AU4246197A - Rapamycin derivatives with unnatural stereochemistries - Google Patents

Rapamycin derivatives with unnatural stereochemistries

Info

Publication number
AU4246197A
AU4246197A AU42461/97A AU4246197A AU4246197A AU 4246197 A AU4246197 A AU 4246197A AU 42461/97 A AU42461/97 A AU 42461/97A AU 4246197 A AU4246197 A AU 4246197A AU 4246197 A AU4246197 A AU 4246197A
Authority
AU
Australia
Prior art keywords
stereochemistries
unnatural
rapamycin derivatives
rapamycin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU42461/97A
Inventor
Craig Eugene Caufield
Alexander Aleksey Grinfield
David Cheng Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of AU4246197A publication Critical patent/AU4246197A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU42461/97A 1996-09-09 1997-09-02 Rapamycin derivatives with unnatural stereochemistries Abandoned AU4246197A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70931896A 1996-09-09 1996-09-09
US08709318 1996-09-09
PCT/US1997/015438 WO1998009972A1 (en) 1996-09-09 1997-09-02 Rapamycin derivatives with unnatural stereochemistries

Publications (1)

Publication Number Publication Date
AU4246197A true AU4246197A (en) 1998-03-26

Family

ID=24849355

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42461/97A Abandoned AU4246197A (en) 1996-09-09 1997-09-02 Rapamycin derivatives with unnatural stereochemistries

Country Status (2)

Country Link
AU (1) AU4246197A (en)
WO (1) WO1998009972A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
TW557297B (en) * 1997-09-26 2003-10-11 Abbott Lab Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
US7455853B2 (en) 1998-09-24 2008-11-25 Abbott Cardiovascular Systems Inc. Medical devices containing rapamycin analogs
WO2001014387A1 (en) 1999-08-24 2001-03-01 Ariad Gene Therapeutics, Inc. 28-epirapalogs
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EP2407473A3 (en) 2002-02-01 2012-03-21 ARIAD Pharmaceuticals, Inc Method for producing phosphorus-containing compounds
ES2296063T3 (en) * 2002-07-16 2008-04-16 Biotica Technology Limited PRODUCTION OF POLYCHETHYDES AND OTHER NATURAL PRODUCTS.
WO2004060283A2 (en) 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US20070203169A1 (en) * 2006-02-28 2007-08-30 Zhao Jonathon Z Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same
US7622477B2 (en) * 2006-02-28 2009-11-24 Cordis Corporation Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same
US9321782B2 (en) * 2010-08-04 2016-04-26 Meril Life Sciences Pvt. Ltd. Process for preparation of novel 42-O-(heteroalkoxyalkyl) rapamicin compounds with anti-proliferative properties
CN102718777B (en) * 2012-06-21 2014-03-12 福建省微生物研究所 Method for preparing iodo sirolimus crystals
JP2016500112A (en) * 2012-11-30 2016-01-07 ハンジョウ ジロックス ファーマ カンパニー リミテッドＨａｎｇｚｈｏｕ Ｚｙｌｏｘ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． Rapamycin analogs and methods for their production
CN103739616B (en) * 2013-12-27 2015-12-30 福建省微生物研究所 Containing thiazolyl rapamycin type derivative and application thereof
CN104327097B (en) * 2014-10-11 2017-02-08 福建省微生物研究所 Triazole derivatives of rapamycin and application
CA2988593C (en) 2015-06-16 2023-10-24 Nanophagix LLC Drug delivery and imaging chemical conjugate, formulations and methods of use thereof
CN114539288B (en) * 2020-11-24 2024-01-30 鲁南制药集团股份有限公司 Preparation method of everolimus
CN115340560B (en) * 2022-06-14 2024-04-02 福建省微生物研究所 Sirolimus analogue and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164399A (en) * 1991-11-18 1992-11-17 American Home Products Corporation Rapamycin pyrazoles
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5525610A (en) * 1994-03-31 1996-06-11 American Home Products Corporation 42-Epi-rapamycin and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
WO1998009972A1 (en) 1998-03-12

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