GB0215676D0
(en)
*
|
2002-07-05 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
GB0325031D0
(en)
|
2003-10-27 |
2003-12-03 |
Novartis Ag |
Organic compounds
|
BRPI0416680A
(pt)
*
|
2003-11-18 |
2007-02-13 |
Novartis Ag |
inibidores da forma mutante de kit
|
JPWO2005063720A1
(ja)
*
|
2003-12-25 |
2007-07-19 |
日本新薬株式会社 |
アミド誘導体及び医薬
|
WO2005089718A2
(en)
|
2004-03-23 |
2005-09-29 |
Novartis Ag |
Pharmaceutical compositions
|
EP1751136B1
(en)
*
|
2004-05-07 |
2014-07-02 |
Amgen Inc. |
Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
|
CA2586605A1
(en)
*
|
2004-11-24 |
2006-06-01 |
Novartis Ag |
Combinations of jak inhibitors and at least one of bcr-abl, flt-3, fak or raf kinase inhibitors
|
CN1939910A
(zh)
*
|
2004-12-31 |
2007-04-04 |
孙飘扬 |
氨基嘧啶类化合物及其盐和其制备方法与药物用途
|
CN101203224B
(zh)
|
2005-01-28 |
2010-11-03 |
诺瓦提斯公司 |
嘧啶基氨基苯甲酰胺在制备治疗对Tie-2激酶活性的调节有响应的疾病的药物中的用途
|
AU2006218020A1
(en)
*
|
2005-02-25 |
2006-08-31 |
Novartis Ag |
Pharmaceutical combination of Bcr-Abl and RAF inhibitors
|
BRPI0609296A2
(pt)
|
2005-05-02 |
2010-03-23 |
Novartis Ag |
uso de derivados de pirimidilaminobenzamida para o tratamento de mastocitose sistÊmica
|
JP5154408B2
(ja)
*
|
2005-05-02 |
2013-02-27 |
ノバルティス アーゲー |
好酸球増加症候群のためのピリミジルアミノベンズアミド誘導体
|
BRPI0608604B8
(pt)
|
2005-05-10 |
2021-05-25 |
Incyte Corp |
moduladores de 2,3-dioxigenase de indolamina e composição farmacêutica
|
US7767688B2
(en)
|
2005-06-03 |
2010-08-03 |
Novartis Ag |
Combination of pyrimidylaminobenzamide compounds and imatinib for treating gastrointestinal stromal tumours
|
SA06270147B1
(ar)
|
2005-06-09 |
2009-12-22 |
نوفارتيس ايه جي |
عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
|
GT200600207A
(es)
|
2005-06-09 |
2007-01-15 |
Novartis Ag |
Proceso para la síntesis de compuestos orgánicos
|
ES2356257T3
(es)
*
|
2005-06-09 |
2011-04-06 |
Novartis Ag |
Proceso para la síntesis del 5-(metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenoamina.
|
AU2013205820B2
(en)
*
|
2005-06-09 |
2015-11-26 |
Novartis Ag |
Process for the synthesis of organic compounds
|
MY146795A
(en)
*
|
2005-06-09 |
2012-09-28 |
Novartis Ag |
Process for the synthesis of organic compounds
|
US8071768B2
(en)
|
2005-06-10 |
2011-12-06 |
Janssen Pharmaceutica, N.V. |
Alkylquinoline and alkylquinazoline kinase modulators
|
US20060281788A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
|
US7825244B2
(en)
|
2005-06-10 |
2010-11-02 |
Janssen Pharmaceutica Nv |
Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
|
WO2006138304A2
(en)
*
|
2005-06-14 |
2006-12-28 |
Taigen Biotechnology |
Pyrimidine compounds
|
US8193206B2
(en)
|
2005-06-14 |
2012-06-05 |
Taigen Biotechnology Co., Ltd. |
Pyrimidine compounds
|
GT200600315A
(es)
*
|
2005-07-20 |
2007-03-19 |
|
Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
|
RU2443418C2
(ru)
*
|
2005-07-20 |
2012-02-27 |
Новартис Аг |
КОМБИНАЦИЯ ПИРИМИДИЛАМИНОБЕНЗАМИДА И ИНГИБИТОРА КИНАЗ mTOR
|
EP1954278A2
(en)
*
|
2005-07-20 |
2008-08-13 |
Novartis AG |
Combination comprising a pyrimidylaminobenzamides and a flt-3 inhibitor for treating proliferative diseases
|
GT200600316A
(es)
*
|
2005-07-20 |
2007-04-02 |
|
Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
|
AU2012203844B2
(en)
*
|
2005-07-20 |
2014-12-11 |
Novartis Ag |
Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
|
KR100674813B1
(ko)
*
|
2005-08-05 |
2007-01-29 |
일양약품주식회사 |
N-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
|
US20080200489A1
(en)
*
|
2005-08-11 |
2008-08-21 |
Peter Wisdom Atadja |
Combination of Organic Compounds
|
US20080200488A1
(en)
*
|
2005-08-11 |
2008-08-21 |
Manley Paul W |
Combinations Comprising a Protein Kinase Inhibitor Being a Pyrimidylaminobenzamide Compound and a Hsp90 Inhibitor Such as 17-Aag
|
EP2270014A1
(en)
|
2005-09-22 |
2011-01-05 |
Incyte Corporation |
Azepine inhibitors of janus kinases
|
US20080255171A1
(en)
*
|
2005-10-07 |
2008-10-16 |
Manley Paul W |
Combination of Nilotinib with Farnesyl Transferase Inhibitors
|
CA2626623C
(en)
|
2005-10-18 |
2016-08-30 |
Janssen Pharmaceutica N.V. |
Method of inhibiting flt3 kinase
|
WO2007051862A1
(en)
*
|
2005-11-07 |
2007-05-10 |
Novartis Ag |
Combination of organic compounds
|
WO2007059143A2
(en)
*
|
2005-11-15 |
2007-05-24 |
Bristol-Myers Squibb Company |
Methods of identifying and treating individuals exhibiting mdr-1 overexpression with protein tyrosine kinase inhibitors and combinations thereof
|
ES2549327T3
(es)
*
|
2005-12-06 |
2015-10-27 |
Novartis Ag |
Derivados de pirimidilaminobenzamida para el tratamiento de la neurofibromatosis
|
BRPI0619817B8
(pt)
|
2005-12-13 |
2021-05-25 |
Incyte Corp |
composto 3-ciclopentil-3-[4-(7h-pirrol[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]propanonitrila e sua composição
|
WO2007109527A1
(en)
*
|
2006-03-17 |
2007-09-27 |
Bristol-Myers Squibb Company |
Methods of identifying and treating individuals exhibiting mutant bcr/abl kinase polypeptides
|
EP2606890A1
(en)
*
|
2006-04-05 |
2013-06-26 |
Novartis AG |
Combinations comprising BCR-ABL/C-KIT/PDGF-R TK inhibitors for treating cancer
|
AU2011202833B2
(en)
*
|
2006-04-07 |
2012-05-24 |
Novartis Ag |
Combination comprising a) a pyrimidylaminobenzamide compound, and b) a Thr315lle kinase inhibitor
|
AU2007235900A1
(en)
*
|
2006-04-07 |
2007-10-18 |
Novartis Ag |
