ATE418559T1 - Verfahren zur herstellung von o-alkylierten rapamycinderivaten - Google Patents
Verfahren zur herstellung von o-alkylierten rapamycinderivatenInfo
- Publication number
- ATE418559T1 ATE418559T1 AT05003238T AT05003238T ATE418559T1 AT E418559 T1 ATE418559 T1 AT E418559T1 AT 05003238 T AT05003238 T AT 05003238T AT 05003238 T AT05003238 T AT 05003238T AT E418559 T1 ATE418559 T1 AT E418559T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- reaction
- rapamycin derivatives
- alkylrapamycin
- alkylated rapamycin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000010934 O-alkylation reaction Methods 0.000 abstract 1
- 125000004945 acylaminoalkyl group Chemical group 0.000 abstract 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 alkyl triflate Chemical compound 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004056233 | 2004-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE418559T1 true ATE418559T1 (de) | 2009-01-15 |
Family
ID=34747599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05003238T ATE418559T1 (de) | 2004-03-01 | 2005-02-16 | Verfahren zur herstellung von o-alkylierten rapamycinderivaten |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7193078B2 (de) |
| EP (1) | EP1571151B1 (de) |
| JP (2) | JP4267053B2 (de) |
| AT (1) | ATE418559T1 (de) |
| DE (1) | DE602005011879D1 (de) |
| ES (1) | ES2315745T3 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1296391A4 (de) | 2001-03-22 | 2006-06-28 | Matsushita Electric Industrial Co Ltd | Positif-elektroden-aktivmaterial und dieses enthaltende nichtwässrige-elektrolyt-sekundärbatterie |
| JP4510331B2 (ja) | 2001-06-27 | 2010-07-21 | パナソニック株式会社 | 非水電解質二次電池 |
| JP3827545B2 (ja) | 2001-09-13 | 2006-09-27 | 松下電器産業株式会社 | 正極活物質、その製造方法および非水電解質二次電池 |
| US8658125B2 (en) | 2001-10-25 | 2014-02-25 | Panasonic Corporation | Positive electrode active material and non-aqueous electrolyte secondary battery containing the same |
| US8241790B2 (en) | 2002-08-05 | 2012-08-14 | Panasonic Corporation | Positive electrode active material and non-aqueous electrolyte secondary battery containing the same |
| CN101522691B (zh) * | 2006-11-27 | 2012-08-22 | 泰尔茂株式会社 | O-烷基化雷帕霉素衍生物的制备方法及o-烷基化雷帕霉素衍生物 |
| US20110098241A1 (en) * | 2008-04-14 | 2011-04-28 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
| TW200948361A (en) * | 2008-05-26 | 2009-12-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Method for synthesizing Biolimus A9 and the like and method for improving stability of the same |
| KR101200210B1 (ko) * | 2009-11-10 | 2012-11-09 | 가톨릭대학교 산학협력단 | 광감작제가 코팅된 의료용 스텐트 및 이의 제조방법 |
| WO2011059216A2 (ko) * | 2009-11-10 | 2011-05-19 | 가톨릭대학교 산학협력단 | 광감작제가 코팅된 의료용 스텐트 및 이의 제조방법 |
| US9321782B2 (en) | 2010-08-04 | 2016-04-26 | Meril Life Sciences Pvt. Ltd. | Process for preparation of novel 42-O-(heteroalkoxyalkyl) rapamicin compounds with anti-proliferative properties |
| CN102174053B (zh) * | 2011-03-09 | 2014-04-16 | 成都雅途生物技术有限公司 | 依维莫司的纯化方法 |
| EP2589383A1 (de) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen |
| WO2014116611A1 (en) * | 2013-01-22 | 2014-07-31 | Biosensors International Group, Ltd. | Low temperature synthesis of rapamycin derivatives |
| KR20160021243A (ko) | 2013-06-20 | 2016-02-24 | 노파르티스 아게 | 알킬 플루오로알킬 술포네이트를 사용한 알킬화 |
| WO2016040806A1 (en) | 2014-09-11 | 2016-03-17 | The Regents Of The University Of California | mTORC1 INHIBITORS |
| FI3788049T3 (fi) | 2018-05-01 | 2023-05-30 | Revolution Medicines Inc | C40-, c28- ja c-32-liittyneitä rapamysiinianalogeja mtor-estäjinä |
| MX2020011564A (es) | 2018-05-01 | 2021-01-29 | Revolution Medicines Inc | Analogos de rapamicina unidos a c26 como inhibidores de mtor. |
| CN108676014A (zh) * | 2018-06-15 | 2018-10-19 | 国药集团川抗制药有限公司 | 纯化依维莫司中间体的方法以及制备依维莫司的方法 |
| TW202402277A (zh) | 2022-05-25 | 2024-01-16 | 美商銳新醫藥公司 | 以mtor抑制劑治療癌症之方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
| US7303758B2 (en) * | 2004-01-20 | 2007-12-04 | Cordis Corporation | Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury |
-
2005
- 2005-02-16 AT AT05003238T patent/ATE418559T1/de not_active IP Right Cessation
- 2005-02-16 DE DE200560011879 patent/DE602005011879D1/de not_active Expired - Lifetime
- 2005-02-16 ES ES05003238T patent/ES2315745T3/es not_active Expired - Lifetime
- 2005-02-16 EP EP20050003238 patent/EP1571151B1/de not_active Expired - Lifetime
- 2005-03-01 US US11/067,718 patent/US7193078B2/en not_active Expired - Lifetime
-
2007
- 2007-03-19 US US11/723,367 patent/US20070160646A1/en not_active Abandoned
-
2008
- 2008-05-19 JP JP2008130382A patent/JP4267053B2/ja not_active Expired - Lifetime
- 2008-12-25 JP JP2008329108A patent/JP5004941B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005011879D1 (de) | 2009-02-05 |
| ES2315745T3 (es) | 2009-04-01 |
| US20070160646A1 (en) | 2007-07-12 |
| US7193078B2 (en) | 2007-03-20 |
| US20050192311A1 (en) | 2005-09-01 |
| JP4267053B2 (ja) | 2009-05-27 |
| JP2008273976A (ja) | 2008-11-13 |
| JP5004941B2 (ja) | 2012-08-22 |
| JP2009136686A (ja) | 2009-06-25 |
| EP1571151B1 (de) | 2008-12-24 |
| EP1571151A1 (de) | 2005-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |