JP4934197B2 - ブルートンチロシンキナーゼ阻害剤 - Google Patents
ブルートンチロシンキナーゼ阻害剤 Download PDFInfo
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- JP4934197B2 JP4934197B2 JP2009529166A JP2009529166A JP4934197B2 JP 4934197 B2 JP4934197 B2 JP 4934197B2 JP 2009529166 A JP2009529166 A JP 2009529166A JP 2009529166 A JP2009529166 A JP 2009529166A JP 4934197 B2 JP4934197 B2 JP 4934197B2
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- Prior art keywords
- compound
- formula
- substituted
- tyrosine kinase
- alkyl
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- 0 CC(C)*N(*)C(C)C Chemical compound CC(C)*N(*)C(C)C 0.000 description 11
- CLXHRDKUVCHURW-QGZVFWFLSA-N C=CC(N(CC1)C[C@@H]1[n](c1ncnc(N)c11)nc1-c(cc1)ccc1Oc1ccccc1)=O Chemical compound C=CC(N(CC1)C[C@@H]1[n](c1ncnc(N)c11)nc1-c(cc1)ccc1Oc1ccccc1)=O CLXHRDKUVCHURW-QGZVFWFLSA-N 0.000 description 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82672006P | 2006-09-22 | 2006-09-22 | |
| US60/826,720 | 2006-09-22 | ||
| US82859006P | 2006-10-06 | 2006-10-06 | |
| US60/828,590 | 2006-10-06 | ||
| PCT/US2006/049626 WO2008039218A2 (en) | 2006-09-22 | 2006-12-28 | Inhibitors of bruton's tyrosine kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155965A Division JP5193256B2 (ja) | 2006-09-22 | 2010-07-08 | ブルートンチロシンキナーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010504324A JP2010504324A (ja) | 2010-02-12 |
| JP2010504324A5 JP2010504324A5 (enExample) | 2010-08-26 |
| JP4934197B2 true JP4934197B2 (ja) | 2012-05-16 |
Family
ID=39225888
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529166A Active JP4934197B2 (ja) | 2006-09-22 | 2006-12-28 | ブルートンチロシンキナーゼ阻害剤 |
| JP2010155965A Active JP5193256B2 (ja) | 2006-09-22 | 2010-07-08 | ブルートンチロシンキナーゼ阻害剤 |
| JP2012049524A Active JP5635544B2 (ja) | 2006-09-22 | 2012-03-06 | ブルートンチロシンキナーゼ阻害剤 |
| JP2012286719A Active JP5718890B2 (ja) | 2006-09-22 | 2012-12-28 | ブルートンチロシンキナーゼ阻害剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155965A Active JP5193256B2 (ja) | 2006-09-22 | 2010-07-08 | ブルートンチロシンキナーゼ阻害剤 |
| JP2012049524A Active JP5635544B2 (ja) | 2006-09-22 | 2012-03-06 | ブルートンチロシンキナーゼ阻害剤 |
| JP2012286719A Active JP5718890B2 (ja) | 2006-09-22 | 2012-12-28 | ブルートンチロシンキナーゼ阻害剤 |
Country Status (28)
| Country | Link |
|---|---|
| US (49) | US7514444B2 (enExample) |
| EP (11) | EP2443929A1 (enExample) |
| JP (4) | JP4934197B2 (enExample) |
| KR (4) | KR20100051863A (enExample) |
| CN (4) | CN101805341B (enExample) |
| AT (1) | ATE531263T1 (enExample) |
| AU (2) | AU2006348662B8 (enExample) |
| BE (1) | BE2015C016I2 (enExample) |
| BR (2) | BRPI0622054B8 (enExample) |
| CA (3) | CA2847852A1 (enExample) |
| CY (11) | CY1112513T1 (enExample) |
| DK (7) | DK2529622T3 (enExample) |
| EA (3) | EA024255B1 (enExample) |
| ES (8) | ES2673973T3 (enExample) |
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| EP2854859B1 (en) | 2012-06-04 | 2026-02-25 | Pharmacyclics LLC | Crystalline forms of a bruton's tyrosine kinase inhibitor |
| EP3550031A1 (en) | 2012-07-24 | 2019-10-09 | Pharmacyclics, LLC | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| RU2705204C2 (ru) | 2013-05-30 | 2019-11-06 | Инфинити Фармасьютикалз, Инк. | Лечение злокачественных опухолей с использованием модуляторов изоформ piз-киназы |
| WO2015017812A1 (en) | 2013-08-02 | 2015-02-05 | Pharmacyclics, Inc. | Methods for the treatment of solid tumors |
| MX2016005283A (es) | 2013-10-25 | 2017-02-20 | Pharmacyclics Llc | Tratamiento que utiliza inhibidores de tirosina quinasa de bruton e inmunoterapia. |
| CN106008514A (zh) | 2014-01-29 | 2016-10-12 | 苏州晶云药物科技有限公司 | 依鲁替尼的新晶型及其制备方法 |
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| JP2013060466A (ja) * | 2006-09-22 | 2013-04-04 | Pharmacyclics Inc | ブルートンチロシンキナーゼ阻害剤 |
| JP2013253089A (ja) * | 2007-03-28 | 2013-12-19 | Pharmacyclics Inc | ブルトンチロシンキナーゼインヒビター |
| US10653696B2 (en) | 2010-06-03 | 2020-05-19 | Pharmacyclics Llc | Use of inhibitors of bruton's tyrosine kinase (BTK) |
| US10004745B2 (en) | 2010-06-03 | 2018-06-26 | Pharmacyclics Llc | Use of inhibitors of Bruton'S tyrosine kinase (Btk) |
| US11672803B2 (en) | 2010-06-03 | 2023-06-13 | Pharmacyclics Llc | Use of inhibitors of Brutons tyrosine kinase (Btk) |
| US10751342B2 (en) | 2010-06-03 | 2020-08-25 | Pharmacyclics Llc | Use of inhibitors of Bruton's tyrosine kinase (Btk) |
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| US10478439B2 (en) | 2010-06-03 | 2019-11-19 | Pharmacyclics Llc | Use of inhibitors of bruton's tyrosine kinase (Btk) |
| US10004746B2 (en) | 2010-06-03 | 2018-06-26 | Pharmacyclics Llc | Use of inhibitors of Bruton's tyrosine kinase (Btk) |
| US10016435B2 (en) | 2010-06-03 | 2018-07-10 | Pharmacyclics Llc | Use of inhibitors of Bruton's tyrosine kinase (Btk) |
| US9273051B2 (en) | 2011-12-30 | 2016-03-01 | Pharmacyclics Llc | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| US10954567B2 (en) | 2012-07-24 | 2021-03-23 | Pharmacyclics Llc | Mutations associated with resistance to inhibitors of Bruton's Tyrosine Kinase (BTK) |
| JP2015536950A (ja) * | 2012-11-02 | 2015-12-24 | ファーマサイクリックス,インク. | Tecファミリーキナーゼ阻害剤アジュバント療法 |
| US9421208B2 (en) | 2013-08-02 | 2016-08-23 | Pharmacyclics Llc | Methods for the treatment of solid tumors |
| US9624224B2 (en) | 2013-09-30 | 2017-04-18 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
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