UA121492C2 - Біциклічні гетероцикли як інгібітори fgfr4 - Google Patents

Біциклічні гетероцикли як інгібітори fgfr4 Download PDF

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Publication number
UA121492C2
UA121492C2 UAA201709220A UAA201709220A UA121492C2 UA 121492 C2 UA121492 C2 UA 121492C2 UA A201709220 A UAA201709220 A UA A201709220A UA A201709220 A UAA201709220 A UA A201709220A UA 121492 C2 UA121492 C2 UA 121492C2
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UA
Ukraine
Prior art keywords
difluoro
dimethoxyphenyl
oxo
acrylamide
alkyl
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UAA201709220A
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English (en)
Ukrainian (uk)
Inventor
Лян Лу
Лянсін У
Лянсин У
Дін-Цюань Цянь
Дин-Цюань Цянь
Веньцін Яо
Веньцин Яо
Original Assignee
Інсайт Корпорейшн
Инсайт Корпорэйшн
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Application filed by Інсайт Корпорейшн, Инсайт Корпорэйшн filed Critical Інсайт Корпорейшн
Publication of UA121492C2 publication Critical patent/UA121492C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UAA201709220A 2015-02-20 2016-02-19 Біциклічні гетероцикли як інгібітори fgfr4 UA121492C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562118699P 2015-02-20 2015-02-20
US201562192661P 2015-07-15 2015-07-15
PCT/US2016/018770 WO2016134314A1 (en) 2015-02-20 2016-02-19 Bicyclic heterocycles as fgfr4 inhibitors

Publications (1)

Publication Number Publication Date
UA121492C2 true UA121492C2 (uk) 2020-06-10

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UAA201709220A UA121492C2 (uk) 2015-02-20 2016-02-19 Біциклічні гетероцикли як інгібітори fgfr4

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US (5) US9890156B2 (enExample)
EP (1) EP3259270A1 (enExample)
JP (2) JP6716586B2 (enExample)
KR (1) KR102643180B1 (enExample)
CN (2) CN113024547B (enExample)
AU (2) AU2016219816B2 (enExample)
BR (1) BR112017017727B1 (enExample)
CA (1) CA2976788C (enExample)
CL (1) CL2017002122A1 (enExample)
CO (1) CO2017008824A2 (enExample)
CR (1) CR20170388A (enExample)
EA (1) EA201791867A1 (enExample)
EC (1) ECSP17062716A (enExample)
IL (1) IL253869B (enExample)
MA (1) MA41551A (enExample)
MX (2) MX383140B (enExample)
MY (1) MY187265A (enExample)
PE (1) PE20180050A1 (enExample)
PH (2) PH12021550394A1 (enExample)
SG (2) SG10201907582WA (enExample)
TW (2) TWI740818B (enExample)
UA (1) UA121492C2 (enExample)
WO (1) WO2016134314A1 (enExample)

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