HUP0400194A2 - Metalloproteináz inhibitor hatású imidazolidindion-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Metalloproteináz inhibitor hatású imidazolidindion-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400194A2 HUP0400194A2 HU0400194A HUP0400194A HUP0400194A2 HU P0400194 A2 HUP0400194 A2 HU P0400194A2 HU 0400194 A HU0400194 A HU 0400194A HU P0400194 A HUP0400194 A HU P0400194A HU P0400194 A2 HUP0400194 A2 HU P0400194A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- derivatives
- imidazolidindion
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000651 prodrug Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
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- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
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Abstract
A találmány tárgyát a metaloproteináz inhibitor hatású általánosképletű vegyületek - ahol előnyösen X -NH-, -N(alkil)- vagy -N(halogén-alkil)- képletű csoport; Y1 és Y2 oxigénatom; R2 alkil-,amino-alkil-, alkil-heteroaril- alkíl-heterocikloalkil- vagyheteroaril-alkil-csoport; R3 és R4 hidrogénatom vagy alkilcsoport; R5adott esetben szubsztituált 2 vagy 3 aromás vagy heteroaromás gyűrűtmagában foglaló csoport A vegyértékvonal; és Z oxigén- vagy kénatom -és sóik vagy prodrugszármazékaik, ezeket tartalmazógyógyszerkészítmények és a gyógyászatban való alkalmazásuk képezik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0100902A SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Compounds |
PCT/SE2002/000473 WO2002074748A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0400194A2 true HUP0400194A2 (hu) | 2004-07-28 |
HUP0400194A3 HUP0400194A3 (en) | 2004-10-28 |
Family
ID=20283374
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400327A HUP0400327A3 (en) | 2001-03-15 | 2002-03-13 | Azole derivatives having metalloproteinase inhibitor effect pharmaceutical compositions containing them and their use |
HU0400194A HUP0400194A3 (en) | 2001-03-15 | 2002-03-13 | Imidazolidindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them |
HU0400202A HUP0400202A3 (en) | 2001-03-15 | 2002-03-13 | Imidazolidindion derivatives having metalloproteinase inhibitor effect, their use and pharmaceutical compositions containing them |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400327A HUP0400327A3 (en) | 2001-03-15 | 2002-03-13 | Azole derivatives having metalloproteinase inhibitor effect pharmaceutical compositions containing them and their use |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400202A HUP0400202A3 (en) | 2001-03-15 | 2002-03-13 | Imidazolidindion derivatives having metalloproteinase inhibitor effect, their use and pharmaceutical compositions containing them |
Country Status (33)
Country | Link |
---|---|
US (8) | US7427631B2 (hu) |
EP (4) | EP1370556B1 (hu) |
JP (4) | JP2004527515A (hu) |
KR (4) | KR100879905B1 (hu) |
CN (5) | CN1304377C (hu) |
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TW200800954A (en) | 2006-03-16 | 2008-01-01 | Astrazeneca Ab | Novel crystal modifications |
TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
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2001
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2002
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2004
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2006
- 2006-10-13 CY CY20061101477T patent/CY1107525T1/el unknown
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2007
- 2007-10-30 US US11/928,040 patent/US7625934B2/en not_active Expired - Fee Related
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2008
- 2008-05-05 US US12/114,901 patent/US7666892B2/en not_active Expired - Fee Related
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2009
- 2009-11-09 JP JP2009256358A patent/JP5140058B2/ja not_active Expired - Fee Related
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2010
- 2010-01-26 US US12/693,852 patent/US8153673B2/en not_active Expired - Fee Related
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