RU2348627C2 - Ингибиторы тирозинкиназ - Google Patents

Ингибиторы тирозинкиназ Download PDF

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Publication number
RU2348627C2
RU2348627C2 RU2005102917/04A RU2005102917A RU2348627C2 RU 2348627 C2 RU2348627 C2 RU 2348627C2 RU 2005102917/04 A RU2005102917/04 A RU 2005102917/04A RU 2005102917 A RU2005102917 A RU 2005102917A RU 2348627 C2 RU2348627 C2 RU 2348627C2
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RU
Russia
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
phenyl
Prior art date
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RU2005102917/04A
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English (en)
Russian (ru)
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RU2005102917A (ru
Inventor
Вернер БРАЙТЕНШТАЙН (CH)
Вернер Брайтенштайн
Паскаль ФЮРЕ (FR)
Паскаль Фюре
Сандра ДЖЕЙКОБ (FR)
Сандра ДЖЕЙКОБ
Пол Уилль м МАНЛИ (CH)
Пол Уилльям МАНЛИ
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2005102917A publication Critical patent/RU2005102917A/ru
Application granted granted Critical
Publication of RU2348627C2 publication Critical patent/RU2348627C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2005102917/04A 2002-07-05 2003-07-04 Ингибиторы тирозинкиназ RU2348627C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0215676.8 2002-07-05
GBGB0215676.8A GB0215676D0 (en) 2002-07-05 2002-07-05 Organic compounds
GB0229893.3 2002-12-20
GBGB0229893.3A GB0229893D0 (en) 2002-07-05 2002-12-20 Organic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2008137927/04A Division RU2445309C2 (ru) 2002-07-05 2008-09-24 Ингибиторы тирозинкиназ

Publications (2)

Publication Number Publication Date
RU2005102917A RU2005102917A (ru) 2005-10-27
RU2348627C2 true RU2348627C2 (ru) 2009-03-10

Family

ID=32178870

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2005102917/04A RU2348627C2 (ru) 2002-07-05 2003-07-04 Ингибиторы тирозинкиназ
RU2008137927/04A RU2445309C2 (ru) 2002-07-05 2008-09-24 Ингибиторы тирозинкиназ

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2008137927/04A RU2445309C2 (ru) 2002-07-05 2008-09-24 Ингибиторы тирозинкиназ

Country Status (30)

Country Link
US (5) US7169791B2 (enExample)
EP (4) EP2368889A1 (enExample)
JP (4) JP4110140B2 (enExample)
KR (2) KR100864740B1 (enExample)
CN (2) CN101045727A (enExample)
AR (1) AR040390A1 (enExample)
AT (1) ATE414699T1 (enExample)
AU (1) AU2003249962C9 (enExample)
BR (1) BRPI0312464B8 (enExample)
CA (3) CA2491632C (enExample)
CO (1) CO5680432A2 (enExample)
CY (1) CY1108813T1 (enExample)
DE (1) DE60324805D1 (enExample)
DK (1) DK1532138T3 (enExample)
EC (1) ECSP055525A (enExample)
ES (2) ES2475066T3 (enExample)
GB (2) GB0215676D0 (enExample)
IL (2) IL165977A (enExample)
MX (1) MXPA05000328A (enExample)
MY (1) MY143466A (enExample)
NO (1) NO331166B1 (enExample)
NZ (1) NZ537396A (enExample)
PE (1) PE20040647A1 (enExample)
PL (3) PL395096A1 (enExample)
PT (2) PT1532138E (enExample)
RU (2) RU2348627C2 (enExample)
SI (1) SI1532138T1 (enExample)
TW (1) TWI313603B (enExample)
WO (1) WO2004005281A1 (enExample)
ZA (1) ZA200410322B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2528408C2 (ru) * 2008-12-25 2014-09-20 Харбин Глориа Фармасьютикалс Ко., Лтд. Сп0соб получения соединений дигидроинденамида, фармацевтические композии, содержащие данные соединение и их применение в качестве ингибитора протеинкиназы
US9708290B2 (en) 2012-03-01 2017-07-18 Array Biopharma Inc. Serine/threonine kinase inhibitors
RU2652121C2 (ru) * 2012-10-19 2018-04-25 Басф Се Многокомпонентная кристаллическая система, содержащая нилотиниб и выбранные сокристаллообразователи

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SI1686997T1 (sl) * 2003-11-18 2009-08-31 Novartis Ag Inhibitorji mutantne oblike KIT
WO2005063720A1 (ja) * 2003-12-25 2005-07-14 Nippon Shinyaku Co., Ltd. アミド誘導体及び医薬
CA2559915C (en) * 2004-03-23 2013-07-02 Novartis Ag Micronization of pharmaceutically active agents
EP1751136B1 (en) 2004-05-07 2014-07-02 Amgen Inc. Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
RU2007123675A (ru) * 2004-11-24 2008-12-27 Новартис АГ (CH) Комбинации ингибиторов jak
CN1972917B (zh) * 2004-12-31 2010-08-25 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
CN1939910A (zh) 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
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DK1879573T3 (da) 2005-05-10 2013-02-25 Incyte Corp Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf
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WO2007109527A1 (en) * 2006-03-17 2007-09-27 Bristol-Myers Squibb Company Methods of identifying and treating individuals exhibiting mutant bcr/abl kinase polypeptides
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BRPI0710496A2 (pt) * 2006-04-07 2011-08-16 Novartis Ag combinação que compreende a) composto de pirimidilaminobenzamida e b) inibidor de thr315iie cinase
AU2011202833B2 (en) * 2006-04-07 2012-05-24 Novartis Ag Combination comprising a) a pyrimidylaminobenzamide compound, and b) a Thr315lle kinase inhibitor
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
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MX2009003082A (es) 2006-09-22 2009-04-01 Novartis Ag Metodo para optimizar el tratamiento de leucemia positiva para filadelfia, con inhibidores de cinasa de tirosina abl.
EP1923053A1 (en) * 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
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RU2528408C2 (ru) * 2008-12-25 2014-09-20 Харбин Глориа Фармасьютикалс Ко., Лтд. Сп0соб получения соединений дигидроинденамида, фармацевтические композии, содержащие данные соединение и их применение в качестве ингибитора протеинкиназы
US9708290B2 (en) 2012-03-01 2017-07-18 Array Biopharma Inc. Serine/threonine kinase inhibitors
RU2650501C2 (ru) * 2012-03-01 2018-04-16 Эррэй Биофарма Инк. Ингибиторы серин/треониновых киназ
US10519126B2 (en) 2012-03-01 2019-12-31 Array Biopharma Inc. Serine/threonine kinase inhibitors
RU2652121C2 (ru) * 2012-10-19 2018-04-25 Басф Се Многокомпонентная кристаллическая система, содержащая нилотиниб и выбранные сокристаллообразователи

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