HUP0400451A2 - Pirrolszármazékok és ezeket tartalmazó gyógyászati készítmények - Google Patents

Pirrolszármazékok és ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0400451A2
HUP0400451A2 HU0400451A HUP0400451A HUP0400451A2 HU P0400451 A2 HUP0400451 A2 HU P0400451A2 HU 0400451 A HU0400451 A HU 0400451A HU P0400451 A HUP0400451 A HU P0400451A HU P0400451 A2 HUP0400451 A2 HU P0400451A2
Authority
HU
Hungary
Prior art keywords
general formula
substituents
pyrrole derivatives
optionally substituted
substituted phenyl
Prior art date
Application number
HU0400451A
Other languages
English (en)
Inventor
Jason Scott Sawyer
Douglas Wade Beight
Paola Ciapetti
Todd Vincent Decollo
Alexander Glenn Godfrey
Theodore Goodson
David Kent Herron
Hong-Yu Li
Junkai Liao
William Thomas Mcmillen
Shawn Christopher Miller
Nicolas Anthony Mort
Jonathan Michael Yingling
Edward C. R. Smith
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP0400451A2 publication Critical patent/HUP0400451A2/hu
Publication of HUP0400451A3 publication Critical patent/HUP0400451A3/hu
Publication of HU228844B1 publication Critical patent/HU228844B1/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
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  • Hospice & Palliative Care (AREA)

Abstract

A találmány tárgyát új pirrolszármazékok és ezeket tartalmazógyógyászati készítmények képezik; e vegyületek TGF-b szignál átvitelinhibitorok és mint ilyenek eredményesen alkalmazhatók rák, fibrózis,resztenózis, sebgyógyulás, HIV-fertőzés, Alzheimer-betegség és/vagyatherosclerosis kezelésére. Az (I) általános képletben aszubsztituensek jelentése igen sokféle, a vegyület (a) általánosképletű része 4, 5 vagy 6 tagú gyűrűt képez, továbbá X jelentése X, C,O vagy S; R, és R2 jelentése például adott esetben szubsztituáltfenil-, naftalin-, piridin- és hasonló gyűrűk, amelyek egy vagy több,igen sokféle szubsztituenst hordozhatnak vagy R2 jelentése (b), (c),(d), (e), (f) vagy (g) általános képletű csoport, ahol aszubsztituensek sokféle jelentésűek; k értéke 1-8, R3 jelentésepéldául alkil-, hidroxil-, karboxil-, benzil-oxi-, acetonitril-, adottesetben szubsztitált fenilcsoport. Ó
HU0400451A 2001-05-24 2002-05-13 Pyrrole derivatives and pharmaceutical compositions containing them HU228844B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29346401P 2001-05-24 2001-05-24
PCT/US2002/011884 WO2002094833A1 (en) 2001-05-24 2002-05-13 Novel pyrrole derivatives as pharmaceutical agents

Publications (3)

Publication Number Publication Date
HUP0400451A2 true HUP0400451A2 (hu) 2004-12-28
HUP0400451A3 HUP0400451A3 (en) 2008-08-28
HU228844B1 HU228844B1 (en) 2013-06-28

Family

ID=23129192

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400451A HU228844B1 (en) 2001-05-24 2002-05-13 Pyrrole derivatives and pharmaceutical compositions containing them

Country Status (38)

Country Link
US (1) US7087626B2 (hu)
EP (1) EP1397364B1 (hu)
JP (2) JP4519407B2 (hu)
KR (1) KR100861630B1 (hu)
CN (2) CN1269820C (hu)
AR (1) AR036034A1 (hu)
AT (1) ATE368041T1 (hu)
AU (1) AU2002339268B2 (hu)
BR (1) BR0209939A (hu)
CA (1) CA2446820C (hu)
CO (1) CO5540282A2 (hu)
CY (1) CY1106871T1 (hu)
CZ (1) CZ303808B6 (hu)
DE (1) DE60221392T2 (hu)
DK (1) DK1397364T3 (hu)
DZ (1) DZ3506A1 (hu)
EA (1) EA007782B1 (hu)
EC (1) ECSP034859A (hu)
EG (1) EG25614A (hu)
ES (1) ES2289116T3 (hu)
HK (1) HK1064375A1 (hu)
HR (1) HRP20030961B1 (hu)
HU (1) HU228844B1 (hu)
IL (2) IL158512A0 (hu)
MX (1) MXPA03010630A (hu)
MY (1) MY134586A (hu)
NO (1) NO326701B1 (hu)
NZ (1) NZ528525A (hu)
PE (1) PE20030117A1 (hu)
PL (1) PL221339B1 (hu)
PT (1) PT1397364E (hu)
SI (1) SI1397364T1 (hu)
SK (1) SK287857B6 (hu)
SV (1) SV2003001054A (hu)
TW (1) TWI329644B (hu)
UA (1) UA76461C2 (hu)
WO (1) WO2002094833A1 (hu)
ZA (1) ZA200308546B (hu)

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