SA519401827B1 - [3، 4- d] مشتق بيريدو بيريميدين وملح مقبول صيدلانياً منه - Google Patents

[3، 4- d] مشتق بيريدو بيريميدين وملح مقبول صيدلانياً منه

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Publication number
SA519401827B1
SA519401827B1 SA519401827A SA519401827A SA519401827B1 SA 519401827 B1 SA519401827 B1 SA 519401827B1 SA 519401827 A SA519401827 A SA 519401827A SA 519401827 A SA519401827 A SA 519401827A SA 519401827 B1 SA519401827 B1 SA 519401827B1
Authority
SA
Saudi Arabia
Prior art keywords
pharmaceutically acceptable
acceptable salt
pyrido
pyrimidine derivative
compound
Prior art date
Application number
SA519401827A
Other languages
English (en)
Inventor
ماروياما اكينوبو
يوكوساكا تاكويا
ميزونو تسويوشي
شيمادا توموهيرو
ينوكي جين
ساساكي كوسوكي
هوري كيوهي
تاكاهاشي هيروشي
ساكاي يوري
Original Assignee
تيجين فارما ليمتد
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by تيجين فارما ليمتد filed Critical تيجين فارما ليمتد
Publication of SA519401827B1 publication Critical patent/SA519401827B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

الغرض من الاختراع الحالي هو توفير مركب له نشاط تثبيطي inhibitory activity ممتاز لـ CDK4/6. الاختراع الحالي عبارة عن مركب تمثله الصيغة (I) أو ملح مقبول صيدلانيًا من المركب. (I)
SA519401827A 2016-11-28 2019-05-20 [3، 4- d] مشتق بيريدو بيريميدين وملح مقبول صيدلانياً منه SA519401827B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016229969 2016-11-28
PCT/JP2017/042443 WO2018097297A1 (ja) 2016-11-28 2017-11-27 ピリド［３，４－ｄ］ピリミジン誘導体及びその薬学的に許容される塩

Publications (1)

Publication Number Publication Date
SA519401827B1 true SA519401827B1 (ar) 2022-07-28

Family

ID=62194988

Family Applications (1)

Application Number Title Priority Date Filing Date
SA519401827A SA519401827B1 (ar) 2016-11-28 2019-05-20 [3، 4- d] مشتق بيريدو بيريميدين وملح مقبول صيدلانياً منه

Country Status (28)

Country Link
US (1) US11084814B2 (ar)
EP (1) EP3546458B1 (ar)
JP (1) JP6785876B2 (ar)
KR (1) KR102290815B1 (ar)
CN (1) CN110036012B (ar)
AR (1) AR110238A1 (ar)
AU (1) AU2017364807B2 (ar)
BR (1) BR112019010674A2 (ar)
CA (1) CA3043561A1 (ar)
CL (1) CL2019001419A1 (ar)
CO (1) CO2019005514A2 (ar)
CY (1) CY1123850T1 (ar)
DK (1) DK3546458T3 (ar)
ES (1) ES2852123T3 (ar)
HR (1) HRP20210285T1 (ar)
HU (1) HUE053220T2 (ar)
IL (1) IL266312B (ar)
LT (1) LT3546458T (ar)
MX (1) MX2019005803A (ar)
MY (1) MY196497A (ar)
PH (1) PH12019501171A1 (ar)
PL (1) PL3546458T3 (ar)
PT (1) PT3546458T (ar)
SA (1) SA519401827B1 (ar)
SI (1) SI3546458T1 (ar)
TW (1) TWI799399B (ar)
WO (1) WO2018097297A1 (ar)
ZA (1) ZA201902893B (ar)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230303564A1 (en) * 2020-08-17 2023-09-28 Medshine Discovery Inc. Pyrimidine ring compound
CN113636973B (zh) * 2021-09-07 2023-04-07 山东铂源药业股份有限公司 一种4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯的工业化制备方法
WO2023155841A1 (zh) * 2022-02-16 2023-08-24 南京明德新药研发有限公司 嘧啶并环类化合物的盐型、晶型
WO2024020419A1 (en) * 2022-07-18 2024-01-25 Iambic Therapeutics, Inc. Aza-quinazoline compounds and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20063909B (en) 2002-01-22 2006-08-25 Warner Lambert Co 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES
JO2924B1 (ar) 2008-08-22 2015-09-15 نوفارتيس ايه جي مركبات بيرولوبيريميدين و استعمالاتهم
EP2341911A4 (en) 2008-10-01 2012-10-24 Univ North Carolina HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE INHIBITORS OF KINASES DEPENDENT ON CYCLINES 4/6
JO2885B1 (ar) 2008-12-22 2015-03-15 ايلي ليلي اند كومباني مثبطات بروتين كيناز
ES2561277T3 (es) 2010-09-01 2016-02-25 Gilead Connecticut, Inc. Piridinonas/pirazinonas, procedimiento de preparación y procedimiento de utilización de las mismas
GB201216017D0 (en) * 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
CN104470921B (zh) * 2013-05-17 2017-05-03 上海恒瑞医药有限公司 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
MX369863B (es) 2013-08-23 2019-11-25 Neupharma Inc Ciertas entidades quimicas, composiciones y metodos.
EP3052573A4 (en) * 2013-09-30 2017-03-22 CertainTeed Corporation Stain repellent and voc eliminating coatings and use thereof
GB201403536D0 (en) * 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
US9828373B2 (en) * 2014-07-26 2017-11-28 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof
EP3305785B1 (en) * 2015-05-29 2021-08-25 Teijin Pharma Limited Pyrido[3,4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
IL266312B (en) 2021-08-31
DK3546458T3 (da) 2021-02-22
RU2019116137A3 (ar) 2021-08-13
AR110238A1 (es) 2019-03-13
KR102290815B1 (ko) 2021-08-18
PT3546458T (pt) 2021-02-25
EP3546458A4 (en) 2019-10-09
PH12019501171A1 (en) 2021-02-08
LT3546458T (lt) 2021-05-10
HRP20210285T1 (hr) 2021-04-02
CN110036012B (zh) 2022-05-10
BR112019010674A2 (pt) 2019-10-01
WO2018097297A1 (ja) 2018-05-31
JP6785876B2 (ja) 2020-11-18
CN110036012A (zh) 2019-07-19
CA3043561A1 (en) 2018-05-31
HUE053220T2 (hu) 2021-06-28
AU2017364807A1 (en) 2019-05-16
CY1123850T1 (el) 2022-05-27
US11084814B2 (en) 2021-08-10
RU2019116137A (ru) 2020-11-27
JPWO2018097297A1 (ja) 2019-06-24
AU2017364807B2 (en) 2021-05-13
MX2019005803A (es) 2019-09-10
TWI799399B (zh) 2023-04-21
KR20190066631A (ko) 2019-06-13
CL2019001419A1 (es) 2019-08-30
CO2019005514A2 (es) 2019-07-31
PL3546458T3 (pl) 2021-06-14
SI3546458T1 (sl) 2021-03-31
EP3546458B1 (en) 2021-01-06
MY196497A (en) 2023-04-17
IL266312A (en) 2019-06-30
EP3546458A1 (en) 2019-10-02
ES2852123T3 (es) 2021-09-13
ZA201902893B (en) 2020-01-29
TW201831476A (zh) 2018-09-01
US20190367510A1 (en) 2019-12-05

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