NO307053B1 - 0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivatene - Google Patents
0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivateneInfo
- Publication number
- NO307053B1 NO307053B1 NO951312A NO951312A NO307053B1 NO 307053 B1 NO307053 B1 NO 307053B1 NO 951312 A NO951312 A NO 951312A NO 951312 A NO951312 A NO 951312A NO 307053 B1 NO307053 B1 NO 307053B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- derivatives
- well
- pharmaceutical preparations
- preparations containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Dental Preparations (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929221220A GB9221220D0 (en) | 1992-10-09 | 1992-10-09 | Organic componds |
PCT/EP1993/002604 WO1994009010A1 (fr) | 1992-10-09 | 1993-09-24 | Derives o-alkyles de la rapamycine et leur utilisation, en particulier comme immunosuppresseurs |
Publications (3)
Publication Number | Publication Date |
---|---|
NO951312D0 NO951312D0 (no) | 1995-04-05 |
NO951312L NO951312L (no) | 1995-06-08 |
NO307053B1 true NO307053B1 (no) | 2000-01-31 |
Family
ID=10723188
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951312A NO307053B1 (no) | 1992-10-09 | 1995-04-05 | 0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivatene |
NO2004001C NO2004001I2 (no) | 1992-10-09 | 2004-03-24 | 40-0-(2-hydroksy)etyl rapamycin (everolimus) |
NO2017067C NO2017067I2 (no) | 1992-10-09 | 2017-12-07 | Everolimus - forlenget SPC |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2004001C NO2004001I2 (no) | 1992-10-09 | 2004-03-24 | 40-0-(2-hydroksy)etyl rapamycin (everolimus) |
NO2017067C NO2017067I2 (no) | 1992-10-09 | 2017-12-07 | Everolimus - forlenget SPC |
Country Status (28)
Country | Link |
---|---|
US (2) | US5665772A (fr) |
EP (3) | EP1413581A1 (fr) |
JP (2) | JP3117462B2 (fr) |
KR (2) | KR100308598B1 (fr) |
AT (2) | ATE272063T1 (fr) |
AU (1) | AU676198B2 (fr) |
BR (1) | BR1100353A (fr) |
CA (2) | CA2145383C (fr) |
CY (2) | CY2125B1 (fr) |
CZ (1) | CZ283333B6 (fr) |
DE (3) | DE69333577T2 (fr) |
DK (2) | DK0867438T3 (fr) |
ES (2) | ES2124793T3 (fr) |
FI (2) | FI109540B (fr) |
FR (1) | FR04C0012I2 (fr) |
GB (1) | GB9221220D0 (fr) |
GE (1) | GEP20002331B (fr) |
HU (1) | HU224074B1 (fr) |
LU (1) | LU91104I2 (fr) |
NL (1) | NL300154I2 (fr) |
NO (3) | NO307053B1 (fr) |
NZ (1) | NZ256026A (fr) |
PL (1) | PL176174B1 (fr) |
PT (1) | PT867438E (fr) |
RO (1) | RO114451B1 (fr) |
RU (1) | RU2143434C1 (fr) |
SK (2) | SK285256B6 (fr) |
WO (1) | WO1994009010A1 (fr) |
Families Citing this family (422)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA935111B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
ZA935110B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
JPH08509499A (ja) | 1993-04-23 | 1996-10-08 | アボツト・ラボラトリーズ | ラパマイシン結合体及び抗体 |
USRE37421E1 (en) | 1993-07-16 | 2001-10-23 | Smithkline Beecham Corporation | Rapamycin derivatives |
SI1033128T2 (sl) * | 1993-09-28 | 2012-02-29 | Scherer Gmbh R P | Izdelava mehke Ĺľelatinaste kapsule |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
JP4105761B2 (ja) * | 1993-11-19 | 2008-06-25 | アボット・ラボラトリーズ | ラパミシン(マクロライド)の半合成類似体免疫調節剤 |
WO1995016691A1 (fr) * | 1993-12-17 | 1995-06-22 | Sandoz Ltd. | Derives de rapamycine utilises comme immonosuppresseurs |
GB9405350D0 (en) * | 1994-03-18 | 1994-05-04 | Sandoz Ltd | Organic compounds |
CZ289773B6 (cs) * | 1994-10-26 | 2002-04-17 | Novartis Ag | Farmaceutický prostředek pro místní aplikaci |
US7205279B2 (en) * | 1995-10-25 | 2007-04-17 | Novartis Ag | Pharmaceutical compositions |
MY129435A (en) | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
CA2219659C (fr) | 1995-06-09 | 2008-03-18 | Novartis Ag | Derives de rapamycine |
FR2736550B1 (fr) * | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
GB9606452D0 (en) * | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
KR100616020B1 (ko) * | 1996-03-27 | 2007-01-31 | 노파르티스 아게 | 맥관장애및이종이식술에서의라파마이신유도체의용도 |
NZ333657A (en) * | 1996-07-30 | 2000-05-26 | Novartis Ag | A pharmaceutical composition comprising cyclosporin A and 40-O-(2-hydroxyethyl)-rapamycin |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
WO1998009970A2 (fr) * | 1996-09-09 | 1998-03-12 | American Home Products Corporation | Derives de rapamycine alkyles |
GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
PT1421939E (pt) * | 1998-03-26 | 2010-07-12 | Astellas Pharma Inc | Preparaão da libertaão sustentada de um composto de macrëlido como tracolimus |
US20050031611A1 (en) * | 1998-05-08 | 2005-02-10 | Beth Israel Deaconess Medical Center | Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis |
AU5487499A (en) * | 1998-08-17 | 2000-03-06 | American Home Products Corporation | Photocyclized rapamycins |
US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
GB9826882D0 (en) * | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
US7276506B2 (en) * | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
US6946465B2 (en) * | 1999-02-02 | 2005-09-20 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
ATE474590T1 (de) | 1999-05-10 | 2010-08-15 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
PT1210350E (pt) * | 1999-08-18 | 2004-10-29 | Wyeth Corp | Esteres de sdz-rad soluveis em agua |
CA2383451A1 (fr) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | Analogues d'epirapamycine-28 |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
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US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
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US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
DE60142677D1 (de) | 2000-01-14 | 2010-09-09 | Univ Pennsylvania | O-methylierte rapamycinderivate zur milderung oder vermeidung lymphoproliferativer erkrankungen |
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US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
DE60134679D1 (de) | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
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ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
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US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
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US5378836A (en) * | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
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WO1995016691A1 (fr) * | 1993-12-17 | 1995-06-22 | Sandoz Ltd. | Derives de rapamycine utilises comme immonosuppresseurs |
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1992
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1993
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- 1993-09-24 WO PCT/EP1993/002604 patent/WO1994009010A1/fr active Application Filing
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1995
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1997
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- 1997-05-23 US US08/862,911 patent/US6440990B1/en not_active Expired - Fee Related
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1998
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1999
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2000
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2001
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2004
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2016
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2017
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