DE19962924A1
(de)
|
1999-12-24 |
2001-07-05 |
Bayer Ag |
Substituierte Oxazolidinone und ihre Verwendung
|
US6710058B2
(en)
|
2000-11-06 |
2004-03-23 |
Bristol-Myers Squibb Pharma Company |
Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
|
DE10105989A1
(de)
|
2001-02-09 |
2002-08-14 |
Bayer Ag |
Substituierte Oxazolidinone und ihre Verwendung
|
DE10129725A1
(de)
*
|
2001-06-20 |
2003-01-02 |
Bayer Ag |
Kombinationstherapie substituierter Oxazolidinone
|
CA2464109A1
(en)
*
|
2001-10-18 |
2003-12-24 |
Michigan State University |
Process for the preparation of oxazolidinones and method of use thereof
|
DE10152460A1
(de)
*
|
2001-10-24 |
2003-05-08 |
Bayer Ag |
Stents
|
EP1443930A1
(en)
|
2001-10-25 |
2004-08-11 |
AstraZeneca AB |
Isoxazoline derivatives useful as antimicrobials
|
US7794965B2
(en)
|
2002-03-13 |
2010-09-14 |
Signum Biosciences, Inc. |
Method of identifying modulators of PP2A methylase
|
DE10300111A1
(de)
*
|
2003-01-07 |
2004-07-15 |
Bayer Healthcare Ag |
Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
|
US7012088B2
(en)
|
2003-02-24 |
2006-03-14 |
Pharmacia & Upjohn Company |
Indolone oxazolidinones and derivatives thereof
|
DE10322469A1
(de)
*
|
2003-05-19 |
2004-12-16 |
Bayer Healthcare Ag |
Heterocyclische Verbindungen
|
DE10336716A1
(de)
*
|
2003-08-11 |
2005-03-10 |
Merck Patent Gmbh |
Verfahren zur Herstellung von N-Aryl-morpholinonen
|
DE10342570A1
(de)
*
|
2003-09-15 |
2005-04-14 |
Bayer Healthcare Ag |
Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon
|
DE10355461A1
(de)
*
|
2003-11-27 |
2005-06-23 |
Bayer Healthcare Ag |
Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
|
DE102004002044A1
(de)
*
|
2004-01-15 |
2005-08-04 |
Bayer Healthcare Ag |
Herstellverfahren
|
US7371743B2
(en)
|
2004-02-28 |
2008-05-13 |
Boehringer Ingelheim International Gmbh |
Carboxylic acid amides, the preparation thereof and their use as medicaments
|
EP1571154A1
(en)
*
|
2004-03-03 |
2005-09-07 |
Aventis Pharma Deutschland GmbH |
Beta-aminoacid-derivatives as factor Xa inhibitors
|
US7550499B2
(en)
|
2004-05-12 |
2009-06-23 |
Bristol-Myers Squibb Company |
Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
CA2562714A1
(en)
*
|
2004-05-13 |
2005-11-24 |
Boehringer Ingelheim International Gmbh |
Substituted thiophene-2-carboxylic acid amides, the production thereof and the use thereof as drugs
|
WO2005111029A1
(de)
|
2004-05-13 |
2005-11-24 |
Boehringer Ingelheim International Gmbh |
Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
|
US7696352B2
(en)
*
|
2004-06-18 |
2010-04-13 |
Millennium Pharmaceuticals, Inc. |
Factor Xa inhibitors
|
AU2005257999B2
(en)
*
|
2004-06-18 |
2011-12-08 |
Millennium Pharmaceuticals, Inc. |
Factor Xa inhibitors
|
EP1768967B1
(en)
*
|
2004-07-20 |
2009-04-22 |
Symed Labs Limited |
Novel intermediates for linezolid and related compounds
|
TW200612923A
(en)
|
2004-07-29 |
2006-05-01 |
Ferrer Int |
Oxazolidinone compounds and compositions and methods related thereto
|
DE102004047840A1
(de)
*
|
2004-09-29 |
2006-03-30 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
|
DE102004050283A1
(de)
*
|
2004-10-15 |
2006-04-27 |
Lanxess Deutschland Gmbh |
4-Aminophenyl-morpholinon-Derivate und deren Herstellung
|
US7662837B2
(en)
|
2004-10-22 |
2010-02-16 |
Janssen Pharmaceutica N.V. |
Inhibitors of c-fms kinase
|
US7645755B2
(en)
|
2004-10-22 |
2010-01-12 |
Janssen Pharmaceutical N.V. |
Inhibitors of c-fms kinase
|
DE102004062475A1
(de)
*
|
2004-12-24 |
2006-07-06 |
Bayer Healthcare Ag |
Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
|
MX2007008434A
(es)
|
2005-01-19 |
2007-07-25 |
Squibb Bristol Myers Co |
Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos.