Combination comprising a) a pyrimidylaminobenzamide compound, and b) a Thr315lle kinase inhibitor
|
US8697716B2
(en)
|
2006-04-20 |
2014-04-15 |
Janssen Pharmaceutica Nv |
Method of inhibiting C-KIT kinase
|
ATE510832T1
(de)
|
2006-04-20 |
2011-06-15 |
Janssen Pharmaceutica Nv |
Heterocyclische verbindungen als c-fms- kinasehemmer
|
UA93085C2
(en)
|
2006-04-20 |
2011-01-10 |
Янссен Фармацевтика Н.В. |
Inhibitors of c-fms kinase
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
WO2007137981A1
(en)
*
|
2006-05-25 |
2007-12-06 |
Novartis Ag |
Inhibitors of tyrosine kinases
|
NZ575113A
(en)
|
2006-09-22 |
2012-03-30 |
Novartis Ag |
Method of optimizing the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitors
|
EP1923053A1
(en)
*
|
2006-09-27 |
2008-05-21 |
Novartis AG |
Pharmaceutical compositions comprising nilotinib or its salt
|
WO2008044041A1
(en)
|
2006-10-12 |
2008-04-17 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
JP5528807B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
EP2079729A1
(en)
*
|
2006-11-03 |
2009-07-22 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
US20100036167A1
(en)
*
|
2006-11-13 |
2010-02-11 |
Toray Fine Chemicals Co., Ltd. |
Process for production of 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl
|
JPWO2008075736A1
(ja)
*
|
2006-12-21 |
2010-04-15 |
アステラス製薬株式会社 |
C−グリコシド誘導体の製造方法及びその合成中間体
|
US8513270B2
(en)
|
2006-12-22 |
2013-08-20 |
Incyte Corporation |
Substituted heterocycles as Janus kinase inhibitors
|
CA2686378C
(en)
*
|
2007-05-04 |
2012-07-24 |
Irm Llc |
Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors
|
CN101720322A
(zh)
|
2007-05-04 |
2010-06-02 |
Irm责任有限公司 |
作为c-kit和pdgfr激酶抑制剂的化合物和组合物
|
EP2152079A4
(en)
*
|
2007-06-04 |
2011-03-09 |
Avila Therapeutics Inc |
HETEROCYCLIC COMPOUNDS AND USES THEREOF
|
ES2607794T3
(es)
|
2007-06-07 |
2017-04-04 |
Intra-Cellular Therapies, Inc. |
Compuestos heterocíclicos novedosos y usos de los mismos
|
EP2170887A2
(en)
|
2007-06-07 |
2010-04-07 |
Amgen Inc. |
Heterocyclic compounds as raf kinase modulators
|
JP5710251B2
(ja)
|
2007-06-07 |
2015-04-30 |
イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. |
新規ヘテロ環化合物およびその使用
|
MX2009013402A
(es)
|
2007-06-13 |
2010-02-24 |
Incyte Corp |
Sales de inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3-d]piri midin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
BRPI0815572A2
(pt)
|
2007-08-22 |
2015-02-18 |
Irm Llc |
Compostos e composições como inibidores de quinases
|
KR20120107538A
(ko)
|
2007-08-22 |
2012-10-02 |
아이알엠 엘엘씨 |
키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
|
US8530480B2
(en)
|
2007-09-04 |
2013-09-10 |
The Scripps Research Institute |
Substituted pyrimidinyl-amines as protein kinase inhibitors
|
JO3240B1
(ar)
|
2007-10-17 |
2018-03-08 |
Janssen Pharmaceutica Nv |
c-fms مثبطات كيناز
|
EP2220068B1
(en)
|
2007-11-16 |
2016-01-27 |
Incyte Holdings Corporation |
4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
|
EP2240172B1
(en)
|
2007-12-21 |
2014-03-19 |
Novartis AG |
Combination of nilotinib and chlorambucil for the treatment of chronic lymphocytic leukemia
|
NZ587928A
(en)
|
2008-03-11 |
2012-08-31 |
Incyte Corp |
Azetidine and cyclobutane derivatives as jak inhibitors
|
JP2011518836A
(ja)
|
2008-04-24 |
2011-06-30 |
インサイト・コーポレイション |
大環状化合物およびそれらのキナーゼ阻害剤としての使用
|
PT2824100T
(pt)
|
2008-07-08 |
2018-05-10 |
Incyte Holdings Corp |
1,2,5-oxadiazoles como inibidores da indoleamina 2,3-dioxigenase
|
US20100016590A1
(en)
*
|
2008-07-17 |
2010-01-21 |
Teva Pharmaceutical Industries Ltd. |
Nilotinib intermediates and preparation thereof
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
RU2011109078A
(ru)
*
|
2008-08-13 |
2012-09-20 |
Новартис АГ (CH) |
Лечение легочной артериальной гипертензии
|
KR20100021321A
(ko)
*
|
2008-08-14 |
2010-02-24 |
일양약품주식회사 |
Ν-페닐-2-피리미딘-아민 유도체의 제조방법
|
EP2326326B1
(en)
|
2008-08-15 |
2019-10-09 |
Boehringer Ingelheim International GmbH |
Dpp-4 inhibitors for use for the treatment of wound healing in diabetic patients
|
CL2009001884A1
(es)
|
2008-10-02 |
2010-05-14 |
Incyte Holdings Corp |
Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
|
JP5486012B2
(ja)
*
|
2008-11-05 |
2014-05-07 |
テバ ファーマシューティカル インダストリーズ リミティド |
ニロチニブHCl結晶形
|
EP2186514B1
(en)
*
|
2008-11-14 |
2016-06-29 |
Kinki University |
Treatment of Malignant Peripheral Nerve Sheath Tumors
|
WO2010060074A1
(en)
*
|
2008-11-24 |
2010-05-27 |
Teva Pharmaceutical Industries Ltd. |
Preparation of nilotinib and intermediates thereof
|
KR20110103968A
(ko)
|
2008-12-23 |
2011-09-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
유기 화합물의 염 형태
|
CN101759683B
(zh)
*
|
2008-12-25 |
2011-12-28 |
哈尔滨誉衡药业股份有限公司 |
二氢化茚酰胺化合物制备方法、包含其的药物组合物、及其作为蛋白激酶抑制剂的应用
|
TW201036975A
(en)
|
2009-01-07 |
2010-10-16 |
Boehringer Ingelheim Int |
Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
|
WO2010085597A1
(en)
|
2009-01-23 |
2010-07-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
TWI466672B
(zh)
|
2009-01-29 |
2015-01-01 |
Boehringer Ingelheim Int |
小兒科病人糖尿病之治療
|
US20120094894A1
(en)
|
2009-02-13 |
2012-04-19 |
Boehringer Ingelheim International Gmbh |
Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
|
WO2010096395A1
(en)
*
|
2009-02-18 |
2010-08-26 |
Syntech Solution Llc |
Amides as kinase inhibitors
|
CA2753637A1
