220398B2
(en)
|
2015-08-20 |
2025-02-11 |
Eisai R&D Management Co., Ltd. |
Tumor therapeutic agent
|
|
EP3347018B1
(en)
|
2015-09-09 |
2021-09-01 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
TWI734699B
(zh)
|
2015-09-09 |
2021-08-01 |
美商英塞特公司 |
Pim激酶抑制劑之鹽
|
|
CA2999253C
(en)
|
2015-09-21 |
2021-10-26 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
US9920032B2
(en)
|
2015-10-02 |
2018-03-20 |
Incyte Corporation |
Heterocyclic compounds useful as pim kinase inhibitors
|
|
US9890163B2
(en)
|
2015-10-15 |
2018-02-13 |
Princeton Drug Discovery Inc |
Inhibitors of protein kinases
|
|
SG11201803438XA
(en)
|
2015-10-26 |
2018-05-30 |
Univ Colorado Regents |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
ES2824120T3
(es)
|
2015-11-19 |
2021-05-11 |
Hoffmann La Roche |
Procedimientos de tratamiento del cáncer usando inhibidores de b-raf e inhibidores de los puntos de control inmunitario
|
|
WO2017100201A1
(en)
|
2015-12-07 |
2017-06-15 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
KR102589056B1
(ko)
|
2015-12-08 |
2023-10-12 |
바이오매트리카 인코포레이티드 |
적혈구 침강 속도의 감소
|
|
KR20180093056A
(ko)
|
2015-12-14 |
2018-08-20 |
레드.컴, 엘엘씨 |
모듈형 디지털 카메라 및 셀룰러 폰
|
|
CA2951911A1
(en)
|
2015-12-17 |
2017-06-17 |
Gilead Sciences, Inc. |
Tank-binding kinase inhibitor compounds
|
|
CA3015768A1
(en)
*
|
2016-02-25 |
2017-08-31 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and intermediates
|
|
EP3430005B1
(en)
|
2016-03-16 |
2021-12-08 |
Plexxikon Inc. |
Compounds and methods for kinase modulation and indications therefore
|
|
WO2017176751A1
(en)
|
2016-04-04 |
2017-10-12 |
Loxo Oncology, Inc. |
Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
LT3439663T
(lt)
|
2016-04-04 |
2024-10-10 |
Loxo Oncology, Inc. |
Vaikų vėžio gydymo būdai
|
|
WO2017180581A1
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
HUE053643T2
(hu)
|
2016-05-18 |
2021-07-28 |
Loxo Oncology Inc |
(S)-N-(5 -((R)-2-(2,5-difluor-fenil)-pirrolidin-1-il)-pirazolo[1,5-A] pirimidin-3-il)-3-hidroxi-pirrolidin-1-karboxamid elõkészítése
|
|
JP7083214B2
(ja)
*
|
2016-06-13 |
2022-06-10 |
ケモセントリックス, インコーポレイテッド |
膵がんを治療する方法
|
|
EP3474879A4
(en)
|
2016-06-24 |
2020-05-06 |
University of Iowa Research Foundation |
Compositions and methods of treating melanoma
|
|
US10407427B2
(en)
|
2016-07-01 |
2019-09-10 |
Fermion Oy |
Processes for the preparation of Vemurafenib
|
|
IL311645B2
(en)
|
2016-07-12 |
2025-11-01 |
Revolution Medicines Inc |
2,5- disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines asallosteric shp2 inhibitors
|
|
CA3032210A1
(en)
|
2016-09-16 |
2018-03-22 |
Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) |
Traf 6 inhibitors
|
|
TW201815766A
(zh)
|
2016-09-22 |
2018-05-01 |
美商普雷辛肯公司 |
用於ido及tdo調節之化合物及方法以及其適應症
|
|
TWI704148B
(zh)
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
JOP20190077A1
(ar)
|
2016-10-10 |
2019-04-09 |
Array Biopharma Inc |
مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
|
|
EP3308773A1
(en)
|
2016-10-11 |
2018-04-18 |
Recordati Industria Chimica E Farmaceutica SPA |
Formulations of cysteamine and cysteamine derivatives
|
|
US11672801B2
(en)
|
2016-10-19 |
2023-06-13 |
United States Government As Represented By The Department Of Veterans Affairs |
Compositions and methods for treating cancer
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
KR20190088513A
(ko)
|