|
EP1685841A1
(en)
*
|
2005-01-31 |
2006-08-02 |
Bayer Health Care Aktiengesellschaft |
Prevention and treatment of thromboembolic disorders
|
EP1843734A4
(en)
|
2005-02-03 |
2008-09-10 |
Signum Biosciences Inc |
COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS
|
US7923041B2
(en)
|
2005-02-03 |
2011-04-12 |
Signum Biosciences, Inc. |
Compositions and methods for enhancing cognitive function
|
DE102005018690A1
(de)
*
|
2005-04-22 |
2006-10-26 |
Bayer Healthcare Ag |
Imino-oxazolidine und ihre Verwendung
|
US20060281788A1
(en)
*
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
|
WO2007002634A1
(en)
|
2005-06-27 |
2007-01-04 |
Bristol-Myers Squibb Company |
Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
|
DE602006017694D1
(de)
|
2005-06-27 |
2010-12-02 |
Bristol Myers Squibb Co |
C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
|
ATE502924T1
(de)
|
2005-06-27 |
2011-04-15 |
Bristol Myers Squibb Co |
Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden
|
KR20080027890A
(ko)
|
2005-06-27 |
2008-03-28 |
브리스톨-마이어스 스큅 컴퍼니 |
혈전성 증상의 치료에 유용한 p2y1 수용체의 n-연결헤테로시클릭 길항제
|
PE20070171A1
(es)
|
2005-06-30 |
2007-03-08 |
Boehringer Ingelheim Int |
GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
|
WO2007007588A1
(ja)
*
|
2005-07-08 |
2007-01-18 |
Ono Pharmaceutical Co., Ltd. |
平面性を有する環状基を母核とする化合物
|
US20070032473A1
(en)
*
|
2005-07-19 |
2007-02-08 |
Kai Gerlach |
Substituted amides and their use as medicaments
|
AR057976A1
(es)
*
|
2005-08-29 |
2008-01-09 |
Boehringer Ingelheim Int |
Biarilos sustituidos y su uso como medicamentos.
|
DE102005045518A1
(de)
*
|
2005-09-23 |
2007-03-29 |
Bayer Healthcare Ag |
2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
|
CA2624310C
(en)
*
|
2005-10-04 |
2014-01-07 |
Bayer Healthcare Ag |
Polymorphic form of 5-chloro-n-({5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide
|
DE102005047561A1
(de)
|
2005-10-04 |
2007-04-05 |
Bayer Healthcare Ag |
Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
|
DE102005047564A1
(de)
|
2005-10-04 |
2007-05-31 |
Bayer Healthcare Ag |
Amorphe Form von 5-Chlor-N-({(5S)2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid
|
DE102005047558A1
(de)
*
|
2005-10-04 |
2008-02-07 |
Bayer Healthcare Ag |
Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
|
DE102005048824A1
(de)
*
|
2005-10-10 |
2007-04-12 |
Bayer Healthcare Ag |
Behandlung und Prophylaxe von Mikroangiopathien
|
NZ595182A
(en)
|
2005-10-18 |
2012-12-21 |
Janssen Pharmaceutica Nv |
Pharmaceutical uses of 4-cyano-1H-imidazole-2-carboxylic acid { 2-cyclohex-1-enyl-4-[1-(2-dimethylamino-acetyl)-piperidin-4-yl]-phenyl} -amide
|
US7962847B2
(en)
*
|
2005-10-20 |
2011-06-14 |
International Business Machines Corporation |
Method for providing dynamic process step annotations
|
DE102005052174A1
(de)
*
|
2005-11-02 |
2007-06-06 |
Bayer Healthcare Ag |
Phenylen-bis-oxazolidin-Derivate und ihre Verwendung
|
JP2007154330A
(ja)
*
|
2005-12-01 |
2007-06-21 |
Nippon Paper Industries Co Ltd |
印刷用塗工紙
|
KR20140107671A
(ko)
*
|
2005-12-30 |
2014-09-04 |
머크 샤프 앤드 돔 코포레이션 |
Cetp 억제제로서 유용한 1,3-옥사졸리딘-2-온 유도체
|
DE102006007146A1
(de)
|
2006-02-16 |
2007-08-23 |
Bayer Healthcare Ag |
Aminoacyl-Prodrugs
|
JP5161070B2
(ja)
|
2006-03-31 |
2013-03-13 |
財団法人乙卯研究所 |
ヘテロ環を有する新規化合物
|
SG171592A1
(en)
|
2006-04-20 |