(en)
*
|
2009-03-06 |
2010-09-10 |
Novartis Ag |
Use of pyrimidylaminobenzamide derivatives for the treatment of disorders mediated by the leucine zipper- and sterile alpha motif-containing kinase (zak)
|
EP2432472B1
(en)
|
2009-05-22 |
2019-10-02 |
Incyte Holdings Corporation |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
BRPI1012159B1
(pt)
|
2009-05-22 |
2022-01-25 |
Incyte Holdings Corporation |
Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos
|
TW201102068A
(en)
*
|
2009-06-02 |
2011-01-16 |
Novartis Ag |
Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms
|
US20110053968A1
(en)
*
|
2009-06-09 |
2011-03-03 |
Auspex Pharmaceuticals, Inc. |
Aminopyrimidine inhibitors of tyrosine kinase
|
ME01838B
(me)
|
2009-06-29 |
2014-12-20 |
Lncyte Holdings Corp |
Pirimidinoni kao inhibitori pi3k
|
WO2011014520A2
(en)
|
2009-07-29 |
2011-02-03 |
Irm Llc |
Compounds and compositions as modulators of gpr119 activity
|
SG10201507362TA
(en)
|
2009-08-05 |
2015-10-29 |
Intra Cellular Therapies Inc |
Novel Regulatory Proteins And Inhibitors
|
US9249145B2
(en)
|
2009-09-01 |
2016-02-02 |
Incyte Holdings Corporation |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
WO2011033307A1
(en)
|
2009-09-17 |
2011-03-24 |
Generics [Uk] Limited |
Nilotinib dihydrochloride salt
|
WO2011039367A2
(en)
|
2009-10-02 |
2011-04-07 |
Boehringer Ingelheim International Gmbh |
Therapeutic uses of pharmaceutical compositions
|
ES2435491T3
(es)
|
2009-10-09 |
2013-12-19 |
Incyte Corporation |
Derivados de hidroxilo, ceto y glucurónido de 3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo
|
JP2013507366A
(ja)
|
2009-10-09 |
2013-03-04 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
Gpr119活性モジュレーターとしての化合物および組成物
|
KR20120099650A
(ko)
*
|
2009-10-23 |
2012-09-11 |
노파르티스 아게 |
Bcr-abl, c-kit, ddr1, ddr2 또는 pdgf-r 키나제 활성에 의해 매개된 증식성 장애 및 다른 병적 상태의 치료 방법
|
JO3634B1
(ar)
*
|
2009-11-17 |
2020-08-27 |
Novartis Ag |
طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
|
MX364651B
(es)
|
2009-11-27 |
2019-05-03 |
Boehringer Ingelheim Int Gmbh Star |
Inhibidores de dpp-iv, tales como la linagliptina, y composiciones farmacéuticas o combinaciones que comprenden los mismos, para usarse en el tratamiento de pacientes diabéticos tipificados genéticamente.
|
US8394858B2
(en)
|
2009-12-03 |
2013-03-12 |
Novartis Ag |
Cyclohexane derivatives and uses thereof
|
WO2011075630A1
(en)
|
2009-12-18 |
2011-06-23 |
Incyte Corporation |
Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
|
WO2011075643A1
(en)
|
2009-12-18 |
2011-06-23 |
Incyte Corporation |
Substituted heteroaryl fused derivatives as pi3k inhibitors
|
HUE045270T2
(hu)
|
2010-01-05 |
2019-12-30 |
Inst Nat Sante Rech Med |
FLT3 receptor anatgonisták fájdalom rendellenességek kezelésére
|
NZ601143A
(en)
|
2010-01-12 |
2014-10-31 |
Ab Science |
Thiazole and oxazole kinase inhibitors
|
IN2010KO00035A
(es)
|
2010-01-15 |
2016-09-02 |
|
|
JP5858434B2
(ja)
|
2010-02-18 |
2016-02-10 |
インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation |
Janusキナーゼ阻害薬としてのシクロブタンおよびメチルシクロブタン誘導体
|
EP4036088B1
(en)
|
2010-03-10 |
2024-04-03 |
Incyte Holdings Corporation |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
WO2011113947A1
(en)
|
2010-03-18 |
2011-09-22 |
Boehringer Ingelheim International Gmbh |
Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions
|
AR081823A1
(es)
|
2010-04-14 |
2012-10-24 |
Incyte Corp |
DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
|
EP2558098A2
(en)
|
2010-04-16 |
2013-02-20 |
Novartis AG |
Treatment of endocrine resistant breast cancer
|
EP2382976A1
(en)
|
2010-04-30 |
2011-11-02 |
Hiroshima University |
Use of pdgf-r inhibitors for the treatment of lymph node metastasis of gastric cancer
|
EP2566469B1
(en)
|
2010-05-05 |
2022-12-21 |
Boehringer Ingelheim International GmbH |
Combination therapy
|
EP3087972A1
(en)
|
2010-05-21 |
2016-11-02 |
Incyte Holdings Corporation |
Topical formulation for a jak inhibitor
|
KR20130042498A
(ko)
*
|
2010-06-21 |
2013-04-26 |
테바 파마슈티컬 인더스트리즈 리미티드 |
닐로티닙 염 및 이의 결정형
|
US9062055B2
(en)
|
2010-06-21 |
2015-06-23 |
Incyte Corporation |
Fused pyrrole derivatives as PI3K inhibitors
|
EP2585101A1
(en)
|
2010-06-24 |
2013-05-01 |
Boehringer Ingelheim International GmbH |
Diabetes therapy
|
US8697739B2
(en)
|
2010-07-29 |
2014-04-15 |
Novartis Ag |
Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
|
US8426418B2
(en)
|
2010-08-27 |
2013-04-23 |
CollabRx Inc. |
Method to treat melanoma in BRAF inhibitor-resistant subjects
|
US9034883B2
(en)
|
2010-11-15 |
2015-05-19 |
Boehringer Ingelheim International Gmbh |
Vasoprotective and cardioprotective antidiabetic therapy
|
CA2818545C
(en)
|
2010-11-19 |
2019-04-16 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
JP5917545B2
(ja)
|
2010-11-19 |
2016-05-18 |
インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation |
Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体
|
US8703788B2
(en)
|
2010-11-26 |
2014-04-22 |
Bandi Parthasaradhi Reddy |
Polymorph of nilotinib hydrochloride
|
AR084366A1
(es)
|
2010-12-20 |
2013-05-08 |
Incyte Corp |
N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
|
MX336051B
(es)
|
2011-01-21 |
2016-01-07 |
Sun Pharma Advanced Res Co Ltd |
Diarilacetileno hidracido que contiene inhibidores de tirosina quinasa.
