WO2008084861A1 - 縮合ピリジン化合物 - Google Patents

縮合ピリジン化合物 Download PDF

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Publication number
WO2008084861A1
WO2008084861A1 PCT/JP2008/050300 JP2008050300W WO2008084861A1 WO 2008084861 A1 WO2008084861 A1 WO 2008084861A1 JP 2008050300 W JP2008050300 W JP 2008050300W WO 2008084861 A1 WO2008084861 A1 WO 2008084861A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
jak3
diseases
therapeutic
confirmed
Prior art date
Application number
PCT/JP2008/050300
Other languages
English (en)
French (fr)
Inventor
Shohei Shirakami
Takayuki Inoue
Koichiro Mukoyoshi
Yutaka Nakajima
Hiroyuki Usuda
Hisao Hamaguchi
Yasuyuki Higashi
Keiko Hatanaka
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Priority to KR1020097016746A priority Critical patent/KR20090106604A/ko
Priority to US12/522,987 priority patent/US20100105661A1/en
Priority to JP2008553128A priority patent/JP5287253B2/ja
Priority to CNA2008800020671A priority patent/CN101578285A/zh
Priority to CA002675288A priority patent/CA2675288A1/en
Priority to MX2009007426A priority patent/MX2009007426A/es
Priority to EP08703164A priority patent/EP2123651A4/en
Publication of WO2008084861A1 publication Critical patent/WO2008084861A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

【課題】優れたJAK3阻害作用を有し、自己免疫疾患、炎症性疾患、アレルギー性疾患を含む、種々の免疫性疾患の治療あるいは予防剤の有効成分として有用な化合物の提供。 【解決手段】 　本発明者らは、新規な縮合へテロ環誘導体について検討した結果、本発明縮合ピリジン化合物が、優れたJAK3阻害作用を有することを確認し本発明を完成させた。即ち、本発明化合物は、JAK3に対する阻害活性を有していることから、望ましくないサイトカインシグナル伝達によって引き起こされる疾患、例えば生体移植における拒絶、自己免疫疾患、喘息、アトピー性皮膚炎、リウマチ、乾癬、アテローム性動脈硬化症、あるいはサイトカインシグナル伝達異常によって引き起こされる疾患、例えば、癌、白血病等の治療剤若しくは予防剤の有効成分として有用であることが確認された。
PCT/JP2008/050300 2007-01-12 2008-01-11 縮合ピリジン化合物 WO2008084861A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020097016746A KR20090106604A (ko) 2007-01-12 2008-01-11 축합 피리딘 화합물
US12/522,987 US20100105661A1 (en) 2007-01-12 2008-01-11 Condensed pyridine compound
JP2008553128A JP5287253B2 (ja) 2007-01-12 2008-01-11 縮合ピリジン化合物
CNA2008800020671A CN101578285A (zh) 2007-01-12 2008-01-11 稠合吡啶化合物
CA002675288A CA2675288A1 (en) 2007-01-12 2008-01-11 Condensed pyridine compound
MX2009007426A MX2009007426A (es) 2007-01-12 2008-01-11 Compuesto de piridina condensado.
EP08703164A EP2123651A4 (en) 2007-01-12 2008-01-11 CONDENSED PYRIDINE COMPOUND

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007005236 2007-01-12
JP2007-005236 2007-01-12

Publications (1)

Publication Number Publication Date
WO2008084861A1 true WO2008084861A1 (ja) 2008-07-17

Family

ID=39608748

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050300 WO2008084861A1 (ja) 2007-01-12 2008-01-11 縮合ピリジン化合物

Country Status (10)

Country Link
US (1) US20100105661A1 (ja)
EP (1) EP2123651A4 (ja)
JP (1) JP5287253B2 (ja)
KR (1) KR20090106604A (ja)
CN (1) CN101578285A (ja)
AR (1) AR064879A1 (ja)
CA (1) CA2675288A1 (ja)
MX (1) MX2009007426A (ja)
TW (1) TW200900061A (ja)
WO (1) WO2008084861A1 (ja)

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