ATE353877T1 - Verfahren zur herstellung von monoifluorierten pyridinyl- und pyrimidinyl-beta-ketoestern - Google Patents
Verfahren zur herstellung von monoifluorierten pyridinyl- und pyrimidinyl-beta-ketoesternInfo
- Publication number
- ATE353877T1 ATE353877T1 AT04717645T AT04717645T ATE353877T1 AT E353877 T1 ATE353877 T1 AT E353877T1 AT 04717645 T AT04717645 T AT 04717645T AT 04717645 T AT04717645 T AT 04717645T AT E353877 T1 ATE353877 T1 AT E353877T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridinyl
- keto esters
- pyrimidinyl
- monoifluorinated
- beta
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 PYRIMIDINYL Chemical class 0.000 title 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 title 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290568A EP1454900A1 (de) | 2003-03-07 | 2003-03-07 | Verfahren zur herstellung von pyridinyl und pyrimidinyl mono-fluorierten beta-keto Estern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353877T1 true ATE353877T1 (de) | 2007-03-15 |
Family
ID=32799102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04717645T ATE353877T1 (de) | 2003-03-07 | 2004-03-05 | Verfahren zur herstellung von monoifluorierten pyridinyl- und pyrimidinyl-beta-ketoestern |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7135569B2 (de) |
| EP (2) | EP1454900A1 (de) |
| JP (1) | JP4805809B2 (de) |
| CN (1) | CN100398518C (de) |
| AT (1) | ATE353877T1 (de) |
| DE (1) | DE602004004767T2 (de) |
| ES (1) | ES2281786T3 (de) |
| RU (1) | RU2330844C2 (de) |
| WO (1) | WO2004078725A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| EP2314289A1 (de) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU556140A1 (ru) * | 1975-01-06 | 1977-04-30 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср | (1-Оксоинданил-2)-пиридины в качестве промежуточных продуктов дл синтеза биологически активных соединений с способ их получени |
| WO1999003802A1 (en) * | 1997-07-18 | 1999-01-28 | F2 Chemicals Limited | Catalysed fluorination of carbonyl compounds |
| US6455728B1 (en) * | 1999-11-01 | 2002-09-24 | Air Products And Chemicals, Inc. | Direct fluorination process for preparing high purity 2-fluoro-1,3-dicarbonyl compounds using oxygen as a radical scavenger |
| EP1295885A1 (de) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | Substituierte 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-on- und 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)onderivate |
| EP1295884A1 (de) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)on Derivate |
| NZ531243A (en) * | 2001-09-21 | 2006-08-31 | Sanofi Aventis | Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-A]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-A]pyrimidin-5(1H)one derivatives |
-
2003
- 2003-03-07 EP EP03290568A patent/EP1454900A1/de not_active Withdrawn
-
2004
- 2004-03-05 ES ES04717645T patent/ES2281786T3/es not_active Expired - Lifetime
- 2004-03-05 EP EP04717645A patent/EP1603876B1/de not_active Expired - Lifetime
- 2004-03-05 AT AT04717645T patent/ATE353877T1/de not_active IP Right Cessation
- 2004-03-05 WO PCT/EP2004/003052 patent/WO2004078725A1/en not_active Ceased
- 2004-03-05 DE DE602004004767T patent/DE602004004767T2/de not_active Expired - Lifetime
- 2004-03-05 JP JP2006504814A patent/JP4805809B2/ja not_active Expired - Fee Related
- 2004-03-05 RU RU2005131007/04A patent/RU2330844C2/ru not_active IP Right Cessation
- 2004-03-05 CN CNB200480009687XA patent/CN100398518C/zh not_active Expired - Fee Related
-
2005
- 2005-09-07 US US11/221,023 patent/US7135569B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN100398518C (zh) | 2008-07-02 |
| US7135569B2 (en) | 2006-11-14 |
| EP1603876B1 (de) | 2007-02-14 |
| ES2281786T3 (es) | 2007-10-01 |
| EP1603876A1 (de) | 2005-12-14 |
| CN1771229A (zh) | 2006-05-10 |
| DE602004004767T2 (de) | 2007-12-06 |
| RU2005131007A (ru) | 2006-06-27 |
| JP4805809B2 (ja) | 2011-11-02 |
| RU2330844C2 (ru) | 2008-08-10 |
| WO2004078725A1 (en) | 2004-09-16 |
| EP1454900A1 (de) | 2004-09-08 |
| DE602004004767D1 (de) | 2007-03-29 |
| JP2006519815A (ja) | 2006-08-31 |
| US20060058526A1 (en) | 2006-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE371657T1 (de) | Verfahren zur herstellung kondensierter oxazinone aus einer aromatischen ortho-aminocarbonsäure und einer carbonsäure in gegenwart eines sulfonylchlorids und pyridin | |
| RU2009105669A (ru) | Способ получения 3-замещенных 2-амино-5-галогенбензамидов | |
| ATE422200T1 (de) | Verfahren zur herstellung substituierter nikotinsäureester | |
| SE9904850D0 (sv) | Novel process and intermediates | |
| MA29464B1 (fr) | Methode de preparation d'acides 1,6-dihydro-6-oxo-4-pyrimidinecarboxyliques eventuellement 2-substitues | |
| WO2008126943A3 (en) | Method for manufacturing neuraminic acid derivatives | |
| DE60233664D1 (de) | Verfahren zur herstellung von pyridinverbindungen | |
| ATE353877T1 (de) | Verfahren zur herstellung von monoifluorierten pyridinyl- und pyrimidinyl-beta-ketoestern | |
| ATE517096T1 (de) | Verfahren zur herstellung von aminopyrimidinen | |
| ATE343385T1 (de) | Verfahren zur herstellung von donepezil | |
| ATE319701T1 (de) | Prozess für die herstellung von 2-(6- substituierten-1,3-dioxan-4-yl) essigsäure derivaten | |
| ATE29883T1 (de) | 5-alkyl-1,6-naphthyridin-2(1h)-one, zwischenprodukte, ihre herstellung und ihre verwendung als cardiotonica. | |
| ATE255103T1 (de) | Verfahren zur herstellung von pyridinmethanol- verbindungen | |
| ATE496907T1 (de) | Verfahren zur herstellung von cilostazol | |
| DE60122539D1 (de) | Neues verfahren zur herstellung einer chinolon-carbonsäure | |
| MEP1708A (xx) | Postupak proizvodnje thip-a | |
| DE602004020050D1 (de) | Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte | |
| ATE553081T1 (de) | Verfahren zur herstellung einer bakteriziden pyridinverbindung, und bakterizide pyridinverbindung | |
| ATE465999T1 (de) | Verfahren zur herstellung substituierter pyrimidine | |
| ATE346845T1 (de) | Ein verfahren zur herstellung substituierter alkylamin-derivate | |
| DE602004028820D1 (de) | Methansulfonsäuresalz einer pyrazolopyrimidinverbindung, kristall davon und verfahren zu deren herstellung | |
| DE60004054D1 (de) | Neue verfahren zur herstellung von 17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstane-3-on | |
| DE60336739D1 (de) | Verfahren zur herstellung eines 2-substituierten pyridinderivats | |
| AU2003213386A1 (en) | Process for production of optically active compounds | |
| DE60008561D1 (de) | Verfahren zur herstellung von oxazol-derivaten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |