AR036034A1 - Compuestos de pirazol fusionado, de aplicacion en el tratamiento de cancer y de enfermedades medidas por la superproduccion de factores tgf-beta; formulaciones farmaceuticas que incluyen dichos compuestos de pirazol fusionado como agente activo; uso de los compuestos mencionados para preparar medica - Google Patents
Compuestos de pirazol fusionado, de aplicacion en el tratamiento de cancer y de enfermedades medidas por la superproduccion de factores tgf-beta; formulaciones farmaceuticas que incluyen dichos compuestos de pirazol fusionado como agente activo; uso de los compuestos mencionados para preparar medicaInfo
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Abstract
Compuestos de pirazol y, respectivamente, de pirazol fusionado de fórmula (1) en donde el grupo de fórmula (2) es un anillo saturado de cuatro, cinco o seis miembros y X es C, O ó S; R1 es fenilo sustituido o no sustituido; piridina sustituida o no sustituida; N-óxido de piridina; N-óxido de piridina sustituido o no sustituido; quinolina sustituida o no sustituida; N-óxido de quinolina; N-óxido de quinolina sustituido o no sustituido; naftiridina sustituida o no sustituida; pirazina sustituida o no sustituida; furilo; tiazolilo; imidazolilo sustituido o no sustituido; pirazolilo sustituido o no sustituido; o tiofenilo sustituido o no sustituido; en donde la sustitución puede ser una o más de las siguientes: alquilo C1-6; alquenilo C2-6; alquinilo C2-6; alcoxi C1-6; alqueniloxi C2-6; alquiniloxi C2-6; alquiltio C1-6; alquilsulfinilo C1-6; alquilsulfonilo C1-6; alquilamino C1-6, di-[alquil C1-6]amino; alcoxicarbonilo C1-6; N-alquil C1-6-carbamoilo; N,N-di-[alquil C1-6]carbamoilo; alcanoílo C2-6; alcanoiloxi C2-6; alcanoilamino C2-6; N-alquil C1-6-alcanoilamino C2-6; alquenoilamino C3-6; N-alquil C1-6-alquenoilamino C3-6; alquinoilamino C3-6; N-alquil C1-6-alquinoilamino C3-6; N-alquilsulfamoilo C1-6; N,N-di-[alquil C1-6]sulfamoilo; alcansulfonilamino C1-6; N-alquil C1-6-alcansulfonilamino C1-6; carboxamida; etileno; tiofenilo; aminofenilo; trifluorometilo; halo; trifluorometoxi; hidroximetilo; N-pirrolidino; N-morfolino; feniltio; dialquilaminometilo C1-4; metoxifenilo; amino; hidroxi; carboxilo; fenilo; arilalquilo; R2 es quinolina sustituida o no sustituida; N-óxido de quinolina sustituido o no sustituido; fenilo sustituido o no sustituido; naftaleno sustituido o no sustituido; piridina sustituida o no sustituida; N-óxido de piridina sustituido o no sustituido; quinazolina sustituida o no sustituida; cinolina sustituida o no sustituida; benzodioxol sustituido o no sustituido; benzodioxano sustituido o no sustituido; pirimidina sustituida o no sustituida; benzotiofeno sustituido o no sustituido; o fenantroleno sustituido o no sustituido; en donde la sustitución puede ser en forma independiente uno o más de los siguientes: hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alquilhaluro C1-6, alcoxi C1-6,alqueniloxi C2-6, alquiniloxi C2-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, alquilamino C1-6, di[alquil C1-6]amino, alcoxicarbonilo C1-6, N-alquilcarbamoilo C1-6, N,N-di[alquil C1-6]carbamoilo, aminooxi, N-alquil C1-6-aminooxi, N,N-di[alquil C1-6]aminooxi, alcanoílo C2-6, alcanoiloxi C2-6, alcanoilamino C2-6, N-alquil C1-6-alcanoilamino C2-6, alquenoilamino C3-6, N-alquil C1-6-alquenoilamino C3-6, alquinoilamino C3-6, N-alquil C1-6-alquinoilamino