|
ES2547916T3
(es)
|
2011-02-18 |
2015-10-09 |
Novartis Pharma Ag |
Terapia de combinación de inhibidores de mTOR/JAK
|
WO2012118599A1
(en)
|
2011-02-28 |
2012-09-07 |
Emory University |
C-abl tyrosine kinase inhibitors useful for inhibiting filovirus replication
|
US9108984B2
(en)
|
2011-03-14 |
2015-08-18 |
Incyte Corporation |
Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
|
US9126948B2
(en)
|
2011-03-25 |
2015-09-08 |
Incyte Holdings Corporation |
Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
|
PL2717883T3
(pl)
|
2011-05-02 |
2017-07-31 |
Stichting Vumc |
Ochrona przed zaburzeniami bariery śródbłonkowej poprzez hamowanie kinazy tyrozynowej Abl-related gene (ARG)
|
AU2012273164B2
(en)
|
2011-06-20 |
2015-05-28 |
Incyte Holdings Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
|
MX366629B
(es)
|
2011-07-15 |
2019-07-17 |
Boehringer Ingelheim Int |
Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas.
|
EP2741747A1
(en)
|
2011-08-10 |
2014-06-18 |
Novartis Pharma AG |
JAK P13K/mTOR COMBINATION THERAPY
|
CN102321073A
(zh)
*
|
2011-08-12 |
2012-01-18 |
西安交通大学 |
一种尼罗替尼的制备方法
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
EA033646B1
(ru)
|
2011-09-02 |
2019-11-13 |
Incyte Holdings Corp |
Гетероциклиламины как ингибиторы pi3k
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
WO2013063000A1
(en)
|
2011-10-28 |
2013-05-02 |
Novartis Ag |
Method of treating gastrointestinal stromal tumors
|
WO2013063003A1
(en)
|
2011-10-28 |
2013-05-02 |
Novartis Ag |
Method of treating gastrointestinal stromal tumors
|
GB2496135B
(en)
|
2011-11-01 |
2015-03-18 |
Valirx Plc |
Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis
|
US20140286965A1
(en)
|
2011-11-07 |
2014-09-25 |
Inserm |
Ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis
|
BR112014011518A2
(pt)
*
|
2011-11-14 |
2017-05-16 |
Novartis Ag |
liberação imediata da formulação 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)fenil] benzamida
|
CN103172617A
(zh)
*
|
2011-12-20 |
2013-06-26 |
天津市国际生物医药联合研究院 |
1,5-二取代-1,2,3-三氮唑三氟甲基类化合物的应用
|
US20130172244A1
(en)
|
2011-12-29 |
2013-07-04 |
Thomas Klein |
Subcutaneous therapeutic use of dpp-4 inhibitor
|
EP2626355B1
(en)
|
2012-02-09 |
2016-02-03 |
Natco Pharma Limited |
Process for the preparation of nilotinib hydrochloride
|
US9061028B2
(en)
|
2012-02-15 |
2015-06-23 |
Natco Pharma Limited |
Process for the preparation of Nilotinib
|
CN106349217B
(zh)
|
2012-03-01 |
2020-08-28 |
阵列生物制药公司 |
丝氨酸/苏氨酸激酶抑制剂
|
AR090548A1
(es)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
|
EP2842946B1
(en)
|
2012-04-24 |
2016-09-28 |
Chugai Seiyaku Kabushiki Kaisha |
Quinazolinedione derivative
|
CA2871237A1
(en)
|
2012-04-24 |
2013-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Benzamide derivative
|
EP3685839A1
(en)
|
2012-05-14 |
2020-07-29 |
Boehringer Ingelheim International GmbH |
Linagliptin for use in the treatment of albuminuria and kidney related diseases
|
ES2929025T3
(es)
|
2012-05-14 |
2022-11-24 |
Boehringer Ingelheim Int |
Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
|
CU24265B1
(es)
*
|
2012-05-15 |
2017-07-04 |
Novartis Ag |
Compuestos derivados de benzamida para inhibir la actividad de abl1, abl2 y bcr-abl1, útiles en el tratamiento del cáncer
|
BR112014027584B1
(pt)
|
2012-05-15 |
2023-01-24 |
Novartis Ag |
Uso de inibidores da atividade de abl1, abl2 e bcr-abl1, e composição farmacêutica
|
CA2871332A1
(en)
*
|
2012-05-15 |
2013-11-21 |
Novartis Ag |
Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
|
CN104302634B
(zh)
|
2012-05-15 |
2017-02-08 |
诺华股份有限公司 |
用于抑制abl1、abl2和bcr‑abl1的活性的苯甲酰胺衍生物
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
WO2013174768A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in the treatment of autoimmune diabetes, particularly lada
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
US9056860B2
(en)
*
|
2012-06-05 |
2015-06-16 |
Gilead Pharmasset Llc |
Synthesis of antiviral compound
|
EP3822273B1
(en)
|
2012-06-13 |
2024-04-10 |
Incyte Holdings Corporation |
Substituted tricyclic compounds as fgfr inhibitors
|
EP2872142A1
(en)
|
2012-07-11 |
2015-05-20 |
Novartis AG |
Method of treating gastrointestinal stromal tumors
|
ES2656091T3
(es)
|
2012-07-27 |
2018-02-23 |
Izumi Technology, Llc. |
Composiciones de inhibidores de eflujo y métodos de tratamiento que las utilizan
|
JOP20180012A1
(ar)
|
2012-08-07 |
2019-01-30 |
Janssen Pharmaceutica Nv |
عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
|
JP6359537B2
(ja)
|
2012-08-07 |
2018-07-18 |
ヤンセン ファーマシューティカ エヌ.ベー. |
複素環エステル誘導体の調製プロセス
|
JP6407504B2
(ja)
|
2012-09-21 |
2018-10-17 |
