NO307053B1 - 0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivatene - Google Patents
0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivateneInfo
- Publication number
- NO307053B1 NO307053B1 NO951312A NO951312A NO307053B1 NO 307053 B1 NO307053 B1 NO 307053B1 NO 951312 A NO951312 A NO 951312A NO 951312 A NO951312 A NO 951312A NO 307053 B1 NO307053 B1 NO 307053B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- derivatives
- well
- pharmaceutical preparations
- preparations containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Dental Preparations (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929221220A GB9221220D0 (en) | 1992-10-09 | 1992-10-09 | Organic componds |
PCT/EP1993/002604 WO1994009010A1 (en) | 1992-10-09 | 1993-09-24 | O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants |
Publications (3)
Publication Number | Publication Date |
---|---|
NO951312D0 NO951312D0 (no) | 1995-04-05 |
NO951312L NO951312L (no) | 1995-06-08 |
NO307053B1 true NO307053B1 (no) | 2000-01-31 |
Family
ID=10723188
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951312A NO307053B1 (no) | 1992-10-09 | 1995-04-05 | 0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivatene |
NO2004001C NO2004001I2 (no) | 1992-10-09 | 2004-03-24 | 40-0-(2-hydroksy)etyl rapamycin (everolimus) |
NO2017067C NO2017067I2 (no) | 1992-10-09 | 2017-12-07 | Everolimus - forlenget SPC |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2004001C NO2004001I2 (no) | 1992-10-09 | 2004-03-24 | 40-0-(2-hydroksy)etyl rapamycin (everolimus) |
NO2017067C NO2017067I2 (no) | 1992-10-09 | 2017-12-07 | Everolimus - forlenget SPC |
Country Status (28)
Country | Link |
---|---|
US (2) | US5665772A (sk) |
EP (3) | EP1413581A1 (sk) |
JP (2) | JP3117462B2 (sk) |
KR (2) | KR100308598B1 (sk) |
AT (2) | ATE272063T1 (sk) |
AU (1) | AU676198B2 (sk) |
BR (1) | BR1100353A (sk) |
CA (2) | CA2145383C (sk) |
CY (2) | CY2125B1 (sk) |
CZ (1) | CZ283333B6 (sk) |
DE (3) | DE69333577T2 (sk) |
DK (2) | DK0867438T3 (sk) |
ES (2) | ES2124793T3 (sk) |
FI (2) | FI109540B (sk) |
FR (1) | FR04C0012I2 (sk) |
GB (1) | GB9221220D0 (sk) |
GE (1) | GEP20002331B (sk) |
HU (1) | HU224074B1 (sk) |
LU (1) | LU91104I2 (sk) |
NL (1) | NL300154I2 (sk) |
NO (3) | NO307053B1 (sk) |
NZ (1) | NZ256026A (sk) |
PL (1) | PL176174B1 (sk) |
PT (1) | PT867438E (sk) |
RO (1) | RO114451B1 (sk) |
RU (1) | RU2143434C1 (sk) |
SK (2) | SK285256B6 (sk) |
WO (1) | WO1994009010A1 (sk) |
Families Citing this family (422)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA935111B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
ZA935110B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
JPH08509499A (ja) | 1993-04-23 | 1996-10-08 | アボツト・ラボラトリーズ | ラパマイシン結合体及び抗体 |
USRE37421E1 (en) | 1993-07-16 | 2001-10-23 | Smithkline Beecham Corporation | Rapamycin derivatives |
SI1033128T2 (sl) * | 1993-09-28 | 2012-02-29 | Scherer Gmbh R P | Izdelava mehke Ĺľelatinaste kapsule |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
JP4105761B2 (ja) * | 1993-11-19 | 2008-06-25 | アボット・ラボラトリーズ | ラパミシン(マクロライド)の半合成類似体免疫調節剤 |
WO1995016691A1 (en) * | 1993-12-17 | 1995-06-22 | Sandoz Ltd. | Rapamycin derivatives useful as immunosuppressants |
GB9405350D0 (en) * | 1994-03-18 | 1994-05-04 | Sandoz Ltd | Organic compounds |
CZ289773B6 (cs) * | 1994-10-26 | 2002-04-17 | Novartis Ag | Farmaceutický prostředek pro místní aplikaci |
US7205279B2 (en) * | 1995-10-25 | 2007-04-17 | Novartis Ag | Pharmaceutical compositions |
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US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
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US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
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FR2736550B1 (fr) * | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
GB9606452D0 (en) * | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
KR100616020B1 (ko) * | 1996-03-27 | 2007-01-31 | 노파르티스 아게 | 맥관장애및이종이식술에서의라파마이신유도체의용도 |
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US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
