DE602005011879D1 - Verfahren zur Herstellung von O-alkylierten Rapamycinderivaten - Google Patents
Verfahren zur Herstellung von O-alkylierten RapamycinderivatenInfo
- Publication number
- DE602005011879D1 DE602005011879D1 DE200560011879 DE602005011879T DE602005011879D1 DE 602005011879 D1 DE602005011879 D1 DE 602005011879D1 DE 200560011879 DE200560011879 DE 200560011879 DE 602005011879 T DE602005011879 T DE 602005011879T DE 602005011879 D1 DE602005011879 D1 DE 602005011879D1
- Authority
- DE
- Germany
- Prior art keywords
- reaction
- preparation
- rapamycin derivatives
- alkylrapamycin
- alkylated rapamycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004056233 | 2004-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005011879D1 true DE602005011879D1 (de) | 2009-02-05 |
Family
ID=34747599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE200560011879 Active DE602005011879D1 (de) | 2004-03-01 | 2005-02-16 | Verfahren zur Herstellung von O-alkylierten Rapamycinderivaten |
Country Status (6)
Country | Link |
---|---|
US (2) | US7193078B2 (de) |
EP (1) | EP1571151B1 (de) |
JP (2) | JP4267053B2 (de) |
AT (1) | ATE418559T1 (de) |
DE (1) | DE602005011879D1 (de) |
ES (1) | ES2315745T3 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4080337B2 (ja) | 2001-03-22 | 2008-04-23 | 松下電器産業株式会社 | 正極活物質およびこれを含む非水電解質二次電池 |
JP4510331B2 (ja) | 2001-06-27 | 2010-07-21 | パナソニック株式会社 | 非水電解質二次電池 |
US8658125B2 (en) | 2001-10-25 | 2014-02-25 | Panasonic Corporation | Positive electrode active material and non-aqueous electrolyte secondary battery containing the same |
US8241790B2 (en) | 2002-08-05 | 2012-08-14 | Panasonic Corporation | Positive electrode active material and non-aqueous electrolyte secondary battery containing the same |
EP2090580B1 (de) * | 2006-11-27 | 2014-06-04 | Terumo Kabushiki Kaisha | Verfahren zur herstellung eines o-alkylierten rapamycinderivats, und o-alkyliertes rapamycinderivat |
WO2009131631A1 (en) * | 2008-04-14 | 2009-10-29 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
TW200948361A (en) * | 2008-05-26 | 2009-12-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Method for synthesizing Biolimus A9 and the like and method for improving stability of the same |
WO2011059216A2 (ko) * | 2009-11-10 | 2011-05-19 | 가톨릭대학교 산학협력단 | 광감작제가 코팅된 의료용 스텐트 및 이의 제조방법 |
KR101200210B1 (ko) * | 2009-11-10 | 2012-11-09 | 가톨릭대학교 산학협력단 | 광감작제가 코팅된 의료용 스텐트 및 이의 제조방법 |
CN103140494A (zh) | 2010-08-04 | 2013-06-05 | 美利奴生命科学有限公司 | 制备具有抗增殖特性的新的42-o-(杂烷氧基烷基)雷帕霉素化合物的方法 |
CN102174053B (zh) * | 2011-03-09 | 2014-04-16 | 成都雅途生物技术有限公司 | 依维莫司的纯化方法 |
EP2589383A1 (de) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen |
ES2645951T3 (es) * | 2013-01-22 | 2017-12-11 | Biosensors International Group, Ltd. | Síntesis a baja temperatura de derivados de rapamicina |
CN109651396B (zh) | 2013-06-20 | 2021-09-14 | 诺华股份有限公司 | 氟代烷基磺酸烷基酯的烷基化 |
CN113620978A (zh) | 2014-09-11 | 2021-11-09 | 加利福尼亚大学董事会 | mTORC1抑制剂 |
WO2019212990A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
JP7381492B2 (ja) | 2018-05-01 | 2023-11-15 | レヴォリューション・メディスンズ,インコーポレイテッド | Mtor阻害剤としてのc26-連結ラパマイシン類似体 |
CN108676014A (zh) * | 2018-06-15 | 2018-10-19 | 国药集团川抗制药有限公司 | 纯化依维莫司中间体的方法以及制备依维莫司的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
US7303758B2 (en) * | 2004-01-20 | 2007-12-04 | Cordis Corporation | Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury |
-
2005
- 2005-02-16 EP EP20050003238 patent/EP1571151B1/de active Active
- 2005-02-16 AT AT05003238T patent/ATE418559T1/de not_active IP Right Cessation
- 2005-02-16 ES ES05003238T patent/ES2315745T3/es active Active
- 2005-02-16 DE DE200560011879 patent/DE602005011879D1/de active Active
- 2005-03-01 US US11/067,718 patent/US7193078B2/en active Active
-
2007
- 2007-03-19 US US11/723,367 patent/US20070160646A1/en not_active Abandoned
-
2008
- 2008-05-19 JP JP2008130382A patent/JP4267053B2/ja active Active
- 2008-12-25 JP JP2008329108A patent/JP5004941B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
ATE418559T1 (de) | 2009-01-15 |
EP1571151B1 (de) | 2008-12-24 |
US20070160646A1 (en) | 2007-07-12 |
JP2008273976A (ja) | 2008-11-13 |
US7193078B2 (en) | 2007-03-20 |
ES2315745T3 (es) | 2009-04-01 |
JP5004941B2 (ja) | 2012-08-22 |
JP2009136686A (ja) | 2009-06-25 |
EP1571151A1 (de) | 2005-09-07 |
US20050192311A1 (en) | 2005-09-01 |
JP4267053B2 (ja) | 2009-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |