FI109540B - Menetelmä terapeuttisesti käyttökelpoisen 40-0-(2-hydroksietyyli) -rapamysiinin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen 40-0-(2-hydroksietyyli) -rapamysiinin valmistamiseksi Download PDF

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Publication number
FI109540B
FI109540B FI951678A FI951678A FI109540B FI 109540 B FI109540 B FI 109540B FI 951678 A FI951678 A FI 951678A FI 951678 A FI951678 A FI 951678A FI 109540 B FI109540 B FI 109540B
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FI
Finland
Prior art keywords
rapamycin
alkyl
compound
novel compound
binding
Prior art date
Application number
FI951678A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI951678A (fi
FI951678A0 (fi
Inventor
Sylvain Cottens
Richard Sedrani
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI951678A publication Critical patent/FI951678A/fi
Publication of FI951678A0 publication Critical patent/FI951678A0/fi
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Dental Preparations (AREA)
FI951678A 1992-10-09 1995-04-07 Menetelmä terapeuttisesti käyttökelpoisen 40-0-(2-hydroksietyyli) -rapamysiinin valmistamiseksi FI109540B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9221220 1992-10-09
GB929221220A GB9221220D0 (en) 1992-10-09 1992-10-09 Organic componds
PCT/EP1993/002604 WO1994009010A1 (en) 1992-10-09 1993-09-24 O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants
EP9302604 1993-09-24

Publications (3)

Publication Number Publication Date
FI951678A FI951678A (fi) 1995-04-07
FI951678A0 FI951678A0 (fi) 1995-04-07
FI109540B true FI109540B (fi) 2002-08-30

Family

ID=10723188

Family Applications (2)

Application Number Title Priority Date Filing Date
FI951678A FI109540B (fi) 1992-10-09 1995-04-07 Menetelmä terapeuttisesti käyttökelpoisen 40-0-(2-hydroksietyyli) -rapamysiinin valmistamiseksi
FI20001943A FI20001943A (fi) 1992-10-09 2000-09-04 O-alkyloituja rapamysiinijohdannaisia ja niiden käyttö, erityisesti immunosupressoivina aineina

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20001943A FI20001943A (fi) 1992-10-09 2000-09-04 O-alkyloituja rapamysiinijohdannaisia ja niiden käyttö, erityisesti immunosupressoivina aineina

Country Status (28)

Country Link
US (2) US5665772A (sk)
EP (3) EP0663916B1 (sk)
JP (2) JP3117462B2 (sk)
KR (2) KR100308598B1 (sk)
AT (2) ATE272063T1 (sk)
AU (1) AU676198B2 (sk)
BR (1) BR1100353A (sk)
CA (2) CA2145383C (sk)
CY (2) CY2125B1 (sk)
CZ (1) CZ283333B6 (sk)
DE (3) DE69322282T2 (sk)
DK (2) DK0867438T3 (sk)
ES (2) ES2124793T3 (sk)
FI (2) FI109540B (sk)
FR (1) FR04C0012I2 (sk)
GB (1) GB9221220D0 (sk)
GE (1) GEP20002331B (sk)
HU (1) HU224074B1 (sk)
LU (1) LU91104I2 (sk)
NL (1) NL300154I2 (sk)
NO (3) NO307053B1 (sk)
NZ (1) NZ256026A (sk)
PL (1) PL176174B1 (sk)
PT (1) PT867438E (sk)
RO (1) RO114451B1 (sk)
RU (1) RU2143434C1 (sk)
SK (2) SK286054B6 (sk)
WO (1) WO1994009010A1 (sk)

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* Cited by examiner, † Cited by third party
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