SG10201801794WA - Solid dispersions containing an apoptosis-inducing agent - Google Patents

Solid dispersions containing an apoptosis-inducing agent

Info

Publication number
SG10201801794WA
SG10201801794WA SG10201801794WA SG10201801794WA SG10201801794WA SG 10201801794W A SG10201801794W A SG 10201801794WA SG 10201801794W A SG10201801794W A SG 10201801794WA SG 10201801794W A SG10201801794W A SG 10201801794WA SG 10201801794W A SG10201801794W A SG 10201801794WA
Authority
SG
Singapore
Prior art keywords
apoptosis
inducing agent
solid dispersions
dispersions containing
solid
Prior art date
Application number
SG10201801794WA
Inventor
Nathaniel D Catron
David J Lindley
Jonathan Miller
Eric A Schmitt
Ping Tong
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of SG10201801794WA publication Critical patent/SG10201801794WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
SG10201801794WA 2010-10-29 2011-10-27 Solid dispersions containing an apoptosis-inducing agent SG10201801794WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40851710P 2010-10-29 2010-10-29

Publications (1)

Publication Number Publication Date
SG10201801794WA true SG10201801794WA (en) 2018-04-27

Family

ID=44947217

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2013029772A SG189471A1 (en) 2010-10-29 2011-10-27 Solid dispersions containing an apoptosis-inducing agent
SG10201801794WA SG10201801794WA (en) 2010-10-29 2011-10-27 Solid dispersions containing an apoptosis-inducing agent

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013029772A SG189471A1 (en) 2010-10-29 2011-10-27 Solid dispersions containing an apoptosis-inducing agent

Country Status (16)