アログ・ファーマシューティカルズ・インコーポレイテッドArog Pharmaceuticals,Inc. |
恒常的に活性であるリン酸化型flt3キナーゼの阻害方法
|
WO2014052619A1
(en)
|
2012-09-27 |
2014-04-03 |
Irm Llc |
Piperidine derivatives and compositions as modulators of gpr119 activity
|
CN104736531A
(zh)
*
|
2012-10-19 |
2015-06-24 |
巴斯夫欧洲公司 |
包含尼洛替尼和所选择的共晶形成剂的多组分结晶体系
|
KR20150074193A
(ko)
|
2012-11-01 |
2015-07-01 |
인사이트 코포레이션 |
Jak 억제제로서 트리사이클릭 융합된 티오펜 유도체
|
IL291391B
(en)
|
2012-11-15 |
2022-11-01 |
Incyte Holdings Corp |
Sustained release dosage forms of roxolitinib
|
BR112015016282A2
(pt)
|
2013-01-07 |
2017-07-11 |
Arog Pharmaceuticals Inc |
crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado
|
CN103910714A
(zh)
*
|
2013-01-09 |
2014-07-09 |
天津泰瑞倍药研科技有限公司 |
氟代环丁烷基咪唑类化合物
|
WO2014124860A1
(en)
|
2013-02-14 |
2014-08-21 |
Boehringer Ingelheim International Gmbh |
Specific pde4b-inhibitors for the treatment of diabetes mellitus
|
TWI736135B
(zh)
|
2013-03-01 |
2021-08-11 |
美商英塞特控股公司 |
吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
|
PT2964650T
(pt)
|
2013-03-06 |
2019-02-26 |
Incyte Holdings Corp |
Processos e intermediários para a preparação de um inibidor de jak
|
CN110075098A
(zh)
|
2013-03-15 |
2019-08-02 |
勃林格殷格翰国际有限公司 |
利格列汀在心脏和肾脏保护性抗糖尿病治疗中的用途
|
TWI649318B
(zh)
|
2013-04-19 |
2019-02-01 |
英塞特控股公司 |
作為fgfr抑制劑之雙環雜環
|
WO2014174496A1
(en)
|
2013-04-25 |
2014-10-30 |
Ranbaxy Laboratories Limited |
Pharmaceutical gastro-retentive solid oral dosage form of nilotinib
|
GB2513615A
(en)
|
2013-05-01 |
2014-11-05 |
Cancer Rec Tech Ltd |
Medical use
|
SI3527263T1
(sl)
|
2013-05-17 |
2021-05-31 |
Incyte Corporation |
Derivati bipirazola kot zaviralci JAK
|
CN103288804A
(zh)
*
|
2013-05-24 |
2013-09-11 |
苏州明锐医药科技有限公司 |
一种尼洛替尼的制备方法
|
MX2016001639A
(es)
|
2013-08-07 |
2016-10-07 |
Incyte Corp |
Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
|
AR097388A1
(es)
|
2013-08-20 |
2016-03-09 |
Incyte Corp |
Beneficio de supervivencia en pacientes con tumores sólidos con niveles elevados de proteína c reactiva
|
EP3757130A1
(en)
|
2013-09-26 |
2020-12-30 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
EP3061749B1
(en)
|
2013-10-23 |
2019-02-27 |
Chugai Seiyaku Kabushiki Kaisha |
Quinazolinone and isoquinolinone derivative
|
US10463658B2
(en)
|
2013-10-25 |
2019-11-05 |
Videra Pharmaceuticals, Llc |
Method of inhibiting FLT3 kinase
|
WO2015092624A1
(en)
|
2013-12-16 |
2015-06-25 |
Ranbaxy Laboratories Limited |
Nilotinib mono-oxalate and its crystalline form
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
KR20160136323A
(ko)
|
2014-02-28 |
2016-11-29 |
인사이트 코포레이션 |
골수형성이상증후군 치료용 jak1 억제제
|
HUE048531T2
(hu)
|
2014-03-14 |
2020-07-28 |
Novartis Ag |
Antitest molekulák a LAG-3-hoz és ezek felhasználása
|
LT3129021T
(lt)
|
2014-04-08 |
2020-12-10 |
Incyte Corporation |
B ląstelių piktybiškumo gydymas jak ir pi3k inhibitorių deriniu
|
AU2015253192B2
(en)
|
2014-04-30 |
2019-05-16 |
Incyte Holdings Corporation |
Processes of preparing a JAK1 inhibitor and new forms thereto
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
WO2015191677A1
(en)
|
2014-06-11 |
2015-12-17 |
Incyte Corporation |
Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
|
CN107001283B
(zh)
|
2014-07-31 |
2021-05-25 |
国家健康与医学研究院 |
Flt3受体拮抗剂
|
WO2016033304A1
(en)
|
2014-08-28 |
2016-03-03 |
Codexis, Inc. |
Imidazoyl anilide derivatives and methods of use
|
WO2016035023A1
(en)
|
2014-09-03 |
2016-03-10 |
Novartis Ag |
Pharmaceutical combinations and their use
|
US9993551B2
(en)
|
2014-09-13 |
2018-06-12 |
Novartis Ag |
Combination therapies of EGFR inhibitors
|
ES2774448T3
(es)
|
2014-10-03 |
2020-07-21 |
Novartis Ag |
Terapias de combinación
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
TN2017000129A1
(en)
|
2014-10-14 |
2018-10-19 |
Dana Farber Cancer Inst Inc |
Antibody molecules to pd-l1 and uses thereof
|
WO2016059220A1
(en)
|
2014-10-16 |
2016-04-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Tcr-activating agents for use in the treatment of t-all
|
CN104592122B
(zh)
*
|
2014-12-09 |
2018-01-23 |
凯莱英医药集团(天津)股份有限公司 |
3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
|
US9586949B2
(en)
|
2015-02-09 |
2017-03-07 |
Incyte Corporation |
Aza-heteroaryl compounds as PI3K-gamma inhibitors
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
PE20171514A1
(es)
|
2015-02-20 |
2017-10-20 |
Incyte Corp |
Heterociclos biciclicos como inhibidores de fgfr
|
WO2016138363A1
(en)
|
2015-02-27 |
2016-09-01 |
Incyte Corporation |
Salts of pi3k inhibitor and processes for their preparation
|
CN105985293B
(zh)
*
|
2015-03-04 |
2018-04-03 |
埃斯特维华义制药有限公司 |
尼洛替尼中间体的制备方法
|
KR20170129802A
(ko)
|
2015-03-10 |
2017-11-27 |
아두로 바이오테크, 인코포레이티드 |