2016-11-23 |
2019-07-26 |
케모센트릭스, 인크. |
국소 분절 사구체경화증의 치료 방법
|
|
US11758928B2
(en)
|
2016-12-15 |
2023-09-19 |
Société des Produits Nestlé S.A. |
Compositions and methods that modulate phosphorus or enzymes in a companion animal
|
|
US10723717B2
(en)
*
|
2016-12-23 |
2020-07-28 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
|
|
US11173211B2
(en)
|
2016-12-23 |
2021-11-16 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
|
|
AU2017395023B2
(en)
|
2016-12-23 |
2022-04-07 |
Plexxikon Inc. |
Compounds and methods for CDK8 modulation and indications therefor
|
|
JP7300394B2
(ja)
*
|
2017-01-17 |
2023-06-29 |
ヘパリジェニックス ゲーエムベーハー |
肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
|
|
WO2018136661A1
(en)
|
2017-01-18 |
2018-07-26 |
Andrews Steven W |
SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
|
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
|
WO2018136264A1
(en)
|
2017-01-23 |
2018-07-26 |
Revolution Medicines, Inc. |
Pyridine compounds as allosteric shp2 inhibitors
|
|
EP3571199A1
(en)
|
2017-01-23 |
2019-11-27 |
Revolution Medicines, Inc. |
Bicyclic compounds as allosteric shp2 inhibitors
|
|
IL312367A
(en)
|
2017-01-31 |
2024-06-01 |
Arvinas Operations Inc |
Cereblon ligands and bifunctional compounds comprising the same
|
|
EP3581183B1
(en)
|
2017-02-08 |
2023-11-29 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
WO2018146253A1
(en)
|
2017-02-10 |
2018-08-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
WO2018175311A1
(en)
|
2017-03-20 |
2018-09-27 |
Plexxikon Inc. |
Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain
|
|
WO2018175324A1
(en)
|
2017-03-20 |
2018-09-27 |
The Broad Institute, Inc. |
Compounds and methods for regulating insulin secretion
|
|
EP3600302A4
(en)
*
|
2017-03-29 |
2020-12-30 |
United States Government as Represented by The Department of Veterans Affairs |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
|
|
CN110891566B
(zh)
|
2017-03-30 |
2023-12-19 |
塔克西斯医药股份有限公司 |
合成方法和合成中间体
|
|
CA3060147A1
(en)
*
|
2017-04-28 |
2018-11-01 |
Quartz Therapeutics, Inc. |
Raf-degrading conjugate compounds
|
|
WO2018210661A1
(en)
*
|
2017-05-15 |
2018-11-22 |
Basf Se |
Heteroaryl compounds as agrochemical fungicides
|
|
JP2020519576A
(ja)
|
2017-05-16 |
2020-07-02 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
肝細胞癌の治療
|
|
ES3030506T3
(en)
*
|
2017-05-19 |
2025-06-30 |
Nflection Therapeutics Inc |
Pyrrolopyridine-aniline compounds for treatment of dermal disorders
|
|
MA49140A
(fr)
|
2017-05-19 |
2020-03-25 |
Nflection Therapeutics Inc |
Composés hétéroaromatiques-aniline fusionnés pour le traitement de troubles dermiques
|
|
US10428067B2
(en)
|
2017-06-07 |
2019-10-01 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
|
CA3067746A1
(en)
|
2017-06-30 |
2019-01-03 |
The Regents Of The University Of California |
Compositions and methods for modulating hair growth
|
|
JP7170030B2
(ja)
|
2017-07-25 |
2022-11-11 |
プレキシコン インコーポレーテッド |
キナーゼを調節する化合物の製剤
|
|
CN109384785B
(zh)
*
|
2017-08-10 |
2021-09-28 |
浙江海正药业股份有限公司 |
吡咯并吡啶酮类衍生物、其制备方法及其在医药上的用途
|
|
CN111373055B
(zh)
|
2017-09-08 |
2024-07-23 |
豪夫迈·罗氏有限公司 |
用于癌症的诊断和治疗方法
|
|
TWI791053B
(zh)
|
2017-10-10 |
2023-02-01 |
美商亞雷生物製藥股份有限公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
|
|
TWI812649B
(zh)
|
2017-10-10 |
2023-08-21 |
美商絡速藥業公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
|