Country Link
US (4) US20120277210A1 (en)
EP (1) EP2632436B1 (en)
JP (1) JP6068352B2 (en)
KR (2) KR20180059560A (en)
CN (1) CN103167867B (en)
AU (1) AU2011319842B2 (en)
BR (1) BR112013009093B1 (en)
CA (2) CA2811805A1 (en)
ES (1) ES2699205T3 (en)
IL (1) IL225340A (en)
MX (1) MX349533B (en)
NZ (1) NZ608274A (en)
RU (1) RU2598345C2 (en)
SG (2) SG189471A1 (en)
TW (1) TWI598333B (en)
WO (1) WO2012058392A1 (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
JP6068352B2 (en) * 2010-10-29 2017-01-25 アッヴィ・インコーポレイテッド Solid dispersion containing apoptosis inducer
UA113500C2 (en) 2010-10-29 2017-02-10 MEL EXTRUSION SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
EP2642999B1 (en) 2010-11-23 2016-09-28 AbbVie Bahamas Ltd. Methods of treatment using selective bcl-2 inhibitors
ES2644230T3 (en) 2010-11-23 2017-11-28 Abbvie Inc. Salts and crystalline forms of an apoptosis inducing agent
AU2012291631A1 (en) 2011-08-01 2014-02-27 Sun Pharmaceutical Industries Limited Dissolution enhanced controlled drug delivery system for poorly water soluble drugs
US10307167B2 (en) 2012-12-14 2019-06-04 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10813630B2 (en) 2011-08-09 2020-10-27 Corquest Medical, Inc. Closure system for atrial wall
US10314594B2 (en) 2012-12-14 2019-06-11 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
BR112014014529A2 (en) 2011-12-13 2019-09-24 Buck Inst For Res On Aging methods to improve medical therapies
KR20200110711A (en) 2012-09-07 2020-09-24 제넨테크, 인크. Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
AU2014248742B2 (en) 2013-03-13 2018-04-05 Abbvie Ireland Unlimited Company Processes for the preparation of an apoptosis-inducing agent
US9006438B2 (en) 2013-03-13 2015-04-14 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
US20140275082A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP6232262B2 (en) * 2013-11-13 2017-11-15 アクアス株式会社 Solid water treatment agent having sustained release and production method thereof
US9566443B2 (en) 2013-11-26 2017-02-14 Corquest Medical, Inc. System for treating heart valve malfunction including mitral regurgitation
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
CA2939121C (en) 2014-01-28 2020-11-24 Mayo Foundation For Medical Education And Research Effective treatment of osteoarthritis, pulmonary disease, ophthalmic disease, and atherosclerosis by removing senescent cells at the site of the disease
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
EP3476392A1 (en) 2014-02-28 2019-05-01 Merck Sharp & Dohme Corp. Method for treating cancer
US9238652B2 (en) * 2014-03-04 2016-01-19 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
HUE056329T2 (en) 2014-08-11 2022-02-28 Acerta Pharma Bv Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor
US10842626B2 (en) 2014-12-09 2020-11-24 Didier De Canniere Intracardiac device to correct mitral regurgitation
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
US11219625B2 (en) * 2015-07-24 2022-01-11 Yale University Inhibitors of N-linked glycosylation and methods using same
CN108601839B (en) 2015-11-03 2021-10-26 基因泰克公司 Bcl-2 inhibitor and MEK inhibitor combination for the treatment of cancer
EP3426655A1 (en) 2016-03-10 2019-01-16 Assia Chemical Industries Ltd. Solid state forms of venetoclax and processes for preparation of venetoclax
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
US20190225607A1 (en) * 2016-07-06 2019-07-25 Concert Pharmaceuticals, Inc. Deuterated Venetoclax
SG10201913643YA (en) * 2016-08-05 2020-03-30 Univ Michigan Regents N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
WO2018069941A2 (en) 2016-10-14 2018-04-19 Mylan Laboratories Limited Polymorphic forms of venetoclax
CN106674085B (en) * 2016-12-20 2020-06-23 苏州汉德创宏生化科技有限公司 Synthesis method of N-1, 3-difluoro isopropyl-4-aminopiperidine compound
WO2018127130A1 (en) 2017-01-07 2018-07-12 Shanghai Fochon Pharmaceutical Co., Ltd. Compounds as bcl-2-selective apoptosis-inducing agents
WO2018157803A1 (en) * 2017-02-28 2018-09-07 苏州科睿思制药有限公司 Venetoclax crystal forms and preparation method therefor
HUE060310T2 (en) 2017-04-18 2023-02-28 Shanghai Fochon Pharmaceutical Co Ltd Apoptosis-inducing agents
CN107501260B (en) * 2017-08-14 2019-08-13 郑州大学第一附属医院 A kind of preparation method of Bcl-2 inhibitor venetoclax and intermediate
IL272762B2 (en) 2017-08-23 2024-03-01 Newave Pharmaceutical Inc Condensed heterocyclic derivatives as bcl-2 inhibitors for the treatment of neoplastic diseases
CN108037196B (en) * 2017-11-23 2020-06-23 中山奕安泰医药科技有限公司 Detection method of 3-nitro-4- [ [ (tetrahydro-2H-pyran-4-yl) methyl ] amino ] benzenesulfonamide
WO2019135253A1 (en) 2018-01-02 2019-07-11 Mylan Laboratories Limited Polymorphic forms of venetoclax
CA3087262A1 (en) 2018-01-10 2019-07-18 Recurium Ip Holdings, Llc Benzamide compounds
CN111868059B (en) * 2018-03-30 2021-12-03 正大天晴药业集团股份有限公司 Trifluoromethyl substituted sulfonamide selective BCL-2 inhibitors
CN117683029A (en) 2018-04-29 2024-03-12 百济神州有限公司 Bcl-2 inhibitors
WO2020023435A1 (en) 2018-07-24 2020-01-30 Albany Molecular Research, Inc. Venetoclax basic salts and processes for the purification of venetoclax
CN114522167A (en) 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2 inhibitor or Bcl-2/Bcl-xL inhibitor and BTK inhibitor combination product and application thereof
AU2019314624B2 (en) 2018-07-31 2022-03-03 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of Bcl-2 inhibitor and MDM2 inhibitor and use thereof in the prevention and/or treatment of diseases
CN110772640B (en) 2018-07-31 2023-02-03 苏州亚盛药业有限公司 Synergistic antitumor effect of Bcl-2 inhibitors in combination with rituximab and/or bendamustine or with CHOP
AU2019314819A1 (en) 2018-07-31 2020-10-22 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
WO2020041406A1 (en) 2018-08-22 2020-02-27 Newave Pharmaceutical Inc. Bcl-2 inhibitors
CN109438441A (en) * 2018-11-30 2019-03-08 重庆三圣实业股份有限公司 It is a kind of dimension how the preparation method and products thereof of appropriate drawing
JP2022533740A (en) * 2019-05-24 2022-07-25 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Disubstituted sulfamide-based selective BCL-2 inhibitors containing methyl and trifluoromethyl groups
MX2022000308A (en) * 2019-07-10 2022-02-03 Recurium Ip Holdings Llc Nanoparticle formulation of bcl-2 inhibitor.
GB201911627D0 (en) * 2019-08-14 2019-09-25 Johnson Matthey Plc Polymorph of venetoclax and method for preparing the polymorph
EP4110298A1 (en) * 2020-02-24 2023-01-04 Guangzhou Lupeng Pharmaceutical Company Ltd. Hot melt extruded solid dispersions containing a bcl2 inhibitor
CN115244051A (en) * 2020-03-12 2022-10-25 南京明德新药研发有限公司 Benzo five-membered ring compound
US20230301946A1 (en) * 2020-07-07 2023-09-28 Atxa Therapeutics Limited Thromboxane receptor antagonist formulations
CN111643458A (en) * 2020-07-28 2020-09-11 青岛市肿瘤医院 Pharmaceutical preparation for treating rhabdomyosarcoma and preparation method thereof
CN114533677A (en) * 2020-11-25 2022-05-27 苏州亚盛药业有限公司 Solid dispersion, preparation method and application thereof
WO2023179774A1 (en) * 2022-03-25 2023-09-28 Shenzhen Pharmacin Co., Ltd. Amorphous solid dispersions and pharmaceutical compositions comprising the same
CN115925511B (en) * 2022-09-21 2024-03-29 苏州汉德创宏生化科技有限公司 Synthesis method of intermediate 4, 4-difluorocyclohexanol
CN115260191B (en) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 Piperidine compound and preparation method and application thereof