C3-6, sulfamoilo, N-alquilsulfamoilo C1-6, N,N-di[alquil C1-6]sulfamoilo, alcansulfonilamino C1-6, N-alquil C1-6-alcansulfonilamino C1-6, carboxamida, etileno, fenilo, tiofenilo, aminofenilo, feniltio, halo, ciano, piridinilo, arilalquilo, hidroxi, N-pirrolidino, N-morfolino, carboxilo, [5-fenil-1,2,4-oxadiazol-3-il]metoxi, 6-metil-piridazin-3-iloxi, (5-oxo-2-pirrolidinil)metoxi, 2-(4,5-dihidro-1H-imidazolilo), N,N-dialquilcarbamoiloxi, 1-hidroxi-1-metiletilo, 4-fluorofenilo, 3,4-metilendioxifenilo, trifluorometilo, trifluorometoxi, o un grupo de la fórmula X1-(CH2)n(CR10R16)(CH2)m-Q1, en donde: X1 es O, N, S, SO2, NR13, C(O), ó enlace; Q1 es hidrógeno, fenilo, 5-(2,2-difluoro-1,3-benzodioxolilo), C(O)Q5, ó piridilo cuando m y n son independientemente 0-2, excepto cuando uno de ellos es cero, el otro no puede ser 0; Q1 es OR11, NR11R12, halo, N-morfolino, N-piperazino-N'R13, N-imidazolilo, N-pirazolilo, N-triazolilo, N-(4-piperidinilpiperidina), SO2R14, SOR14, NHSO2R15, acetamido, N-ftalimido, N-oxazolidino, N-imidazolino, N-benzoxazolidino, N-pirrolidinonilo, N(N'-metilbencimidazolino), N,N-dialquilamino C1-4-alcoxi C1-4, N-bencimidazolino; cuando m y n son independientemente 0-2, pero uno o el otro de m ó n no es 0; Q5 es hidroxi, metoxi, amino, dietilamino, dimetilamino; R10 es hidrógeno, halo, alquilo C1-6; R11 y R12 son independientemente hidrógeno, alquilo C1-6, alcoxi C1-6, arilalquilo, cicloalquilo C3-8, cicloalquilmetilo C3-8, 4-(N-metilpiperidinilo), piridilo, ó R11 y R10 pueden tomarse juntos para formar un anillo de 4, 5, 6 ó 7 miembros, ó R11 y R12 pueden tomarse juntos para formar un anillo de 3, 4, 5, 6 ó 7 miembros; R13 es hidrógeno, alquilo C1-6, 2-metoxifenilo, 2-piridimidinilo; R14 es 2-pirimidinilo, N-metil-2-imidazolilo, 4-clorofenilo, 2-piridilmetilo; R15 es alquilo C1-6, N-metil-4-imidazolilo; R16 es hidrógeno, halo, arilalquilo, arilo o un grupo de fórmula -C(O)-NR20-(CH2)o(CR21R22)(CH2)p-Q2, donde: Q2 es hidrógeno, 4-imidazolilo, ó C(O)NR24R25 cuando o y p son independientemente 0-2; Q2 es OR23, NR24R25 ó N-morfolino, cuando o y p son independientemente 0-2, pero uno o el otro de o ó p no es 0; R20 es hidrógeno o alquilo C1-6; R21 es hidrógeno, alquilo C1-6, ó R21 y R20 pueden tomarse juntos para formar un anillo de 4, 5, 6 ó 7 miembros; R22 es hidrógeno, alquilo C1-6, arilalquilo, arilo, ó R21 y R22 pueden tomarse juntos para ser un anillo de 3, 4, 5, 6, 7 miembros; R23 es hidrógeno o alquilo C1-6; R24 es hidrógeno, alquilo C1-6, ó R24 y R25 pueden tomarse juntos para formar un anillo de 3, 4, 5, 6 ó 7 miembros, ó R24 y R20 pueden tomarse juntos para formar un anillo de 6 ó 7 miembros; R25 es hidrógeno, alquilo C1-6, o acetilo, o un grupo de la fórmula -C(O)NR30R31, en donde: R30 es hidrógeno, o alquilo C1-6; R31 es hidrógeno, alquilo C1-6, 2-piridilo, piridilmetilo, amino, o hidroxi, o un grupo de la fórmula -NR32R33, en donde: R32 y R33 son cada uno en forma independiente hidrógeno, alquilo C1-6, acetilo, alquilsulfonilo C1-4, ó R32 y R33 pueden tomarse juntos para formar un anillo de 4, 5, 6 ó 7 miembros, o un grupo de fórmula -NR35C(O)X2(CH2)q-Q3, en donde: X2 es CH2, O ó N; q es 2-3 excepto cuando Q3 es un enlace, q es 0-3; Q3 es NR36R37 u OR38, y R35 es hidrógeno, o R35 y Q3 pueden tomarse juntos para formar un anillo de 5 miembros; R36, R37 y R38 son cada uno en forma independiente hidrógeno, o alquilo C1-6 o un fenoxi