"인터페론 유전자의 자극인자"-의존적 신호전달을 활성화하는 조성물 및 방법
|
EP3271351A1
(en)
|
2015-03-20 |
2018-01-24 |
Cipla Limited |
Novel polymorphic form x of nilotinib dihydrochloride hydrate
|
US20160362424A1
(en)
|
2015-05-11 |
2016-12-15 |
Incyte Corporation |
Salts of (s)-7-(1-(9h-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one
|
US9732097B2
(en)
|
2015-05-11 |
2017-08-15 |
Incyte Corporation |
Process for the synthesis of a phosphoinositide 3-kinase inhibitor
|
US9988401B2
(en)
|
2015-05-11 |
2018-06-05 |
Incyte Corporation |
Crystalline forms of a PI3K inhibitor
|
EP3095782A1
(en)
|
2015-05-18 |
2016-11-23 |
Esteve Química, S.A. |
New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
|
CN104860929B
(zh)
*
|
2015-05-26 |
2017-10-31 |
凯莱英医药集团(天津)股份有限公司 |
尼洛替尼的制备方法
|
US20180340025A1
(en)
|
2015-07-29 |
2018-11-29 |
Novartis Ag |
Combination therapies comprising antibody molecules to lag-3
|
JP6878405B2
(ja)
|
2015-07-29 |
2021-05-26 |
ノバルティス アーゲー |
Pd−1に対する抗体分子を含む組み合わせ治療
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
WO2017079112A1
(en)
|
2015-11-03 |
2017-05-11 |
Janssen Biotech, Inc. |
Antibodies specifically binding pd-1 and their uses
|
HRP20220599T1
(hr)
|
2015-11-06 |
2022-06-24 |
Incyte Corporation |
Heterociklički spojevi kao inhibitori pi3k-gama
|
JP2019503349A
(ja)
|
2015-12-17 |
2019-02-07 |
ノバルティス アーゲー |
Pd−1に対する抗体分子およびその使用
|
CN106905298A
(zh)
*
|
2015-12-22 |
2017-06-30 |
江苏先声药业有限公司 |
盐酸尼洛替尼杂质的制备方法
|
AR107293A1
(es)
|
2016-01-05 |
2018-04-18 |
Incyte Corp |
COMPUESTOS DE PIRIDINA Y PIRIDIMINA COMO INHIBIDORES DE PI3K-g
|
AU2017226004B2
(en)
|
2016-03-01 |
2021-07-22 |
Propellon Therapeutics Inc. |
Inhibitors of WDR5 protein-protein binding
|
AU2017226005A1
(en)
|
2016-03-01 |
2018-09-06 |
Propellon Therapeutics Inc. |
Inhibitors of WDR5 protein-protein binding
|
CN105801559B
(zh)
*
|
2016-04-28 |
2019-03-01 |
北京化工大学 |
4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸乙酯的制备方法
|
EP3254698A1
(en)
|
2016-06-08 |
2017-12-13 |
Universite De Montpellier |
Flt3 receptor inhibitor at low dosage for the treatment of neuropathic pain
|
WO2017211979A1
(en)
|
2016-06-10 |
2017-12-14 |
Boehringer Ingelheim International Gmbh |
Combinations of linagliptin and metformin
|
TW201803871A
(zh)
|
2016-06-24 |
2018-02-01 |
英塞特公司 |
作為PI3K-γ抑制劑之雜環化合物
|
WO2018002958A1
(en)
|
2016-06-30 |
2018-01-04 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazide containing compounds as btk inhibitors
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
SG11201903889TA
(en)
|
2016-11-02 |
2019-05-30 |
Arog Pharmaceuticals Inc |
Crenolanib for treating flt3 mutated proliferative disorders associated mutations
|
WO2018148533A1
(en)
|
2017-02-09 |
2018-08-16 |
Georgetown University |
Compositions and methods for treating lysosomal storage disorders
|
WO2018165718A1
(en)
|
2017-03-17 |
2018-09-20 |
Cardio Therapeutics Pty Ltd |
Heterocyclic inhibitors of pcsk9
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
EP3404025B1
(en)
|
2017-05-16 |
2019-12-04 |
F.I.S.- Fabbrica Italiana Sintetici S.p.A. |
Process for the preparation of pure nilotinib and its salt
|
CN111093640A
(zh)
|
2017-05-17 |
2020-05-01 |
国家健康与医学研究院 |
用于改善阿片类药物疼痛治疗的flt3抑制剂
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
CN107188887A
(zh)
*
|
2017-06-15 |
2017-09-22 |
苏州立新制药有限公司 |
一种尼洛替尼氧化降解杂质及其制备方法
|
EP3642240A1
(en)
|
2017-06-22 |
2020-04-29 |
Novartis AG |
Antibody molecules to cd73 and uses thereof
|
WO2019057649A1
(en)
|
2017-09-19 |
2019-03-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA
|
HUE056615T2
(hu)
|
2017-10-18 |
2022-02-28 |
Incyte Corp |
Tercier hidroxicsoportokkal szubsztituált kondenzált imidazol-származékok mint PI3K-gamma inhibitorok
|
US10596161B2
(en)
|
2017-12-08 |
2020-03-24 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
CZ2017821A3
(cs)
|
2017-12-20 |
2019-07-03 |
Zentiva, K.S. |
Léková forma obsahující krystalický nilotinib
|
WO2019126505A1
(en)
|
2017-12-21 |
2019-06-27 |
Incyte Corporation |
3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as pi3k-gamma kinase inhibitors for treating e.g. cancer
|
RS63312B1
(sr)
|
2018-01-30 |
2022-07-29 |
Incyte Corp |
Procesi za pripremu (1-(3-fluoro-2-(trifluorometil)izonikotinil)piperidin-4-on)
|
CN111936135A
(zh)
|
2018-02-16 |
2020-11-13 |
因赛特公司 |
用于治疗细胞因子相关的病症的jak1通路抑制剂
|
CN117903140A
(zh)
|
2018-02-27 |
2024-04-19 |
因赛特公司 |
作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶
|
JP7268049B2
(ja)
|
2018-03-08 |
2023-05-02 |
インサイト・コーポレイション |
PI3K-γ阻害剤としてのアミノピラジンジオール化合物
|
MX2020010322A
(es)
|
2018-03-30 |
2022-11-30 |
Incyte Corp |
Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak).
|
US11220510B2
(en)
|
2018-04-09 |
2022-01-11 |
Incyte Corporation |
Pyrrole tricyclic compounds as A2A / A2B inhibitors
|
CN108530364B
(zh)
*
|
2018-04-10 |
2020-01-21 |
江苏创诺制药有限公司 |
一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
|
AU2019262195A1
(en)
|
2018-05-04 |
2020-12-24 |
Incyte Corporation |
Solid forms of an FGFR inhibitor and processes for preparing the same
|
CR20200591A
(es)
|
2018-05-04 |
2021-03-31 |
Incyte Corp |
Sales de un inhibidor de fgfr
|
MA52940A
(fr)
|
2018-05-18 |
2021-04-28 |
Incyte Corp |
Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
|
ES2929415T3
(es)
|
2018-05-25 |
2022-11-29 |
Incyte Corp |
Compuestos heterocíclicos tricíclicos como activadores de STING
|
UY38247A
(es)
|
2018-05-30 |
2019-12-31 |
Novartis Ag |
Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
|
CN116808044A
(zh)
|
2018-06-15 |
2023-09-29 |
汉达癌症医药责任有限公司 |
激酶抑制剂的盐类及其组合物
|
JP2020002108A
(ja)
*
|
2018-06-29 |
2020-01-09 |
住友化学株式会社 |
安息香酸化合物の製造方法
|
US11046658B2
(en)
|
2018-07-02 |
2021-06-29 |
Incyte Corporation |
Aminopyrazine derivatives as PI3K-γ inhibitors
|
JP2020007240A
(ja)
*
|
2018-07-04 |
2020-01-16 |
住友化学株式会社 |
ベンズアミド化合物の製造方法
|
JP7490631B2
(ja)
|
2018-07-05 |
2024-05-27 |
インサイト・コーポレイション |
A2a/a2b阻害剤としての縮合ピラジン誘導体
|
US20210299129A1
(en)
|
2018-07-17 |
2021-09-30 |
Boehringer Ingelheim International Gmbh |
Cardiosafe Antidiabetic Therapy
|
CN112437666A
(zh)
|
2018-07-17 |
2021-03-02 |
勃林格殷格翰国际有限公司 |
心脏和肾脏安全的抗糖尿病疗法
|
US11008344B2
(en)
|
2018-07-31 |
2021-05-18 |
Incyte Corporation |
Tricyclic heteroaryl compounds as STING activators
|
WO2020028566A1
(en)
|
2018-07-31 |
2020-02-06 |
Incyte Corporation |
Heteroaryl amide compounds as sting activators
|
HRP20240252T1
(hr)
|
2018-09-05 |
2024-05-24 |
Incyte Corporation |
Kristalni oblici inhibitora fosfoinozitid 3 kinaze (pi3k)
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
WO2020102216A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Substituted heterocyclic derivatives as pi3k inhibitors
|
US11078204B2
(en)
|
2018-11-13 |
2021-08-03 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
US11161838B2
(en)
|
2018-11-13 |
2021-11-02 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
US11596692B1
(en)
|
2018-11-21 |
2023-03-07 |
Incyte Corporation |
PD-L1/STING conjugates and methods of use
|
AU2019407426A1
(en)
|
2018-12-21 |
2021-07-22 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and kinase inhibitor
|
US20220056049A1
(en)
|
2019-01-07 |
2022-02-24 |
Incyte Corporation |
Heteroaryl amide compounds as sting activators
|
TWI829857B
(zh)
|
2019-01-29 |
2024-01-21 |
美商英塞特公司 |
作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
|
EP3923949A1
(en)
|
2019-02-15 |
2021-12-22 |
Incyte Corporation |
Cyclin-dependent kinase 2 biomarkers and uses thereof
|
US11384083B2
(en)
|
2019-02-15 |
2022-07-12 |
Incyte Corporation |
Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
WO2020185532A1
(en)
|
2019-03-08 |
2020-09-17 |
Incyte Corporation |
Methods of treating cancer with an fgfr inhibitor
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
WO2020223469A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
|
US11602536B2
(en)
|
2019-06-10 |
2023-03-14 |
Incyte Corporation |
Topical treatment of vitiligo by a JAK inhibitor
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
CN114502196A
(zh)
|
2019-08-01 |
2022-05-13 |
因赛特公司 |
Ido抑制剂的给药方案
|
JP2023509260A
(ja)
|
2019-08-14 |
2023-03-08 |
インサイト・コーポレイション |
Cdk2阻害剤としてのイミダゾリルピリミジニルアミン化合物
|
WO2021041360A1
(en)
|
2019-08-26 |
2021-03-04 |
Incyte Corporation |
Triazolopyrimidines as a2a / a2b inhibitors
|
US20220348651A1
(en)
|
2019-09-18 |
2022-11-03 |
Novartis Ag |
Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
|
KR20220099970A
(ko)
|
2019-10-11 |
2022-07-14 |
인사이트 코포레이션 |
Cdk2 억제제로서의 이환식 아민
|
SG10201909596RA
(en)
*
|
2019-10-14 |
2021-05-28 |
Esco Aster Pte Ltd |
Synthesis of Tyrosine Kinase Inhibitors
|
MX2022004513A
(es)
|
2019-10-14 |
2022-07-19 |
Incyte Corp |
Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr).