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69222182T2 (en) * 1991-12-18 1998-02-26 Warner Lambert Co METHOD FOR PRODUCING A SOLID DISPERSION
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
FR2736550B1 (en) 1995-07-14 1998-07-24 Sandoz Sa PHARMACEUTICAL COMPOSITION IN THE FORM OF A SOLID DISPERSION COMPRISING A MACROLIDE AND A VEHICLE
EP1019385B1 (en) 1995-09-15 2004-01-14 PHARMACIA & UPJOHN COMPANY Aminoaryl oxazolidinone n-oxides
CN1300173C (en) 1996-02-09 2007-02-14 艾博特生物技术有限公司 Human antibodies that bind huma TNF 'alpha'
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
CZ200172A3 (en) 1998-07-06 2001-08-15 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual antagonists of angiotensin receptor and endothelin receptor
DE19913692A1 (en) 1999-03-25 2000-09-28 Basf Ag Mechanically stable pharmaceutical dosage forms containing liquid or semi-solid surface-active substances
DE19929361A1 (en) 1999-06-25 2001-01-04 Basf Ag Mechanically stable pharmaceutical dosage forms containing liquid or semi-solid surface-active substances
US20030236236A1 (en) 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
WO2001047891A1 (en) 1999-12-28 2001-07-05 Eisai Co., Ltd. Heterocyclic compounds having sulfonamide groups
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
UY26942A1 (en) 2000-09-20 2002-04-26 Abbott Lab PROMOTING N-ACILSULFONAMIDS OF APOPTOSIS
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
CZ20033296A3 (en) 2001-06-06 2004-04-14 Eli Lilly And Company Benzoyl sulfonamides and sulfonyl benzamidines functioning as antineoplastic compounds
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
EP1480650B1 (en) 2002-02-26 2010-04-28 AstraZeneca AB Novel crystalline forms of the anti-cancer compound zd1839
DE60313956T2 (en) 2002-02-26 2008-05-15 Astrazeneca Ab PHARMACEUTICAL IRESSA COMPOSITION CONTAINING A WATER SOLUBLE CELLULOSE DERIVATIVE
FR2836914B1 (en) 2002-03-11 2008-03-14 Aventis Pharma Sa SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
JP4336678B2 (en) 2003-09-04 2009-09-30 株式会社日立超エル・エス・アイ・システムズ Semiconductor device
US7642260B2 (en) 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
US8614318B2 (en) 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US7767684B2 (en) 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
US7790190B2 (en) 2004-03-20 2010-09-07 Yasoo Health, Inc. Aqueous emulsions of lipophile solubilized with vitamin E TPGS and linoleic acid
PL1737850T3 (en) 2004-04-19 2008-02-29 Symed Labs Ltd A novel process for the preparation of linezolid and related compounds
JP2007536299A (en) 2004-05-04 2007-12-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Solid pharmaceutical form containing LTB4 antagonite
ES2325401T3 (en) 2004-07-20 2009-09-03 Symed Labs Limited NEW INTERMEDIATES FOR LINEZOLID AND RELATED COMPOUNDS.
ATE395905T1 (en) 2004-08-27 2008-06-15 Bayer Pharmaceuticals Corp PHARMACEUTICAL COMPOSITIONS IN THE FORM OF SOLID DISPERSIONS FOR THE TREATMENT OF CANCER
MY191349A (en) 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
JP2008514702A (en) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド Novel cyclosporine analogues and their pharmaceutical use
CA2606147C (en) 2005-05-12 2011-07-05 Abbott Laboratories Apoptosis promoters
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
MX2007014327A (en) 2005-05-16 2008-02-11 Irm Llc Pyrrolopyridine derivatives as protein kinase inhibitors.
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
HUE027370T2 (en) 2005-06-22 2016-10-28 Plexxikon Inc Pyrrolo [2,3-b]pyridine derivatives as protein kinase inhibitors
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
ES2358618T3 (en) 2006-07-14 2011-05-12 Chemocentryx, Inc. TRIAZOL PIRIDIL BENCENOSULFONAMIDAS AS MODULATORS OF CCR2 OR CCR9 FOR THE TREATMENT OF ARTERIOSCLEROSIS.
EP1880715A1 (en) 2006-07-19 2008-01-23 Abbott GmbH & Co. KG Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same
US7799790B2 (en) 2006-07-20 2010-09-21 Helm Ag Amorphous aripiprazole and process for the preparation thereof
