HUP0400193A2 - Metalloproteináz inhibitor hatású imidazolidindion-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Metalloproteináz inhibitor hatású imidazolidindion-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400193A2 HUP0400193A2 HU0400193A HUP0400193A HUP0400193A2 HU P0400193 A2 HUP0400193 A2 HU P0400193A2 HU 0400193 A HU0400193 A HU 0400193A HU P0400193 A HUP0400193 A HU P0400193A HU P0400193 A2 HUP0400193 A2 HU P0400193A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- derivatives
- imidazolindion
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- ODZYMSKQIROSOC-UHFFFAOYSA-N 1h-imidazole-4,5-dione Chemical class O=C1NC=NC1=O ODZYMSKQIROSOC-UHFFFAOYSA-N 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000651 prodrug Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Neurology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Urology & Nephrology (AREA)
- Obesity (AREA)
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Abstract
A találmány tárgyát a metalloproteináz inhibitor hatású általánosképletű vegyületek - ahol előnyösen, bizonyos megkötésekkel X imino-vagy -N(1-3 szénatomos alkil)- képletű csoport; Y1, Y2 és Zoxigénatom; A vegyértékvonal; R2, R3 és R4 hidrogénatom, alkil- vagyhalogén-alkil-csoport; R5 adott esetben szubsztituált cikloalkil-,aril-, heterocikloalkil- vagy heteroarilcsoport; és R6 alkil-,hidroxi-alkil-, amino-alkil-, cikloalkil-alkil-, alkil-cikloalkil-,aralkil-, alkil-aril-, heteroalkil-, heterocikloalkil-alkil-, alkil- -heterocikloalkil-, heteroaril-alkil vagy heteroalkil-aril-csoport - éssóik vagy prodrug-származékaik, alkalmazásuk és ezeket tartalmazógyógyszerkészítmények képezik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0100903A SE0100903D0 (sv) | 2001-03-15 | 2001-03-15 | Compounds |
PCT/SE2002/000474 WO2002074749A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0400193A2 true HUP0400193A2 (hu) | 2004-07-28 |
HUP0400193A3 HUP0400193A3 (en) | 2004-10-28 |
Family
ID=20283375
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400193A HUP0400193A3 (en) | 2001-03-15 | 2002-03-13 | Imidazolindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them |
HU0400328A HUP0400328A3 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitor azoles and pharmaceutical compositions containing them |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400328A HUP0400328A3 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitor azoles and pharmaceutical compositions containing them |
Country Status (25)
Country | Link |
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US (2) | US20040110809A1 (hu) |
EP (2) | EP1370535A1 (hu) |
JP (2) | JP2004527512A (hu) |
KR (2) | KR100865836B1 (hu) |
CN (2) | CN1313448C (hu) |
AR (1) | AR035444A1 (hu) |
AU (1) | AU2002237633B2 (hu) |
BR (2) | BR0207985A (hu) |
CA (2) | CA2440475A1 (hu) |
CZ (2) | CZ20032501A3 (hu) |
EE (2) | EE200300450A (hu) |
HU (2) | HUP0400193A3 (hu) |
IL (2) | IL157650A0 (hu) |
IS (2) | IS6945A (hu) |
MX (2) | MXPA03008187A (hu) |
MY (1) | MY129188A (hu) |
NO (2) | NO326088B1 (hu) |
NZ (2) | NZ528108A (hu) |
PL (2) | PL365107A1 (hu) |
RU (2) | RU2293730C2 (hu) |
SE (1) | SE0100903D0 (hu) |
SK (2) | SK10912003A3 (hu) |
UA (2) | UA74624C2 (hu) |
WO (2) | WO2002074749A1 (hu) |
ZA (2) | ZA200306738B (hu) |
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SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
SE0202692D0 (sv) * | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
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ES2313841B1 (es) * | 2007-06-26 | 2010-01-12 | Proyecto De Biomedicina Cima, S.L. | Composiciones para tratamiento anti-fibrinolitico. |
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EP2907512A1 (en) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibitors of MMP-12 as antiviral Agents |
CU24573B1 (es) | 2016-12-16 | 2022-01-13 | Pfizer | Ácidos carboxílicos de benzimidazoles y 4-aza, 5-aza, 7-aza y 4,7-diaza-benzimidazoles como agonistas receptores de glp-1, útiles para tratar o prevenir enfermedades cardiometabólicas |
TWI798435B (zh) | 2018-05-15 | 2023-04-11 | 逸達生物科技股份有限公司 | 基質金屬蛋白酶(mmp)抑制劑及其使用方法 |
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2001
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2002
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