sustituido con X3, en donde X3 es ciano, carboxamida, N,N-dimetilcarboxamida, N,N-dimetiltiocarboxamida, N,N-dimetilaminometilo, 4-metilpiperazin-1-il-metilo o carboxilato, o un grupo de la fórmula -O-CH2-C(O)NR40-(CH2)r-Q6, en donde: Q6 es NR41R42; r es 2-3; R40 es hidrógeno, o alquilo C1-6; R41 y R42 son hidrógeno, alquilo C1-6, ó R41 y R40 pueden tomarse juntos para formar un anillo de 6 ó 7 miembros, o un grupo de la fórmula -CH=CH-C(O)Q7 en donde: Q7 es hidroxi, metoxi, dimetilamino, o N-piperidinilo; con la condición que cuando uno de R1 ó R2 es fenilo sustituido o no sustituido, el otro no puede ser fenilo sustituido o no sustituido o tiofen-2-ilo, y con la condición que cuando R2 es quinolin-4-ilo, la sustitución en la posición 7 de quinolina no puede incluir arilo, heteroarilo, arilo fusionado, o heteroarilo fusionado; k es 1-8; R3 es uno o más de los siguientes: hidrógeno, alquilo C1-4; alquilhidroxi C1-4, hidroxi, N,N-dialquilamino C1-4-alcoxi C1-4; benciloximetilo; feniloximetilo; oxo; carboxilo; alquilarilo C1-4; benciloxi; acetoxi; aminoalquilo C1-4; alquenilo C2-4; halo; -O-alquilo C1-4. clorofenetilo; acetonitrilo; fenilo sustituido o no sustituido; en donde la sustitución puede ser uno o más de los siguientes: alcoxi C1-6, halo, carboxi o alcoxicarbonilo C1-6; y las sales, ésteres y profármacos farmacéuticamente aceptables de los mismos. Los compuestos tienen aplicación en el tratamiento del cáncer y de enfermedades mediadas por la superproducción de factores TGF-beta. Formulaciones farmacéuticas que incluyen dichos compuestos como agente activo, uso de los compuestos mencionados para preparar medicamentos para el tratamiento de cáncer y métodos para tratar cáncer utilizando dichos compuestos, sus sales ésteres y sus profármacos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US29346401P | 2001-05-24 | 2001-05-24 | |
PCT/US2002/011884 WO2002094833A1 (en) | 2001-05-24 | 2002-05-13 | Novel pyrrole derivatives as pharmaceutical agents |
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AR036034A1 true AR036034A1 (es) | 2004-08-04 |
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ARP020101974A AR036034A1 (es) | 2001-05-24 | 2002-05-27 | Compuestos de pirazol fusionado, de aplicacion en el tratamiento de cancer y de enfermedades medidas por la superproduccion de factores tgf-beta; formulaciones farmaceuticas que incluyen dichos compuestos de pirazol fusionado como agente activo; uso de los compuestos mencionados para preparar medica |
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---|---|---|---|---|
SI1397364T1 (sl) * | 2001-05-24 | 2007-12-31 | Lilly Co Eli | Novi pirolni derivati kot farmacevtske uäśinkovine |
EP1453830B1 (en) * | 2001-12-11 | 2007-09-12 | SmithKline Beecham Corporation | Pyrazolo-pyridine derivatives as antiherpes agents |
US7365066B2 (en) | 2002-09-17 | 2008-04-29 | Eli Lilly And Company | Pyrazolopyridine derivatives as pharmaceutical agents |
CA2506799A1 (en) * | 2002-11-21 | 2004-06-10 | Eli Lilly And Company | Mixed lineage kinase modulators |
EP1578749A2 (en) * | 2002-11-22 | 2005-09-28 | Eli Lilly And Company | Pyrazoloazepine compounds as pharmaceutical agents |
UA80571C2 (en) * | 2002-11-22 | 2007-10-10 | Lilly Co Eli | Quinolinyl-pyrrolopyrazoles |
EP1567527A1 (en) * | 2002-11-27 | 2005-08-31 | Eli Lilly And Company | Condensed pyrazolo derivatives |
