BR112022012918A2 - Variantes de enzima de exaustão de metiltioadenosina/adenosina humana melhorada para terapia do câncer - Google Patents

Variantes de enzima de exaustão de metiltioadenosina/adenosina humana melhorada para terapia do câncer

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Publication number
BR112022012918A2
BR112022012918A2 BR112022012918A BR112022012918A BR112022012918A2 BR 112022012918 A2 BR112022012918 A2 BR 112022012918A2 BR 112022012918 A BR112022012918 A BR 112022012918A BR 112022012918 A BR112022012918 A BR 112022012918A BR 112022012918 A2 BR112022012918 A2 BR 112022012918A2
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Brazil
Prior art keywords
adenosine
variants
enzyme
exhaust
cancer therapy
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BR112022012918A
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English (en)
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Stone Everett
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Univ Texas
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02028—S-Methyl-5'-thioadenosine phosphorylase (2.4.2.28)

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Abstract

VARIANTES DE ENZIMA DE EXAUSTÃO DE METILTIOADENOSINA/ADENOSINA HUMANA MELHORADA PARA TERAPIA DO CÂNCER. A presente invenção refere-se a composições relacionadas a polipeptídeos conjugados com atividade enzimática de degradação de MTA/ADO. Os polipeptídeos conjugados são projetados para permitir a conjugação máxima, mantendo as atividades catalíticas. Também são divulgados ácidos nucleicos, vetores de expressão e células hospedeiras relacionadas aos polipeptídeos conjugados. São ainda divulgados métodos de utilização das formulações farmacêuticas que compreendem acima para tratar o câncer.
BR112022012918A 2020-01-07 2021-01-06 Variantes de enzima de exaustão de metiltioadenosina/adenosina humana melhorada para terapia do câncer BR112022012918A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062958161P 2020-01-07 2020-01-07
PCT/US2021/012291 WO2021141977A1 (en) 2020-01-07 2021-01-06 Improved human methyl thioadenosine/adenosine depleting enzyme variants for cancer therapy

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BR112022012918A2 true BR112022012918A2 (pt) 2022-09-06

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US (2) US11396647B2 (pt)
EP (1) EP4087922A4 (pt)
JP (1) JP2023509516A (pt)
KR (1) KR20220124718A (pt)
CN (1) CN115244175A (pt)
AU (1) AU2021206202A1 (pt)
BR (1) BR112022012918A2 (pt)
CA (1) CA3161733A1 (pt)
IL (1) IL294557A (pt)
MX (1) MX2022008412A (pt)
WO (1) WO2021141977A1 (pt)

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BR112022012918A2 (pt) 2020-01-07 2022-09-06 Univ Texas Variantes de enzima de exaustão de metiltioadenosina/adenosina humana melhorada para terapia do câncer
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US20220042001A1 (en) 2022-02-10
EP4087922A1 (en) 2022-11-16
WO2021141977A1 (en) 2021-07-15
CN115244175A (zh) 2022-10-25
KR20220124718A (ko) 2022-09-14
US11591579B2 (en) 2023-02-28
IL294557A (en) 2022-09-01
US11396647B2 (en) 2022-07-26
EP4087922A4 (en) 2024-01-10
MX2022008412A (es) 2022-08-08
WO2021141977A8 (en) 2021-08-19
AU2021206202A1 (en) 2022-06-30
US20220047683A1 (en) 2022-02-17
JP2023509516A (ja) 2023-03-08
CA3161733A1 (en) 2021-05-15

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