2011-06-29 |
Janssen Pharmaceutica Nv |
Method of inhibiting c-kit kinase
|
UA93085C2
(en)
|
2006-04-20 |
2011-01-10 |
Янссен Фармацевтика Н.В. |
Inhibitors of c-fms kinase
|
EP2021335B1
(en)
|
2006-04-20 |
2011-05-25 |
Janssen Pharmaceutica N.V. |
Heterocyclic compounds as inhibitors of c-fms kinase
|
JP5480619B2
(ja)
|
2006-04-20 |
2014-04-23 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
c−fmsキナーゼの阻害剤
|
US8697716B2
(en)
|
2006-04-20 |
2014-04-15 |
Janssen Pharmaceutica Nv |
Method of inhibiting C-KIT kinase
|
EP2016072B1
(en)
|
2006-05-05 |
2014-07-16 |
Millennium Pharmaceuticals, Inc. |
Factor xa inhibitors
|
DE102006025319A1
(de)
*
|
2006-05-31 |
2007-12-06 |
Bayer Healthcare Aktiengesellschaft |
Substituierte Heterozyklen und ihre Verwendung
|
DE102006025314A1
(de)
*
|
2006-05-31 |
2007-12-06 |
Bayer Healthcare Ag |
Arylsubstituierte Heterozyklen und ihre Verwendung
|
DE102006034916A1
(de)
*
|
2006-07-28 |
2008-01-31 |
Bayer Healthcare Ag |
Beschichtung künstlicher Oberflächen von medizinischen Hilfsmitteln und Geräten sowie Reinigung und/oder Vorbehandlung von Kathetern und anderen medizinischen Hilfsmitteln und Geräten
|
DE102006039589A1
(de)
*
|
2006-08-24 |
2008-03-06 |
Bayer Healthcare Ag |
Aminoacyl-Prodrugs II
|
US7960569B2
(en)
|
2006-10-17 |
2011-06-14 |
Bristol-Myers Squibb Company |
Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
DE102006051625A1
(de)
*
|
2006-11-02 |
2008-05-08 |
Bayer Materialscience Ag |
Kombinationstherapie substituierter Oxazolidinone
|
ES2546815T3
(es)
|
2006-12-15 |
2015-09-28 |
Bristol-Myers Squibb Company |
Análogos de arilpropilamida, arilacrilamida, arilpropinamida o arilmetilurea como inhibidores del factor XIa
|
PE20081775A1
(es)
|
2006-12-20 |
2008-12-18 |
Bristol Myers Squibb Co |
Compuestos macrociclicos como inhibidores del factor viia
|
EP2114930A2
(en)
*
|
2007-01-05 |
2009-11-11 |
Millennium Pharmaceuticals, Inc. |
Factor xa inhibitors
|
JPWO2008120655A1
(ja)
*
|
2007-03-30 |
2010-07-15 |
株式会社医薬分子設計研究所 |
I型11βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体
|
DE102007018662A1
(de)
|
2007-04-20 |
2008-10-23 |
Bayer Healthcare Ag |
Oxazolidinone zur Behandlung und Prophylaxe von pulmonaler Hypertonie
|
BRPI0810462A2
(pt)
|
2007-04-23 |
2014-10-14 |
Sanofi Aventis |
Derivados de quinolina-carboxamida como antagonistas de p2y12
|
WO2008140220A1
(en)
*
|
2007-05-09 |
2008-11-20 |
Legochem Bioscience Ltd. |
Fxa inhibitors with cyclic amidines as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
|
KR101009594B1
(ko)
|
2007-05-09 |
2011-01-20 |
주식회사 레고켐 바이오사이언스 |
P4 위치에 사이클릭 아미딘을 가지는 FXa 저해제, 이의유도체, 제조방법 및 이를 함유하는 의약 조성물
|
DE102007028319A1
(de)
*
|
2007-06-20 |
2008-12-24 |
Bayer Healthcare Ag |
Substituierte Oxazolidinone und ihre Verwendung
|
DE102007028407A1
(de)
*
|
2007-06-20 |
2008-12-24 |
Bayer Healthcare Ag |
Substituierte Oxazolidinone und ihre Verwendung
|
DE102007028318A1
(de)
|
2007-06-20 |
2008-12-24 |
Bayer Healthcare Ag |
Oxazolidinone zur Behandlung und Prophylaxe von Sepsis
|
DE102007028320A1
(de)
|
2007-06-20 |
2008-12-24 |
Bayer Healthcare Ag |
Substituierte Oxazolidinone und ihre Verwendung
|
DE102007028406A1
(de)
*
|
2007-06-20 |
2008-12-24 |
Bayer Healthcare Ag |
Substituierte Oxazolidinone und ihre Verwendung
|
DE102007037373A1
(de)
|
2007-08-06 |
2009-02-19 |
Schebo Biotech Ag |
Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie
|
WO2009018807A1
(de)
*
|
2007-08-06 |
2009-02-12 |
Schebo Biotech Ag |
Oxazolidinone als faktor xa- inhibitoren, verfahren zu ihrer herstellung und ihre verwendung in der therapie
|
US20090076264A1
(en)
*
|
2007-09-15 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched rivaroxaban
|
EP2669283A1
(en)
|
2007-10-02 |
2013-12-04 |
Shionogi&Co., Ltd. |
Oxazolidinone derivative having 7-membered hetero ring
|
JO3240B1
(ar)
|
2007-10-17 |
2018-03-08 |
Janssen Pharmaceutica Nv |
c-fms مثبطات كيناز
|
US8741890B2
(en)
|
2007-11-15 |
2014-06-03 |
Boehringer Ingelheim International Gmbh |
Substituted amides, manufacturing and use thereof as medicaments
|
NZ586002A
(en)
*
|
2007-12-11 |
2012-06-29 |
Bayer Schering Pharma Ag |
Oxazolidinones for the treatment and/or prophylaxis of heart failure
|
WO2009080226A2
(en)
|
2007-12-26 |
2009-07-02 |
Sanofis-Aventis |
Heterocyclic pyrazole-carboxamides as p2y12 antagonists
|
CN102014897B
(zh)
|
2008-04-21 |
2015-08-05 |
西格纳姆生物科学公司 |
化合物、组合物和其制备方法
|
DE102008028071A1
(de)
|
2008-06-12 |
2009-12-17 |
Bayer Schering Pharma Aktiengesellschaft |
Neue Cokristall-Verbindung von Rivaroxaban und Malonsäure
|
EP2138178A1
(en)
*
|
2008-06-28 |
2009-12-30 |
Bayer Schering Pharma Aktiengesellschaft |
Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
|
KR100898361B1
(ko)
*
|
2008-07-03 |
2009-05-20 |
주식회사 레고켐 바이오사이언스 |
P4 위치에 사이클릭 아미독심 또는 사이클릭 아미드라존기를 가지는 FXa 저해제, 이의 유도체, 제조방법 및이를 함유하는 의약 조성물
|
EP2140866A1
(en)
*
|
2008-07-04 |
2010-01-06 |
Bayer Schering Pharma Aktiengesellschaft |
Oxazolidinones for the treatment of inflammatory conditions of the gastrointestinal tract
|
EP2303240A1
(en)
|
2008-07-08 |
2011-04-06 |
Ratiopharm GmbH |
Pharmaceutical compositions comprising 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
|
KR101023174B1
(ko)
*
|
2008-09-24 |
2011-03-18 |
주식회사 레고켐 바이오사이언스 |
사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
|
US20100168111A1
(en)
*
|
2008-12-31 |
2010-07-01 |
Apotex Pharmachem Inc. |
Polymorphic form of 5 chloro n {[(5s) 2 oxo 3 [4 (3 oxomorpholin 4 yl)phenyl]oxa-zolidin 5 yl]-methyl}thiophene 2 carboxamide
|
PE20120003A1
(es)
*
|
2009-01-30 |
2012-02-12 |
Glaxosmithkline Llc |
Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
|
US7816355B1
(en)
*
|
2009-04-28 |
2010-10-19 |
Apotex Pharmachem Inc |
Processes for the preparation of rivaroxaban and intermediates thereof
|
EP2266541A1
(en)
|
2009-06-18 |
2010-12-29 |
Krka Tovarna Zdravil, D.D., Novo Mesto |
Solid pharmaceutical composition comprising rivaroxaban
|
WO2010146179A2
(en)
|
2009-06-18 |
2010-12-23 |
Krka, Tovarna Zdravil, D.D., Novo Mesto |
Solid pharmaceutical composition comprising rivaroxaban
|
KR101037051B1
(ko)
*
|
2009-07-08 |
2011-05-26 |
주식회사 레고켐 바이오사이언스 |
(s)-5-클로로-n-((3-(4-(5,6-다이하이드로-4h-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법
|
KR101037052B1
(ko)
*
|
2009-07-08 |
2011-05-26 |
주식회사 레고켐 바이오사이언스 |
5-클로로-n-(((5s)-2-옥소-3-(4-(5,6-디하이드로-1,2,4-트리아진-1(4h)-일)페닐)-1,3-옥사졸리딘-5-일)메틸)티오펜-2-카르복사미드 유도체의 제조방법 및 그 제조중간체
|
WO2011012321A1
(en)
|
2009-07-31 |
2011-02-03 |
Krka, D.D., Novo Mesto |
Processes for crystallization of rivaroxaban
|
EP2308472A1
(en)
|
2009-10-06 |
2011-04-13 |
ratiopharm GmbH |
Pharmaceutical compositions comprising rivaroxaban
