ATE253571T1 - 2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel - Google Patents

2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel

Info

Publication number
ATE253571T1
ATE253571T1 AT93918407T AT93918407T ATE253571T1 AT E253571 T1 ATE253571 T1 AT E253571T1 AT 93918407 T AT93918407 T AT 93918407T AT 93918407 T AT93918407 T AT 93918407T AT E253571 T1 ATE253571 T1 AT E253571T1
Authority
AT
Austria
Prior art keywords
heterocyclic
hydroxy
inflammatory agent
pyrimidines
pyrimidines used
Prior art date
Application number
AT93918407T
Other languages
English (en)
Inventor
David Thomas Connor
Catherine Rose Kostlan
Paul Charles Unangst
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE253571T1 publication Critical patent/ATE253571T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT93918407T 1992-08-03 1993-07-27 2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel ATE253571T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/924,212 US5240929A (en) 1992-08-03 1992-08-03 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
PCT/US1993/007034 WO1994003448A1 (en) 1992-08-03 1993-07-27 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents

Publications (1)

Publication Number Publication Date
ATE253571T1 true ATE253571T1 (de) 2003-11-15

Family

ID=25449891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93918407T ATE253571T1 (de) 1992-08-03 1993-07-27 2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel

Country Status (12)

Country Link
US (2) US5240929A (de)
EP (1) EP0652874B1 (de)
JP (1) JP3223190B2 (de)
KR (1) KR100275428B1 (de)
AT (1) ATE253571T1 (de)
AU (1) AU672619B2 (de)
CA (1) CA2139731C (de)
DE (1) DE69333285T2 (de)
DK (1) DK0652874T3 (de)
ES (1) ES2206460T3 (de)
PT (1) PT652874E (de)
WO (1) WO1994003448A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0569493A4 (en) * 1991-01-31 1993-11-24 Warner-Lambert Company Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines
AU7090201A (en) 2000-07-20 2002-02-05 Lauras As Method
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
ES2264734T3 (es) * 2001-08-13 2007-01-16 Janssen Pharmaceutica N.V. Derivados de tiazolilo 2,4,5-trisustituidos y su actividad antiinflamatoria.
DE10329955A1 (de) * 2003-07-03 2005-02-03 Merck Patent Gmbh Verwendung eines hydroalkoholischen Extrakts aus Bauhinia zur Herstellung einer Zubereitung
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
PT1919290E (pt) * 2005-07-12 2014-03-20 Ampio Pharmaceuticals Inc Métodos e produtos para tratamento de doenças
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
EP3395372B1 (de) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Freisetzungssystem für glutathionbasiertes arzneimittel
KR101357438B1 (ko) 2009-04-29 2014-02-06 아마린 코포레이션 피엘씨 Epa 및 심혈관 제제를 포함하는 제약 조성물 및 그의 사용 방법
SG175896A1 (en) 2009-05-06 2011-12-29 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9675587B2 (en) 2013-03-14 2017-06-13 Allergan Holdings Unlimited Company Opioid receptor modulator dosage formulations
CN117677386A (zh) * 2021-07-23 2024-03-08 瓦伦塔有限责任公司 具有亲溶酶体和抗病毒活性的化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636516A (en) * 1981-02-19 1987-01-13 Yamanouchi Pharmaceutical Co., Ltd. 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds

Also Published As

Publication number Publication date
CA2139731A1 (en) 1994-02-17
EP0652874A1 (de) 1995-05-17
PT652874E (pt) 2004-03-31
US5312821A (en) 1994-05-17
JP3223190B2 (ja) 2001-10-29
KR100275428B1 (ko) 2000-12-15
WO1994003448A1 (en) 1994-02-17
ES2206460T3 (es) 2004-05-16
DK0652874T3 (da) 2004-03-22
DE69333285D1 (de) 2003-12-11
EP0652874B1 (de) 2003-11-05
JPH08500101A (ja) 1996-01-09
CA2139731C (en) 2004-01-13
US5240929A (en) 1993-08-31
AU672619B2 (en) 1996-10-10
DE69333285T2 (de) 2004-08-26
AU4787093A (en) 1994-03-03
KR950702554A (ko) 1995-07-29

Similar Documents

Publication Publication Date Title
ATE165825T1 (de) Phenyl heterocyclen als cyclooxygenase-2 inhibitoren
MX9102209A (es) Derivados de acido hidroxamico y n-hidroxiurea novedosos y su uso.
NO960393L (no) Heterosykliske fenylforbindelser som COX-2-inhibitorer
ATE253571T1 (de) 2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel
ES2075845T3 (es) 3,5-di-terc-butil-4-hidroxifenil-1,3,4-tiadiazoles, oxadiazoles y 3,5-di-terc-butil-4-hidroxifenil-1,2,4-tiadiazoles, oxadiazoles y triazoles como agentes antiinflamatorios.
IE940525L (en) Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
NL300175I2 (nl) Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2.
HUP0400451A2 (hu) Pirrolszármazékok és ezeket tartalmazó gyógyászati készítmények
EA200200708A1 (ru) Производные бензазола и их применение в качестве модуляторов jnk
DK0468012T3 (da) 17beta-substituerede 4-aza-5alfa-androstan-3-on-derivater og fremgangsmåde til fremstilling deraf
ES2123652T3 (es) 7-(2-aminoetil)-benzotiazolonas.
FI935777A0 (fi) Inhibitorer foer HIV-proteas anvaendbara vid behandling av AIDS
ATE223376T1 (de) Bisarylcyclobutenderivate als cyclooxygenasehemmer
FI891986A (fi) Farmaceutiska sammansaettningar foer behandling av psoriasis.
ATE266027T1 (de) Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten
IL113706A (en) N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them
ES2059204T3 (es) Derivados del acido hidroxamico inhibidores de lipoxigenasa.
ATE16150T1 (de) Xanthinoxydasehemmer und verwendung von benztriazinderivaten.
DK520787D0 (da) Terapeutisk middel indeholdende propentofyllin eller derivater deraf til brug ved behandling af peptisk ulcus
HUP0202340A2 (hu) Hatóanyagként kondenzált heterociklusos vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0204144A2 (en) N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0652874

Country of ref document: EP

REN Ceased due to non-payment of the annual fee