SG11201706495RA - Bicyclic heterocycles as fgfr4 inhibitors - Google Patents

Bicyclic heterocycles as fgfr4 inhibitors

Info

Publication number
SG11201706495RA
SG11201706495RA SG11201706495RA SG11201706495RA SG11201706495RA SG 11201706495R A SG11201706495R A SG 11201706495RA SG 11201706495R A SG11201706495R A SG 11201706495RA SG 11201706495R A SG11201706495R A SG 11201706495RA SG 11201706495R A SG11201706495R A SG 11201706495RA
Authority
SG
Singapore
Prior art keywords
bicyclic heterocycles
fgfr4 inhibitors
fgfr4
inhibitors
heterocycles
Prior art date
Application number
SG11201706495RA
Inventor
Liang Lu
Liangxing Wu
Ding-Quan Qian
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55697447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201706495R(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of SG11201706495RA publication Critical patent/SG11201706495RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201706495RA 2015-02-20 2016-02-19 Bicyclic heterocycles as fgfr4 inhibitors SG11201706495RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562118699P 2015-02-20 2015-02-20
US201562192661P 2015-07-15 2015-07-15
PCT/US2016/018770 WO2016134314A1 (en) 2015-02-20 2016-02-19 Bicyclic heterocycles as fgfr4 inhibitors

Publications (1)

Publication Number Publication Date
SG11201706495RA true SG11201706495RA (en) 2017-09-28

Family

ID=55697447

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201907582W SG10201907582WA (en) 2015-02-20 2016-02-19 Bicyclic heterocycles as fgfr4 inhibitors
SG11201706495RA SG11201706495RA (en) 2015-02-20 2016-02-19 Bicyclic heterocycles as fgfr4 inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201907582W SG10201907582WA (en) 2015-02-20 2016-02-19 Bicyclic heterocycles as fgfr4 inhibitors

Country Status (23)

Country Link
US (5) US9890156B2 (en)
EP (1) EP3259270A1 (en)
JP (2) JP6716586B2 (en)
KR (1) KR102643180B1 (en)
CN (2) CN107438608B (en)
AU (2) AU2016219816B2 (en)
BR (1) BR112017017727B1 (en)
CA (1) CA2976788C (en)
CL (1) CL2017002122A1 (en)
CO (1) CO2017008824A2 (en)
CR (1) CR20170388A (en)
EA (1) EA201791867A1 (en)
EC (1) ECSP17062716A (en)
IL (1) IL253869B (en)
MA (1) MA41551A (en)
MX (2) MX2017010672A (en)
MY (1) MY187265A (en)
PE (1) PE20180050A1 (en)
PH (1) PH12017501483A1 (en)
SG (2) SG10201907582WA (en)
TW (2) TWI817189B (en)
UA (1) UA121492C2 (en)
WO (1) WO2016134314A1 (en)

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CN110997637B (en) 2017-09-05 2022-09-27 保仕健生物科技(上海)有限公司 Aromatic derivative, preparation method and application thereof in medicine
UA127059C2 (en) * 2018-03-30 2023-03-29 Ле Лаборатуар Сервьє Heterobicyclic inhibitors of mat2a and methods of use for treating cancer
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
JP2021523118A (en) 2018-05-04 2021-09-02 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ FGFR inhibitor salt
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US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
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US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
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WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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WO2022199045A1 (en) * 2021-03-26 2022-09-29 杭州普洛药物研究院有限公司 Bicyclic heterocyclic fgfr4 inhibitor, pharmaceutical composition and preparation comprising same, and application thereof
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