RU2015110632A - Молекулы, связывающиеся с 4-1вв - Google Patents
Молекулы, связывающиеся с 4-1вв Download PDFInfo
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- RU2015110632A RU2015110632A RU2015110632/10A RU2015110632A RU2015110632A RU 2015110632 A RU2015110632 A RU 2015110632A RU 2015110632/10 A RU2015110632/10 A RU 2015110632/10A RU 2015110632 A RU2015110632 A RU 2015110632A RU 2015110632 A RU2015110632 A RU 2015110632A
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- A61K38/00—Medicinal preparations containing peptides
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
1. Выделенное антитело или его антигенсвязывающий фрагмент, где указанное антитело или его антигенсвязывающий фрагмент связываются с внеклеточным доменом человеческого 4-1ВВ в эпитопе, локализованном в пределах аминокислотных остатков 115-156 в SEQ ID NO: 68.2. Антитело или его антигенсвязывающий фрагмент по п. 1, где указанное антитело или его антигенсвязывающий фрагмент связываются с человеческим 4-1ВВ с константной диссоциации (K) 10 нМ или менее для внеклеточного домена человеческого 4-1ВВ, как измерено с использованием анализа посредством поверхностного плазмонного резонанса.3. Антитело или антигенсвязывающий фрагмент по п. 2, где указанное антитело или его антигенсвязывающий фрагмент содержат Vи Vобласть, где аминокислотная последовательность Vобласти изложена в SEQ ID NO: 43, и аминокислотная последовательность Vобласти изложена в SEQ ID NO: 45.4. Фармацевтическая композиция, содержащая антитело или его антигенсвязывающий фрагмент по п. 1 и фармацевтически приемлемый носитель.5. Способ снижения опухолевого роста у нуждающегося в этом субъекта, включающий введение указанному субъекту эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.6. Способ лечения рака у млекопитающего, включающий введение млекопитающему, нуждающемуся в лечении, терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.7. Способ по п. 6, где указанный рак выбран из группы, состоящей из колоректального рака, неходжкинской лимфомы, рака предстательной железы или меланомы.8. Способ лечения рака у млекопитающего, вкл
Claims (14)
1. Выделенное антитело или его антигенсвязывающий фрагмент, где указанное антитело или его антигенсвязывающий фрагмент связываются с внеклеточным доменом человеческого 4-1ВВ в эпитопе, локализованном в пределах аминокислотных остатков 115-156 в SEQ ID NO: 68.
2. Антитело или его антигенсвязывающий фрагмент по п. 1, где указанное антитело или его антигенсвязывающий фрагмент связываются с человеческим 4-1ВВ с константной диссоциации (KD) 10 нМ или менее для внеклеточного домена человеческого 4-1ВВ, как измерено с использованием анализа посредством поверхностного плазмонного резонанса.
3. Антитело или антигенсвязывающий фрагмент по п. 2, где указанное антитело или его антигенсвязывающий фрагмент содержат VH и VL область, где аминокислотная последовательность VH области изложена в SEQ ID NO: 43, и аминокислотная последовательность VL области изложена в SEQ ID NO: 45.
4. Фармацевтическая композиция, содержащая антитело или его антигенсвязывающий фрагмент по п. 1 и фармацевтически приемлемый носитель.
5. Способ снижения опухолевого роста у нуждающегося в этом субъекта, включающий введение указанному субъекту эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.
6. Способ лечения рака у млекопитающего, включающий введение млекопитающему, нуждающемуся в лечении, терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.
7. Способ по п. 6, где указанный рак выбран из группы, состоящей из колоректального рака, неходжкинской лимфомы, рака предстательной железы или меланомы.
8. Способ лечения рака у млекопитающего, включающий введение млекопитающему терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 3 в комбинации с иммунотерапевтическим агентом.
9. Способ по п. 8, где указанный иммунотерапевтический агент представляет собой ритуксимаб.
10. Способ снижения опухолевого роста у нуждающегося в этом субъекта, включающий введение указанному субъекту эффективного количества антитела или его антигенсвязывающего фрагмента по п. 3 и фармацевтически приемлемого носителя.
11. Способ лечения рака у млекопитающего, включающий введение млекопитающему, нуждающемуся в лечении, терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 3 и фармацевтически приемлемого носителя.
12. Способ по п. 11, где указанный рак выбран из группы, состоящей из колоректального рака, неходжкинской лимфомы, рака предстательной железы или меланомы.