KR100767349B1 (en) * 2006-08-01 2007-10-17 삼천당제약주식회사 A pharmaceutical composition for oral comprising fenofibrate and preparation method thereof
WO2008030836A2 (en) 2006-09-05 2008-03-13 Abbott Laboratories Bcl inhibitors treating platelet excess
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
WO2008067164A2 (en) 2006-11-15 2008-06-05 Abbott Laboratories Solid pharmaceutical dosage formulations
WO2008064116A2 (en) 2006-11-16 2008-05-29 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
AU2008214774A1 (en) 2007-02-15 2008-08-21 F. Hoffmann-La Roche Ag 2-aminooxazolines as TAAR1 ligands
US8536157B2 (en) 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
CA2686545C (en) 2007-04-19 2010-11-02 Concert Pharmaceuticals Inc. Deuterated morpholinyl compounds
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
US20090131485A1 (en) 2007-09-10 2009-05-21 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
JP2010540634A (en) 2007-10-01 2010-12-24 ザ・ジョンズ・ホプキンス・ユニバーシティー Method for treating autoimmune neurological diseases using cyclophosphamide
JP2010540635A (en) 2007-10-02 2010-12-24 コンサート ファーマシューティカルズ インコーポレイテッド Pyrimidinedione derivatives
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
EP2212298B1 (en) 2007-10-18 2013-03-27 Concert Pharmaceuticals Inc. Deuterated etravirine
WO2009055006A1 (en) 2007-10-26 2009-04-30 Concert Pharmaceuticals, Inc. Deuterated darunavir
NZ601350A (en) 2007-11-16 2013-08-30 Abbvie Inc Method of treating arthritis
US20090149461A1 (en) 2007-12-06 2009-06-11 Abbott Laboratories Method of treating cancer
RU2502800C2 (en) 2008-01-15 2013-12-27 Эббви Инк. Improved expression vectors of mammals and their use
CN101548960B (en) 2008-04-01 2012-11-07 沈阳药科大学 High-dissolution oral bifendate capsule and preparation method thereof
BRPI0920604B1 (en) * 2008-10-07 2021-11-23 Kudos Pharmaceuticals Limited IMMEDIATE RELEASE PHARMACEUTICAL FORMULATION IN THE FORM OF A SOLID DISPERSION COMPRISING AS ACTIVE THE COMPOUND 4-[3-(4-CYCLOPROPANCARBONYL-PIPERAZINE-1-CARBONYL)-4-FLUORINE-BENZYL]-2H-PHTALAZIN-1-ONE (OLAPARIB)
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100160322A1 (en) * 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (en) * 2008-12-04 2015-04-10 APOPTOZINDUCE FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTO-IMMUNE DISEASES
US8563735B2 (en) * 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
HUE029289T2 (en) * 2008-12-05 2017-02-28 Abbvie Inc Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
WO2010077740A2 (en) 2008-12-09 2010-07-08 Cytokine Pharmasciences, Inc. Novel antiviral compounds, compositions, and methods of use
US20120094963A1 (en) 2008-12-23 2012-04-19 of Queen Elizabeth near Dublin Targeting prodrugs and compositions for the treatment of gastrointestinal diseases
EP3095784A1 (en) 2009-01-19 2016-11-23 AbbVie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP2511264B1 (en) * 2009-01-19 2015-03-11 AbbVie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100297194A1 (en) 2009-04-30 2010-11-25 Nathaniel Catron Formulation for oral administration of apoptosis promoter
CA2759182C (en) * 2009-05-26 2016-06-07 Abbott Laboratories (hetero)aryl substituted sulfonyl-2-(1h-pyrrolo[2,3-b]pyridine-5-oxy) benzamide compounds and their use as apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI471321B (en) * 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Pharmaceutical dosage form for oral administration of a bcl-2 family inhibitor
NZ591973A (en) 2009-06-11 2013-03-28 Abbott Lab Anti-viral compounds to treat hcv infection
TWI520960B (en) 2010-05-26 2016-02-11 艾伯維有限公司 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP6068352B2 (en) 2010-10-29 2017-01-25 アッヴィ・インコーポレイテッド Solid dispersion containing apoptosis inducer
UA113500C2 (en) 2010-10-29 2017-02-10 MEL EXTRUSION SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
ES2644230T3 (en) 2010-11-23 2017-11-28 Abbvie Inc. Salts and crystalline forms of an apoptosis inducing agent
EP2642999B1 (en) 2010-11-23 2016-09-28 AbbVie Bahamas Ltd. Methods of treatment using selective bcl-2 inhibitors