|
EP2485715A1
(en)
|
2009-10-06 |
2012-08-15 |
Ratiopharm GmbH |
Pharmaceutical compositions comprising rivaroxaban
|
WO2011061760A1
(en)
*
|
2009-11-18 |
2011-05-26 |
Cadila Healthcare Limited |
Novel antithrombotic agents
|
US8742120B2
(en)
*
|
2009-12-17 |
2014-06-03 |
Millennium Pharmaceuticals, Inc. |
Methods of preparing factor xa inhibitors and salts thereof
|
CA2784921A1
(en)
|
2009-12-17 |
2011-07-14 |
Millennium Pharmaceuticals, Inc. |
Salts and crystalline forms of a factor xa inhibitor
|
EP2521723A1
(en)
*
|
2010-01-04 |
2012-11-14 |
Enantia, S.L. |
Process for the preparation of rivaroxaban and intermediates thereof
|
EP2354128A1
(en)
*
|
2010-02-10 |
2011-08-10 |
Sandoz Ag |
Method for the preparation of rivaroxaban
|
EP2534152B1
(en)
|
2010-02-11 |
2018-05-02 |
Bristol-Myers Squibb Company |
Macrocycles as factor xia inhibitors
|
EA015918B1
(ru)
|
2010-03-03 |
2011-12-30 |
Дмитрий Геннадьевич ТОВБИН |
УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
|
DE102010018299A1
(de)
|
2010-04-23 |
2011-10-27 |
Archimica Gmbh |
Verfahren zur Herstellung von 4-(4-Aminophenyl)-morpholin-3-on
|
DE102010028362A1
(de)
|
2010-04-29 |
2011-11-03 |
Bayer Schering Pharma Aktiengesellschaft |
Herstellverfahren
|
KR101799429B1
(ko)
*
|
2010-05-03 |
2017-11-21 |
에스케이바이오팜 주식회사 |
신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물
|
EP2388260A1
(de)
|
2010-05-21 |
2011-11-23 |
Archimica GmbH |
Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors
|
CN107021932A
(zh)
*
|
2010-06-29 |
2017-08-08 |
欧美嘉股份有限公司 |
制备5‑左旋‑氨甲基‑3‑芳基‑2‑恶唑烷酮类的方法
|
EP2404920A1
(en)
|
2010-07-06 |
2012-01-11 |
Sandoz AG |
Crystalline form of Rivaroxaban dihydrate
|
US20130253187A1
(en)
|
2010-09-14 |
2013-09-26 |
Medichem, S.A. |
Process for Determining the Suitability for Distribution of a Batch of Thiophene-2-Carboxamide Derivative
|
CZ2010714A3
(cs)
|
2010-09-30 |
2012-04-11 |
Farmak, A. S. |
Zpusob výroby 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morfolinyl)fenyl]-1,3oxazolidin-5-yl}methyl)-1H-isoindol-1,3(2H)-dionu ve vysoké optické cistote
|
EP2630143B1
(en)
*
|
2010-10-18 |
2017-11-29 |
Apotex Pharmachem Inc. |
Processes for the preparation of rivaroxaban and intermediates thereof
|
CN102464658B
(zh)
*
|
2010-11-03 |
2014-04-16 |
天津药物研究院 |
噁唑烷酮衍生物及其制备方法和用途
|
DE102010063127A1
(de)
|
2010-12-15 |
2012-06-21 |
Bayer Schering Pharma Aktiengesellschaft |
Flüssige, oral applizierbare pharmazeutische Zusammensetzungen enthaltend 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
|
EP2665751A1
(en)
|
2011-01-19 |
2013-11-27 |
Bayer Intellectual Property GmbH |
Binding proteins to inhibitors of coagulation factors
|
CN102199150A
(zh)
*
|
2011-04-01 |
2011-09-28 |
中国药科大学 |
光学活性噁唑烷酮类衍生物及其制备方法与在制药中的用途
|
US9221771B2
(en)
|
2011-04-11 |
2015-12-29 |
Sandoz Ag |
Method for the preparation of substituted oxazolidinones
|
GEP20156397B
(en)
*
|
2011-05-06 |
2015-11-10 |
Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság |
Process for the preparation of a rivaroxaban and intermediates formed in said process
|
WO2012156983A1
(en)
*
|
2011-05-16 |
2012-11-22 |
Symed Labs Limited |
Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
|
ES2395304B1
(es)
|
2011-05-20 |
2014-01-16 |
Interquim, S.A. |
Procedimiento de obtención de una tiofen-2-carboxamida.