13. Способ лечения рака у млекопитающего, включающий введение млекопитающему терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 в комбинации с иммунотерапевтическим агентом.
14. Способ по п. 13, где указанный иммунотерапевтический агент представляет собой ритуксимаб.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38121010P | 2010-09-09 | 2010-09-09 | |
US61/381,210 | 2010-09-09 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2013110576/10A Division RU2551963C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1вв |
Publications (3)
Publication Number | Publication Date |
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RU2015110632A true RU2015110632A (ru) | 2015-08-10 |
RU2015110632A3 RU2015110632A3 (ru) | 2018-11-30 |
RU2710717C2 RU2710717C2 (ru) | 2020-01-10 |
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Application Number | Title | Priority Date | Filing Date |
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RU2013110576/10A RU2551963C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1вв |
RU2015110632A RU2710717C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1ВВ |
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RU2013110576/10A RU2551963C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1вв |
Country Status (27)
Country | Link |
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US (5) | US8337850B2 (ru) |
EP (2) | EP2614082B1 (ru) |
JP (4) | JP6105470B2 (ru) |
KR (2) | KR101527300B1 (ru) |
CN (2) | CN103221428B (ru) |
AR (2) | AR082916A1 (ru) |
AU (3) | AU2011300445B2 (ru) |
BR (1) | BR112013005699B1 (ru) |
CA (1) | CA2810359C (ru) |
CO (1) | CO6690759A2 (ru) |
DK (1) | DK2614082T3 (ru) |
ES (1) | ES2699648T3 (ru) |
HK (2) | HK1187627A1 (ru) |
HU (1) | HUE041958T2 (ru) |
IL (3) | IL225001A (ru) |
MX (1) | MX337040B (ru) |
MY (2) | MY162737A (ru) |
NZ (4) | NZ714128A (ru) |
PE (1) | PE20131465A1 (ru) |
PL (1) | PL2614082T3 (ru) |
PT (1) | PT2614082T (ru) |
RU (2) | RU2551963C2 (ru) |
SG (3) | SG188313A1 (ru) |
SI (1) | SI2614082T1 (ru) |
TW (4) | TWI520969B (ru) |
WO (1) | WO2012032433A1 (ru) |
ZA (1) | ZA201502914B (ru) |
Families Citing this family (332)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2551963C2 (ru) * | 2010-09-09 | 2015-06-10 | Пфайзер Инк. | Молекулы, связывающиеся с 4-1вв |
WO2012145183A2 (en) * | 2011-04-19 | 2012-10-26 | Pfizer Inc. | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
AU2013268418B2 (en) | 2012-05-30 | 2017-12-07 | Chugai Seiyaku Kabushiki Kaisha | Target-tissue-specific antigen-binding molecule |
US9834610B2 (en) * | 2013-01-31 | 2017-12-05 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector T cells |
US9944992B2 (en) | 2013-03-15 | 2018-04-17 | The University Of Chicago | Methods and compositions related to T-cell activity |
EP2982689B1 (en) | 2013-04-02 | 2020-08-26 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
US10781242B2 (en) | 2013-09-24 | 2020-09-22 | Medicenna Therapeutics Inc. | Interleukin-2 fusion proteins and uses thereof |
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WO2015083764A1 (ja) | 2013-12-04 | 2015-06-11 | 中外製薬株式会社 | 化合物の濃度に応じて抗原結合能の変化する抗原結合分子及びそのライブラリ |
DK3466949T3 (da) | 2013-12-24 | 2021-03-15 | Bristol Myers Squibb Co | Tricyklisk forbindelse som anticancermidler |
TW201613635A (en) | 2014-02-04 | 2016-04-16 | Pfizer | Combination of a PD-1 antagonist and a 4-1BB agonist for treating cancer |
KR101503341B1 (ko) | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
EP3134102B1 (en) | 2014-04-24 | 2019-07-03 | The Board of Trustees of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
WO2015179236A1 (en) | 2014-05-21 | 2015-11-26 | Pfizer Inc. | Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer |
WO2015188085A1 (en) | 2014-06-06 | 2015-12-10 | Flexus Biosciences, Inc. | Immunoregulatory agents |
HUE047385T2 (hu) | 2014-06-06 | 2020-04-28 | Bristol Myers Squibb Co | Antitestek glükokortikoid indukált tumornekrózis faktor receptor (GITR) ellen és annak felhasználásai |
WO2016032927A1 (en) | 2014-08-25 | 2016-03-03 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
CA2964276A1 (en) | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
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