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US20050031611A1 (en) * | 1998-05-08 | 2005-02-10 | Beth Israel Deaconess Medical Center | Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis |
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ATE474590T1 (de) | 1999-05-10 | 2010-08-15 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
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US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
DE60142677D1 (de) | 2000-01-14 | 2010-09-09 | Univ Pennsylvania | O-methylierte rapamycinderivate zur milderung oder vermeidung lymphoproliferativer erkrankungen |
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US5378836A (en) * | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
WO1995016691A1 (en) * | 1993-12-17 | 1995-06-22 | Sandoz Ltd. | Rapamycin derivatives useful as immunosuppressants |
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1992
- 1992-10-09 GB GB929221220A patent/GB9221220D0/en active Pending
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1993
- 1993-09-24 ES ES93920822T patent/ES2124793T3/es not_active Expired - Lifetime
- 1993-09-24 DE DE69333577T patent/DE69333577T2/de not_active Expired - Lifetime
- 1993-09-24 ES ES97114343T patent/ES2225919T3/es not_active Expired - Lifetime
- 1993-09-24 CA CA002145383A patent/CA2145383C/en not_active Expired - Lifetime
- 1993-09-24 DE DE69322282T patent/DE69322282T2/de not_active Expired - Lifetime
- 1993-09-24 GE GEAP19932516A patent/GEP20002331B/en unknown
- 1993-09-24 JP JP06509552A patent/JP3117462B2/ja not_active Expired - Lifetime
- 1993-09-24 CZ CZ95899A patent/CZ283333B6/cs not_active IP Right Cessation
- 1993-09-24 EP EP20030028783 patent/EP1413581A1/en not_active Ceased
- 1993-09-24 AU AU48192/93A patent/AU676198B2/en not_active Expired
- 1993-09-24 AT AT97114343T patent/ATE272063T1/de active
- 1993-09-24 KR KR1019950701346A patent/KR100308598B1/ko not_active IP Right Cessation
- 1993-09-24 EP EP97114343A patent/EP0867438B1/en not_active Expired - Lifetime
- 1993-09-24 PT PT97114343T patent/PT867438E/pt unknown
- 1993-09-24 HU HU9501016A patent/HU224074B1/hu active Protection Beyond IP Right Term
- 1993-09-24 SK SK465-95A patent/SK285256B6/sk not_active IP Right Cessation
- 1993-09-24 AT AT93920822T patent/ATE173736T1/de active
- 1993-09-24 DE DE1993622282 patent/DE122004000033I2/de active Active
- 1993-09-24 US US08/416,673 patent/US5665772A/en not_active Expired - Lifetime
- 1993-09-24 SK SK49-2006A patent/SK286054B6/sk not_active IP Right Cessation
- 1993-09-24 NZ NZ256026A patent/NZ256026A/en not_active IP Right Cessation
- 1993-09-24 WO PCT/EP1993/002604 patent/WO1994009010A1/en active Application Filing
- 1993-09-24 DK DK97114343T patent/DK0867438T3/da active
- 1993-09-24 EP EP93920822A patent/EP0663916B1/en not_active Expired - Lifetime
- 1993-09-24 CA CA002476257A patent/CA2476257C/en not_active Expired - Lifetime
- 1993-09-24 RU RU95110053A patent/RU2143434C1/ru active Protection Beyond IP Right Term
- 1993-09-24 DK DK93920822T patent/DK0663916T3/da active
- 1993-09-24 RO RO95-00686A patent/RO114451B1/ro unknown
-
1995
- 1995-03-23 PL PL93308268A patent/PL176174B1/pl unknown
- 1995-04-05 NO NO951312A patent/NO307053B1/no not_active IP Right Cessation
- 1995-04-07 FI FI951678A patent/FI109540B/fi active Protection Beyond IP Right Term
-
1997
- 1997-04-24 BR BR1100353-7A patent/BR1100353A/pt active IP Right Grant
- 1997-05-23 US US08/862,911 patent/US6440990B1/en not_active Expired - Fee Related
-
1998
- 1998-10-29 JP JP30835598A patent/JP3568800B2/ja not_active Expired - Lifetime
-
1999
- 1999-01-08 CY CY9900001A patent/CY2125B1/xx unknown
-
2000
- 2000-09-04 FI FI20001943A patent/FI20001943A/fi unknown
-
2001
- 2001-01-17 KR KR1020017000705A patent/KR100307831B1/ko not_active IP Right Cessation
-
2004
- 2004-03-24 NO NO2004001C patent/NO2004001I2/no unknown
- 2004-04-30 FR FR04C0012C patent/FR04C0012I2/fr active Active
- 2004-07-13 NL NL300154C patent/NL300154I2/nl unknown
- 2004-09-29 LU LU91104C patent/LU91104I2/xx unknown
-
2016
- 2016-07-14 CY CY2005010C patent/CY2005010I2/el unknown
-
2017
- 2017-12-07 NO NO2017067C patent/NO2017067I2/no unknown
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