CA2863243A1 - Analogue de la rapamycine et procedes de fabrication associes - Google Patents
Analogue de la rapamycine et procedes de fabrication associes Download PDFInfo
- Publication number
- CA2863243A1 CA2863243A1 CA2863243A CA2863243A CA2863243A1 CA 2863243 A1 CA2863243 A1 CA 2863243A1 CA 2863243 A CA2863243 A CA 2863243A CA 2863243 A CA2863243 A CA 2863243A CA 2863243 A1 CA2863243 A1 CA 2863243A1
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Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/085631 WO2014082286A1 (fr) | 2012-11-30 | 2012-11-30 | Analogue de la rapamycine et procédés de fabrication associés |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2863243A1 true CA2863243A1 (fr) | 2014-06-05 |
Family
ID=50827071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2863243A Abandoned CA2863243A1 (fr) | 2012-11-30 | 2012-11-30 | Analogue de la rapamycine et procedes de fabrication associes |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2809675A4 (fr) |
| JP (1) | JP2016500112A (fr) |
| KR (1) | KR20150003156A (fr) |
| CN (1) | CN104854112A (fr) |
| AU (1) | AU2012395673A1 (fr) |
| CA (1) | CA2863243A1 (fr) |
| SG (1) | SG11201404432QA (fr) |
| WO (1) | WO2014082286A1 (fr) |
| ZA (1) | ZA201405746B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104327097B (zh) * | 2014-10-11 | 2017-02-08 | 福建省微生物研究所 | 雷帕霉素的三氮唑衍生物和用途 |
| CN104341434B (zh) * | 2014-10-16 | 2016-04-06 | 福建省微生物研究所 | 取代的雷帕霉素三氮唑衍生物和用途 |
| CN104557975B (zh) * | 2014-12-23 | 2017-06-20 | 连云港恒运医药有限公司 | 依维莫司中间体及其降解杂质的制备方法 |
| ES2666133T3 (es) | 2015-02-27 | 2018-05-03 | Warszawski Uniwersytet Medyczny | Derivado de protoescigenina, proceso de su preparación, uso de dicho compuesto y composición farmacéutica que comprende ese compuesto |
| CN104876944B (zh) * | 2015-05-13 | 2017-11-10 | 普济生物科技（台州）有限公司 | 一种依维莫司的制备方法 |
| EP3109250A1 (fr) * | 2015-06-23 | 2016-12-28 | Synbias Pharma AG | Procede pour la synthese de derives de rapamycine |
| EP3345601A4 (fr) * | 2015-09-03 | 2019-05-15 | Nippon Kayaku Kabushiki Kaisha | Composition pharmaceutique contenant de la rapamycine ou un dérivé de celle-ci |
| CN105481704A (zh) * | 2016-01-12 | 2016-04-13 | 西安近代化学研究所 | 一种键合剂n-炔丙基二乙醇胺的合成与提纯方法 |
| CN107759616B (zh) * | 2016-08-23 | 2020-11-17 | 上海微创医疗器械（集团）有限公司 | 一种化合物及其制备方法和用途 |
| TWI863657B (zh) * | 2017-04-05 | 2024-11-21 | 哈佛大學校長及研究員協會 | 巨環化合物及其用途 |
| CN110770243A (zh) * | 2017-05-02 | 2020-02-07 | 锐新医药公司 | 作为mtor抑制剂的雷帕霉素类似物 |
| CN109776569A (zh) * | 2017-11-14 | 2019-05-21 | 上海医药工业研究院 | 一种依维莫司的制备方法 |
| CN108484637A (zh) * | 2018-03-13 | 2018-09-04 | 福建省微生物研究所 | 靶向抗癌新药x-76成盐化合物及其用途、制备方法 |
| US20190336609A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors |
| MX2020011564A (es) | 2018-05-01 | 2021-01-29 | Revolution Medicines Inc | Analogos de rapamicina unidos a c26 como inhibidores de mtor. |
| CN109776571B (zh) * | 2019-01-31 | 2021-06-11 | 哈药慈航制药股份有限公司 | 一种雷帕霉素类似物及其制备方法和应用 |
| CN112057425A (zh) * | 2020-09-30 | 2020-12-11 | 严鹏科 | 一种雷帕霉素制剂及其制备方法 |
| US20240082249A1 (en) | 2022-05-25 | 2024-03-14 | Revolution Medicines, Inc. | Methods of treating cancer with an mtor inhibitor |
| CN115160343B (zh) * | 2022-06-09 | 2023-11-14 | 福建省微生物研究所 | 一种雷帕霉素衍生物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| AU4246197A (en) * | 1996-09-09 | 1998-03-26 | American Home Products Corporation | Rapamycin derivatives with unnatural stereochemistries |
| EP0927182A2 (fr) * | 1996-09-09 | 1999-07-07 | American Home Products Corporation | Derives de rapamycine alkyles |
| TW557297B (en) * | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
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2012
- 2012-11-30 CA CA2863243A patent/CA2863243A1/fr not_active Abandoned
- 2012-11-30 JP JP2015544291A patent/JP2016500112A/ja active Pending
- 2012-11-30 WO PCT/CN2012/085631 patent/WO2014082286A1/fr not_active Ceased
- 2012-11-30 SG SG11201404432QA patent/SG11201404432QA/en unknown
- 2012-11-30 EP EP12889107.4A patent/EP2809675A4/fr not_active Withdrawn
- 2012-11-30 CN CN201280077424.7A patent/CN104854112A/zh active Pending
- 2012-11-30 AU AU2012395673A patent/AU2012395673A1/en not_active Abandoned
- 2012-11-30 KR KR20147024024A patent/KR20150003156A/ko not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2809675A4 (fr) | 2015-08-12 |
| WO2014082286A9 (fr) | 2014-11-13 |
| AU2012395673A1 (en) | 2014-08-14 |
| ZA201405746B (en) | 2015-11-25 |
| AU2012395673A8 (en) | 2015-06-11 |
| CN104854112A (zh) | 2015-08-19 |
| JP2016500112A (ja) | 2016-01-07 |
| WO2014082286A1 (fr) | 2014-06-05 |
| KR20150003156A (ko) | 2015-01-08 |
| EP2809675A1 (fr) | 2014-12-10 |
| SG11201404432QA (en) | 2014-10-30 |
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