|
WO2019075086A1
(en)
|
2017-10-11 |
2019-04-18 |
Chemocentryx, Inc. |
TREATMENT OF FOCAL SEGMENTAL GLOBEROSCLEROSIS WITH CCR2 ANTAGONISTS
|
|
AU2018347516A1
(en)
|
2017-10-12 |
2020-05-07 |
Revolution Medicines, Inc. |
Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
|
|
US10717735B2
(en)
|
2017-10-13 |
2020-07-21 |
Plexxikon Inc. |
Solid forms of a compound for modulating kinases
|
|
US11306086B2
(en)
|
2017-10-26 |
2022-04-19 |
Xynomic Pharmaceuticals, Inc. |
Crystalline salts of a B-RAF kinase inhibitor
|
|
EP3700574B1
(en)
|
2017-10-27 |
2024-08-28 |
Plexxikon Inc. |
Formulations of a compound modulating kinases
|
|
US10596161B2
(en)
|
2017-12-08 |
2020-03-24 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
TW201927791A
(zh)
|
2017-12-15 |
2019-07-16 |
美商銳新醫藥公司 |
作為變構shp2抑制劑的多環化合物
|
|
CA3086765A1
(en)
|
2017-12-28 |
2019-07-04 |
Tract Pharmaceuticals, Inc. |
Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
|
|
EP3740491A1
(en)
|
2018-01-18 |
2020-11-25 |
Array Biopharma, Inc. |
Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
|
|
JP7061195B2
(ja)
|
2018-01-18 |
2022-04-27 |
アレイ バイオファーマ インコーポレイテッド |
RETキナーゼ阻害剤としての置換ピラゾロ[3,4-d]ピリミジン化合物
|
|
WO2019143994A1
(en)
|
2018-01-18 |
2019-07-25 |
Array Biopharma Inc. |
Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
|
|
SI3746429T1
(sl)
|
2018-01-30 |
2023-01-31 |
Incyte Corporation |
Postopki za pripravo (1-(3-fluoro-2-(trifluorometil)izonikotinil) piperidin-4-ona)
|
|
FI3746437T3
(fi)
|
2018-01-31 |
2024-11-21 |
Heparegenix Gmbh |
Proteiinikinaasi mkk4:n estäjiä maksan regeneraation edistämiseen tai maksasolujen kuolemisen vähentämiseen tai ehkäisyyn
|
|
US20210008047A1
(en)
|
2018-02-13 |
2021-01-14 |
Vib Vzw |
Targeting minimal residual disease in cancer with rxr antagonists
|
|
CN112119072A
(zh)
|
2018-03-20 |
2020-12-22 |
普莱希科公司 |
用于ido和tdo调节的化合物和方法,以及其适应症
|
|
PT3773593T
(pt)
|
2018-03-30 |
2024-06-25 |
Incyte Corp |
Tratamento da hidradenite supurativa com inibidores de jak
|
|
EP3774767B1
(en)
|
2018-04-05 |
2025-10-29 |
Beth Israel Deaconess Medical Center, Inc. |
Aryl hydrocarbon receptor modulators and uses thereof
|
|
EP3560516A1
(en)
*
|
2018-04-27 |
2019-10-30 |
Bergen Teknologioverforing AS |
Combination therapy including beta-sitosterol in combination with at least one of a braf inhibitor, a mek inhibitor or an erk inhibitor and methods and use thereof
|
|
TW201946919A
(zh)
|
2018-05-17 |
2019-12-16 |
威斯塔研究所 |
Ebna1抑制劑晶形、其製備方法及其使用方法
|
|
GB201808321D0
(en)
*
|
2018-05-21 |
2018-07-11 |
Univ College Dublin Nat Univ Ireland Dublin |
Compositions and uses thereof
|
|
RU2687107C1
(ru)
*
|
2018-06-18 |
2019-05-07 |
федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" |
Ингибитор braf киназы n-(3-(5-(4-хлорофенил)-1h-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил) пропан-1-сульфонамид
|
|
US11731968B2
(en)
|
2018-06-21 |
2023-08-22 |
Heparegenix Gmbh |
Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
AU2019295632B2
(en)
|
2018-06-25 |
2025-03-06 |
Dana-Farber Cancer Institute, Inc. |
Taire family kinase inhibitors and uses thereof
|
|
CN112654700B
(zh)
|
2018-07-06 |
2023-06-16 |
科罗拉多州立大学董事会法人团体 |
用于构建和检测生物活性剂的基因编码系统
|
|
SG11202012732UA
(en)
*
|
2018-07-16 |
2021-02-25 |
Heparegenix Gmbh |
Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
KR102592556B1
(ko)
*
|
2018-07-19 |
2023-10-23 |