Also Published As

Publication number Publication date
SG189471A1 (en) 2013-05-31
KR20140056137A (en) 2014-05-09
US20120277210A1 (en) 2012-11-01
US20220125796A1 (en) 2022-04-28
US20190275051A1 (en) 2019-09-12
AU2011319842A1 (en) 2013-04-04
NZ608274A (en) 2015-05-29
ES2699205T3 (en) 2019-02-07
EP2632436B1 (en) 2018-08-29
KR20180059560A (en) 2018-06-04
CN103167867B (en) 2016-12-21
TW201240967A (en) 2012-10-16
MX349533B (en) 2017-08-02
US10213433B2 (en) 2019-02-26
CA3152557A1 (en) 2012-05-03
CN103167867A (en) 2013-06-19
CA2811805A1 (en) 2012-05-03
EP2632436A1 (en) 2013-09-04
RU2598345C2 (en) 2016-09-20
MX2013004778A (en) 2013-06-03
KR102095698B1 (en) 2020-04-01
IL225340A0 (en) 2013-06-27
IL225340A (en) 2017-05-29
WO2012058392A1 (en) 2012-05-03
AU2011319842B2 (en) 2014-05-29
JP6068352B2 (en) 2017-01-25
BR112013009093B1 (en) 2022-04-19
JP2013540823A (en) 2013-11-07
TWI598333B (en) 2017-09-11
RU2013124824A (en) 2014-12-10
US20150157639A1 (en) 2015-06-11
BR112013009093A2 (en) 2016-07-19

Similar Documents

Publication Publication Date Title
HRP20171884T1 (en) Melt-extruded solid dispersions containing an apoptosis-inducing agent
IL225340A0 (en) Solid dispersions containing an apoptosis-inducing agent
PL3176649T3 (en) Cartridge
EP2724729A4 (en) Apoptosis-inducing agent
EP2657031A4 (en) Cartridge
EP2590647A4 (en) Pro-neurogenic compounds
HK1182327A1 (en) Solid dispersions containing kinase inhibitors
EP2605658A4 (en) Spiroxazolidinone compounds
PL2865271T3 (en) An improved formulation
EP2531023A4 (en) An improved formulation
EP2937099A4 (en) Apoptosis-inducing agent
PL2374979T3 (en) Plug-connector
EP2649050A4 (en) Compounds
HK1173368A1 (en) Pigmentation-preventing or-ameliorating agent
GB201114642D0 (en) Toner processes
GB201013703D0 (en) An approved
GB2481021B (en) Quick fixine
PL2397641T3 (en) Plug-connector
EP2640832A4 (en) New ethiological agent
GB201115171D0 (en) An improved container
PL2363354T3 (en) Dispenser of an agent
PL390823A1 (en) Yoke
AU333211S (en) Housing
GB201009052D0 (en) Vector