EP2254412A4 - Macrocyclic lactone compounds and methods for their use - Google Patents

Macrocyclic lactone compounds and methods for their use

Info

Publication number
EP2254412A4
EP2254412A4 EP08731883A EP08731883A EP2254412A4 EP 2254412 A4 EP2254412 A4 EP 2254412A4 EP 08731883 A EP08731883 A EP 08731883A EP 08731883 A EP08731883 A EP 08731883A EP 2254412 A4 EP2254412 A4 EP 2254412A4
Authority
EP
European Patent Office
Prior art keywords
methods
macrocyclic lactone
lactone compounds
compounds
macrocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08731883A
Other languages
German (de)
French (fr)
Other versions
EP2254412A1 (en
Inventor
John Yan
Xiaoxia Zheng
Vinayak D Bhat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elixir Medical Corp
Original Assignee
Elixir Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elixir Medical Corp filed Critical Elixir Medical Corp
Publication of EP2254412A1 publication Critical patent/EP2254412A1/en
Publication of EP2254412A4 publication Critical patent/EP2254412A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EP08731883A 2008-03-11 2008-03-11 Macrocyclic lactone compounds and methods for their use Withdrawn EP2254412A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/056501 WO2009114010A1 (en) 2008-03-11 2008-03-11 Macrocyclic lactone compounds and methods for their use

Publications (2)

Publication Number Publication Date
EP2254412A1 EP2254412A1 (en) 2010-12-01
EP2254412A4 true EP2254412A4 (en) 2012-05-09

Family

ID=41065507

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08731883A Withdrawn EP2254412A4 (en) 2008-03-11 2008-03-11 Macrocyclic lactone compounds and methods for their use

Country Status (6)

Country Link
EP (1) EP2254412A4 (en)
JP (1) JP2011525890A (en)
CN (1) CN102215682A (en)
BR (1) BRPI0822405A8 (en)
IL (1) IL208026A0 (en)
WO (1) WO2009114010A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8088789B2 (en) 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
ES2666857T3 (en) 2011-07-18 2018-05-08 Mor-Research Applications Ltd. A device to adjust intraocular pressure
CN103387572B (en) * 2013-07-17 2015-09-30 成都雅途生物技术有限公司 Everolimus defects inspecting reference marker and preparation method thereof
CN107759616B (en) * 2016-08-23 2020-11-17 上海微创医疗器械（集团）有限公司 Compound and preparation method and application thereof
US11654036B2 (en) 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use
CN113801104B (en) * 2020-06-15 2023-12-08 鲁南制药集团股份有限公司 Preparation method of hydrolysis impurity of ivermectin Mo Sida cyclic lactone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002136A1 (en) * 1992-07-17 1994-02-03 Smithkline Beecham Corporation Rapamycin derivatives
WO1994012655A1 (en) * 1992-11-20 1994-06-09 Smithkline Beecham Corporation Process for producing rapamycin derivatives
WO2008033956A2 (en) * 2006-09-13 2008-03-20 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
CN104146795B (en) * 2005-04-05 2017-11-10 万能医药公司 Degradable implantable medical devices
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
PL1904056T3 (en) * 2005-07-18 2009-09-30 Minu Llc Use of a macrolide to restore corneal sensation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002136A1 (en) * 1992-07-17 1994-02-03 Smithkline Beecham Corporation Rapamycin derivatives
US5728710A (en) * 1992-07-17 1998-03-17 Smithkline Beecham Corporation Rapamycin derivatives
WO1994012655A1 (en) * 1992-11-20 1994-06-09 Smithkline Beecham Corporation Process for producing rapamycin derivatives
WO2008033956A2 (en) * 2006-09-13 2008-03-20 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2009114010A1 *

Also Published As

Publication number Publication date
EP2254412A1 (en) 2010-12-01
CN102215682A (en) 2011-10-12
BRPI0822405A8 (en) 2018-06-05
WO2009114010A1 (en) 2009-09-17
JP2011525890A (en) 2011-09-29
IL208026A0 (en) 2010-12-30
BRPI0822405A2 (en) 2018-05-15

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20101004

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

A4 Supplementary search report drawn up and despatched

Effective date: 20120405

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 27/02 20060101ALI20120330BHEP

Ipc: A01N 43/04 20060101AFI20120330BHEP

Ipc: A61K 31/70 20060101ALI20120330BHEP

17Q First examination report despatched

Effective date: 20131217

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ELIXIR MEDICAL CORPORATION

18D Application deemed to be withdrawn

Effective date: 20161025