썬전 링팡 바이오테크 컴퍼니 리미티드 |
아자인돌 유도체 및 이의 FGFR과 C-Met 억제제로서의 용도
|
|
CN117281803A
(zh)
|
2018-07-31 |
2023-12-26 |
罗索肿瘤学公司 |
喷雾干燥的分散体和制剂
|
|
EP3849986B1
(en)
|
2018-09-10 |
2022-06-08 |
Array Biopharma, Inc. |
Fused heterocyclic compounds as ret kinase inhibitors
|
|
EP3860598B1
(en)
|
2018-10-03 |
2023-09-06 |
Jyväskylän Yliopisto |
Vemurafenib and salts thereof for use in the treatment of enteroviral infections
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
JP2022504905A
(ja)
|
2018-10-16 |
2022-01-13 |
ノバルティス アーゲー |
標的化療法に対する応答を予測するためのバイオマーカーとしての単独の又は免疫マーカーと組み合わせた腫瘍突然変異負荷
|
|
JP2022507514A
(ja)
|
2018-11-16 |
2022-01-18 |
カリフォルニア インスティチュート オブ テクノロジー |
Erkインヒビター及びその使用
|
|
MA55144A
(fr)
|
2018-11-20 |
2021-09-29 |
Nflection Therapeutics Inc |
Composés naphthyridinone-aniline destinés au traitement d'affections de la peau
|
|
WO2020106305A1
(en)
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Thienyl-aniline compounds for treatment of dermal disorders
|
|
WO2020106306A1
(en)
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Cyanoaryl-aniline compounds for treatment of dermal disorders
|
|
WO2020114892A1
(en)
*
|
2018-12-03 |
2020-06-11 |
Merck Patent Gmbh |
4-heteroarylcarbonyl-n-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases
|
|
WO2020131674A1
(en)
|
2018-12-19 |
2020-06-25 |
Array Biopharma Inc. |
7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
|
|
WO2020131627A1
(en)
|
2018-12-19 |
2020-06-25 |
Array Biopharma Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
|
|
EP3902542A4
(en)
|
2018-12-28 |
2022-09-07 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 and uses thereof
|
|
LT3924340T
(lt)
|
2019-02-11 |
2025-03-10 |
Merck Patent Gmbh |
Indazolil-izoksazolo dariniai, skirti ligų, tokių kaip vėžys, gydymui
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
WO2020210366A1
(en)
|
2019-04-09 |
2020-10-15 |
Plexxikon Inc. |
Condensed azines for ep300 or cbp modulation and indications therefor
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
MA56047A
(fr)
*
|
2019-05-29 |
2022-04-06 |
Ifm Due Inc |
Composés et compositions destinés au traitement d'états pathologiques associés à une activité de sting
|
|
WO2020239124A1
(en)
*
|
2019-05-31 |
2020-12-03 |
Fochon Pharmaceuticals, Ltd. |
SUBSTITUTED PYRROLO [2, 3-b] PYRIDINE AND PYRAZOLO [3, 4-b] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
|
|
KR102878355B1
(ko)
|
2019-07-29 |
2025-10-28 |
헤파레게닉스 게엠베하 |
간 재생 촉진 또는 간세포 사멸 감소 또는 예방을 위한 헤테로아릴-치환된 피라졸로-피리딘 단백질 키나제 억제제
|
|
BR112022002698A2
(pt)
|
2019-08-14 |
2022-07-19 |
Incyte Corp |
Compostos de imidazolil pirimidinilamina como inibidores de cdk2
|
|
WO2021067749A2
(en)
*
|
2019-10-02 |
2021-04-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for the treatment of osteoarthritis
|
|
BR112022006977A2
(pt)
|
2019-10-11 |
2022-09-20 |
Incyte Corp |
Aminas bicíclicas como inibidores de cdk2
|
|
CN111004210A
(zh)
*
|
2019-10-23 |
2020-04-14 |
中山大学 |
化合物单晶及其制备方法
|
|
US20230101747A1
(en)
|
2019-12-06 |
2023-03-30 |
Schrödinger, Inc. |
Cyclic compounds and methods of using same
|
|
US12509444B2
(en)
|
2019-12-06 |
2025-12-30 |
Plexxikon Inc. |
Compounds and methods for CD73 modulation and indications therefor
|
|
MX2022007678A
(es)
|
2019-12-19 |
2022-09-19 |
Arvinas Operations Inc |
Compuestos y metodos para la degradacion dirigida del receptor de androgenos.