CL2004000234A1 (es) * | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
US7511065B2 (en) * | 2003-11-12 | 2009-03-31 | Eli Lilly And Company | Mixed lineage kinase modulators |
US7368445B2 (en) | 2004-03-01 | 2008-05-06 | Eli Lilly And Company | Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms |
TW200639163A (en) | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
SG161217A1 (en) | 2005-04-01 | 2010-05-27 | Insa Rouen | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents |
EP1910370B1 (en) | 2005-07-22 | 2015-04-22 | Eli Lilly And Company | A pyridin quinolin substituted pyrrolo [1,2-b] pyrazole monohydrate as tgf-beta inhibitor |
CA2618377A1 (en) | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate hsp90 activity |
EP1973909A2 (en) * | 2005-12-22 | 2008-10-01 | Biogen Idec MA Inc. | Transforming growth factor modulators |
DE102005061840A1 (de) | 2005-12-23 | 2007-06-28 | Merck Patent Gmbh | Triazolderivate |
WO2007139951A2 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders associated with protooncogene products |
EP2918288B1 (en) | 2006-10-03 | 2017-08-16 | Genzyme Corporation | Use of TGF beta antagonists to treat infants at risk of developing bronchopulmonary dysplasia |
PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
KR20100110815A (ko) | 2007-12-12 | 2010-10-13 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 살균제 이환식 피라졸 |
ES2422263T3 (es) * | 2008-12-19 | 2013-09-10 | Nerviano Medical Sciences Srl | Pirazoles bicíclicos como inhibidores de la proteinquinasa |
CN102695511A (zh) * | 2009-04-17 | 2012-09-26 | 舒玛健康系统有限责任公司 | 抑制眼部瘢痕形成的转化生长因子-β受体抑制剂的用途 |
AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
US9205086B2 (en) | 2010-04-19 | 2015-12-08 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor |
EP2402339A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
EP2402338A1 (en) | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
EP2402337A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
EP2402340A1 (en) | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
EP2401915A1 (en) | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
WO2012138945A1 (en) | 2011-04-08 | 2012-10-11 | Aestus Therapeutics, Inc. | Methods of treating schizophrenia with pyrazole derivative inhibitors of tgf - beta |
US20140308275A1 (en) | 2011-07-27 | 2014-10-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale | Methods for diagnosing and treating myhre syndrome |
CA2853484C (en) | 2011-10-26 | 2018-08-21 | Seattle Children's Research Institute | Cysteamine in the treatment of fibrotic disease |
CA2853806C (en) | 2011-11-02 | 2020-07-14 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with platinum-containing agents |
EP2773345A1 (en) | 2011-11-02 | 2014-09-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
AU2012339679A1 (en) | 2011-11-14 | 2014-06-12 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with BRAF inhibitors |
US9782452B2 (en) | 2011-11-22 | 2017-10-10 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling |
US10023640B2 (en) | 2012-10-05 | 2018-07-17 | Kadmon Corporation, Llc | Human anti-VEGFR-2/KDR antibodies |
TWI443096B (zh) | 2012-12-18 | 2014-07-01 | Ind Tech Res Inst | 3-(5-(4-(3-氟丙基)哌嗪-1-基)苯並咪唑-2-基)-1-氮雜薁-2-酮之單水合晶型及其製備方法與藥學組成物 |
EP2953933A1 (en) * | 2013-02-07 | 2015-12-16 | Merck Patent GmbH | Substituted acetylene derivatives and their use as positive allosteric modulators of mglur4 |