|
CN102796092B
(zh)
*
|
2011-05-24 |
2015-04-08 |
北大方正集团有限公司 |
噁唑烷酮衍生物及其制备方法和应用
|
CN102796091A
(zh)
*
|
2011-05-24 |
2012-11-28 |
北大方正集团有限公司 |
取代的噁唑烷酮化合物及其制备方法和应用
|
CN102320988B
(zh)
*
|
2011-06-03 |
2014-04-09 |
中国科学院上海有机化学研究所 |
4-(4-氨基苯基)-3-吗啉酮中间体酰胺、合成方法和用途
|
CN102827154B
(zh)
|
2011-06-14 |
2015-04-22 |
上海科胜药物研发有限公司 |
一种合成利伐沙班中间体4-{4-[(5s)-5-(氨基甲基)-2-氧代-1,3-恶唑烷-3-基]苯基}吗啉-3-酮的方法
|
TW201319068A
(zh)
|
2011-08-05 |
2013-05-16 |
必治妥美雅史谷比公司 |
作為xia因子抑制劑之環狀p1接合劑
|
TW201311689A
(zh)
|
2011-08-05 |
2013-03-16 |
必治妥美雅史谷比公司 |
作為因子xia抑制劑之新穎巨環化合物
|
WO2013098833A2
(en)
|
2011-09-08 |
2013-07-04 |
Cadila Healthcare Limited |
Processes and intermediates for preparing rivaroxaban
|
EP2573084A1
(en)
|
2011-09-22 |
2013-03-27 |
Enantia, S.L. |
Novel crystalline forms of rivaroxaban and processes for their preparation
|
WO2013046211A1
(en)
*
|
2011-09-27 |
2013-04-04 |
Symed Labs Limited |
Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
|
WO2013053739A1
(en)
|
2011-10-10 |
2013-04-18 |
Laboratorios Lesvi, S. L. |
Process for preparing factor xa inhibitors
|
HU230734B1
(hu)
|
2011-10-10 |
2017-12-28 |
EGIS Gyógyszergyár Nyrt |
Gyógyászati készítmény előállítására alkalmazható rivaroxaban kokristályok
|
EP2766373B1
(en)
*
|
2011-10-11 |
2016-08-17 |
Council of Scientific & Industrial Research |
Sila analogs of oxazolidinone derivatives and synthesis thereof
|
JP6033318B2
(ja)
|
2011-10-14 |
2016-11-30 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
第XIa因子阻害剤としての置換テトラヒドロイソキノリン化合物
|
ES2625256T3
(es)
|
2011-10-14 |
2017-07-19 |
Bristol-Myers Squibb Company |
Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIA
|
EP2899183B1
(en)
|
2011-10-14 |
2018-09-19 |
Bristol-Myers Squibb Company |
Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors
|
CN102408420B
(zh)
*
|
2011-10-19 |
2014-10-22 |
汕头经济特区鮀滨制药厂 |
一种利伐沙班及其中间体的制备方法以及中间体化合物
|
US20150011756A1
(en)
|
2012-02-06 |
2015-01-08 |
Megafine Pharma (P) Ltd |
Process for preparation of rivaroxaban and intermediates thereof
|
CZ2012111A3
(cs)
|
2012-02-16 |
2013-08-28 |
Zentiva, K.S. |
Zpusob prípravy rivaroxabanu zalozený na vyuzití (S)-epichlorhydrinu
|
CZ2012114A3
(cs)
|
2012-02-17 |
2013-02-20 |
Zentiva, K.S. |
Zpusob prípravy rivaroxabanu zalozený na úspore 1,1´ -karbonyldiimidazolu
|
CN103288814B
(zh)
|
2012-02-24 |
2016-07-06 |
国药集团国瑞药业有限公司 |
一种利伐沙班中间体的制备方法
|
WO2013151719A2
(en)
*
|
2012-04-05 |
2013-10-10 |
Scifluor Life Sciences, Llc |
Fluorinated oxazolidinone derivatives
|
US9562040B2
(en)
|
2012-04-06 |
2017-02-07 |
Indiana University Research And Technology Corporation |
Processes for preparing Rivaroxaban
|
WO2013156936A1
(en)
|
2012-04-16 |
2013-10-24 |
Ranbaxy Laboratories Limited |
Process for the preparation of rivaroxaban and intermediates thereof
|
US9376427B2
(en)
|
2012-05-02 |
2016-06-28 |
Symed Labs Limited |
Process for preparing rivaroxaban using intermediates
|
SG11201407518SA
(en)
*
|
2012-05-24 |
2014-12-30 |
Ranbaxy Lab Ltd |
Process for the preparation of rivaroxaban
|
CN102746287B
(zh)
*
|
2012-06-21 |
2014-05-28 |
成都苑东药业有限公司 |
一种恶唑烷酮化合物及其制备方法
|
UY34856A
(es)
|
2012-07-03 |
2013-12-31 |
Bayer Pharma AG |
Formas de presentación farmacéuticas que contienen 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4- morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida
|
CN102757424B
(zh)
*
|
2012-07-09 |
2014-10-15 |
云南大学 |
2-苄基取代苯并呋喃—咪唑盐类化合物及其制备方法
|
CN102746288B
(zh)
*
|
2012-07-24 |
2015-04-08 |
常州制药厂有限公司 |
一种抗凝血药及其关键中间体的制备方法
|
AU2013296258A1
(en)
|
2012-08-03 |
2015-03-19 |
Bristol-Myers Squibb Company |
Dihydropyridone P1 as factor XIa inhibitors
|
TW201410667A
(zh)
|
2012-08-03 |
2014-03-16 |
必治妥美雅史谷比公司 |
二氫吡啶酮p1作爲凝血因子xia抑制劑
|
JOP20180012A1
(ar)
|
2012-08-07 |
2019-01-30 |
Janssen Pharmaceutica Nv |
عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
|
JP6359537B2
(ja)
|
2012-08-07 |
2018-07-18 |
ヤンセン ファーマシューティカ エヌ.ベー. |
複素環エステル誘導体の調製プロセス
|
CN103626749A
(zh)
*
|
2012-08-21 |
2014-03-12 |
苏州泽璟生物制药有限公司 |
取代的噁唑烷酮化合物和包含该化合物的药物组合物及其用途
|
IN2015DN02600A
(bg)
|
2012-09-26 |
2015-09-18 |
Ranbaxy Lab Ltd |
|
CN103864773B
(zh)
*
|
2012-12-13 |
2017-03-15 |
北京藏卫信康医药研发有限公司 |
利伐沙班及其中间体的制备方法
|
PL2935255T3
(pl)
*
|
2012-12-21 |
2018-01-31 |
Farma Grs D O O |
Sposób wytwarzania rywaroksabanu
|