|
|
BR112022012684A2
(pt)
|
2019-12-27 |
2023-03-07 |
Schroedinger Inc |
Compostos cíclicos e métodos de uso dos mesmos
|
|
CN115052663A
(zh)
|
2020-01-08 |
2022-09-13 |
辛瑟斯治疗股份有限公司 |
Alk5抑制剂缀合物及其用途
|
|
US12466826B2
(en)
|
2020-01-15 |
2025-11-11 |
Heparegenix Gmbh |
3-benzoyl-1H-pyrrolo[2,3-b]pyridine derivatives as MKK4 inhibitors for treating liver diseases
|
|
EP4065553B1
(en)
*
|
2020-01-17 |
2025-01-29 |
Daegu-Gyeongbuk Medical Innovation Foundation |
Novel compound, preparation method thereof, and use thereof
|
|
EP4097234A1
(en)
|
2020-01-28 |
2022-12-07 |
Université de Strasbourg |
Antisense oligonucleotide targeting linc00518 for treating melanoma
|
|
US20230242536A1
(en)
*
|
2020-04-15 |
2023-08-03 |
Pyramid Biosciences, Inc. |
Methods for preparing tyrosine receptor kinase inhibitors
|
|
WO2021216898A1
(en)
|
2020-04-23 |
2021-10-28 |
Plexxikon Inc. |
Compounds and methods for cd73 modulation and indications therefor
|
|
EP4143168A1
(en)
|
2020-04-29 |
2023-03-08 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
KR102841083B1
(ko)
*
|
2020-05-04 |
2025-07-31 |
아주대학교산학협력단 |
톨-유사 수용체 7/9 억제 기능이 있는 길항성 소분자 화합물
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
US11529335B2
(en)
|
2020-07-31 |
2022-12-20 |
University Of Iowa Research Foundation |
Compositions and methods for treating cancer
|
|
US11628176B2
(en)
|
2020-08-21 |
2023-04-18 |
Opna Bio SA |
Combinational drug therapies
|
|
JP2023539663A
(ja)
|
2020-08-28 |
2023-09-15 |
アルビナス・オペレーションズ・インコーポレイテッド |
急速進行性線維肉腫タンパク質分解化合物及び関連する使用方法
|
|
CN116490507A
(zh)
|
2020-09-10 |
2023-07-25 |
薛定谔公司 |
用于治疗癌症的杂环包缩合cdc7激酶抑制剂
|
|
US20240360154A1
(en)
*
|
2020-09-23 |
2024-10-31 |
Genfleet Therapeutics (Shanghai) Inc. |
Aroyl substituted tricyclic compound, preparation method therefor and use thereof
|
|
CN114478528A
(zh)
*
|
2020-10-28 |
2022-05-13 |
劲方医药科技(上海)有限公司 |
芳甲酰取代的三环化合物及其制法和用途
|
|
CN116568686A
(zh)
*
|
2020-11-17 |
2023-08-08 |
重庆复尚源创医药技术有限公司 |
作为蛋白激酶抑制剂的取代的吡咯并[2,3-b]吡啶及吡唑并[3,4-b]吡啶衍生物
|
|
WO2022125524A1
(en)
*
|
2020-12-07 |
2022-06-16 |
Lieber Institute, Inc. |
Compounds for inhibiting inositol hexakisphosphate kinase (ip6k) and methods of use thereof
|
|
US20240002377A1
(en)
*
|
2020-12-07 |
2024-01-04 |
Medshine Discovery Inc. |
Pyrrolopyridine compound and application thereof
|
|
JP2024500919A
(ja)
|
2020-12-23 |
2024-01-10 |
ジェンザイム・コーポレーション |
重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤
|
|
WO2022164789A1
(en)
|
2021-01-26 |
2022-08-04 |
Schrödinger, Inc. |
Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disoders
|
|
CN112574200B
(zh)
*
|
2021-02-26 |
2021-06-11 |
安润医药科技(苏州)有限公司 |
Btk和/或btk的突变体c481s的小分子抑制剂
|
|
CN115073469B
(zh)
*
|
2021-03-15 |
2023-12-22 |
药雅科技(上海)有限公司 |
吡咯并嘧啶类化合物作为激酶抑制剂的制备及其应用
|
|
EP4308935A1
(en)
|
2021-03-18 |
2024-01-24 |
Novartis AG |
Biomarkers for cancer and methods of use thereof
|
|
TW202300150A
(zh)
|
2021-03-18 |
2023-01-01 |
美商薛定諤公司 |
環狀化合物及其使用方法
|
|
TW202304890A
(zh)
*
|
2021-04-14 |
2023-02-01 |
美商百歐克斯製藥公司 |
Klk5雙環雜芳香族抑制劑
|
|
US12371667B2
(en)
|
2021-05-13 |
2025-07-29 |
Washington University |
Enhanced methods for inducing and maintaining naive human pluripotent stem cells
|
|
KR102635126B1
(ko)
|
2021-05-27 |
2024-02-13 |
한국과학기술연구원 |
엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
US20250042895A1
(en)
*
|
2021-10-06 |
2025-02-06 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Inhibitors of ulk1 and methods of use
|
|
MX2024006058A
(es)
|
2021-11-23 |
2024-07-10 |
Nflection Therapeutics Inc |
Formulaciones de compuestos de pirrolopiridina-anilina.
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
WO2023174300A1
(zh)
*
|
2022-03-15 |
2023-09-21 |
劲方医药科技(上海)有限公司 |
Btk抑制剂的晶型及其酸式盐和其酸式盐的晶型
|
|
US20250186439A1
(en)
*
|
2022-03-16 |
2025-06-12 |
The Children's Medical Center Corporation |
Pyk2 inhibition modulates immune cell function
|
|
KR102710574B1
(ko)
*
|
2022-03-28 |
2024-09-27 |
주식회사 비엔에이치리서치 |
약물의 전기생리학적 스크리닝 방법
|
|
WO2024003350A1
(en)
|
2022-06-30 |
2024-01-04 |
Universite De Strasbourg |
Combination therapy for melanoma
|
|
CN115141197B
(zh)
*
|
2022-07-27 |
2024-03-26 |
安徽医科大学 |
一种3-芳杂环取代苯基衍生物及其制备方法与用途
|
|
WO2024033381A1
(en)
|
2022-08-10 |
2024-02-15 |
Vib Vzw |
Inhibition of tcf4/itf2 in the treatment of cancer
|
|
TW202432544A
(zh)
|
2022-09-07 |
2024-08-16 |
美商亞文納營運公司 |
快速加速纖維肉瘤降解化合物及相關使用方法
|
|
CN120322558A
(zh)
*
|
2022-11-25 |
2025-07-15 |
吉诺利私人有限公司 |
核酸适配体
|
|
CN115991705B
(zh)
*
|
2022-12-26 |
2025-04-08 |
安徽医科大学 |
3-(1H吡咯并[2,3-b]吡啶-5-基)苯甲酰基衍生物及其制备与应用
|
|
CN116768886B
(zh)
*
|
2022-12-26 |
2025-09-16 |
安徽医科大学 |
N-(4-(1H-吡咯并[2,3-b]吡啶-5-基)苯基)酰胺衍生物及制备与用途
|
|
WO2024209717A1
(ja)
|
2023-04-06 |
2024-10-10 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療用医薬組成物
|
|
WO2024258967A1
(en)
|
2023-06-13 |
2024-12-19 |
Synthis Therapeutics, Inc. |
Anti-cd5 antibodies and their uses
|
|
CN117105936B
(zh)
*
|
2023-08-24 |
2025-01-24 |
遵义医科大学 |
一种作为FLT3抑制剂的咪唑并[1,2-a]吡啶化合物及其制备方法和用途
|
|
WO2025059027A1
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