ATE424385T1 - 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz - Google Patents

1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz

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Publication number
ATE424385T1
ATE424385T1 AT05014117T AT05014117T ATE424385T1 AT E424385 T1 ATE424385 T1 AT E424385T1 AT 05014117 T AT05014117 T AT 05014117T AT 05014117 T AT05014117 T AT 05014117T AT E424385 T1 ATE424385 T1 AT E424385T1
Authority
AT
Austria
Prior art keywords
orl1
pain
treatment
benzoxazole
piperidinyl
Prior art date
Application number
AT05014117T
Other languages
English (en)
Inventor
Qun Sun
Richard R Goehring
Donald Kyle
Zhengming Chen
Sam Victory
John Whitehead
Original Assignee
Euro Celtique Sa
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Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE424385T1 publication Critical patent/ATE424385T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Finishing Walls (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
AT05014117T 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz ATE424385T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28466901P 2001-04-18 2001-04-18
US28466601P 2001-04-18 2001-04-18
US28466701P 2001-04-18 2001-04-18
US28466801P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
ATE424385T1 true ATE424385T1 (de) 2009-03-15

Family

ID=27501377

Family Applications (4)

Application Number Title Priority Date Filing Date
AT05014117T ATE424385T1 (de) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
AT02764236T ATE410165T1 (de) 2001-04-18 2002-04-18 Nociceptin-analoga
AT05014116T ATE434607T1 (de) 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2h- benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
AT05014115T ATE423098T1 (de) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-indol-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT02764236T ATE410165T1 (de) 2001-04-18 2002-04-18 Nociceptin-analoga
AT05014116T ATE434607T1 (de) 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2h- benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
AT05014115T ATE423098T1 (de) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-indol-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz

Country Status (25)

Country Link
US (4) US6867222B2 (de)
EP (7) EP1598340B1 (de)
JP (4) JP4364513B2 (de)
KR (2) KR100878774B1 (de)
CN (1) CN100352816C (de)
AT (4) ATE424385T1 (de)
AU (1) AU2002307416B2 (de)
BR (1) BR0209129A (de)
CA (1) CA2444198C (de)
CL (2) CL2009001279A1 (de)
CY (4) CY1108707T1 (de)
CZ (1) CZ20032850A3 (de)
DE (4) DE60231442D1 (de)
DK (4) DK1379246T3 (de)
ES (4) ES2323876T3 (de)
HU (1) HUP0401109A3 (de)
IL (4) IL158484A0 (de)
MX (1) MXPA03009600A (de)
NO (1) NO20034661L (de)
NZ (5) NZ540233A (de)
PL (1) PL367310A1 (de)
PT (4) PT1379246E (de)
SI (4) SI1379246T1 (de)
WO (1) WO2002085357A1 (de)
YU (1) YU82303A (de)

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DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
WO2004064835A1 (en) * 2003-01-17 2004-08-05 Neurosearch A/S Use of ion channel modulating agents for treating pain
MXPA05009104A (es) 2003-02-28 2006-05-31 Bayer Pharmaceuticals Corp Derivados de urea biciclica novedosa utiles en el tratamiento del cancer y otros trastornos.
WO2005060947A2 (en) * 2003-12-19 2005-07-07 Sri International Agonist and antagonist ligands of the nociceptin receptor
EP1711484A4 (de) * 2004-02-03 2007-06-20 Euro Celtique Sa Synthese von cyanoiminobenzimidazolen
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