BR112015011033A2
(pt)
*
|
2012-12-26 |
2017-07-11 |
Wanbury Ltd |
derivado aldeído de oxazolidinonas substituídas
|
PT2895176T
(pt)
|
2012-12-26 |
2017-01-27 |
Wanbury Ltd |
Intermediário de rivaroxabano e a sua preparação
|
IN2013MU01113A
(bg)
*
|
2013-03-25 |
2015-06-19 |
Glenmark Generics Ltd |
|
EP2978751B1
(en)
|
2013-03-25 |
2018-12-05 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors
|
CN104098556B
(zh)
*
|
2013-04-09 |
2019-01-08 |
浙江九洲药物科技有限公司 |
一种利伐沙班的合成工艺
|
CN103242307B
(zh)
*
|
2013-05-17 |
2015-08-12 |
天津药物研究院有限公司 |
一种噁唑烷酮类衍生物晶型ⅰ及其制备方法和用途
|
WO2014183667A1
(zh)
*
|
2013-05-17 |
2014-11-20 |
天津药物研究院 |
一种噁唑烷酮衍生物的乙酸溶剂化物及其制备方法和用途
|
US20160108027A1
(en)
*
|
2013-06-03 |
2016-04-21 |
Bayer Pharma Aktiengesellschaft |
Substituted benzoxazoles
|
UY35592A
(es)
|
2013-06-03 |
2014-12-31 |
Bayer Pharma AG |
Benzoxazoles sustituidos
|
CN105408331A
(zh)
*
|
2013-06-03 |
2016-03-16 |
拜耳制药股份公司 |
作为用于治疗血栓栓塞病症的凝血酶抑制剂的三唑并吡啶
|
WO2015011617A1
(en)
|
2013-07-23 |
2015-01-29 |
Ranbaxy Laboratories Limited |
Process for the preparation of rivaroxaban
|
US9598403B2
(en)
|
2013-08-19 |
2017-03-21 |
Amneal Pharmaceuticals Llc |
Process for the preparation of rivaroxaban
|
WO2015104605A1
(en)
|
2014-01-08 |
2015-07-16 |
Wockhardt Limited |
A process for preparing rivaroxaban or a pharmaceutically acceptable salt thereof
|
WO2015111076A2
(en)
|
2014-01-23 |
2015-07-30 |
Symed Labs Limited |
Improved processes for the preparation of highly pure rivaroxaban crystal modification i
|
NO2760821T3
(bg)
|
2014-01-31 |
2018-03-10 |
|
|
SG11201606209PA
(en)
|
2014-01-31 |
2016-08-30 |
Bristol Myers Squibb Co |
Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
|
WO2015124995A1
(en)
|
2014-02-19 |
2015-08-27 |
Aurobindo Pharma Ltd |
Solid dosage forms of rivaroxaban
|
EP2929885A1
(en)
|
2014-04-11 |
2015-10-14 |
Sanovel Ilac Sanayi ve Ticaret A.S. |
Pharmaceutical combinations of rivaroxaban and proton pump inhibitors
|
CN104974149B
(zh)
*
|
2014-04-14 |
2018-05-01 |
北大方正集团有限公司 |
一种利伐沙班的制备方法
|
KR101499867B1
(ko)
*
|
2014-04-22 |
2015-03-06 |
에스케이케미칼주식회사 |
활성 성분 (i) 함유 조성물 및 이의 제조 방법
|
CN105085370B
(zh)
*
|
2014-04-22 |
2017-04-12 |
北大方正集团有限公司 |
(s)‑1‑卤代‑2‑[2‑(1,3‑二氧异吲哚)基]乙基氯甲酸酯及其制备方法
|
CN105085371B
(zh)
*
|
2014-04-22 |
2017-06-16 |
北大方正集团有限公司 |
(s)‑{1‑(氯甲酸酯基)‑2‑[2‑(1,3‑二氧异吲哚)基]乙基}卤化盐及其制备方法
|
WO2015169957A1
(en)
|
2014-05-09 |
2015-11-12 |
Sanovel Ilac Sanayi Ve Ticaret A.S. |
Pharmaceutical combinations of rivaroxaban and h2-receptor antagonists
|
CN104031036A
(zh)
*
|
2014-05-16 |
2014-09-10 |
南通常佑药业科技有限公司 |
一种利伐沙班的制备方法
|
JP2017516845A
(ja)
|
2014-05-22 |
2017-06-22 |
ノース チャイナ ファーマシューティカル カンパニー リミテッド |
血液凝固因子Xa阻害剤としてのヒドラジド化合物
|
CN103980221B
(zh)
*
|
2014-05-26 |
2016-03-23 |
山东康美乐医药科技有限公司 |
4-(硝基苯基)-3-吗啉酮的制备方法及利用其制备利伐沙班的方法
|
DE102014108210A1
(de)
|
2014-06-11 |
2015-12-17 |
Dietrich Gulba |
Rodentizid
|
WO2015198259A1
(en)
|
2014-06-26 |
2015-12-30 |
Erregierre S.P.A. |
Process for the synthesis of rivaroxaban and intermediate for the production thereof
|
TW201607923A
(zh)
|
2014-07-15 |
2016-03-01 |
歌林達有限公司 |
被取代之氮螺環(4.5)癸烷衍生物
|
EP3169666B1
(en)
|
2014-07-15 |
2018-06-06 |
Grünenthal GmbH |
Substituted azaspiro(4.5)decane derivatives
|
CN104086539A
(zh)
*
|
2014-07-17 |
2014-10-08 |
天津炜捷制药有限公司 |
一种利伐沙班的制备方法
|
EP3186246A1
(en)
|
2014-08-25 |
2017-07-05 |
Cipla Limited |
Process for the preparation of rivaroxaban
|
NO2721243T3
(bg)
|
2014-10-01 |
2018-10-20 |
|
|
CN104356124A
(zh)
*
|
2014-10-30 |
2015-02-18 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其组合物和用途
|
CN104402876A
(zh)
*
|
2014-11-25 |
2015-03-11 |
沈阳药科大学 |
噁唑烷酮类化合物及其应用
|
CN104447729A
(zh)
*
|
2014-12-05 |
2015-03-25 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其在药物中的应用
|
CN104478866B
(zh)
*
|
2014-12-05 |
2017-07-07 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其在药物中的应用
|
CN104447728B
(zh)
*
|
2014-12-05 |
2017-01-04 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其在药物中的应用
|
CN104478869B
(zh)
*
|
2014-12-05 |
2017-04-12 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其在药物中的应用
|
CN104497008B
(zh)
*
|
2014-12-09 |
2016-11-16 |
广东东阳光药业有限公司 |
取代噁唑烷酮类化合物及其使用方法和用途
|
CN104496978A
(zh)
*
|
2014-12-09 |
2015-04-08 |
广东东阳光药业有限公司 |
取代噁唑烷酮类化合物及其使用方法和用途
|
CN104530029B
(zh)
*
|
2014-12-09 |
2017-04-12 |
广东东阳光药业有限公司 |
作为Xa因子抑制剂的杂环化合物及其使用方法和用途
|
CN104530080B
(zh)
*
|
2014-12-10 |
2017-01-11 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其在药物中的应用
|
CN104530031A
(zh)
*
|
2014-12-10 |
2015-04-22 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其在药物中的应用
|
CN104530030A
(zh)
*
|
2014-12-10 |
2015-04-22 |
广东东阳光药业有限公司 |
噁唑烷酮类化合物及其在药物中的应用
|
CN105777734A
(zh)
*
|
2014-12-22 |
2016-07-20 |
常州方楠医药技术有限公司 |
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|
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(zh)
*
|
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|
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*
|
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|
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(en)
|
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|
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(ru)
*
|
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|
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(en)
|
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|
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(zh)
*
|
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|
US10160750B2
(en)
|
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|
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(en)
|
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|
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(ja)
|
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|
WO2017076844A1
(en)
*
|
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|
WO2017147074A1
(en)
|
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|
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(zh)
|
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|
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(en)
|
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|
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(zh)
*
|
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|
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(es)
|
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|
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(zh)
*
|
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|
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*
|
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|
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(zh)
*
|
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|
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(zh)
*
|
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|
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(en)
|
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|
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(hu)
|
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|
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(en)
|
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|
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(en)
|
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|
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(zh)
*
|
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|
US10722486B2
(en)
|
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|
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(zh)
*
|
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|
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(zh)
*
|
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|
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(en)
|
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|
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(zh)
*
|
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|
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(zh)
*
|
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|
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(en)
|
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|
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(de)
|
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|
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(en)
|
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|
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(zh)
*
|
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|