CO2019005514A2 - Derivado de pirido[3,4–d]pirimidina y su sal farmacéuticamente aceptable - Google Patents

Derivado de pirido[3,4–d]pirimidina y su sal farmacéuticamente aceptable

Info

Publication number
CO2019005514A2
CO2019005514A2 CONC2019/0005514A CO2019005514A CO2019005514A2 CO 2019005514 A2 CO2019005514 A2 CO 2019005514A2 CO 2019005514 A CO2019005514 A CO 2019005514A CO 2019005514 A2 CO2019005514 A2 CO 2019005514A2
Authority
CO
Colombia
Prior art keywords
pharmaceutically acceptable
acceptable salt
pyrido
pyrimidine derivative
present
Prior art date
Application number
CONC2019/0005514A
Other languages
English (en)
Inventor
Tsuyoshi Mizuno
Tomohiro Shimada
Gen Unoki
Kosuke Sasaki
Takuya Yokosaka
Akinobu Maruyama
Hiroshi Takahashi
Kyohei Horie
Yuri Sakai
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of CO2019005514A2 publication Critical patent/CO2019005514A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un objeto de la presente invención es proporcionar un compuesto que exhibe una actividad inhibidora de CDK4/6 superior. La presente invención proporciona un compuesto representado por la fórmula (I) o una de sus sales farmacéuticamente aceptables: (I)
CONC2019/0005514A 2016-11-28 2019-05-27 Derivado de pirido[3,4–d]pirimidina y su sal farmacéuticamente aceptable CO2019005514A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016229969 2016-11-28
PCT/JP2017/042443 WO2018097297A1 (ja) 2016-11-28 2017-11-27 ピリド［３，４－ｄ］ピリミジン誘導体及びその薬学的に許容される塩

Publications (1)

Publication Number Publication Date
CO2019005514A2 true CO2019005514A2 (es) 2019-07-31

Family

ID=62194988

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0005514A CO2019005514A2 (es) 2016-11-28 2019-05-27 Derivado de pirido[3,4–d]pirimidina y su sal farmacéuticamente aceptable

Country Status (28)

Country Link
US (1) US11084814B2 (es)
EP (1) EP3546458B1 (es)
JP (1) JP6785876B2 (es)
KR (1) KR102290815B1 (es)
CN (1) CN110036012B (es)
AR (1) AR110238A1 (es)
AU (1) AU2017364807B2 (es)
BR (1) BR112019010674A2 (es)
CA (1) CA3043561A1 (es)
CL (1) CL2019001419A1 (es)
CO (1) CO2019005514A2 (es)
CY (1) CY1123850T1 (es)
DK (1) DK3546458T3 (es)
ES (1) ES2852123T3 (es)
HR (1) HRP20210285T1 (es)
HU (1) HUE053220T2 (es)
IL (1) IL266312B (es)
LT (1) LT3546458T (es)
MX (1) MX2019005803A (es)
MY (1) MY196497A (es)
PH (1) PH12019501171A1 (es)
PL (1) PL3546458T3 (es)
PT (1) PT3546458T (es)
SA (1) SA519401827B1 (es)
SI (1) SI3546458T1 (es)
TW (1) TWI799399B (es)
WO (1) WO2018097297A1 (es)
ZA (1) ZA201902893B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230303564A1 (en) * 2020-08-17 2023-09-28 Medshine Discovery Inc. Pyrimidine ring compound
CN113636973B (zh) * 2021-09-07 2023-04-07 山东铂源药业股份有限公司 一种4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯的工业化制备方法
WO2023155841A1 (zh) * 2022-02-16 2023-08-24 南京明德新药研发有限公司 嘧啶并环类化合物的盐型、晶型
WO2024020419A1 (en) * 2022-07-18 2024-01-25 Iambic Therapeutics, Inc. Aza-quinazoline compounds and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101001857B (zh) 2002-01-22 2011-06-22 沃尼尔·朗伯有限责任公司 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮
CN102186856B (zh) 2008-08-22 2014-09-24 诺华股份有限公司 作为cdk抑制剂的吡咯并嘧啶化合物
WO2010039997A2 (en) 2008-10-01 2010-04-08 The University Of North Carolina At Chapel Hill Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors
PA8852901A1 (es) 2008-12-22 2010-07-27 Lilly Co Eli Inhibidores de proteina cinasa
KR101837223B1 (ko) 2010-09-01 2018-03-09 질레드 코네티컷 인코포레이티드 피리디논/피라지논, 그의 제조 방법 및 사용 방법
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
CN104470921B (zh) * 2013-05-17 2017-05-03 上海恒瑞医药有限公司 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
PH12019500143A1 (en) * 2013-08-23 2020-03-02 Neupharma Inc Certain chemical entities, compositions, and methods
SG11201602359RA (en) * 2013-09-30 2016-04-28 Certain Teed Corp Stain repellent and voc eliminating coatings and use thereof
GB201403536D0 (en) * 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
EP3172214B1 (en) * 2014-07-26 2020-05-13 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
TWI714590B (zh) * 2015-05-29 2021-01-01 日商帝人製藥股份有限公司 吡啶並［３，４－ｄ］嘧啶衍生物及其藥學上可被許可的鹽

Also Published As

Publication number Publication date
EP3546458B1 (en) 2021-01-06
CN110036012A (zh) 2019-07-19
DK3546458T3 (da) 2021-02-22
AU2017364807B2 (en) 2021-05-13
EP3546458A4 (en) 2019-10-09
CY1123850T1 (el) 2022-05-27
PT3546458T (pt) 2021-02-25
LT3546458T (lt) 2021-05-10
HUE053220T2 (hu) 2021-06-28
TWI799399B (zh) 2023-04-21
PL3546458T3 (pl) 2021-06-14
TW201831476A (zh) 2018-09-01
CA3043561A1 (en) 2018-05-31
PH12019501171A1 (en) 2021-02-08
EP3546458A1 (en) 2019-10-02
AR110238A1 (es) 2019-03-13
CN110036012B (zh) 2022-05-10
ES2852123T3 (es) 2021-09-13
SA519401827B1 (ar) 2022-07-28
IL266312A (en) 2019-06-30
RU2019116137A (ru) 2020-11-27
JP6785876B2 (ja) 2020-11-18
WO2018097297A1 (ja) 2018-05-31
IL266312B (en) 2021-08-31
KR20190066631A (ko) 2019-06-13
AU2017364807A1 (en) 2019-05-16
US20190367510A1 (en) 2019-12-05
HRP20210285T1 (hr) 2021-04-02
MX2019005803A (es) 2019-09-10
BR112019010674A2 (pt) 2019-10-01
SI3546458T1 (sl) 2021-03-31
MY196497A (en) 2023-04-17
KR102290815B1 (ko) 2021-08-18
RU2019116137A3 (es) 2021-08-13
US11084814B2 (en) 2021-08-10
ZA201902893B (en) 2020-01-29
JPWO2018097297A1 (ja) 2019-06-24
CL2019001419A1 (es) 2019-08-30

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