CN102174053B - 依维莫司的纯化方法 - Google Patents
依维莫司的纯化方法 Download PDFInfo
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- CN102174053B CN102174053B CN201110055086.4A CN201110055086A CN102174053B CN 102174053 B CN102174053 B CN 102174053B CN 201110055086 A CN201110055086 A CN 201110055086A CN 102174053 B CN102174053 B CN 102174053B
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- everolimus
- rapamycin
- ethanol
- obtains
- purifying
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201110055086.4A CN102174053B (zh) | 2011-03-09 | 2011-03-09 | 依维莫司的纯化方法 |
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CN201110055086.4A CN102174053B (zh) | 2011-03-09 | 2011-03-09 | 依维莫司的纯化方法 |
Publications (2)
Publication Number | Publication Date |
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CN102174053A CN102174053A (zh) | 2011-09-07 |
CN102174053B true CN102174053B (zh) | 2014-04-16 |
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CN201110055086.4A Active CN102174053B (zh) | 2011-03-09 | 2011-03-09 | 依维莫司的纯化方法 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103360411B (zh) * | 2013-07-17 | 2015-09-30 | 成都雅途生物技术有限公司 | 依维莫司结晶提纯方法 |
CN104892632B (zh) * | 2015-06-03 | 2017-12-26 | 道中道(菏泽)制药有限公司 | 一种晶体形式的依维莫司及其制备方法 |
CN108676014A (zh) * | 2018-06-15 | 2018-10-19 | 国药集团川抗制药有限公司 | 纯化依维莫司中间体的方法以及制备依维莫司的方法 |
JP2023028473A (ja) * | 2021-08-19 | 2023-03-03 | 日本マイクロバイオファーマ株式会社 | エベロリムスの製造方法 |
CN116813642B (zh) * | 2023-06-29 | 2024-04-19 | 浙江康润制药有限公司 | 一种依维莫司纯化方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994009010A1 (en) * | 1992-10-09 | 1994-04-28 | Sandoz Ltd. | O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants |
US20020128470A1 (en) * | 1996-09-11 | 2002-09-12 | Peter Fuenfschilling | Purification process |
CN1856500A (zh) * | 2003-07-24 | 2006-11-01 | 特瓦药厂私人有限公司 | 纯化大环内酯类化合物的方法 |
US7193078B2 (en) * | 2004-03-01 | 2007-03-20 | Terumo Kabushiki Kaisha | Process for production of O-alkylated rapamycin derivatives |
CN100369920C (zh) * | 2003-03-31 | 2008-02-20 | 特瓦药厂私人有限公司 | 大环内酯物质的结晶与纯化 |
CN101522691A (zh) * | 2006-11-27 | 2009-09-02 | 泰尔茂株式会社 | O-烷基化雷帕霉素衍生物的制备方法及o-烷基化雷帕霉素衍生物 |
-
2011
- 2011-03-09 CN CN201110055086.4A patent/CN102174053B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994009010A1 (en) * | 1992-10-09 | 1994-04-28 | Sandoz Ltd. | O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants |
US5665772A (en) * | 1992-10-09 | 1997-09-09 | Sandoz Ltd. | O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants |
US20020128470A1 (en) * | 1996-09-11 | 2002-09-12 | Peter Fuenfschilling | Purification process |
CN100369920C (zh) * | 2003-03-31 | 2008-02-20 | 特瓦药厂私人有限公司 | 大环内酯物质的结晶与纯化 |
CN1856500A (zh) * | 2003-07-24 | 2006-11-01 | 特瓦药厂私人有限公司 | 纯化大环内酯类化合物的方法 |
US7193078B2 (en) * | 2004-03-01 | 2007-03-20 | Terumo Kabushiki Kaisha | Process for production of O-alkylated rapamycin derivatives |
CN101522691A (zh) * | 2006-11-27 | 2009-09-02 | 泰尔茂株式会社 | O-烷基化雷帕霉素衍生物的制备方法及o-烷基化雷帕霉素衍生物 |
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CN102174053A (zh) | 2011-09-07 |
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ASS | Succession or assignment of patent right |
Owner name: SICHUAN NUOYI BIOPHARMACEUTICAL CO., LTD. Effective date: 20111212 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20111212 Address after: 610041, Sichuan, Chengdu Tianfu Road South extension high-tech incubator Park Building No. A-D07 Applicant after: Chengdu Yatu Biotechnology Co., Ltd. Co-applicant after: Sichuan Connaught Biological Pharmaceutical Co., Ltd. Address before: 610041, Sichuan, Chengdu Tianfu Road South extension high-tech incubator Park Building No. A-D07 Applicant before: Chengdu Yatu Biotechnology Co., Ltd. |
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