DK2970890T3 (da) | 2013-03-14 | 2020-05-04 | Brigham & Womens Hospital Inc | Sammensætninger og fremgangsmåder til opformering og dyrkning af epitelstamceller |
US8975417B2 (en) * | 2013-05-27 | 2015-03-10 | Novartis Ag | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
DK3102576T3 (da) | 2014-02-03 | 2019-07-22 | Vitae Pharmaceuticals Llc | Dihydropyrrolopyridininhibitorer af ror-gamma |
WO2016037016A1 (en) | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
TWI582083B (zh) | 2014-10-07 | 2017-05-11 | 美國禮來大藥廠 | 胺基吡啶基氧基吡唑化合物 |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
EP3277673B1 (en) | 2015-04-01 | 2022-05-04 | Rigel Pharmaceuticals, Inc. | Tgf-beta inhibitors |
WO2016210292A1 (en) | 2015-06-25 | 2016-12-29 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
MA53943A (fr) * | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
US11021687B2 (en) | 2016-01-08 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
DK3429603T3 (da) | 2016-03-15 | 2022-03-14 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende ekspansion af hæmatopoietiske stamceller |
KR102412035B1 (ko) * | 2016-06-13 | 2022-06-22 | 젠플리트 테라퓨틱스 (상하이) 아이엔씨. | TGF-βRI 억제제인 벤조트리아졸에서 유도된 α,β-불포화 아미드계 화합물 |
US11466003B2 (en) | 2016-07-29 | 2022-10-11 | Shanghai Yingli Pharmaceutical Co., Ltd | Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof |
US11066419B2 (en) | 2016-12-30 | 2021-07-20 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using same |
ES2953349T3 (es) * | 2017-05-05 | 2023-11-10 | Arcus Biosciences Inc | Derivados de quinazolina-piridina para el tratamiento de trastornos relacionados con el cáncer |
AU2018307919B2 (en) | 2017-07-24 | 2022-12-01 | Vitae Pharmaceuticals, Llc | Inhibitors of RORϒ |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
SG11202003035SA (en) | 2017-10-05 | 2020-04-29 | Fulcrum Therapeutics Inc | Use of p38 inhibitors to reduce expression of dux4 |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
RU2020114670A (ru) | 2017-10-11 | 2021-11-12 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения для применения в качестве ингибиторов rip1 киназы |
JP2021035911A (ja) * | 2017-11-15 | 2021-03-04 | 大日本住友製薬株式会社 | 縮環ピラゾール誘導体及びその医薬用途 |
PT3725786T (pt) | 2017-12-13 | 2023-10-17 | Genfleet Therapeutics Shanghai Inc | Forma cristalina e forma salina de inibidor de tgf-bri e método de preparação das mesmas |
CN110066277B (zh) | 2018-01-24 | 2021-07-23 | 上海璎黎药业有限公司 | 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用 |
CN110066276B (zh) | 2018-01-24 | 2020-09-18 | 上海璎黎药业有限公司 | 芳香杂环化合物、其中间体、制备方法、药物组合物和应用 |
CA3093340A1 (en) | 2018-03-20 | 2019-09-26 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
WO2019236766A1 (en) | 2018-06-06 | 2019-12-12 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds |
WO2020019108A1 (en) | 2018-07-23 | 2020-01-30 | Guangzhou Othrotx Co., Ltd. | Bisphosphonate drug conjugates |
EP3837352A1 (en) | 2018-08-17 | 2021-06-23 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
CN112839946B (zh) * | 2018-10-31 | 2022-04-12 | 江苏奥赛康药业有限公司 | 作为TGF-βR1激酶抑制剂的双环吡唑类化合物 |
US20220089600A1 (en) * | 2018-11-22 | 2022-03-24 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | TGFß INHIBITOR AND PRODRUGS |
ES2972516T3 (es) | 2018-12-27 | 2024-06-13 | Nexys Therapeutics Inc | Derivados de (piridin-2-il)amina como inhibidores de TFG-BETA R1 (Alk5) para el tratamiento del cáncer |
AU2019419414A1 (en) | 2018-12-31 | 2023-04-06 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
WO2020151749A1 (zh) | 2019-01-24 | 2020-07-30 | 南京明德新药研发有限公司 | 作为TGF-βR1激酶抑制剂的5-(4-吡啶氧基)吡唑类化合物 |
JP7532385B2 (ja) * | 2019-01-31 | 2024-08-13 | 杏林製薬株式会社 | 15-pgdh阻害薬 |
EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
WO2020248908A1 (zh) * | 2019-06-10 | 2020-12-17 | 中国科学院广州生物医药与健康研究院 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
CA3164037A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
WO2022017208A1 (zh) * | 2020-07-23 | 2022-01-27 | 江苏奥赛康药业有限公司 | 作为TGF-βR1抑制剂的吡啶氧基连吡唑类化合物的盐型、晶型以及其药物组合物 |
EP4219453A1 (en) | 2020-09-28 | 2023-08-02 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Pyrazole compound and preparation method therefor and use thereof |
CN115703750B (zh) * | 2021-08-17 | 2024-07-02 | 黑龙江华瑞生物科技有限公司 | 一种1-氨基-4-甲基哌嗪的提取纯化方法 |
CN114249742B (zh) * | 2021-11-22 | 2022-11-01 | 郑州大学 | 一种光气探针、荧光书写检测笔及其在光气检测中的应用 |
CN115969801B (zh) * | 2023-03-21 | 2023-08-25 | 劲方医药科技(上海)有限公司 | 用于癌症的药物组合物及其制备方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
ES2130269T3 (es) * | 1992-06-17 | 1999-07-01 | Upjohn Co | Oximas sustituidas con piridina, pirrolidina y azepina utiles como agentes contra la aterosclerosis y antihipercolesterolemicos. |
GB9303993D0 (en) * | 1993-02-26 | 1993-04-14 | Fujisawa Pharmaceutical Co | New heterocyclic derivatives |
DE69428977T2 (de) * | 1993-07-27 | 2002-07-11 | Kyowa Hakko Kogyo Co., Ltd. | Arzneimittel gegen Parkinsonsche Krankheit |
US5358947A (en) | 1993-09-13 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones |
AUPN419395A0 (en) * | 1995-07-17 | 1995-08-10 | Treescope Development Co. Pty. Ltd. | Plant protector |
FR2746306B1 (fr) | 1996-03-22 | 1998-04-30 | Oreal | Compositions de teinture des fibres keratiniques contenant des pyrazolo-azoles ; leur utilisation pour la teinture comme coupleurs, procede de teinture |
GEP20033053B (en) | 1997-05-22 | 2003-08-25 | Searle & Co | Substituted Pyrazoles as P38 Kinase Inhibitors, Methods for their Production, Pharmaceutical Compositions Containing Them and Methods for Treatment |
FR2772379B1 (fr) * | 1997-12-16 | 2000-02-11 | Oreal | Compositions de teinture des fibres keratiniques contenant des pyrazolo-azoles; leur utilisation pour la teinture comme base d'oxydation, procede de teinture; nouveaux pyrazolo-azoles |
GB9809869D0 (en) | 1998-05-09 | 1998-07-08 | Medical Res Council | Inhibition of protein kinases |
AU2319100A (en) | 1999-01-28 | 2000-08-18 | Nippon Shinyaku Co. Ltd. | Amide derivatives and drug compositions |
DE60001229T2 (de) | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
MXPA02002111A (es) * | 1999-08-27 | 2002-10-31 | Abbott Lab | Compuestos de sulfonilfenilpirazol utiles como inhibidores de cox-2. |
GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
EP1326619A2 (en) * | 2000-10-11 | 2003-07-16 | Merck & Co., Inc. | Pyrrolidine modulators of ccr5 chemokine receptor activity |
WO2002066462A1 (en) | 2001-02-02 | 2002-08-29 | Glaxo Group Limited | Pyrazole derivatives against tgf overexpression |
SI1397364T1 (sl) * | 2001-05-24 | 2007-12-31 | Lilly Co Eli | Novi pirolni derivati kot farmacevtske uäśinkovine |
DK1633912T3 (da) * | 2003-05-28 | 2014-10-06 | Oerlikon Textile Gmbh & Co Kg | En fremgangsmåde og en fiberfordeler til at tørlægge fibre |
JP4882198B2 (ja) | 2003-09-25 | 2012-02-22 | 日産自動車株式会社 | 燃料電池システム |
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