ATE434607T1 - 1-(4-amino-cyclohexyl)-1,3-dihydro-2h- benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz - Google Patents

1-(4-amino-cyclohexyl)-1,3-dihydro-2h- benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz

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Publication number
ATE434607T1
ATE434607T1 AT05014116T AT05014116T ATE434607T1 AT E434607 T1 ATE434607 T1 AT E434607T1 AT 05014116 T AT05014116 T AT 05014116T AT 05014116 T AT05014116 T AT 05014116T AT E434607 T1 ATE434607 T1 AT E434607T1
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AT
Austria
Prior art keywords
orl1
pain
treatment
benzimidazole
dihydro
Prior art date
Application number
AT05014116T
Other languages
English (en)
Inventor
Qun Sun
Richard R Goehring
Donald Kyle
Zhengming Chen
Sam Victory
John Whitehead
Original Assignee
Euro Celtique Sa
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Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
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Publication of ATE434607T1 publication Critical patent/ATE434607T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A—HUMAN NECESSITIES
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Finishing Walls (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05014116T 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2h- benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz ATE434607T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28466901P 2001-04-18 2001-04-18
US28466601P 2001-04-18 2001-04-18
US28466701P 2001-04-18 2001-04-18
US28466801P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
ATE434607T1 true ATE434607T1 (de) 2009-07-15

Family

ID=27501377

Family Applications (4)

Application Number Title Priority Date Filing Date
AT05014116T ATE434607T1 (de) 2001-04-18 2002-04-18 1-(4-amino-cyclohexyl)-1,3-dihydro-2h- benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
AT05014115T ATE423098T1 (de) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-indol-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
AT02764236T ATE410165T1 (de) 2001-04-18 2002-04-18 Nociceptin-analoga
AT05014117T ATE424385T1 (de) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT05014115T ATE423098T1 (de) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-indol-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
AT02764236T ATE410165T1 (de) 2001-04-18 2002-04-18 Nociceptin-analoga
AT05014117T ATE424385T1 (de) 2001-04-18 2002-04-18 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz

Country Status (25)

Country Link
US (4) US6867222B2 (de)
EP (7) EP1598340B1 (de)
JP (4) JP4364513B2 (de)
KR (2) KR100847296B1 (de)
CN (1) CN100352816C (de)
AT (4) ATE434607T1 (de)
AU (1) AU2002307416B2 (de)
BR (1) BR0209129A (de)
CA (1) CA2444198C (de)
CL (2) CL2009001279A1 (de)
CY (4) CY1108707T1 (de)
CZ (1) CZ20032850A3 (de)
DE (4) DE60231257D1 (de)
DK (4) DK1598338T5 (de)
ES (4) ES2315394T3 (de)
HU (1) HUP0401109A3 (de)
IL (4) IL158484A0 (de)
MX (1) MXPA03009600A (de)
NO (1) NO20034661L (de)
NZ (5) NZ551453A (de)
PL (1) PL367310A1 (de)
PT (4) PT1598340E (de)
SI (4) SI1379246T1 (de)
WO (1) WO2002085357A1 (de)
YU (1) YU82303A (de)

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DE10252665A1 (de) 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
WO2004064835A1 (en) * 2003-01-17 2004-08-05 Neurosearch A/S Use of ion channel modulating agents for treating pain
EP1608639A2 (de) 2003-02-28 2005-12-28 Bayer Pharmaceuticals Corporation Neue bicyclische harnstoffderivate, die sich für die behandlung von krebs und anderen erkrankungen eignen
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20080214827A1 (en) * 2004-02-03 2008-09-04 Euro-Celtique S.A. Synthesis of Cyanoimino-Benzoimidazoles
US20090181948A1 (en) * 2005-01-31 2009-07-16 Kyowa Hakko Kogyo Co., Ltd. Diamine derivative
ES2322965T3 (es) * 2005-09-30 2009-07-02 F. Hoffmann-La Roche Ag Derivados de indano como antagonistas de receptores de mch.
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JP2009525269A (ja) * 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
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