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
US11992490B2
(en)
|
2019-10-16 |
2024-05-28 |
Incyte Corporation |
Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
|
WO2021076124A1
(en)
|
2019-10-16 |
2021-04-22 |
Incyte Corporation |
Use of jak1 inhibitors for the treatment of cutaneous lupus erythematosus and lichen planus (lp)
|
EP4069696A1
(en)
|
2019-12-04 |
2022-10-12 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
PE20221504A1
(es)
|
2019-12-04 |
2022-09-30 |
Incyte Corp |
Derivados de un inhibidor de fgfr
|
JP2023513045A
(ja)
|
2020-01-31 |
2023-03-30 |
ナノコピーア リミテッド ライアビリティ カンパニー |
非晶質ニロチニブ微粒子及びその使用
|
EP4103560A1
(en)
|
2020-02-15 |
2022-12-21 |
Cipla Limited |
Novel salts of nilotinib and polymorphic forms thereof
|
KR20230017165A
(ko)
|
2020-03-06 |
2023-02-03 |
인사이트 코포레이션 |
Axl/mer 및 pd-1/pd-l1 억제제를 포함하는 병행 요법
|
CA3179692A1
(en)
|
2020-04-16 |
2021-10-21 |
Incyte Corporation |
Fused tricyclic kras inhibitors
|
EP3904342A1
(en)
|
2020-04-28 |
2021-11-03 |
Grindeks, A Joint Stock Company |
Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
|
EP4142699A1
(en)
|
2020-04-30 |
2023-03-08 |
Nanocopoeia LLC |
Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
|
WO2021231526A1
(en)
|
2020-05-13 |
2021-11-18 |
Incyte Corporation |
Fused pyrimidine compounds as kras inhibitors
|
WO2021228983A1
(en)
|
2020-05-13 |
2021-11-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
A pharmaceutical composition comprising an arsenic compound, an inductor of type-1 ifn and a protein kinase inhibitor for treating cancer
|
PE20231102A1
(es)
|
2020-06-02 |
2023-07-19 |
Incyte Corp |
Procesos para preparar un inhibidor de jak1
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
WO2022019998A1
(en)
|
2020-07-20 |
2022-01-27 |
Arog Pharmaceuticals, Inc. |
Crystal forms of crenolanib and methods of use thereof
|
US11999752B2
(en)
|
2020-08-28 |
2024-06-04 |
Incyte Corporation |
Vinyl imidazole compounds as inhibitors of KRAS
|
CA3195357A1
(en)
|
2020-09-16 |
2022-03-24 |
Incyte Corporation |
Topical treatment of vitiligo
|
WO2022072783A1
(en)
|
2020-10-02 |
2022-04-07 |
Incyte Corporation |
Bicyclic dione compounds as inhibitors of kras
|
US11969420B2
(en)
|
2020-10-30 |
2024-04-30 |
Arog Pharmaceuticals, Inc. |
Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders
|
TW202237089A
(zh)
|
2020-12-08 |
2022-10-01 |
美商英塞特公司 |
用於治療白斑病之jak1途徑抑制劑
|
CN112745300A
(zh)
*
|
2021-01-21 |
2021-05-04 |
杭州浙中医药科技有限公司 |
一种制备n-(5-羧基-2-甲基苯基)-4-(3-吡啶)-2-嘧啶胺的方法
|
WO2022155941A1
(en)
|
2021-01-25 |
2022-07-28 |
Qilu Regor Therapeutics Inc. |
Cdk2 inhibitors
|
WO2022206888A1
(en)
|
2021-03-31 |
2022-10-06 |
Qilu Regor Therapeutics Inc. |
Cdk2 inhibitors and use thereof
|
JP2024513575A
(ja)
|
2021-04-12 |
2024-03-26 |
インサイト・コーポレイション |
Fgfr阻害剤及びネクチン-4標的化剤を含む併用療法
|
WO2022261159A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
WO2022261160A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
CR20240059A
(es)
|
2021-07-07 |
2024-03-21 |
Incyte Corp |
Compuestos tricíclicos como inhibidores de kras.
|
US20230114765A1
(en)
|
2021-07-14 |
2023-04-13 |
Incyte Corporation |
Tricyclic compounds as inhibitors of kras
|
US20230174555A1
(en)
|
2021-08-31 |
2023-06-08 |
Incyte Corporation |
Naphthyridine compounds as inhibitors of kras
|
CN113717152B
(zh)
*
|
2021-09-08 |
2022-06-17 |
上海皓鸿生物医药科技有限公司 |
一种特异性mrk小分子抑制剂的制备方法
|
WO2023049697A1
(en)
|
2021-09-21 |
2023-03-30 |
Incyte Corporation |
Hetero-tricyclic compounds as inhibitors of kras
|
CA3234375A1
(en)
|
2021-10-01 |
2023-04-06 |
Incyte Corporation |
Pyrazoloquinoline kras inhibitors
|
IL312114A
(en)
|
2021-10-14 |
2024-06-01 |
Incyte Corp |
Quinoline compounds as Kras inhibitors
|
CA3237696A1
(en)
|
2021-11-08 |
2023-05-11 |
Progentos Therapeutics, Inc. |
Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
|
US20230226040A1
(en)
|
2021-11-22 |
2023-07-20 |
Incyte Corporation |
Combination therapy comprising an fgfr inhibitor and a kras inhibitor
|
WO2023102184A1
(en)
|
2021-12-03 |
2023-06-08 |
Incyte Corporation |
Bicyclic amine compounds as cdk12 inhibitors
|
WO2023107705A1
(en)
|
2021-12-10 |
2023-06-15 |
Incyte Corporation |
Bicyclic amines as cdk12 inhibitors
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
US20230192722A1
(en)
|
2021-12-22 |
2023-06-22 |
Incyte Corporation |
Salts and solid forms of an fgfr inhibitor and processes of preparing thereof
|
WO2023168686A1
(en)
|
2022-03-11 |
2023-09-14 |
Qilu Regor Therapeutics Inc. |
Substituted cyclopentanes as cdk2 inhibitors
|
WO2023116884A1
(en)
|
2021-12-24 |
2023-06-29 |
Qilu Regor Therapeutics Inc. |
Cdk2 inhibitors and use thereof
|
WO2023172921A1
(en)
|
2022-03-07 |
2023-09-14 |
Incyte Corporation |
Solid forms, salts, and processes of preparation of a cdk2 inhibitor
|
EP4260848A1
(en)
|
2022-04-11 |
2023-10-18 |
Lotus Pharmaceutical Co., Ltd. |
Pharmaceutical composition for solid dosage form containing nilotinib and process for its preparation
|
US20230399331A1
(en)
|
2022-06-14 |
2023-12-14 |
Incyte Corporation |
Solid forms of jak inhibitor and process of preparing the same
|
WO2023250430A1
(en)
|
2022-06-22 |
2023-12-28 |
Incyte Corporation |
Bicyclic amine cdk12 inhibitors
|
US20240101557A1
(en)
|
2022-07-11 |
2024-03-28 |
Incyte Corporation |
Fused tricyclic compounds as inhibitors of kras g12v mutants
|
US20240058343A1
(en)
|
2022-08-05 |
2024-02-22 |
Incyte Corporation |
Treatment of urticaria using jak inhibitors
|